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    Greenville County, SC Medical Office Space for Lease

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    Medical Office Space For Lease
    Updated: Jan 27
    Medical Office Space For Lease

    10 Enterprise Blvd., Greenville, SC 29615

    $26.50 SF/Yr
    45,200 sqft
    Prime Location: One block from Prisma Health Patewood Campus & Bon Secours Francis Eastside.
    Medical/Healthcare Focus: Ideal office space for medical or healthcare practices.
    Flexible Lease Terms: Adaptable lease options to suit tenant needs.
    Available Space: 1,634 - 3,297 SF available, offering options for different sized practices.
    Renovated Common Areas: Updated and well‑maintained shared spaces.
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    Medical Office Space For Lease
    Updated: Sep 25, 2025
    Medical Office Space For Lease

    3535 Pelham Road, Greenville, SC 29615

    $13.95 SF/Yr
    8,000 sqft
    Prime location on Pelham Road corridor in Greenville County.
    Convenient access: Less than a mile to I‑85.
    Medical office space suitable for various practices.
    Flexible space: Can be divided to suit tenant needs.
    Features 9 private offices, 2 conference rooms, lobby, and break room.
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    Second-Generation Medical Office
    Second-Generation Medical Office

    35 Ray E Talley Ct, Simpsonville, SC 29680

    Contact for pricing
    7,880 sqft

    Located near Fairview Road with convenient access to I-385.

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    Medical Office Building in Medical Park
    Medical Office Building in Medical Park

    10 Memorial Medical Drive, Greenville, SC 29605

    Contact for pricing
    7,000 sqft

    Medical office building in Memorial Medical Park near I-185, offering space for healthcare practices or related offices.

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    Retail or Medical Corner Opportunity
    Retail or Medical Corner Opportunity

    6414 State Park Rd, Travelers Rest, SC 29690

    Contact for pricing
    13,813 sqft

    Hard-corner retail/medical site at a signalized intersection with exposure to multiple major thoroughfares.

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    Turn-Key ADA Accessible Professional Office
    Turn-Key ADA Accessible Professional Office

    106 MEMORIAL DR, Greer, SC 29650

    Contact for pricing
    1,442 sqft 0.32 AC lot

    Newly remodeled office with reception, three private offices, lounge, kitchen, and 10 on-site parking spaces.

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    Medical Office Space with Marquee Signage
    Medical Office Space with Marquee Signage

    800 Pelham Rd, Greenville, SC 29615

    Contact for pricing

    Second-generation medical space with existing clinical lab infrastructure and free surface parking near Prisma and Bon Secours.

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    Greenville Office/Medical Space For Rent
    Greenville Office/Medical Space For Rent

    20 Creekview Ct, Greenville, SC

    Contact for pricing
    1,005 sqft 1.17 AC lot

    Office or medical space available in Greenville, SC.

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    Lower-Level Office Suite with Lab Room
    Lower-Level Office Suite with Lab Room

    1405 Grove Road, Greenville, SC 29605

    Contact for pricing

    Lower-level suite with private offices, conference room, and lab/work room for medical or professional operations.

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    Medical Office Space
    Medical Office Space

    634 Fairview Road, Simpsonville, SC 29680

    Contact for pricing

    Established healthcare setting with SC-418 frontage, I-385 connectivity, and more than 120 medical providers within 3 miles.

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    Medical Office Space Available
    Medical Office Space Available

    300 Regent Park Ct, Greenville, SC 29607

    Contact for pricing

    Office spaces for healthcare providers near I-385 & Butler Rd.

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    Retail Space in Growing Town
    Retail Space in Growing Town

    Fountain Inn, SC 29644

    Contact for pricing

    Retail and QSR spaces available near Prisma Health Hospital.

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    334,000 SF Office Building For Lease
    334,000 SF Office Building For Lease

    300 South St, Simpsonville, SC 29681

    $19 SF/Yr

    334,000 SF Office Building For Lease

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    Eastside Building Near Medical Campuses
    Eastside Building Near Medical Campuses

    800 Pelham Rd, Greenville, SC 29615

    Contact for pricing

    Full building opportunity on the Eastside, near Prisma Health.

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    Turn Key Medical Office Space
    Turn Key Medical Office Space

    100 Constantine Wy, Greer, SC

    Contact for pricing
    5,000 sqft 0.61 AC lot

    New construction medical office space in close proximity to airport.

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    Medical Office Space Near Hospital
    Medical Office Space Near Hospital

    1200 W Faris Rd, Greenville, SC 29605

    Contact for pricing
    4,232 sqft

    Stand-alone building ideal for medical use near Greenville Memorial.

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    Greenville Office Space For Rent
    Greenville Office Space For Rent

    127 Halton Village Cir, Greenville, SC

    Contact for pricing
    5,600 sqft 0.15 AC lot

    Flexible office space near Patewood Medical Campus available for rent.

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    Based on your search, we've compiled 29 Potential Opportunities for your consideration. Besides 17 Active listings in Greenville County, SC, we suggest exploring alternatives. Similar 12 Properties for Sales.

    Similar Spaces for Sale in Greenville County, SC

    Consider Similar Space for Sale. We found 12 Spaces matching your search parameters.

    Single-Level Brick Medical Office
    Single-Level Brick Medical Office

    203 S Weston Street, Fountain Inn, SC 29644

    $1,500,000
    0.59 AC lot

    C-1 zoning, an included adjacent lot, and a detached brick outbuilding support flexible medical-office use.

    View details
    Absolute NNN Dental Office
    Absolute NNN Dental Office

    1173 Ashmore Bridge Rd, Greenville, SC 29605

    Contact for pricing
    4,200 sqft

    Newly delivered dental office offered on an Absolute NNN basis with a long-term lease and corporate guarantee.

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    Second-Generation Medical Office
    Second-Generation Medical Office

    35 Ray E Talley Ct, Simpsonville, SC 29680

    Contact for pricing
    7,880 sqft

    Well-maintained medical and office space in Simpsonville’s retail corridor near I-385 access.

    View details
    Medical Office with Basement
    Medical Office with Basement

    202 Memorial Drive, Greer, SC 29650

    Contact for pricing
    1,144 sqft 0.34 AC lot

    The property includes on-site parking and additional basement area for potential office conversion.

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    Medical Office with Parking
    Medical Office with Parking

    21 Memorial Medical Dr, Greenville, SC 29605

    Contact for pricing
    3,400 sqft 0.50 AC lot

    Former dermatology practice with dedicated parking near I-85 and Faris Road.

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    All-Brick Medical Office Building
    All-Brick Medical Office Building

    3115 Brushy Creek Rd, Greer, SC 29650

    Contact for pricing
    6,244 sqft

    All-brick medical office building in a professional office park with a 10-year leaseback.

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    Remodeled Office Space Near Downtown
    Remodeled Office Space Near Downtown

    106 Memorial Dr, Greer, SC 29650

    Contact for pricing
    1,442 sqft 0.32 AC lot

    Charming, remodeled office space suitable for medical or professional services.

    View details

    Greenville County, SC Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in Greenville County, SC with 17 listings featured on our commercial real estate exchange. The current inventory includes 99,172 square feet of properties with an estimated lease value of $59.45.

    Estimated lease rates for Medical Office Space in Greenville County, SC begin at $13.95 SF/Yr, with an average of $19.82 SF/Yr and extend to $26.50 SF/Yr.
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    Featured Greenville County Real Estate Agencies

    Realmo connects you with licensed Greenville County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Keller Williams Greenville Upstate
    403 Woods Lake Rd Greenville, SC 29607
    Phone: 18642347500
    www.kwgreenvillesc.com
    BlackStream International Real Estate
    20 Overbrook Court, Suite 400 Greenville, SC 29607
    Phone: 18645531998
    www.blackstreaminternational.com
    Coldwell Banker Caine
    111 Williams Street Greenville, SC 29601
    Phone: 18642502800
    cbcaine.com

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