Charleston County, SC Medical Office Space for Rent & Lease

Updated: Oct 12

Medical Office Space with Clinical Upfit

2320 Cosgrove Avenue, North Charleston, SC 29405

$24 SF/Yr

4,935 sqft 0.31 AC lot

4,935 SF medical office building on 0.305 acres
Former oral surgery office with plumbing and medical hookups throughout
On‑site parking
Located in an opportunity zone
Shopping and dining locations nearby

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Updated: Jun 1

Renovating Office Park Suites

15 Gamecock Ave, Charleston, SC 29407

$2,500/Mo

3,625 sqft

Two office suites available in Orange Grove Office Park: Unit 1A (+/-720 SF) and Unit B (+/-3,625 SF).
Unit 1A listed at $2,500/month; Unit B listed at $28/SF on a NNN basis.
Ongoing renovations at the office park.
Located in Charleston’s West Ashley submarket within Orange Grove Office Park, just off Sam Rittenberg.
Immediate access to I‑26; minutes to Downtown Charleston and Charleston International Airport.

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Medical Office Suites with Ample Parking

1300 Hospital Dr, Mt Pleasant, SC 29464

$1,757/Mo

3,425 sqft

Three-story medical office building offers suites for lease with ample on-site paved parking.

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Mount Pleasant Retail/Office/Medical Space

1123 Queensborough Boulevard, Mount Pleasant, SC 29464

$30 SF/Yr

3,949 sqft

3,949 SF space ideal for retail, office, or medical.

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Single-Story Office Building

255 East Bay Street, Charleston, SC 29401

$35 SF/Yr

4,730 sqft

Centrally located office building with flexible lease terms and included parking to support medical or professional users.

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Class A Medical Office Building

1200 Innovation Way, Mount Pleasant, SC 29466

$28 SF/Yr

14,084 sqft

Renovated medical/office building with ample parking in Mt. Pleasant.

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Medical Office in Mt. Pleasant

1300 Hospital Dr, Mount Pleasant, SC 29464

$34 SF/Yr

60,809 sqft

Medical office space available for sublease in Mt. Pleasant.

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Medical Office Suite

3210 Landmark Drive, North Charleston, SC 29418

Contact for pricing

1,880 sqft

Move-in ready OB-GYN medical space with strong visibility, signage, and ample parking for healthcare practices.

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Two-Story Freestanding Office Building

2125 Charlie Hall Blvd, Charleston, SC 29414

Contact for pricing

13,113 sqft

Entire first floor is available in a centrally located, medically oriented freestanding office building with ample parking.

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Dental-To-Medical Office Suite

1065-C Johnnie Dodds Blvd, Mount Pleasant, SC 29464

Contact for pricing

1,500 sqft

Turn-key office currently set up for dental use, positioned across from a major hospital with convenient highway access.

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Updated Freestanding Office Building

2132 Dorchester Road, North Charleston, SC 29405

Contact for pricing

Updated commercial space includes private offices, a kitchen, restroom, and surface parking.

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Freestanding Medical Office Space

159 Wentworth Street, Charleston, SC 29401

Contact for pricing

First-floor layout includes reception, private offices, and exam rooms.

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Fitness and Chiropractic Sublease Space

1291 Folly Rd, Charleston, SC 29412

Contact for pricing

5,650 sqft

Sublease 1,130± SF within Gold’s Gym, with a former cafe space and a chiropractic suite offering private offices.

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Renovated Office/Medical Space Available

1200 Innovation Way, Mount Pleasant, SC 29466

Contact for pricing

7,042 sqft

High-end commercial building in a rapidly growing area.

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Mt. Pleasant Office/Medical Space

900 Bowman Rd, Mt Pleasant, SC

Contact for pricing

6,185 sqft 2.98 AC lot

Office and medical suites available in Mt. Pleasant location.

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Medical Office Near Hospital Campus

1300 Hospital Dr, Mt Pleasant, SC 29464

Contact for pricing

60,809 sqft

Three-story medical office building near East Cooper Medical Center.

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Based on your search, we've compiled 22 Potential Opportunities for your consideration. Besides 16 Active listings in Charleston County, SC, we suggest exploring alternatives. Similar 6 Properties for Sales.

Similar Spaces for Sale in Charleston County, SC

Consider Similar Space for Sale. We found 6 Spaces matching your search parameters.

Office Redevelopment Opportunity

3841 Rivers Avenue, North Charleston, SC 29405

$1,200,000

5,161 sqft

Two-building office property with multiple private offices, conference areas, and an X-ray room.

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Freestanding Office Building

4425 Belle Oaks Drive, North Charleston, SC 29405

Contact for pricing

6,793 sqft

The building is presented for office, medical, or flex-type use and includes on-site parking.

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Renovated Standalone Storefront

3169 W Montague Avenue, North Charleston, SC 29418

Contact for pricing

4,000 sqft

Renovated standalone building with open-plan space, ADA bathrooms, and a lead-lined imaging room.

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Light Industrial Flex Buildings

3605 Meeting Street Road, North Charleston, SC 29405

Contact for pricing

7,726 sqft 0.64 AC lot

Two freestanding light industrial buildings total about 7,726 SF on roughly 0.64 acres, zoned M-1 and currently delivered vacant.

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Downtown Medical Office Condo

198 Rutledge Avenue, Charleston, SC 29403

$1,740,000

First-floor office condo with dedicated parking near Charleston’s hospital district.

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1300 Hospital Drive, Mount Pleasant, SC 29464

1300 Hospital Dr, Mount Pleasant, SC 29464

Contact for pricing

60,809 sqft

Medical office building near East Cooper Medical Center for sale.

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