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    South Carolina Office Spaces for Lease

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    Columbia, SC Greenville, SC Charleston, SC North Charleston, SC Spartanburg, SC Rock Hill, SC Myrtle Beach, SC Summerville, SC
    1,460 properties
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    Downtown Columbia Office Space Available
    Downtown Columbia Office Space Available

    1333 Main Street, Columbia, SC 29201

    $21.75 SF/Yr
    17,594 sqft

    Prime office space for rent in downtown Columbia.

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    Class A Office Space Available
    Class A Office Space Available

    1430 48th Avenue North, Myrtle Beach, SC 29577

    $30 SF/Yr
    20,000 sqft

    Class A office building with customizable floor plans for rent.

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    Mount Pleasant Office Space Available
    Mount Pleasant Office Space Available

    1671 Belle Isle Avenue, Mount Pleasant, SC 29464

    $26 SF/Yr
    2,227 sqft

    Office space available for lease in Mount Pleasant, SC.

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    Highway 290 Retail Development Space
    Highway 290 Retail Development Space

    1723 East Main Street, Duncan, SC 29334

    $40 SF/Yr
    9,850 sqft

    Retail/office space in growing Duncan market near Highway 290.

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    Columbia Office Building For Lease
    Columbia Office Building For Lease

    1628 Browning Road, Columbia, SC 29210

    $15.75 SF/Yr
    16,966 sqft 4.00 AC lot

    Class B office space with interstate visibility and modern amenities.

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    Myrtle Beach Office Space Available
    Myrtle Beach Office Space Available

    601 19th Avenue N,Unit 202A, Myrtle Beach, SC 29577

    $16 SF/Yr
    4,500 sqft

    Office space for lease near Myrtle Beach's financial corridor.

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    Standalone Office/Retail Building
    Standalone Office/Retail Building

    22 Sams Point Way, Beaufort, SC 29907

    $6,400/Mo
    1.94 AC lot

    +/-3,526 SF standalone building in Commercial zoning, gutted to the studs and ready for a tailored buildout.

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    Class A Office Space Available
    Class A Office Space Available

    1400 Browning Road, Columbia, SC 29210

    $20.75 SF/Yr
    35,838 sqft

    Premium office building with high-tech infrastructure and convenient access.

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    New Construction Office Suite
    New Construction Office Suite

    102-3369 Argent Blvd, Ridgeland, SC 29936

    $4,250/Mo
    1,500 sqft

    New office suite includes a conference room, five offices, storage, and kitchens, available by April 30, 2026.

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    Accessible Office Suite
    Accessible Office Suite

    9a Rue Du Bois, Beaufort, SC 29907

    $600/Mo

    Commercially zoned suite with shared restrooms and water, sewer, and electricity included in base rent.

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    Premier Office Complex in Columbia
    Premier Office Complex in Columbia

    300 Arbor Lake Drive, Columbia, SC 29223

    $12.50 SF/Yr
    20,733 sqft

    Centrally located office complex with amenities and interstate visibility.

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    Renovated Office Building
    Renovated Office Building

    812 W Whitner Street, Anderson, SC 29624

    $3,500/Mo
    0.76 AC lot

    A converted historic residence provides private offices, hardwood flooring, and substantial on-site parking.

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    Park Circle Freestanding Retail Building
    Park Circle Freestanding Retail Building

    1086 East Montague Avenue, North Charleston, SC 29405

    $35 SF/Yr
    1,800 sqft

    Freestanding building in Park Circle, ideal for retail or office.

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    North End Office Spaces
    North End Office Spaces

    100 Exchange Street, Hilton Head Island, SC 29926

    $22.50 SF/Yr
    4,335 sqft

    North end office spaces for lease in Hilton Head.

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    First-Floor Office Unit
    First-Floor Office Unit

    613 Carteret Street, Beaufort, SC 29902

    $5,000/Mo

    Glass storefront, dedicated side and rear parking, and an ADA-compliant restroom support professional office use.

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    West Columbia Office/Medical Suite
    West Columbia Office/Medical Suite

    3618 Sunset Blvd., West Columbia, SC 29169

    $18 SF/Yr
    12,000 sqft

    Office/medical suite for lease near Lexington Medical Hospital.

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    Rock Hill Retail/Office Space
    Rock Hill Retail/Office Space

    1029 Oakland Avenue, Rock Hill, SC 29732

    $2,000/Mo
    1,000 sqft

    Versatile 1,000 SF space near Winthrop University.

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    Downtown Greenville Office Space Available
    Downtown Greenville Office Space Available

    101 North Main Street, Greenville, SC 29601

    $36.50 SF/Yr
    18,457 sqft

    Office space for rent in downtown Greenville with amenities.

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    Updated Office Suite with Private Offices
    Updated Office Suite with Private Offices

    413 Vardry Street, Greenville, SC 29601

    $2,499/Mo
    0.15 AC lot

    Updated workspace includes private offices, conference facilities, reception, and an ADA bathroom.

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    Office Units with Parking
    Office Units with Parking

    712 N Fraser St, Georgetown, SC 29440

    $6,600/Mo
    7,200 sqft

    Subdividable office space is available within a commercial building with on-site parking.

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    Medical Office Space For Lease
    Medical Office Space For Lease

    161 Medical Circle, West Columbia, SC 29169

    $20 SF/Yr
    7,659 sqft

    Medical office space in prime healthcare corridor location.

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    Greenville Office Building For Rent
    Greenville Office Building For Rent

    84 Villa Road, Greenville, SC 29615

    $21.50 SF/Yr
    25,640 sqft 1.00 AC lot

    Up to 25,640 SF available near I-385.

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    Executive Office Units
    Executive Office Units

    5000 Woodside Executive Ct, Aiken, SC 29803

    $4,278/Mo
    8.00 AC lot

    Two suite configurations support office, medical, administrative, and related professional uses.

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    Rock Hill Coworking Space Available
    Rock Hill Coworking Space Available

    116 E Main St, Suite 201, Rock Hill, SC 29730

    $22 SF/Yr
    2,878 sqft

    Flexible coworking and dedicated desk space in vibrant Knowledge Park.

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