Advertise
    South Carolina
    Medical Space

    Richland County, SC Medical Office Space for Lease

    Notify Me
    List
    Map
    Myrtle Beach, SC Greenville, SC Columbia, SC Charleston, SC North Charleston, SC Spartanburg, SC Rock Hill, SC Murrells Inlet, SC
    Found 17 medical office space listings for lease in Richland County, SC, averaging $23/SF/YR. Use lease type data to compare options faster.
    Sort:
    Turnkey Medical Office Suites
    Updated: Jun 2
    Turnkey Medical Office Suites

    4100 N. Main Street, Columbia, SC 29203

    $20 SF/Yr
    3,742 sqft
    1987‑built medical office with turnkey suites featuring exam rooms with plumbing
    Suite 101: ±2,484 SF available 8/1/26
    Suite 200: ±1,226 SF with reception, 3 exam rooms (with plumbing), 1 private office, and restroom
    Suite 201: ±2,516 SF with large reception/waiting area, 6 exam rooms (with plumbing), 2 private offices, IT/storage rooms, and restroom
    Major renovations in 2019 included new roof, building façade, and common area upgrades
    View details
    Two-Building Office Medical Park
    Updated: Jun 29
    Two-Building Office Medical Park

    3600 Forest Dr, Columbia, SC 29204

    $22 SF/Yr
    150,000 sqft
    Two‑building office/medical park totaling approximately 150,000 RSF (Year built 1973)
    Existing tenants include a mix of regional and local medical practices and general office users
    Ownership group plans significant building upgrades in 2026, including updated common areas and upgraded building façade improvements
    Planned improvements also include upgraded entrances and class A tenant amenities
    High visibility from Forest Drive and less than 5 minutes from downtown Columbia
    View details
    Medical Office Park Buildings
    Medical Office Park Buildings

    3700 Forest Dr, Columbia, SC 29204

    $22 SF/Yr
    600–1,000 people  3 spaces  150,000 sqft  Built 1973

    Two office/medical buildings comprise an approximately 150,000 RSF park on Forest Drive.

    View details
    Medical Office Space with Imaging Rooms
    Medical Office Space with Imaging Rooms

    74 Polo Rd, Columbia, SC 29223

    Triple net (NNN)
    Contact for pricing
    9,975 sqft
    Highway access

    Purpose-built medical suite with diagnostic rooms, laboratory space, private offices, and on-site parking.

    View details
    Medical Office Complex For Rent
    Medical Office Complex For Rent

    2750 Laurel St., 2601 Laurel St. & 1655 Bernardin Ave., Columbia, SC 29206

    Pinehurst Community Council
    $28 SF/Yr
    126,002 sqft

    Medical office complex in Columbia's Central Business District, renovated.

    View details
    Columbia Office/Medical Space For Lease
    Columbia Office/Medical Space For Lease

    120 & 122 Highland Center Dr., Columbia, SC 29203

    $21 SF/Yr
    20,822 sqft

    Office and medical space available for lease in Columbia, SC.

    View details
    Medical Office Suite
    Medical Office Suite

    125 ALPINE CIR, Columbia, SC 29223

    Contact for pricing
    5,017 sqft  brick
    Highway access  Road access

    The interior includes reception and waiting areas, private offices, exam rooms, and a separate staff-only section.

    On-site parking
    View details
    Medical Office Space with Exam Rooms
    Medical Office Space with Exam Rooms

    113-117 Barton Creek Ct, Columbia, SC 29223

    Gross
    Contact for pricing
    2,740 sqft

    Eight offices or exam rooms support clinical and administrative layouts.

    View details
    Downtown Medical Office Space
    Downtown Medical Office Space

    1331 Lady St, Columbia, SC 29201

    Downtown Neighborhood Association
    $25 SF/Yr
    Built 1949

    Medical office space for lease in downtown Columbia at the corner of Lady Street and Marion Street.

    View details
    Medical Office Suite with Private Offices
    Medical Office Suite with Private Offices

    101 Rice Bent Way, Columbia, SC 29229

    Triple net (NNN)
    Contact for pricing
    1,500 sqft

    Office suite includes five private offices, reception, conference room, break room, and two ADA restrooms.

    Reception room  Conference room  Break room
    View details
    Retail, Restaurant, or Medical Office
    Retail, Restaurant, or Medical Office

    2800 Rosewood Dr., Columbia, SC 29205

    Central Rosewood Neighborhood Association
    Contact for pricing
    24,000 sqft

    Located in a Publix-anchored shopping center with high visibility.

    View details
    Medical Office Space with New Roof
    Medical Office Space with New Roof

    90 Brighton Hill Rd, Columbia, SC 29223

    Triple net (NNN)
    Contact for pricing
    6,564 sqft  1.75 acres
    GC

    Flexible medical office space on a substantial commercial parcel with GC zoning and updated building systems.

    View details
    Medical Office Building For Sale
    Medical Office Building For Sale

    1701 Saint Julian Pl, Columbia, SC 29204

    Modified gross Shandon
    Contact for pricing
    14,442 sqft

    Medical office building with ample parking near medical campuses.

    View details
    Forest Acres Office Space Available
    Forest Acres Office Space Available

    4700 Forest Dr, Columbia, SC 29206

    Contact for pricing
    Built 1975

    Office space for rent in the heart of Forest Acres.

    View details
    Medical Office Space
    Medical Office Space

    8910 Two Notch Rd, Columbia, SC 29223

    Full service
    Contact for pricing
    28–47 people  1 space  7,072 sqft
    Highway access + Road access

    Professional office space available near major interstates and retail centers in northeast Columbia.

    View details
    Class A Medical Office Building
    Class A Medical Office Building

    2611 Forest Dr, Columbia, SC 29204

    Forest Hills Neighborhood
    Contact for pricing
    5,004 sqft

    Medical office building near MUSC Health Columbia Medical Center.

    View details
    Medical Office Suite with Exam Rooms
    Medical Office Suite with Exam Rooms

    2113 Adams Grove, Columbia, SC 29203

    Full service Booker Washington Heights Neighborhood
    Contact for pricing
    5,000 sqft

    Second-floor medical office suite with a central waiting area, nurses station, and multiple exam and procedure rooms.

    View details
    17 active listings match your search: Medical Office for lease in Richland County, SC. Based on your search, we've also compiled 11 Potential Opportunities for your consideration: 11 properties for sale.

    Similar Spaces for Sale in Richland County, SC

    Consider Similar Space for Sale. We found 11 Spaces matching your search parameters.

    Class A Medical Office Building
    Class A Medical Office Building

    140 Wildewood Park Dr, Columbia, SC 29223

    $2,700,000
    17,838 sqft

    Flexible lease terms and on-site parking support professional office and medical occupancy.

    View details
    Renovated Office Building
    Renovated Office Building

    8311 Two Notch Road, Columbia, SC 29223

    $850,000
    5,969 sqft

    Multiple private entrances support separate business functions or multi-tenant use.

    View details
    Medical Office with Exam Rooms
    Medical Office with Exam Rooms

    125 ALPINE CIR, Columbia, SC 29223

    Contact for pricing
    5,017 sqft

    A reception and waiting area connects to private offices, exam rooms, and a separate staff zone.

    View details
    Freestanding Spa and Wellness Property
    Freestanding Spa and Wellness Property

    7211 Broad River Rd, Irmo, SC 29063

    Contact for pricing
    3,845 sqft 0.51 AC lot

    Freestanding salon building at a signalized intersection with parking and proximity to major healthcare and retail destinations.

    View details
    Office Building with Courtyard
    Office Building with Courtyard

    2712 Middleburg Dr, Columbia, SC 29204

    Contact for pricing
    48,184 sqft 3.32 AC lot

    Partially occupied office property with vacant suites available for immediate upfit and occupancy.

    View details
    NNN Dental Property
    NNN Dental Property

    4547 Hardscrabble Rd, Columbia, SC 29229

    Contact for pricing

    Heartland Dental leases the recently built property, with four extension periods available beyond its initial term.

    View details
    Four-Story Medical Office Building
    Four-Story Medical Office Building

    8 Medical Park Road, Columbia, SC 29203

    Contact for pricing

    Connected to Prisma Health Heart Hospital, the property is master-leased to Prisma Health-Midlands under a net lease.

    View details

    Richland County, SC Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in Richland County, SC with 17 listings featured on our commercial real estate exchange. The current inventory includes 531,880 square feet of properties with an estimated lease value of $138.

    Estimated lease rates for Medical Office Space in Richland County, SC begin at $20 SF/Yr, with an average of $23 SF/Yr and extend to $28 SF/Yr.
    List
    Map

    Medical Office Space by market

    Browse Medical Office Space for Lease Near Richland, SC

    Popular Categories

    Featured Richland County Real Estate Agencies

    Realmo connects you with licensed Richland County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Real Estatee Professional
    Real Estate Professional, 71 sunset maple court Blythewood, SC 29016
    Phone: (803) 360-4098
    Why this one?
    Saved

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!