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    Florence County, SC Medical Office Space for Lease

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    Special-Use Office Building
    Updated: Jun 19
    Special-Use Office Building

    191 South Cashua Drive, Florence, SC 29501

    Contact for pricing
    2,560 sqft 0.58 AC lot
    Special‑use office building totaling 2,560 SF available September 2026
    Former veterinary office layout suitable for medical, professional, service‑based, or specialty office use
    Located on S Cashua Dr in Florence’s 5 Points commercial district in a high‑traffic area
    On‑site parking includes nine lined spaces in front, with additional parking available at the rear
    Set on a 0.58‑acre lot
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    Retail Space in Mixed-Use District
    Updated: Mar 18
    Retail Space in Mixed-Use District

    2295 Hoffmeyer Rd, Florence, SC 29501

    Contact for pricing
    7,420 sqft
    Anchored just off Hoffmeyer Road in West Florence as part of a mixed‑use redevelopment repurposing existing buildings.
    Located on/near Hoffmeyer Rd (AADT 18,300+) and W. Darlington St (AADT 11,700+), with combined counts exceeding 30,000 VPD.
    Minutes from the I‑95 & I‑20 interchange.
    Positioned between Magnolia Mall and Florence Mall.
    Adjacent to Palmetto Peddlers (30,000 SF, 130+ vendors).
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    Mixed-Use Retail and Office Space
    Mixed-Use Retail and Office Space

    2295 Hoffmeyer Rd, Florence, SC 29501

    Contact for pricing
    7,465 sqft

    7,465-square-foot property within a redevelopment featuring retail, office, medical, dining, and lifestyle spaces.

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    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    Based on your search, we've compiled 13 Potential Opportunities for your consideration. Besides 3 Active listings in Florence County, SC, we suggest exploring alternatives. Similar 6 Properties for Sales.

    Similar Spaces for Sale in Florence County, SC

    Consider Similar Space for Sale. We found 6 Spaces matching your search parameters.

    Medical Office Building with 13 Exam Rooms
    Medical Office Building with 13 Exam Rooms

    1706 2nd Loop Rd., Florence, SC 29501

    $1,650,000
    8,291 sqft 1.34 AC lot

    CI-zoned medical office facility with 13 exam rooms, covered patient drop-off, and 62 parking spaces.

    View details
    Remodeled Office Building
    Remodeled Office Building

    910 W Evans st, Florence, SC 29501

    $300,000
    2,165 sqft 0.27 AC lot

    Updated office property with private rooms, a modern kitchen, wood flooring, and two bathrooms.

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    Medical Office Building with Parking
    Medical Office Building with Parking

    1706 2nd Loop Rd., Florence, SC 29501

    Contact for pricing
    8,300 sqft 1.34 AC lot

    Multi-room medical office building with 13 exam rooms, imaging room, and 62 parking spaces on 1.34 acres.

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    Two-Story Single-Tenant Medical Office
    Two-Story Single-Tenant Medical Office

    1604 E Cheves St, Florence, SC 29506

    Contact for pricing
    16,444 sqft

    Fee simple interest in a purpose-built two-story medical office building, single-tenant and leased to a neurosurgery practice.

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    Timmonsville Medical Office Building
    Timmonsville Medical Office Building

    101 W Market St, Timmonsville, SC 29161

    Contact for pricing
    1,978 sqft

    Well-maintained building suitable for medical or business office.

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    Fully Furnished Medical Office Suite
    Fully Furnished Medical Office Suite

    1523 Heritage Lane Unit B, Florence, SC 29505

    $590,000

    Medical office suite with four exam rooms, a treatment room, waiting areas, and on-site staff rooms.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Development Opportunity in Greenville
    Prime Development Opportunity in Greenville

    39 Airpark Ct, Greenville, SC 29607

    Contact for pricing
    1.27 AC lot

    1.27 acre interstate-visible land for ground lease or build-to-suit.

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    General Business Retail Development Site
    General Business Retail Development Site

    Tift Avenue N, Tifton, GA 31794

    $7,500/Mo

    Approximately 0.66-acre commercial land parcel zoned GB General Business in Tifton.

    View details
    Prime Lexington Outlot Opportunity
    Prime Lexington Outlot Opportunity

    3330 Partner Place, Lexington, KY 40503

    Contact for pricing

    Outlot for ground lease or build-to-suit in South Lexington.

    View details
    Corner Office Unit
    Corner Office Unit

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft

    C4 zoning allows commercial, medical, and residential uses at this accessible corner property.

    View details

    Florence County, SC Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in Florence County, SC with 3 listings featured on our commercial real estate exchange. The current inventory includes 17,445 square feet of properties.
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