Bluffton, SC Office Spaces for Lease

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10 properties

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Updated: Sep 18

Turnkey Medical Office Space

53 Persimmon Street, Bluffton, SC 29910

$33 SF/Yr

0.10 AC lot

3,445 SF medical and professional office space
Existing medical‑office buildout with tile flooring
Central air conditioning and electric heat
Parking lot with accessible approach and ramp
Public water and public sewer service

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Updated: Jun 3

Office Suites with Highway Frontage

2 Westbury Park Way, Bluffton, SC 29910

$32 SF/Yr

3,870 sqft

2002‑built office property fronting Hwy 278 (Fording Island Road) with 250'+ highway frontage
2 suites available: 1,790 SF and 3,870 SF (total 5,660 SF)
Bluffton side of Hwy 278 with easy access to major thoroughfares
Ample on‑site parking for employees and visitors
Existing tenant mix includes medical, professional, institutional, and local tenants

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Highway 170 Retail/Office/Medical Space

Bluffton, SC 29909

$36.50 SF/Yr

3,970 sqft

Retail, office, or medical space for sale on Highway 170.

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Office Unit with Delivery Access

49 Pennington Dr, Bluffton, SC 29910

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1,250 sqft

Unit D includes a reception area, six offices, a restroom, and rear doors for deliveries and shipping.

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New Flex Space Development

225-235 Gibbet Rd, Bluffton, SC 29910

$21 SF/Yr

New commercial units combine storefront access with adaptable layouts for office, service, medical, and contractor users.

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Single-Story Retail Office Medical Building

128 Bluffton Rd, Bluffton, SC 29910

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2,730 sqft

Pre-leasing is underway for a single-story retail, office, and medical building with a planned Fall 2026 delivery.

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Single-Story Medical Office Retail

128 Bluffton Rd, Bluffton, SC 29910

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2,655 sqft

Pre-leasing single-story retail and office building planned for delivery in Fall 2026.

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New Flex Space For Lease

5 Kitties Landing Dr, Bluffton, SC

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3,360 sqft 1.42 AC lot

New construction flex space suitable for office, retail, or warehouse.

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Class A Office Medical Building

5 Buck Island Rd, Bluffton, SC 29910

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17,525 sqft

Class A office and medical building with floor-to-ceiling windows and an interior elevator at a highway intersection.

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Class A Office Space

New Riverside Vlg Wy, Bluffton, SC 29910

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Office space in mixed-use center with retail and residential.

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Based on your search, we've compiled 30 Potential Opportunities for your consideration. Besides 10 Active listings in Bluffton, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 16 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Office Space with High-End Finishes

386 Spanish Wells Rd, Unit B-3, Hilton Head Island, SC 29926

$3,000/Mo

2,175 sqft

Office space featuring high-end finishes in a desirable location.

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New Construction Office Suite

102-3369 Argent Blvd, Ridgeland, SC 29936

$4,250/Mo

1,500 sqft

New office suite includes a conference room, five offices, storage, and kitchens, available by April 30, 2026.

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Flex Space with Warehouse

61 Schinger Ave, Ridgeland, SC 29936

Contact for pricing

1,680 sqft

Unit 101 pairs administrative offices with a dedicated warehouse area and break room.

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Medical Building on Hilton Head

4101 Main St, Suite E & F, Hilton Head Island, SC 29926

$17 SF/Yr

Stand-alone medical building for lease on Hilton Head Island.

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Similar Spaces for Sale in Bluffton, SC

Consider Similar Space for Sale. We found 16 Spaces matching your search parameters.

Office-Showroom Warehouse Building

29 Kitties Landing Road, Bluffton, SC 29910

$2,475,000

10,000 sqft 1.00 AC lot

Metal-frame office, showroom, and warehouse building with four roll-up doors and full HVAC on about one acre.

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Custom Office Building

10 Bruin Rd, Bluffton, SC 29910

$850,000

1,400 sqft

Stand-alone property with custom woodwork, parking, and signage opportunities in the Neighborhood Core Historic District.

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Renovated Office Unit

29 Plantation Park Drive, Bluffton, SC 29910

Contact for pricing

1,300 sqft

Three private offices, a reception area, conference room, restroom, and kitchenette create a practical multi-room layout.

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Highway 278 Frontage Office Building

5 Buck Island Rd, Bluffton, SC 29910

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8,800 sqft

Class A office/medical building on Highway 278 in Bluffton.

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Updated Mixed-Use Property

217 Goethe Road, Bluffton, SC 29910

$1,749,900

Two commercial buildings provide office, retail, and flex configurations with existing tenant occupancy.

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Bluffton Office/Medical Building For Sale

5 Buck Island Rd, Bluffton, SC 29910

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17,525 sqft

Class A office/medical building fronting Highway 278 in Bluffton.

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Class A Office Building Space

1 Carecore Drive, Bluffton, SC 29910

Contact for pricing

30,065 sqft

Office space for sale in Buckwalter Place, Bluffton.

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Medical Office Suite

4 Okatie Center Boulevard South, Okatie, SC 29909

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3,075 sqft

Medical office suite available in Okatie Center, located just off Hwy 170 near the Hwy 278 interchange.

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Flex Space with Climate-Controlled Warehouse

3095 Soperton Drive, Bluffton, SC 29910

$2,499,000

Built in 2023 with office suites, conference space, and a full kitchen.

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Built-Out Medical Office Space

53 Persimmons Street, Bluffton, SC 29910

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Existing professional improvements support medical, healthcare, and other office uses with limited additional build-out needs.

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Furnished Medical Office Suite

4 Okatie Center Boulevard S, Bluffton, SC 29909

$950,000

Ground-floor medical office with patient-facing areas, substantial storage, and ADA-compliant access.

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Renovated Office Units

29 Plantation Park Drive, Bluffton, SC 29910

$487,500

Three private offices include reception, a conference room, restroom, and kitchenette.

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Furnished Medical Office Space

102-4 Okatie Center Blvd S, Bluffton, SC 29909

$950,000

Ground-floor practice features exam rooms, patient amenities, storage, and ADA-compliant access.

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Retail Building with Highway Frontage

1504 Fording Island Rd, Bluffton, SC 29910

Contact for pricing

4,521 sqft

Office and retail improvements offer direct access from both a major highway and Buckingham Plantation Drive.

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Bluffton, SC Office Spaces Lease Rates & Market Statistics

Explore 10 Office Spaces for lease in Bluffton, SC on Realmo, a commercial real estate exchange covering the Bluffton area. The current inventory totals 35,360 square feet of properties — an average of ~3,550 SF per listing.

Asking lease rates for Office Spaces in Bluffton start at $21 SF/Yr, average $30.63 SF/Yr, and reach $36.50 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $30.63 SF/Yr is 26% above the South Carolina state average of $24.23 SF/Yr.

Bluffton accounts for 15% of the 66 office spaces currently available across Beaufort County, where nearby markets include Beaufort and Hilton Head Island. By space type, the market includes 6 office units and 5 medical office space listings.

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