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    Lexington County, SC Medical Office Space for Lease

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    28 properties
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    Turnkey Medical Office Suites
    Updated: Jun 2
    Turnkey Medical Office Suites

    4100 N. Main Street, Columbia, SC 29203

    $20 SF/Yr
    3,742 sqft $6,236/Mo
    1987‑built medical office with turnkey suites featuring exam rooms with plumbing
    Suite 101: ±2,484 SF available 8/1/26
    Suite 200: ±1,226 SF with reception, 3 exam rooms (with plumbing), 1 private office, and restroom
    Suite 201: ±2,516 SF with large reception/waiting area, 6 exam rooms (with plumbing), 2 private offices, IT/storage rooms, and restroom
    Major renovations in 2019 included new roof, building façade, and common area upgrades
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    West Columbia Office/Medical Suite
    Updated: Jan 27
    West Columbia Office/Medical Suite

    3618 Sunset Blvd., West Columbia, SC 29169

    $18 SF/Yr
    12,000 sqft $18,000/Mo
    Prime Location: Minutes from Lexington Medical Hospital, I‑26, and I‑20, offering convenient access.
    Excellent Signage and Visibility: Prominent monument and façade signage at a signalized intersection on Hwy. 378.
    Versatile Layout: Suite C (± 1,650 SF) with 5 private offices, conference room, breakroom, and restroom, suitable for various users.
    Convenient Parking: Dedicated parking available for tenants and customers.
    Strategic Location: Situated off Sunset Blvd. (Hwy. 378) in West Columbia.
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    Medical Office Space For Lease
    Medical Office Space For Lease

    161 Medical Circle, West Columbia, SC 29169

    $20 SF/Yr
    7,659 sqft $12,765/Mo

    Medical office space in prime healthcare corridor location.

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    Medical Office Complex For Rent
    Medical Office Complex For Rent

    2601 Laurel St, Columbia, SC

    $28 SF/Yr
    1,797 sqft $4,193/Mo

    Medical office complex in Columbia's Central Business District.

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    Columbia Office/Medical Space For Lease
    Columbia Office/Medical Space For Lease

    120 & 122 Highland Center Dr., Columbia, SC 29203

    $21 SF/Yr
    20,822 sqft $36,438/Mo

    Office and medical space available for lease in Columbia, SC.

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    Medical Office Complex For Rent
    Medical Office Complex For Rent

    2750 Laurel St., 2601 Laurel St. & 1655 Bernardin Ave., Columbia, SC 29206

    $28 SF/Yr
    126,002 sqft $294,004/Mo

    Medical office complex in Columbia's Central Business District, renovated.

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    Standalone Office Building Suite
    Standalone Office Building Suite

    300 Rice Meadow Way, Columbia, SC

    $22 SF/Yr
    4,000 sqft $7,333/Mo

    Office suite with reception, offices, bathrooms, and break room.

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    Move-in Ready Office Space
    Move-in Ready Office Space

    144 Leisure Ln, Columbia, SC

    $15 SF/Yr
    4,000 sqft $5,000/Mo

    4,000 SF office space for lease in Columbia, SC.

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    Cayce Office/Medical Space Available
    Cayce Office/Medical Space Available

    1105 State St, Cayce, SC

    $20 SF/Yr
    5,670 sqft $9,450/Mo

    5,670 SF building suitable for office or medical use.

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    Office Suite in Medical Corridor
    Office Suite in Medical Corridor

    3634 Sunset Blvd, W, Columbia, SC

    $19 SF/Yr
    3,566 sqft $5,646/Mo

    Office suite with private offices near Lexington Medical Center.

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    Move-in Ready Medical Office Space
    Move-in Ready Medical Office Space

    1538 Main St, Columbia, SC

    $20 SF/Yr
    2,466 sqft $4,110/Mo

    Medical office space for lease in Columbia's CBD.

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    Move-In Ready Medical Office Suite
    Move-In Ready Medical Office Suite

    7041 Saint Andrews Road, Columbia, SC 29212

    Contact for pricing
    2,752 sqft

    Purpose-built clinical space with reception, admin office, multiple operatories, and private suite features for healthcare practices.

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    Dental Space Available for Rent
    Dental Space Available for Rent

    108 Palmetto Park Blvd, Lexington, SC

    $24 SF/Yr
    2,606 sqft $5,212/Mo

    Turn-key dental space with equipment in Lexington, SC.

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    Medical Office Space Available
    Medical Office Space Available

    3221, 3223, 3225, & 3231 Sunset Blvd., West Columbia, SC 29169

    Contact for pricing
    39,722 sqft

    Accessible medical office space in a growing Columbia corridor.

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    Retail, Restaurant, or Medical Office
    Retail, Restaurant, or Medical Office

    2800 Rosewood Dr., Columbia, SC 29205

    Contact for pricing
    24,000 sqft

    Located in a Publix-anchored shopping center with high visibility.

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    Medical/Office Space Near Veterans Hospital
    Medical/Office Space Near Veterans Hospital

    200 Byron Rd, Columbia, SC

    $10 SF/Yr
    800 sqft $666.67/Mo

    800 SF medical/office space with ample parking, easy access.

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    Highland Center Office Space Available
    Highland Center Office Space Available

    122 Highland Center Dr, Columbia, SC

    $21 SF/Yr
    7,000 sqft $12,250/Mo

    Office and medical space available for lease in Columbia.

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    Class A Medical Office Space
    Class A Medical Office Space

    1600 Lake Murray Blvd, Columbia, SC 29212

    Contact for pricing

    Highly visible medical office location in Irmo, South Carolina.

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    Renovated Medical Office Space Available
    Renovated Medical Office Space Available

    1777 St Julian Pl, Columbia, SC 29204

    $25 SF/Yr
    10,000 sqft $20,833/Mo

    Newly renovated medical office space for lease in Columbia, SC.

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    New Mixed-Use Building For Lease
    New Mixed-Use Building For Lease

    1514 Brentwood Dr, Columbia, SC 29206

    $33 SF/Yr
    14,660 sqft $40,315/Mo

    New mixed-use building in thriving retail corridor available for lease.

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    Forest Acres Office Space Available
    Forest Acres Office Space Available

    4700 Forest Dr, Columbia, SC

    $17 SF/Yr
    4,106 sqft $5,816/Mo

    Office space for rent in the heart of Forest Acres.

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    Renovated Medical Space Available
    Renovated Medical Space Available

    1012 Calhoun St, Columbia, SC

    Contact for pricing
    2,865 sqft

    Renovated medical Class A space with convenient access.

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    Class-A Office/Medical Space Available
    Class-A Office/Medical Space Available

    1074 Pinnacle Point Dr, Columbia, SC

    $22.50 SF/Yr
    3,100 sqft $5,812/Mo

    Class-A office/medical space for lease in Northeast Columbia.

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    Medical Office Space For Rent
    Medical Office Space For Rent

    710 Rabon Rd, Columbia, SC 29203

    $28 SF/Yr

    Professional second-floor medical office space in Columbia, SC.

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    Lexington County, SC Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in Lexington County, SC with 28 listings featured on our commercial real estate exchange. The current inventory includes 235,707 square feet of properties with an estimated lease value of $403.50 /Mo.

    Estimated lease rates for Medical Office Space in Lexington County, SC begin at $10 SF/Yr, with an average of $21.24 SF/Yr and extend to $33 SF/Yr.
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