Simpsonville, SC Office Spaces for Lease

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14 properties

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Updated: Jun 23

Former Bank Drive-Thru Building

124 NE Main Street, Simpsonville, SC 29680

$22.50 SF/Yr

2,200 sqft

±2,200 SF former bank building available for lease
Former bank building on Main Street in Simpsonville, SC
Ample onsite parking for customers and staff
Separate drive‑thru included and could be utilized by the tenant
Multiple points of ingress/egress

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Updated: Aug 12

Flex Space with Dock Access

201 Greer Drive, Simpsonville, SC 29681

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18,000 sqft 1.50 AC lot

Approximately ±18,000 SF building on ±1.5 acres
Approximately ±15,000 SF warehouse and ±3,000 SF office space
3‑phase, 480V power with suspended gas heat in the warehouse
Four dock doors and three drive‑in doors
Ceiling heights of 15'7" at center and 14' at eaves

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Historic Mill Office Units

300 South St, Simpsonville, SC 29681

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8,082 sqft

NNN office availability combines open-plan workspace, private rooms, restrooms, a mezzanine, and outdoor patio space.

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Former Office Building Lease Opportunity

118 NE Main St, Simpsonville, SC 29681

$15 SF/Yr

Lease a former office building with an 18-month short-term option on Main Street in Simpsonville.

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Second-Generation Medical Office

35 Ray E Talley Ct, Simpsonville, SC 29680

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7,880 sqft

Located near Fairview Road with convenient access to I-385.

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Newly Renovated Office Space

205 New Harrison Bridge Road, Simpsonville, SC 29680

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1,425 sqft 5.00 AC lot

Newly renovated office space with a fenced laydown yard for outdoor storage.

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Office Suite with Multiple Offices

131 Southeast Main Street, Simpsonville, SC 29681

$7,549/Mo

Office space offering up to eight offices, a functional kitchen, and 13 parking spots.

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Warehouse with Office Space

502 Palmetto Dr, Simpsonville, SC 29681

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18,000 sqft 1.50 AC lot

18,000 SF warehouse with suspended gas heat, heavy 3-phase power, docks and drive-ins, plus 3,000 SF office.

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Two-Story Office Units

419-421 SE Main St, Simpsonville, SC 29681

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Lease space across two office buildings with Main Street exposure, monument signage, and on-site parking.

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Medical Office Space

634 Fairview Road, Simpsonville, SC 29680

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Established healthcare setting with SC-418 frontage, I-385 connectivity, and more than 120 medical providers within 3 miles.

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334,000 SF Office Building For Lease

300 South St, Simpsonville, SC 29681

$19 SF/Yr

334,000 SF Office Building For Lease

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Beck Plaza

1028 NE Main Street, Simpsonville, SC 29681

$15 SF/Yr

1,100 SF Retail Building

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Downtown Simpsonville New Construction Retail

114 E Curtis St, Simpsonville, SC 29681

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New construction retail and office space in downtown Simpsonville.

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0 Bridgeway

0 Bridgeway Simpsonville, SC 29681, Simpsonville, SC 29681

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±6,197 SF of office space availalble

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Based on your search, we've compiled 27 Potential Opportunities for your consideration. Besides 14 Active listings in Simpsonville, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 8 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Creative Office Space Available

11 Forrester Drive |, Mauldin, SC 29662

$6.95 SF/Yr

86 sqft

Creative office space for lease in Mauldin, South Carolina.

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Retail Space with Monument Signage

107 East Butler Road, Mauldin, SC 29662

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Retail space along East Butler Road with monument signage and convenient proximity to Main Street and Interstate 385.

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Office Suite with Atrium Lobby

220 North Main Street, Suite 500, Greenville, SC 29601

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Leasing opportunity with an impressive atrium, lounge, and videoconferencing facilities, plus an in-building restaurant.

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Office Suites Available For Rent

301 N Main St, Greenville, SC 29601

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Office suites of various sizes available for rent.

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Similar Spaces for Sale in Simpsonville, SC

Consider Similar Space for Sale. We found 8 Spaces matching your search parameters.

Historic Creative Workspace

300 South St, Simpsonville, SC 29681

$1,750,000

8,082 sqft

Flexible commercial layout with open work areas, private rooms, offices, restrooms, a breakroom, and an outdoor patio.

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Simpsonville Commercial Building For Sale

313 N Main Street, Simpsonville, SC 29681

$3,995,000

24,000 sqft

24,000 SF building in Simpsonville, SC, renovated in 2013.

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Second-Generation Medical Office

35 Ray E Talley Ct, Simpsonville, SC 29680

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7,880 sqft

Well-maintained medical and office space in Simpsonville’s retail corridor near I-385 access.

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Office Building with Metal Roof

717 NE Main St, Simpsonville, SC 29681

$499,000

Office property featuring a metal roof and two existing HVAC systems.

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Mixed-Use Building

107 South Maple Street, Simpsonville, SC 29681

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2,057 sqft 0.41 AC lot

Office and retail use potential is supported by on-site parking and additional street parking.

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Versatile Commercial Property For Sale

1306 NE Main St, Simpsonville, SC 29861

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2,200 sqft

Adaptable commercial space with high visibility and convenient highway access.

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Office Unit with Laydown Yard

205 New Harrison Bridge Rd, Simpsonville, SC 29680

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1,425 sqft

Office space paired with a dedicated outdoor storage and staging area.

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New Retail Space with End Caps

00 Scuffletown Road, Simpsonville, SC 29681

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Planned retail space offers flexible suite configurations for commercial users.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Prime Development Opportunity in Greenville

39 Airpark Ct, Greenville, SC 29607

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1.27 AC lot

1.27 acre interstate-visible land for ground lease or build-to-suit.

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Simpsonville, SC Office Spaces Lease Rates & Market Statistics

Browse 14 Office Spaces for lease in Simpsonville, SC on Realmo, a commercial real estate marketplace serving the Simpsonville area. The current inventory totals 55,587 square feet of properties — an average of ~3,950 SF per listing.

Asking lease rates for Office Spaces in Simpsonville start at $15 SF/Yr, average $17.88 SF/Yr, and reach $22.50 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $17.88 SF/Yr, the local average runs 23% below South Carolina's state average of $23.19 SF/Yr.

Simpsonville accounts for 5% of the 257 office spaces currently available across Greenville County, where nearby markets include Greenville and Greer. By space type, the market includes 10 office units, 5 office buildings and 3 medical office space listings.

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