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    Bluffton, SC Office Spaces for Lease

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    Found 8 office space listings for lease in Bluffton, SC, averaging $34/SF/YR. Use lease type data to compare options faster.
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    Turnkey Medical Office Space
    Updated: Sep 18
    Turnkey Medical Office Space

    53 Persimmon Street, Bluffton, SC 29910

    $33 SF/Yr
    0.10 AC lot
    3,445 SF medical and professional office space
    Existing medical‑office buildout with tile flooring
    Central air conditioning and electric heat
    Parking lot with accessible approach and ramp
    Public water and public sewer service
    View details
    Office Suites with Highway Frontage
    Updated: Jun 3
    Office Suites with Highway Frontage

    2 Westbury Park Way, Bluffton, SC 29910

    $32 SF/Yr
    3,870 sqft
    2002‑built office property fronting Hwy 278 (Fording Island Road) with 250'+ highway frontage
    2 suites available: 1,790 SF and 3,870 SF (total 5,660 SF)
    Bluffton side of Hwy 278 with easy access to major thoroughfares
    Ample on‑site parking for employees and visitors
    Existing tenant mix includes medical, professional, institutional, and local tenants
    View details
    Highway 170 Retail/Office/Medical Space
    Highway 170 Retail/Office/Medical Space

    Bluffton, SC 29909

    $36.50 SF/Yr
    3,970 sqft

    Retail, office, or medical space for sale on Highway 170.

    View details
    Office Unit with Delivery Access
    Office Unit with Delivery Access

    49 Pennington Dr, Bluffton, SC 29910

    Triple net (NNN)
    Contact for pricing
    5–8 people  1 space  1,250 sqft
    6 private offices  Highway access

    Unit D includes a reception area, six offices, a restroom, and rear doors for deliveries and shipping.

    View details
    Single-Story Retail Office Medical Building
    Single-Story Retail Office Medical Building

    128 Bluffton Rd, Bluffton, SC 29910

    Triple net (NNN)
    Contact for pricing
    2,730 sqft

    Pre-leasing is underway for a single-story retail, office, and medical building with a planned Fall 2026 delivery.

    View details
    Single-Story Medical Office Retail
    Single-Story Medical Office Retail

    128 Bluffton Rd, Bluffton, SC 29910

    Triple net (NNN)
    Contact for pricing
    Multi-tenant  2,655 sqft  1-story
    C4

    Pre-leasing single-story retail and office building planned for delivery in Fall 2026.

    View details
    New Flex Space For Lease
    New Flex Space For Lease

    5 Kitties Landing Dr, Bluffton, SC

    Triple net (NNN)
    Contact for pricing
    3,360 sqft

    New construction flex space suitable for office, retail, or warehouse.

    View details
    Class A Office Medical Building
    Class A Office Medical Building

    5 Buck Island Rd, Bluffton, SC 29910

    Triple net (NNN) Class A
    Contact for pricing
    70–116 people  1 space  17,525 sqft  2-story
    Highway access + Road access

    Class A office and medical building with floor-to-ceiling windows and an interior elevator at a highway intersection.

    Interior elevator  Floor to ceiling windows  Covered drive thru
    View details
    8 active listings match your search: Office for lease in Bluffton, SC. Based on your search, we've also compiled 15 Potential Opportunities for your consideration: 4 spaces in nearby cities and 11 properties for sale.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Office Space with High-End Finishes
    Office Space with High-End Finishes

    386 Spanish Wells Rd, Unit B-3, Hilton Head Island, SC 29926

    $3,000/Mo
    8–14 people  1 space  2,175 sqft  Built 1986

    Office space featuring high-end finishes in a desirable location.

    View details
    New Construction Office Suite
    New Construction Office Suite

    102-3369 Argent Blvd, Ridgeland, SC 29936

    Class A
    $4,250/Mo
    6–10 people  1,500 sqft

    New office suite includes a conference room, five offices, storage, and kitchens, available by April 30, 2026.

    View details
    Flex Space with Warehouse
    Flex Space with Warehouse

    61 Schinger Ave, Ridgeland, SC 29936

    Triple net (NNN)
    Contact for pricing
    1,680 sqft
    Highway access  Road access

    Unit 101 pairs administrative offices with a dedicated warehouse area and break room.

    View details
    Renovated First-Floor Office Suite
    Renovated First-Floor Office Suite

    8 Lafayette Pl, Hilton Head Island, SC 29926

    Triple net (NNN) Class A
    Contact for pricing
    12–20 people  1 space  3,025 sqft  Floor 1
    6 private offices  1 meeting room  Highway access + Road access

    Recently updated workspace with reception, private offices, conference room, kitchenette, and lobby access.

    Monument signage  Split HVAC system  Kitchenette  Common restrooms
    View details

    Similar Spaces for Sale in Bluffton, SC

    Consider Similar Space for Sale. We found 11 Spaces matching your search parameters.

    Built-Out Medical Office Space
    Built-Out Medical Office Space

    53 Persimmons Street, Bluffton, SC 29910

    Contact for pricing
    3,445 sqft

    Existing professional improvements support medical, healthcare, and other office uses with limited additional build-out needs.

    View details
    Custom Office Building
    Custom Office Building

    10 Bruin Rd, Bluffton, SC 29910

    $850,000
    1,400 sqft

    Stand-alone property with custom woodwork, parking, and signage opportunities in the Neighborhood Core Historic District.

    View details
    Built-Out Medical Office Space
    Built-Out Medical Office Space

    53 Persimmons Street STE 105, Bluffton, SC 29910

    Contact for pricing
    3,445 sqft

    Existing medical-office improvements support healthcare and professional occupancy, subject to the current lease and landlord approval.

    View details
    Leased Medical Office Space
    Leased Medical Office Space

    53 Persimmons Street, Bluffton, SC 29910

    $1,395,000

    A long-term medical tenant occupies the property under a lease with annual rent increases.

    View details
    Medical Office with CT Scanner
    Medical Office with CT Scanner

    14 Oak Forest Road, Bluffton, SC 29910

    $1,600,000

    Renovated in 2024, the suite combines imaging equipment with exam, laboratory, and patient-support areas.

    View details
    Updated Mixed-Use Property
    Updated Mixed-Use Property

    217 Goethe Road, Bluffton, SC 29910

    $1,749,900

    Two commercial buildings provide office, retail, and flex configurations with existing tenant occupancy.

    View details
    Highway 278 Frontage Office Building
    Highway 278 Frontage Office Building

    5 Buck Island Rd, Bluffton, SC 29910

    Contact for pricing
    8,800 sqft

    Class A office/medical building on Highway 278 in Bluffton.

    View details
    Medical Office Suite with CT Scanner
    Medical Office Suite with CT Scanner

    D-14 Oak Forest Road, Bluffton, SC 29910

    $1,600,000

    Clinical space combines exam rooms with laboratory, reception, and patient waiting areas.

    View details
    Bluffton Office/Medical Building For Sale
    Bluffton Office/Medical Building For Sale

    5 Buck Island Rd, Bluffton, SC 29910

    Contact for pricing
    17,525 sqft

    Class A office/medical building fronting Highway 278 in Bluffton.

    View details
    Class A Office Building Space
    Class A Office Building Space

    1 Carecore Drive, Bluffton, SC 29910

    Contact for pricing
    30,065 sqft

    Office space for sale in Buckwalter Place, Bluffton.

    View details
    Commercial Land Near Medical Development
    Commercial Land Near Medical Development

    280 Old Bridge Drive, Bluffton, SC 29910

    Contact for pricing

    Corner commercial site with planned retail, office, and drive-through building options near major healthcare projects.

    View details

    Bluffton, SC Office Spaces Lease Rates & Market Statistics

    Explore 8 Office Spaces for lease in Bluffton, SC on Realmo, a commercial real estate exchange covering the Bluffton area. The current inventory totals 35,360 square feet of properties.

    Asking lease rates for Office Spaces in Bluffton start at $32 SF/Yr, average $33.83 SF/Yr, and reach $36.50 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $33.83 SF/Yr is 35% above the South Carolina state average of $25.07 SF/Yr.

    Bluffton accounts for 14% of the 59 office spaces currently available across Beaufort County, where nearby markets include Beaufort and Hilton Head Island. By space type, the market includes 5 medical office space listings and 4 office units.

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    Most Searched ZIP Codes in Bluffton, SC

    • 29910
    • 29909

    Featured Bluffton Real Estate Agencies

    Realmo connects you with licensed Bluffton CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Daniel Ravenel Sotheby's International Realty
    6 Promenade Street, Suite 1001 Bluffton, SC 29910
    Phone: (843) 723-7150
    www.danielravenelsir.com/
    Palmetto Bluff Real Estate Co
    19 Village Square Park Bluffton, SC 29910
    Phone: (843) 706-6400
    Lowcountry Live Oak Realty
    3 Lost Hollow Ln, Unit 3B Bluffton, SC 29910
    Phone: (843) 384-1685
    www.lowcountryliveoak.com/
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