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    Florence, SC Office Spaces for Lease

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    Darlington, SC Timmonsville, SC Hartsville, SC
    14 results
    Adaptable Office Space in Florence
    $2,900/Mo
    3,100 SF
    Adaptable Office Space in Florence

    720 S Coit St, Florence, SC 29501

    Well-located office building for lease in a desirable professional location.
    • Prime location directly across from Timrod Park and minutes from downtown Florence.
    • Functional layout with multiple private offices, meeting room, and reception area.
    • Ample on‑site parking for employees and visitors.
    • Classic architectural character, hardwood floors, and abundant natural light.
    • Full kitchen and basement storage.
    Updated: May 6
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    Versatile Commercial Space in Florence
    $5,000/Mo
    11,390 SF
    Versatile Commercial Space in Florence

    374 Darlington St., Florence, SC 29501

    Commercial property with bay doors, ideal for automotive or warehouse.
    • Prime Downtown Florence, SC location
    • Multiple bay doors for easy access and operations
    • Versatile space suitable for automotive, warehouse, or service‑related businesses
    • Abundant open space for vehicles, equipment, or flexible use
    • Dedicated office space for administrative functions
    Updated: Oct 11, 2025
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    Florence Flex/Industrial Property for Lease
    Contact for pricing
    4,800 SF
    Florence Flex/Industrial Property for Lease

    4,800 SF flex/industrial building with drive-through capability and outside storage.

    3731 East National Cemetery Road, Florence, SC 29506

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    Commercial Office Space For Rent
    $1,950/Mo
    2,000 SF
    Commercial Office Space For Rent

    Office space available in Shoppes at Celebration shopping center.

    2527 S Cashua Dr, Florence, SC 29501

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    Modern Office Space For Rent
    $22 SF/Yr
    7,145 SF
    Modern Office Space For Rent

    7,145 SF customizable office space in Florence, SC.

    2701 Alex Lee Blvd, Florence, SC 29506

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    Refreshed Office Building For Lease
    $216 SF/Yr
    3,000 SF
    Refreshed Office Building For Lease

    Standalone office building with private parking near Downtown Florence, SC.

    620 W Evans St, Florence, SC 29501

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    New Office Space Available
    $26 SF/Yr
    3,600 SF
    New Office Space Available

    Shell space in a new building, build-out to suit.

    609 2nd Loop Rd, Florence, SC 29505

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    Downtown Florence Open Concept Office
    $226 SF/Yr
    Downtown Florence Open Concept Office

    Open concept office space with exceptional visibility in Downtown Florence.

    620 W Evans St, Florence, SC 29501

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    Office/Storage Space For Lease
    $10 SF/Yr
    2,300 SF
    Office/Storage Space For Lease

    Office or storage space with access to I-95 and I-20.

    1092 S Church St, Florence, SC 29506

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    Established Commercial Complex on Second Loop
    Contact for pricing
    2,000 SF
    Established Commercial Complex on Second Loop

    Multi-tenant commercial complex with high visibility and convenient access.

    1800 2nd Loop Rd, Florence, SC 29501

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    Florence Commercial Space For Rent
    Contact for pricing
    Florence Commercial Space For Rent

    Commercial space suitable for office, professional, or retail use.

    2843 W Palmetto Street Suite C, Florence, SC 29501

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    New Metal Building Near Highways
    Contact for pricing
    New Metal Building Near Highways

    Newly constructed flex/industrial/office space near major highways.

    2315 Prosperity Way, Florence, SC 29501

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    Modern Flex Space For Lease
    $11 SF/Yr
    2,450 SF
    Modern Flex Space For Lease

    Flex space with office and warehouse components available for lease.

    1838 Habersham Square, Florence, SC 29501

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    Prestigious Office Suites in Florence
    $25 SF/Yr
    4,453 SF
    Prestigious Office Suites in Florence

    Corporate office suites available for lease in Florence, SC.

    1831 W Evans St, Florence, SC 29501

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    Based on your search, we've compiled 42 Potential Opportunities for your consideration. Besides 14 Active listings in Florence, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 20 Properties for Sales.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Remodeled Office Building For Rent
    $1,800/Mo
    1,874 SF
    Remodeled Office Building For Rent

    Remodeled office building with high traffic count in Dillon, SC.

    1013 N Highway 301, Dillon, SC 29536

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    Office Space in Marion, SC
    $1,000/Mo
    2,000 SF
    Office Space in Marion, SC

    Office space featuring a reception area, offices, and conference room.

    1450 E Northside Avenue, Marion, SC 29571

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    Renovated Industrial Facility with Laydown
    Contact for pricing
    53,920 SF
    Renovated Industrial Facility with Laydown

    53,920 SF industrial facility with laydown area for lease.

    1317 E Main Street, Dillon, SC 29536

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    Industrial Warehouse with Office Space
    $11 SF/Yr
    3,600 SF
    Industrial Warehouse with Office Space

    Marion County warehouse with office, ideal for storage or manufacturing.

    Carol White Ct, Marion, SC 29571

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    Similar Spaces for Sale in Florence, SC

    Consider Similar Space for Sale. We found 20 Spaces matching your search parameters.

    Remodeled Commercial Building Near Downtown
    $320,000
    2,165 SF
    Remodeled Commercial Building Near Downtown

    Turnkey commercial property in prime location with excellent visibility.

    910 W Evans st, Florence, SC 29501

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    Historic Downtown Florence Commercial Building
    $2,700,000
    16,304 SF
    Historic Downtown Florence Commercial Building

    16,000 SF historic building in thriving downtown Florence.

    248-260 W Evans st., Florence, SC 29501

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    Prime Commercial Property on Palmetto
    $250,000
    1,405 SF
    Prime Commercial Property on Palmetto

    High-visibility commercial property on a high-traffic street in Florence.

    2228 W Palmetto St., Florence, SC 29501

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    Florence Office Building For Sale
    $1,500,000
    7,517 SF
    Florence Office Building For Sale

    7,517 SF office building on 1.34 acres in Florence.

    1706 Second Loop Rd., Florence, SC 29501

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    Florence Commercial Building on Evans
    $79,000
    1,200 SF
    Florence Commercial Building on Evans

    Standalone building on Evans Street with redevelopment potential.

    617 W Evans St, Florence, SC 29501

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    McLeod Physician Associates For Sale
    $1,384,320
    2,666 SF
    McLeod Physician Associates For Sale

    2,666 SF medical office in Florence, SC for sale.

    1540 American Dr, Florence, SC

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    Versatile Commercial Parcel Near Downtown
    $499,900
    67,518 SF
    Versatile Commercial Parcel Near Downtown

    Office, showroom, and warehouse space less than one mile from Downtown.

    121 N Lawson St, Florence, SC 29501

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    Medical Office Building Near MUSC
    $2,200,000
    7,950 SF
    Medical Office Building Near MUSC

    Medical office building near MUSC campus with ample parking.

    1929 Mountain Laurel Court, Florence, SC

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    Downtown Florence Business Technology Center
    $12,000,000
    119,567 SF
    Downtown Florence Business Technology Center

    Office building in downtown Florence with investment and value-add potential.

    187 E Evans St, Florence, SC

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    Standalone Industrial Building on Harrell
    $189,000
    40,000 SF
    Standalone Industrial Building on Harrell

    Industrial building suitable for fabrication, automotive, contractor, or storage.

    120 N Guerry St, Florence, SC 29501

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land in Murrells Inlet
    $2,500/Mo
    Commercial Land in Murrells Inlet

    1.49 acres of commercial land for lease.

    Inlet Square Dr., Murrells Inlet, SC 29576

    View details
    Land Lease Opportunity in Waxhaw
    $8,000/Mo
    Land Lease Opportunity in Waxhaw

    5.341-acre commercial land for lease in a high-growth area.

    5325 Waxhaw Marvin Road, Waxhaw, NC 28173

    View details
    Wilmington Corner Lot For Lease
    $9,000/Mo
    Wilmington Corner Lot For Lease

    Corner lot in Wilmington, NC, zoned for regional business.

    2726 Shipyard Boulevard, Wilmington, NC 28403

    View details
    Commercial Land with Water Frontage
    $4,500/Mo
    Commercial Land with Water Frontage

    Commercial land for rent with deep water frontage.

    Old Bridge Street, Jacksonville, NC 28540

    View details

    Florence, SC Office Spaces Leasing Opportunities Market Analysis

    Explore Office Spaces leasing options in Florence, SC with 14 listings featured on our commercial real estate exchange. The current inventory includes 39,438 square feet of properties with an estimated lease value of $338 /Mo.

    Estimated lease rates for Office Spaces in Florence, SC begin at $5 SF/Yr, with an average of $37 SF/Yr and extend to $216 SF/Yr.
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