Greenville County, SC Office Spaces for Rent & Lease

$129-$6,596/Mo

(972) 764-8885

SC, Greenville - E Stone Avenue

Flexible workspace in SC, Greenville - E Stone Avenue

17 1St St, Unit 2ND, Greenville, SC 29609

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$1,650/Mo

Piedmont Commercial Office Space

2514 River Road, Piedmont, SC 29673

1,200 SF office space with high visibility and accessibility.

High‑visibility location on a high‑traffic road, ideal for attracting clients and customers.
Convenient access to I‑85 highway, facilitating easy commuting for employees and clients.
Flexible, customizable 1,200 square foot open layout suitable for various business types.
Includes water, trash, and all NNN costs in monthly rent of $1,700.
Modern finishes and on‑site parking create a professional and inviting atmosphere.

Updated: Mar 24

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$1,500/Mo

Office Studio Suite in Park Square Center

1322 E Washington Street, Greenville, SC 29607

Freshly painted rear lower-level office studio with a private bath in a thriving, multi-tenant center.

700 SF office/studio space on the rear lower level at Park Square Center with 1 bath
Space is freshly painted and ready for a new tenant
Asking $1,500 per month with a 2‑year lease; tenant pays all utilities and provides commercial tenant’s insurance
Park Square Center is centrally located in Greenville, SC, blocks from downtown, I‑385, and about 2 miles from Hwy 85
Center is leased with tenants including Rocky Creek Dental, llyn Strong Gallery, Peak Performance, Neelys, PT Solutions, Browning Salon, and MJT Designs

Updated: Jun 3

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$550/Mo

Main Street Professional Office Space

Newly renovated office spaces overlooking Main Street in Greenville, SC.

200 N Main Street, Greenville, SC 29601

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$5,084/Mo

Historic Downtown Simpsonville Office Space

Charming office space in historic downtown Simpsonville with ample parking.

312 S Main Street, Simpsonville, SC 29681

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$4,100/Mo

2,500 SF

New Commercial Unit For Lease

Brand new commercial unit with versatile space in Travelers Rest.

1 Brookside Drive, Travelers Rest, SC 20690

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Downtown Greenville Office Space Available

$1,542/Mo

1,750 SF

Downtown Greenville Office Space Available

Office suites available in downtown Greenville, utilities included.

1010 E North Street, Greenville, SC 29601

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$585/Mo

Furnished Office Space Available

Furnished and unfurnished offices with included utilities and amenities.

552 Memorial Drive Extension, Greer, SC 29651

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$129-$5,274/Mo

Millport at Butler

Discover many ways to work your way in Millport at Butler

128 Millport Cir, Unit 200, Greenville, SC 29607

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$129-$6,037/Mo

NOMA Tower

Discover many ways to work your way in NOMA Tower

220 Main St, Unit 500, Greenville, SC 29601

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$19 SF/Yr

1,422 SF

Premier Greenville Office Complex

Variety of office spaces with extensive upgrades and easy access.

37 Villa Rd, Greenville, SC 29615

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$12 SF/Yr

5,048 SF

Office Warehouse Space For Lease

Office warehouse space for lease in Greenville, SC.

180 Commerce Center, Greenville, SC 29615

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Conditioned Industrial Building in Greer

$16 SF/Yr

10,000 SF

Conditioned Industrial Building in Greer

10,000 SF fully conditioned industrial building with office space.

19 Concourse Way, Greer, SC 29650

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$550/Mo

900 SF

Main Street Professional Office Spaces

Newly renovated office spaces with Main Street views for lease.

200 North Main Street, Greenville, SC 29601

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$45 SF/Yr

5,024 SF

Class A Office Space

Premier office space in Greenville's award-winning downtown.

110 East Court Street, Greenville, SC 29601

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$20 SF/Yr

2,035 SF

Textile Mill Lofts in Greenville

Live, work, and play spaces with industrial architecture.

201 Smythe Street, Greenville, SC 29611

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$22 SF/Yr

10,308 SF

Downtown Greenville Office Space

Turnkey office space with high-end finishes and Main Street views.

22 S Main St, Greenville, SC 29601

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$20 SF/Yr

20,000 SF

Loft Retail and Office Space

Retail and office spaces in historic Woodside Mill district.

1 E Main Street, Greenville, SC 29611

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Greer Retail/Office/Medical Space For Rent

$14 SF/Yr

2,100 SF

Greer Retail/Office/Medical Space For Rent

Flexible 2,100 SF space ideal for retail, office, or medical.

1317 West Poinsett Street, Greer, SC

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$850/Mo

4,667 SF

West Greenville Studio Space Available

Creative studios and workspaces in dynamic West Greenville neighborhood.

31 Burdette St, Greenville, SC 29611

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$28 SF/Yr

3,190 SF

Class A Mixed-Use Redevelopment

Located in Greenville’s Historic Westend, easily accessible to major routes.

400 Augusta Street, Greenville, SC 29601

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Revitalized Downtown Greenville Retail/Office Space

$41 SF/Yr

14,052 SF

Revitalized Downtown Greenville Retail/Office Space

Prime retail and office spaces in a rejuvenated downtown location.

300 East McBee Avenue, Greenville, SC 29601

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$27 SF/Yr

7,915 SF

Modern Office Space with Amenities

Office space with tenant lounge, fitness center, and food trucks.

30 Patewood Drive, Greenville, SC 29615

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$129-$5,465/Mo

Sapaces Falls Tower

Find fully flexible work and meeting space in Sapaces Falls Tower

355 And, Unit 2ND, Greenville, SC 29601

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Greenville County, SC Office Spaces Leasing Opportunities Market Analysis

Explore Office Spaces leasing options in Greenville County, SC with 240 listings featured on our commercial real estate exchange. The current inventory includes 1,967,312 square feet of properties with an estimated lease value of $8,253,771.

Estimated lease rates for Office Spaces in Greenville County, SC begin at $1.93 SF/Yr, with an average of $54,301 and extend to $8,250,000.