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    Spartanburg County, SC Medical Office Space for Lease

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    Greenville, SC Columbia, SC Charleston, SC
    6 results
    Premier Medical Office Space Available
    $20 SF/Yr
    7,039 SF

    Premier Medical Office Space Available

    1650 Skylyn Drive, Spartanburg, SC 29307

    Class A medical office space in Spartanburg's prime location.

    • Premier Class A medical office space, strategically located on the Mary Black campus, unique to the Spartanburg market.
    • On‑site wellness amenity suite featuring a fitness gym, swimming pool, and smoothie bar exclusively for building tenants.
    • Lower NNN fees than comparable properties.
    • Direct access to the Drayton Mills Trail and proximity to the vibrant Drayton Mills mixed‑use development.
    • Abundant parking.
    Updated: Mar 7
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    Westside Office/Medical Space Available
    $16 SF/Yr
    5,461 SF

    Westside Office/Medical Space Available

    225 E Blackstock Rd, Spartanburg, SC

    5461± sq ft office/medical space for rent.

    • 5461 ± sq. ft. office/medical space
    • Convenient westside location, ½ mile from I‑26
    • Includes reception, 2 private offices, 5 exam rooms & breakroom
    • Benefit from a lead lined X‑Ray room
    • Features 4 restrooms
    Updated: Jul 4, 2025
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    Medical Office Space For Rent
    Contact for pricing
    5,200 SF

    Medical Office Space For Rent

    Medical office space with high visibility and easy access.

    3610 Moore Duncan Hwy, Moore, SC 29369
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    Renovated Office Space on Main
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    1,000 SF

    Renovated Office Space on Main

    Recently renovated office space with flexible layout in Duncan, SC.

    705 East Main Street, Duncan, SC 29334
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    Spartanburg Medical Office Space Available
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    3,000 SF

    Spartanburg Medical Office Space Available

    Medical office space for lease with ample parking.

    478-480 Floyd Rd, Spartanburg, SC
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    Class A Medical Office Space
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    Class A Medical Office Space

    Premier medical office space with wellness amenities and convenient location.

    1650 Skylyn Dr, Spartanburg, SC 29307
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    Based on your search, we've compiled 18 Potential Opportunities for your consideration. Besides 6 Active listings in Spartanburg County, SC, we suggest exploring alternatives. Similar 8 Properties for Sales.

    Similar Spaces for Sale in Spartanburg County, SC

    Consider Similar Space for Sale. We found 8 Spaces matching your search parameters.

    Commercial Land Near Highway 290
    $1,250,000
    1,250 SF
    Commercial Land Near Highway 290

    5.2 acres near intersection of Hwy 290 and SC 296.

    6046 Reidville Road, Moore, SC 29369

    View details
    Spartanburg Office Building For Sale
    $1,810,000
    7,200 SF
    Spartanburg Office Building For Sale

    7,200 SF office building near Spartanburg Medical District.

    130 Dillon Drive, Spartanburg, SC 29307

    View details
    Medical/Professional Office Space Available
    $775,000
    10,000 SF
    Medical/Professional Office Space Available

    10,000 SF property near Mary Black Regional Hospital.

    125 Dillon Dr, Spartanburg, SC 29307

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    Spartanburg Medical/Office Building For Sale
    $825,000
    9,594 SF
    Spartanburg Medical/Office Building For Sale

    9,594 SF medical/office building near downtown Spartanburg.

    1770 Skylyn Dr, Spartanburg, SC

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    Medical Office Space Available
    $430,000
    4,645 SF
    Medical Office Space Available

    4,645 SF medical office space for lease.

    1241 Boiling Springs Rd, Spartanburg, SC

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    Professional Office/Medical Pads For Sale
    $150,000
    3,500 SF
    Professional Office/Medical Pads For Sale

    Two office/medical pads with utilities, parking, and infrastructure included.

    108 Burton St, Spartanburg, SC

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    11,058 SF Office Building For Sale
    Contact for pricing
    11,058 SF
    11,058 SF Office Building For Sale

    11,058 SF fantastic medical investment opportunity

    480 Floyd Rd, Spartanburg, SC 29307

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    Versatile Commercial Building Near Hospital
    $845,000
    11,925 SF
    Versatile Commercial Building Near Hospital

    Adaptable commercial building suitable for medical, retail, or storage use.

    200 Dillon Cir, Spartanburg, SC 29307

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Development Opportunity in Greenville
    Contact for pricing

    Prime Development Opportunity in Greenville

    1.27 acre interstate-visible land for ground lease or build-to-suit.

    39 Airpark Ct, Greenville, SC 29607
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    Prime Lexington Outlot Opportunity
    Contact for pricing

    Prime Lexington Outlot Opportunity

    Outlot for ground lease or build-to-suit in South Lexington.

    3330 Partner Place, Lexington, KY 40503
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    Prime Commercial Lot For Rent
    $7,500/Mo

    Prime Commercial Lot For Rent

    0.66 acre commercial lot with high visibility.

    Tift Avenue N, Tifton, GA 31794
    View details
    Beaumont Centre Outparcel Opportunity
    Contact for pricing

    Beaumont Centre Outparcel Opportunity

    Outparcel opportunity in established shopping center for ground lease.

    3199 Beaumont Centre Circle, Lexington, KY 40513
    View details

    Spartanburg County, SC Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Spartanburg County, SC with 6 listings featured on our commercial real estate exchange. The current inventory includes 12,500 square feet of properties with an estimated lease value of $36 SF/Yr.

    Estimated lease rates for Medical Office Space in Spartanburg County, SC begin at $16 SF/Yr, with an average of $18 SF/Yr and extend to $20 SF/Yr.
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    Browse Medical Office Space for Lease Near Spartanburg, SC

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