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    Buffalo, NY Mixed-use Properties for Sale

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    Tonawanda, NY Lancaster, NY Amherst, NY
    63 results
    Five-Unit Mixed-Use Building
    $699,900
    3,641 SF
    Five-Unit Mixed-Use Building

    4444 Main Street, Buffalo, NY 14226

    Fully renovated five-unit mix of office and retail/studio spaces with on-site parking and multiple private entrances.
    • 5‑unit mixed‑use commercial building on Main Street
    • Lower level includes two office suites with multiple rooms and private office/waiting areas
    • First floor offers two commercial spaces: front unit with private entrance and large windows; rear unit with open layout and reception area
    • Second floor features an executive office suite with private offices, waiting area, and conference room
    • On‑site parking lot for approx. 9 spaces; two shared restrooms on the main level
    Updated: Apr 14
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    Harlem Road Commercial Opportunity
    $519,999
    6,119 SF
    Harlem Road Commercial Opportunity

    1113- 1125 Harlem Road, Buffalo, NY 14227

    6,119 Sqft building on 0.62-acre lot in high-traffic location.
    • High‑traffic location on Harlem Road near Clinton with excellent visibility and frontage.
    • 6,119 Sqft of flexible building space on a 0.62‑acre lot suitable for office, retail, service business, or mixed‑use redevelopment.
    • Ample on‑site parking and convenient ingress/egress.
    • Centrally located near major highways, shopping, and restaurants.
    • Solid structure built in 1930 with potential for future expansion or site improvements.
    Updated: Nov 14, 2025
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    Harlem Road Commercial Opportunity
    $519,999
    6,119 SF
    Harlem Road Commercial Opportunity

    High-traffic location suitable for office, retail, or mixed-use redevelopment.

    1113- 1125 Harlem Road, Buffalo, NY 14227

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    Mixed-Use Building with Retail Spaces
    $425,000
    6,787 SF
    Mixed-Use Building with Retail Spaces

    Affordable mixed-use building with ample parking, featuring ground-floor commercial space and two second-floor apartments.

    2895 Seneca Street, West Seneca, NY 14224

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    Mixed-Use Building in West Seneca
    $425,000
    6,787 SF
    Mixed-Use Building in West Seneca

    Mixed-use building with commercial spaces and apartments, fully rented.

    2895 Seneca Street, West Seneca, NY 14224

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    Main Street Mixed-Use Investment
    $399,000
    4,620 SF
    Main Street Mixed-Use Investment

    High-visibility mixed-use property with income potential on Main Street.

    2290 Main Street, Buffalo, NY 14214

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    Mixed-Use Building on Bailey Avenue
    $425,000
    10,541 SF
    Mixed-Use Building on Bailey Avenue

    10,541 SF mixed-use building with retail and warehouse space.

    2824 Bailey Ave, Buffalo, NY 14215

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    Versatile Mixed-Use Investment Opportunity
    $259,900
    4,002 SF
    Versatile Mixed-Use Investment Opportunity

    Mixed-use property with commercial space and remodeled residential unit.

    543 S Park Avenue, Buffalo, NY 14204

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    Mixed-Use Building with Updated Retail
    $225,000
    4,275 SF
    Mixed-Use Building with Updated Retail

    Three-unit mixed-use building with updated retail space and apartments.

    662 Hertel Avenue, Buffalo, NY 14207

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    Mixed-Use Building with Vacant Storefronts
    $449,900
    4,515 SF
    Mixed-Use Building with Vacant Storefronts

    Two vacant storefronts and four updated 1-bedroom apartments offer leasing flexibility on Seneca Street.

    2096 Seneca Street, Buffalo, NY 14210

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    Two-Story Retail and Apartment Property
    $449,900
    7,748 SF
    Two-Story Retail and Apartment Property

    Two updated buildings combine street-level retail with three-bedroom apartments above, supporting multiple revenue streams.

    2342 Seneca Street, Buffalo, NY 14210

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    Mixed-Use Storefront with Apartment
    $149,900
    2,806 SF
    Mixed-Use Storefront with Apartment

    Two-level property offers a storefront below and a 3-bedroom rental unit on top, currently under major rehab.

    2346 Seneca Street, Buffalo, NY 14210

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    Renovated Mixed-Use Building, Buffalo
    $499,000
    2,626 SF
    Renovated Mixed-Use Building, Buffalo

    Fully renovated mixed-use building in a convenient Buffalo location.

    970 Sycamore Street, Buffalo, NY 14212

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    Mixed-Use Property Near Larkin Square
    $249,000
    3,408 SF
    Mixed-Use Property Near Larkin Square

    Mixed-use property with recent improvements, near Larkin Square.

    995 Exchange Street, Buffalo, NY 14210

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    Mixed-Use Property Near New Development
    $259,900
    4,002 SF
    Mixed-Use Property Near New Development

    Investment opportunity near new apartments, suitable for various businesses.

    543 S Park Avenue, Buffalo, NY 14204

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    Elmwood Village Mixed-Use Investment
    $449,000
    4,746 SF
    Elmwood Village Mixed-Use Investment

    Mixed-use property in desirable location with income and appreciation potential.

    1094 Elmwood Avenue, Buffalo, NY 14222

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    Mixed-Use Building with Renovation Potential
    $199,000
    6,100 SF
    Mixed-Use Building with Renovation Potential

    Five-unit mixed-use building with renovation and income growth potential.

    696 Genesee Street, Buffalo, NY 14211

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    Mixed-Use Property in Buffalo, NY
    $149,000
    4,160 SF
    Mixed-Use Property in Buffalo, NY

    Versatile mixed-use property with established bar/restaurant and residential income.

    1263 Clinton Street, Buffalo, NY 14206

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    Mixed-Use Property in Buffalo, NY
    $149,000
    4,160 SF
    Mixed-Use Property in Buffalo, NY

    Mixed-use property with bar/restaurant and two apartments for sale.

    1263 Clinton Street, Buffalo, NY 14206

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    Tenant-Occupied Mixed-Use Building
    $249,900
    4,824 SF
    Tenant-Occupied Mixed-Use Building

    Mixed-use property with tenant-occupied retail and apartments, plus a vacant lot next door for expansion or parking.

    2322 Seneca Street, Buffalo, NY 14210

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    Mixed-Use Retail and Apartments
    $224,900
    4,001 SF
    Mixed-Use Retail and Apartments

    Tenant-occupied deli storefront with two-bedroom apartments, plus recent roof and commercial window replacements.

    1892 Seneca Street, Buffalo, NY 14210

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    Updated Mixed-Use Building
    $224,900
    4,517 SF
    Updated Mixed-Use Building

    Fully updated commercial space with tenant-occupied upper and lower 3-bedroom apartments.

    1890 Seneca Street, Buffalo, NY 14210

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    Mixed-Use Building on Corner Lot
    $450,000
    3,219 SF
    Mixed-Use Building on Corner Lot

    Versatile commercial building with retail, warehouse, and office space.

    2010 Eggert Rd, Eggertsville, NY 14226

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    Kaisertown Mixed-Use Investment Opportunity
    $199,900
    4,656 SF
    Kaisertown Mixed-Use Investment Opportunity

    Mixed-use property with storefront and residential units in Buffalo.

    2047 Clinton Street, Buffalo, NY 14206

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    Buffalo, NY Mixed-Use Properties Investment Opportunities Market Analysis

    Explore 72 mixed-use properties for sale in Buffalo, NY, showcased through 63 active listings on our real estate platform. These investment opportunities span a total of 421,893 square feet of properties for sale, with an estimated market value of $31,217,398.

    Sale prices for multi use buildings in Buffalo, NY start at $149,000, averaging $637,089, and reaching up to $2,650,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

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    Property Size Breakdown

    The majority of commercial real estate listings in Buffalo fall within the 10,000 to 25,000 square foot range.

    Demographics Overview

    Population 586K
    Population Growth (5Y) +6.8%
    Median Household Income $63,542
    College Educated 37.6%

    High-Yield Neighborhoods for Investment

    Identify Buffalo submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    14206 $159.9K
    14211 $199K
    14204 $259.9K
    14215 $282.5K
    14210 $306K

    Taxes & Financing

    Tax Rate (average for all types) 2.47%
    Property Tax per SF $30.36 per sq ft
    Tax Rate vs County Average 1.02 pp below county avg
    Average Loan-to-Value 65.0%

    Listings Trend

    Total CRE Area on Market Trend

    Average Price per SF — Residential Income

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    Most Searched ZIP Codes in Buffalo, NY

    • 14210
    • 14206
    • 14214
    • 14213
    • 14224
    • 14202
    • 14207
    • 14209
    • 14215
    • 14222
    • 14204

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