Buffalo, NY Medical Office Space for Lease

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Cheektowaga, NY Tonawanda, NY Amherst, NY Town Of Tonawanda, NY North Tonawanda, NY Queens, NY Grand Island, NY Bowmansville, NY

24 properties

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Updated: Jun 11

Medical Office Space with Exam Rooms

4085 Seneca Street, Buffalo, NY 14224

$2,750/Mo

1,900 sqft 0.47 AC lot

1,900‑square‑foot medical office property on 0.47 acres
Four exam rooms, waiting room, and dedicated billing office
Individual rooms may be available for lease, subject to owner approval
Ample parking and accessible approach with ramp
Forced‑air heating with natural gas and central air conditioning

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Updated: Sep 5

New Retail Space Near I-90

6842 Main Street, Williamsville, NY 14221

$22 SF/Yr

2,000 sqft

2,000 SF retail space available for lease
Built in 2025
Suitable for retail, light medical, or small professional office use
Physical therapy and chiropractic uses specifically identified
Located at 6842 Main Street, Williamsville, NY 14221

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Private-Entrance Office Suite

4085 Seneca Street, West Seneca, NY 14224

$2,750/Mo

1,843 sqft

Flexible office space with private entrance, lobby, air conditioning, and handicap-accessible ramp in a four-office complex.

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West Seneca Medical/Office Space

220 Center Road, West Seneca, NY 14224

$4,000/Mo

4,500 sqft

4,500+/- SF medical/office space in high-traffic West Seneca location.

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Medical Office Suites

1829 Maple Road, Williamsville, NY 14221

$18 SF/Yr

Two available suite sizes, on-site parking, and natural light support a range of professional office configurations.

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Medical Office Suites

700 Michigan Ave., Buffalo, NY 14203

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3,500 sqft

Two adjacent medical office suites total 6,026 SF within a dedicated parking-equipped medical arts center.

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Medical Office Building with Adjacent Lot

3083 William St, Buffalo, NY 14227

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7,404 sqft

Medical-focused building with an adjacent parcel and second-floor office space.

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Medical Office Space with Flexible Layouts

400 International Dr, Buffalo, NY 14221

$19 SF/Yr

Lease modern medical office space with flexible layouts, modern finishes, and ample parking near major transportation routes.

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West Seneca Medical Office Suites

550 Orchard Park Road, West Seneca, NY 14224

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6,495 sqft

Medical office suites available for lease in West Seneca.

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Built-Out Medical Office Space

551 Farber Lakes Drive, Williamsville, NY 14221

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3,507 sqft

Specialized professional space includes medical office and spa-oriented improvements with dedicated building signage.

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Medical Office Suite on Second Floor

52 South Union Road, Williamsville, NY 14221

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7,162 sqft

7,162 SF second-floor office suite in a two-story, elevator-equipped medical/professional building with ample parking.

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Medical Office Space Available

700 Michigan Ave., Buffalo, NY 14203

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3,500 sqft

Medical office suites in downtown Buffalo near medical campus.

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Medical Office Suites

550 Orchard Park Rd, Buffalo, NY 14224

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2,550 sqft

Healthcare-focused office suites are available within Western New York Medical Park, featuring attractive common areas and ample parking.

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Medical Office Suite with Common Areas

550 Orchard Park Rd, West Seneca, NY 14224

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1,200 sqft

Healthcare office suite with common areas and vending options, plus ample parking.

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Modern Office/Medical Space Available

6691 - 6693 Transit Rd., Williamsville, NY 14221, Williamsville, NY 14221

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Modern office/medical space with ample parking and excellent accessibility.

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Updated Medical Space on Abbott

306 Abbott Road, Buffalo, NY 14220

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Updated medical space in South Buffalo's business district.

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Williamsville Medical Office Space Available

1150 Youngs Rd, Williamsville, NY 14221

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20,000 sqft

Well-located medical office space near Millard Fillmore Suburban Hospital.

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Medical Office Suite with Parking

550 Orchard Park Rd, Buffalo, NY 14224

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925 sqft

Office suite within a medical park featuring attractive common areas with vending and ample parking for visitors.

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Turnkey Medical Office Space

Buffalo, NY 14224

$15 SF/Yr

10,000 sqft

Well-appointed medical office space with ample parking near downtown.

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Medical Office Space Near Hospital

1630 Maple Rd, Buffalo, NY 14221

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1,400 sqft

Medical office suite with high visibility near Millard Fillmore Hospital.

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Medical Office Suite

550 Orchard Park Rd, Buffalo, NY 14224

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3,020 sqft

Healthcare-focused office space with shared common areas, vending options, and ample parking.

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Turnkey Medical Office Space Available

725 Orchard Park Rd, Buffalo, NY

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1,744 sqft 1.34 AC lot

Well-appointed medical office space for rent, 1744 square feet.

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Renovated Medical Hub with Amenities

6255 Sheridan Dr, Buffalo, NY

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7,167 sqft 2.93 AC lot

Newly renovated medical hub near healthcare organizations with on-site amenities.

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Medical Office Building with Multiple Suites

1177 Ridge Road, Lackawanna, NY 14218

$800-$3,000/Mo

3,842 sqft

Neighborhood commercial zoning permits office, medical, and dental office uses.

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Based on your search, we've compiled 24 Potential Opportunities for your consideration. Besides 24 Active listings in Buffalo, NY, we suggest exploring alternatives.

Buffalo, NY Medical Office Space Lease Rates & Market Statistics

Explore 24 Medical Office Space listings for lease in Buffalo, NY on Realmo, a commercial real estate exchange covering the Buffalo area. The current inventory totals 93,659 square feet of properties — an average of ~3,900 SF per listing.

Asking lease rates for Medical Office Space in Buffalo start at $2.50 SF/Yr, average $14.65 SF/Yr, and reach $22 SF/Yr at the top of the market. That's a 9x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $14.65 SF/Yr is 54% below the New York state average of $32.01 SF/Yr.

Buffalo accounts for 50% of the 48 medical office space listings currently available across Erie County, where nearby markets include Williamsville and Hamburg. Medical Office Space listings make up 15% of the 161 Office Spaces currently for lease in Buffalo, with asking rates in line with the citywide Office Spaces average. Tenants comparing options may also consider Office Units (118 listings) and Office buildings (27 listings) elsewhere in the Buffalo market.

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