West Seneca, NY Medical Office Space for Sale

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27 properties

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Updated: May 21

Accessible Two-Story Office Building

1609 Genesee Street, Buffalo, NY 14211

$499,900

5,012 sqft 0.43 AC lot

5,012 SF two‑story brick office building on a 0.43‑acre lot
Valid Certificate of Occupancy with flexible office and multipurpose layouts
Full elevator, wheelchair ramp, and wide hallways for accessible circulation
Four bathrooms, with two on each floor, plus dedicated laundry areas
Oversized parking lot with 25+ spaces and multiple entry points

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Updated: Jul 27

Mixed-Use Property with Office

3723 Seneca Street, Buffalo, NY 14224

$359,900

3,472 sqft 0.38 AC lot

3,472‑square‑foot mixed‑use building on a 0.3834‑acre lot
Lower‑level physician’s office with waiting room, reception area, and 3 private rooms
Upstairs 2‑bedroom, 1‑bath apartment
Additional lot included; backs up to the West Seneca soccer fields
Newer electric, roof, siding, furnaces, and air conditioning

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Mixed-Use Property with Dental Office

484 Ontario Street, Buffalo, NY 14207

$194,900

4,785 sqft 0.08 AC lot

Operating dental office with an upstairs three-bedroom apartment and updated building systems.

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We check every for-sale listing in the county against comparable properties across the country. Most price about where you would expect. A few are worth a second look.

We check every listing here. A few are worth a second look.

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Medical Office Building

2084 Sheridan Dr, Buffalo, NY 14223

$599,900

4,500 sqft 0.38 AC lot

One-story medical office property with three suites, basement storage, and on-site parking along Sheridan Drive.

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Mixed-Use Property with Dental Office

484 Ontario Street, Buffalo, NY 14207

$194,900

4,785 sqft 0.08 AC lot

Two-level property combines an operating dental practice with an upstairs residential apartment and updated building systems.

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Gutted Mixed-Use Property

2746 Main Street, Buffalo, NY 14214

$250,000

2,241 sqft 0.22 AC lot

Interior is cleared for a buyer-directed commercial, residential, or mixed-use layout.

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Three-Story Office Building

1281 Union Road, West Seneca, NY 14224

$799,900

4,855 sqft

Elevator service reaches every level, supporting accessible circulation for occupants and visitors.

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Two-Story Office Building

1176 Main St, Buffalo, NY 14209

$1,400,000

22,228 sqft 0.58 AC lot

N-1C-zoned property with Main Street frontage and public transportation access.

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Medical Office with Upstairs Apartment

484 Ontario St, Buffalo, NY 14207

$194,900

4,785 sqft

Operating dental office with a separate three-bedroom apartment and multiple recent building-system updates.

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Mixed-Use Office and Residential Duplex

2533 Sheridan Dr, Buffalo, NY 14150

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4,380 sqft

High-visibility property with first-floor medical or professional office space and second-floor office or two residential units.

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Medical Office Building with Adjacent Lot

3083 William Street, Buffalo, NY 14227

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6,400 sqft

Partially leased medical-focused office building with an adjacent developable parcel for expansion or additional parking.

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Updated Office Unit with Private Offices

1161 Abbott Road, Buffalo, NY 14220

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3,458 sqft

Renovated professional space combines a practical office layout with accessible entry, on-site parking, and Abbott Road exposure.

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Medical Office with Dental Buildout

476 Hertel Ave, Buffalo, NY 14207

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3,685 sqft 0.40 AC lot

Medical office space featuring a dental buildout and parking.

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Renovated Historic Office Building

1131 Broadway, Buffalo, NY 14212

$850,000

Multi-floor office property with central HVAC, elevator service, and parking for 30 vehicles.

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Two-Suite Medical Office Property

721 Union Rd, West Seneca, NY 14224

$599,000

Upper- and lower-level suites support immediate occupancy for office or medical users.

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Stabilized Medical Office NNN Building

2556 Delaware Ave, Buffalo, NY 14216

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4,921 sqft

Fully leased corner medical office building is stabilized on NNN terms with a tenant extending through 2031.

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Renovated Office Space Near Campus

11 Summer St, Buffalo, NY

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2,740 sqft 0.57 AC lot

Renovated office space suitable for medical or standard offices.

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Four-Story Medical/Office Building

11 Summer St, Buffalo, NY 14209

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20,425 sqft

Four-story building with turnkey first-floor suite and recently completed medical buildouts on floors two and three.

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Mixed-Use Building With Apartment

3723 Seneca Street, West Seneca, NY 14224

$359,900

Ground-floor office space is paired with an upstairs residential unit and additional land adjoining soccer fields.

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Single-Tenant Medical NNN Property

2550 Delaware Ave, Buffalo, NY 14216

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8,650 sqft

Stabilized NNN investment featuring a single credit medical tenant with ample parking and Delaware Avenue frontage.

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Remodeled Medical/Office Property in Elmwood Village

142 Bidwell Pkwy, Buffalo, NY

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2,643 sqft 0.08 AC lot

High-end medical/office property in Buffalo's Elmwood Village.

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Mixed-Use Property with Apartments

2148 Main Street, Buffalo, NY 14214

$499,777

Former medical office, two remodeled apartments, attic storage, and multiple garage spaces support varied occupancy.

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Office Building for Office or Medical Use

1430 Colvin Blvd, Buffalo, NY 14223

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3,821 sqft

Versatile office building zoned A and fully leased at 100% occupancy, built in 1979.

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Historic Mixed-Use Church Property

360 Genesee Street, Buffalo, NY 14204

$880,000

Historic church with a medical suite, dining hall, kitchen, and three on-site apartments, plus off-street parking.

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West Seneca, NY Medical Office Space Market Trends and Statistics

Explore 28 medical office space for sale in West Seneca, NY, showcased through 27 active listings on our real estate platform. These investment opportunities span a total of 159,108 square feet of properties for sale, with an estimated market value of $7,682,977.

Sale prices for medical spaces in West Seneca, NY start at $194,900, averaging $548,784, and reaching up to $1,400,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 100K

Population Growth (5Y) +7.0%

Median Household Income $60,381

College Educated 30.9%

High-Yield Neighborhoods for Investment

Identify West Seneca submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
Buffalo - 14224	$586.3K

Listings Trend

New vs delisted commercial listings in Erie County

New Delisted

Total CRE Inventory on Market (SF)

Average Property Price per SF

For-sale pricing trends across core commercial property types in Erie County

Retail

Residential Income

Property Size Breakdown

The majority of commercial real estate listings in West Seneca fall within the 100,000+ square foot range.

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