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    South Carolina Mixed-use Properties for Lease

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    Columbia, SC Greenville, SC Charleston, SC
    54 results
    New Ellenton Office/Mixed-Use Space
    $1,100/Mo
    840 SF

    New Ellenton Office/Mixed-Use Space

    413 Main Street S unit: 3, New Ellenton, SC 29809

    Move-in ready office/mixed-use space in the heart of New Ellenton.

    • Turn key and move in ready condition
    • Office/mixed use space
    • Located in the heart of New Ellenton
    • NNN Lease
    • Year Built: 1948
    Updated: Feb 23
    View details
    Commercial Space in Beaufort, SC
    $2,300/Mo

    Commercial Space in Beaufort, SC

    8 Celadon Drive unit: A, Beaufort, SC 29907

    Ground floor commercial space with open floor plan available for rent.

    • Ground floor location with 1150 sq ft open floor plan.
    • Rent includes water, trash, HOA, insurance, and property taxes.
    • Two private offices, half‑bath, and utility room/kitchenette included.
    • Concrete and wood flooring.
    • Heat pump for both heating and cooling.
    Updated: Nov 1, 2025
    View details
    New Ellenton Office/Mixed-Use Space
    $800/Mo
    510 SF

    New Ellenton Office/Mixed-Use Space

    Ready-to-build office or mixed-use space in New Ellenton.

    413 Main Street S unit: 1, New Ellenton, SC 29809
    View details
    New Bluffton Flex and Retail
    Contact for pricing
    8,000 SF

    New Bluffton Flex and Retail

    New flex and retail buildings in the heart of Bluffton.

    5 Kitties Landing, Bluffton, SC 29910
    View details
    Mixed-Use Property in Cayce, SC
    $825/Mo
    7,541 SF

    Mixed-Use Property in Cayce, SC

    Mixed-use property suitable for redevelopment, retail, or office use.

    528-532 Knox Abbott Dr, Cayce, SC 29033
    View details
    Textile Mill Lofts in Greenville
    $20 SF/Yr
    2,035 SF

    Textile Mill Lofts in Greenville

    Live, work, and play spaces with industrial architecture.

    201 Smythe Street, Greenville, SC 29611
    View details
    Historic Mill Office Space Available
    $28 SF/Yr
    53,571 SF

    Historic Mill Office Space Available

    Creative office space in a vibrant mixed-use community.

    1802 Drayton Road, Suite 140B, Spartanburg, SC 29307
    View details
    Historic Mixed-Use Building on Main
    $14 SF/Yr
    64,799 SF

    Historic Mixed-Use Building on Main

    Mixed-use building in Columbia's Central Business District.

    1350 Main Street, Columbia, SC 29201
    View details
    New Mixed-Use Development Space
    Contact for pricing
    8,093 SF

    New Mixed-Use Development Space

    First-generation office and retail space in Greenville, SC.

    20 Liberty Lane, Greenville, SC 29607
    View details
    Myrtle Beach Mixed-Use Office Space
    $21 SF/Yr
    4,135 SF

    Myrtle Beach Mixed-Use Office Space

    Office space in vibrant Myrtle Beach district with live-work-play lifestyle.

    1101 Johnson Ave, Myrtle Beach, SC
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    Historic Greer Mill Mixed-Use Space
    Contact for pricing
    5,000 SF

    Historic Greer Mill Mixed-Use Space

    Vibrant mixed-use community with retail, restaurant, and office opportunities.

    300 Connecticut Avenue, Greer, SC 29650
    View details
    Class-A Mixed-Use Development For Rent
    Contact for pricing
    15,000 SF

    Class-A Mixed-Use Development For Rent

    New mixed-use development with commercial and residential spaces available for rent.

    351 Meeting Street, West Columbia, SC 29169
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    New Mixed-Use Suites Available
    Contact for pricing
    1,262 SF

    New Mixed-Use Suites Available

    New commercial spaces for lease in mixed-use development.

    50 Tanner Rd, Greenville, SC 29607
    View details
    Updated Mixed-Use Commercial Space
    Contact for pricing
    2,201 SF

    Updated Mixed-Use Commercial Space

    Updated mixed-use space with parking and high-speed internet in Columbia.

    746 Harden St., Columbia, SC 29205
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    Adaptable Commercial Space Available
    Contact for pricing

    Adaptable Commercial Space Available

    Versatile commercial space suitable for various business types.

    441 Hwy 183, Piedmont, SC 29673
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    Rivers Avenue Renovated Flex Space
    Contact for pricing
    4,420 SF

    Rivers Avenue Renovated Flex Space

    Renovated flex space available on highly traveled retail strip.

    5640 Rivers Ave, Charleston, SC 29406
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    Spartanburg Flexible Space For Rent
    $8 SF/Yr
    34,053 SF

    Spartanburg Flexible Space For Rent

    Flexible space suitable for retail or mixed-use purposes.

    1201 Union, Spartanburg, SC
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    Retail Space on Forest Drive
    Contact for pricing
    1,920 SF

    Retail Space on Forest Drive

    Retail space available in mixed-use development on Forest Drive.

    4609 Forest Dr, Columbia, SC
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    Mixed-Use Destination Retail Space
    Contact for pricing
    2,245 SF

    Mixed-Use Destination Retail Space

    Retail space in a mixed-use destination with shops and restaurants.

    1596 Palmetto Grande Dr, Mt Pleasant, SC
    View details
    43,466 SF Industrial Building For Lease
    $4 SF/Yr

    43,466 SF Industrial Building For Lease

    43,466 SF Industrial Building For Sale or For Lease

    124 N Charleston St, Blacksburg, SC 29702
    View details
    Planned Mixed-Use Development Opportunity
    Contact for pricing

    Planned Mixed-Use Development Opportunity

    Mixed-use development opportunity at Chapin Road and Primrose Lane.

    565 Chapin Rd, Chapin, SC 29036
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    Planned Mixed-Use Development Opportunity
    Contact for pricing

    Planned Mixed-Use Development Opportunity

    Mixed-use development opportunity at Chapin Road and Primrose Lane.

    573 Chapin Rd, Chapin, SC 29036
    View details
    Design-Forward Mixed-Use Campus Retail Space
    Contact for pricing
    4,238 SF

    Design-Forward Mixed-Use Campus Retail Space

    Retail space available in Charleston's emerging NoMo district.

    804 Meeting St, Charleston, SC
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    Mixed-Use Property Near Clemson Campus
    Contact for pricing

    Mixed-Use Property Near Clemson Campus

    Mixed-use property with residential and retail components near Clemson University.

    111 Earle Street, Clemson, SC 29631
    View details

    South Carolina Mixed-use properties Leasing Opportunities Market Analysis

    Explore Mixed-use properties leasing options in South Carolina with 54 listings featured on our commercial real estate exchange. The current inventory includes 167,484 square feet of properties with an estimated lease value of $127 SF/Yr.

    Estimated lease rates for Mixed-use properties in South Carolina begin at $1.31 SF/Yr, with an average of $15 SF/Yr and extend to $28 SF/Yr.
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