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    Buffalo, NY Medical Office Space for Sale

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    Accessible Two-Story Office Building
    Updated: May 21
    Accessible Two-Story Office Building

    1609 Genesee Street, Buffalo, NY 14211

    $499,900
    5,012 sqft 0.43 AC lot
    5,012 SF two‑story brick office building on a 0.43‑acre lot
    Valid Certificate of Occupancy with flexible office and multipurpose layouts
    Full elevator, wheelchair ramp, and wide hallways for accessible circulation
    Four bathrooms, with two on each floor, plus dedicated laundry areas
    Oversized parking lot with 25+ spaces and multiple entry points
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    Mixed-Use Property with Office
    Updated: Jul 27
    Mixed-Use Property with Office

    3723 Seneca Street, Buffalo, NY 14224

    $359,900
    3,472 sqft 0.38 AC lot
    3,472‑square‑foot mixed‑use building on a 0.3834‑acre lot
    Lower‑level physician’s office with waiting room, reception area, and 3 private rooms
    Upstairs 2‑bedroom, 1‑bath apartment
    Additional lot included; backs up to the West Seneca soccer fields
    Newer electric, roof, siding, furnaces, and air conditioning
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    Mixed-Use Property with Dental Office
    Mixed-Use Property with Dental Office

    484 Ontario Street, Buffalo, NY 14207

    $194,900
    4,785 sqft 0.08 AC lot

    Operating dental office with an upstairs three-bedroom apartment and updated building systems.

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    Spacious Commercial Building in Buffalo
    Spacious Commercial Building in Buffalo

    1609 Genesee Street, Buffalo, NY 14211

    $499,900
    5,012 sqft 0.43 AC lot

    Versatile 5,012 sq ft building ideal for various businesses.

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    Mixed-Use Property with Dental Office
    Mixed-Use Property with Dental Office

    484 Ontario Street, Buffalo, NY 14207

    $194,900
    4,785 sqft 0.08 AC lot

    Two-level property combines an operating dental practice with an upstairs residential apartment and updated building systems.

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    Mixed-Use Property with Apartments
    Mixed-Use Property with Apartments

    Buffalo, NY 14226

    $799,000
    0.34 AC lot

    Former medical-office space combines with two apartments and potential owner occupancy.

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    Gutted Mixed-Use Property
    Gutted Mixed-Use Property

    2746 Main Street, Buffalo, NY 14214

    $250,000
    2,241 sqft 0.22 AC lot

    Flexible Buffalo property with commercial, residential, and mixed-use potential, plus a detached garage and paved rear area.

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    Mixed-Use Office and Residential Duplex
    Mixed-Use Office and Residential Duplex

    2533 Sheridan Dr, Buffalo, NY 14150

    Contact for pricing
    4,380 sqft

    High-visibility property with first-floor medical or professional office space and second-floor office or two residential units.

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    Medical Office Building with Adjacent Lot
    Medical Office Building with Adjacent Lot

    3083 William Street, Buffalo, NY 14227

    Contact for pricing
    6,400 sqft

    Partially leased medical-focused office building with an adjacent developable parcel for expansion or additional parking.

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    Medical Office with Dental Buildout
    Medical Office with Dental Buildout

    476 Hertel Ave, Buffalo, NY 14207

    Contact for pricing
    3,685 sqft 0.40 AC lot

    Medical office space featuring a dental buildout and parking.

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    Historic Mixed-Use Church Property
    Historic Mixed-Use Church Property

    360 Genesee St, Buffalo, NY 14204

    $880,000
    16,438 sqft

    Historic church with a medical suite, dining hall, kitchen, and three on-site apartments, plus off-street parking.

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    Stabilized Medical Office NNN Building
    Stabilized Medical Office NNN Building

    2556 Delaware Ave, Buffalo, NY 14216

    Contact for pricing
    4,921 sqft

    Fully leased corner medical office building is stabilized on NNN terms with a tenant extending through 2031.

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    Renovated Office Space Near Campus
    Renovated Office Space Near Campus

    11 Summer St, Buffalo, NY

    Contact for pricing
    2,740 sqft 0.57 AC lot

    Renovated office space suitable for medical or standard offices.

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    Four-Story Medical/Office Building
    Four-Story Medical/Office Building

    11 Summer St, Buffalo, NY 14209

    Contact for pricing
    20,425 sqft

    Four-story building with turnkey first-floor suite and recently completed medical buildouts on floors two and three.

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    Mixed-Use Building With Apartment
    Mixed-Use Building With Apartment

    3723 Seneca Street, West Seneca, NY 14224

    $359,900

    Ground-floor office space is paired with an upstairs residential unit and additional land adjoining soccer fields.

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    Single-Tenant Medical NNN Property
    Single-Tenant Medical NNN Property

    2550 Delaware Ave, Buffalo, NY 14216

    Contact for pricing
    8,650 sqft

    Stabilized NNN investment featuring a single credit medical tenant with ample parking and Delaware Avenue frontage.

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    Remodeled Medical/Office Property in Elmwood Village
    Remodeled Medical/Office Property in Elmwood Village

    142 Bidwell Pkwy, Buffalo, NY

    Contact for pricing
    2,643 sqft 0.08 AC lot

    High-end medical/office property in Buffalo's Elmwood Village.

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    Mixed-Use Property with Apartments
    Mixed-Use Property with Apartments

    2148 Main Street, Buffalo, NY 14214

    $499,777

    Former medical office, two remodeled apartments, attic storage, and multiple garage spaces support varied occupancy.

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    Office Building for Office or Medical Use
    Office Building for Office or Medical Use

    1430 Colvin Blvd, Buffalo, NY 14223

    Contact for pricing
    3,821 sqft

    Versatile office building zoned A and fully leased at 100% occupancy, built in 1979.

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    Office/Medical Building Near Medical Campus
    Office/Medical Building Near Medical Campus

    235 North St, Buffalo, NY 14201

    Contact for pricing
    19,000 sqft

    Office/medical building near Buffalo Medical Campus with private parking.

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    Two-Story Medical Office Building
    Two-Story Medical Office Building

    825 Wehrle Dr, Buffalo, NY 14221

    Contact for pricing
    11,822 sqft

    Class A medical office includes exam rooms, reception area, conference rooms, and ample on-site parking.

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    South Buffalo Retail/Office/Medical Space
    South Buffalo Retail/Office/Medical Space

    184 Abbott Rd, Buffalo, NY

    Contact for pricing
    5,666 sqft 0.68 AC lot

    5,666 SF retail, medical, or office space in Buffalo.

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    Based on your search, we've compiled Potential Opportunities for your consideration. Besides 22 Active Listings in Buffalo, NY, we suggest to view alternatives - similar 50 Off-Market properties to explore as potential leads.

    Off-Market Properties in Buffalo, NY

    Consider similar Off-Market properties in Buffalo, NY. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    2497 Delaware Ave
    MEDICAL CLINIC

    2497 Delaware Ave, Buffalo, NY 14216-1712

    $1,595,000
    Estimated value
    7,583 sqft 0.54 AC lot
    View details
    235 North St
    Medical Office Space

    235 North St, Buffalo, NY 14201

    Value Estimation by Request
    19,000 sqft 0.75 AC lot
    View details

    Buffalo, NY Medical Office Space Market Trends and Statistics

    Explore 72 medical office space for sale in Buffalo, NY, showcased through 22 active listings on our real estate platform. These investment opportunities span a total of 135,898 square feet of properties for sale, with an estimated market value of $4,538,177.

    Sale prices for medical spaces in Buffalo, NY start at $194,900, averaging $453,817, and reaching up to $880,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 284
    Office buildings 145
    Medical Office Space 79
    Coworking space 10
    Creative space 6

    Demographics Overview

    Population 586K
    Population Growth (5Y) +6.8%
    Median Household Income $63,542
    College Educated 37.6%

    High-Yield Neighborhoods for Investment

    Identify Buffalo submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    14207 $194.9K
    14221 $300K
    14224 $370K
    14214 $399K
    14211 $499.9K

    Taxes & Financing

    Tax Rate (average for all types) 2.47%
    Property Tax per SF $30.36 per SF
    Tax Rate vs County Average 1.02 pp below county avg
    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Erie County

    New Delisted

    Total CRE Inventory on Market (SF)

    Average Property Price per SF

    For-sale pricing trends across core commercial property types in Erie County

    Retail

    Residential Income

    Property Size Breakdown

    The majority of commercial real estate listings in Buffalo fall within the 10,000 to 25,000 square foot range.

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    Most Searched ZIP Codes in Buffalo, NY

    • 14207
    • 14211
    • 14214
    • 14216
    • 14224
    • 14150
    • 14201
    • 14204
    • 14209
    • 14221
    • 14223

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