South Carolina Mixed-use properties for Rent & Lease

Updated: Sep 8

New Mixed-Use Space

5100 Highway 17 Bypass, Murrells Inlet, SC 29576

$3,125/Mo

2,500 sqft 1.90 AC lot

2,500 SF available within a 12,000 SF mixed‑use building
Can be configured as two 1,250 SF suites or one 2,500 SF space
Direct exposure on Highway 17 Bypass with approximately 36,700 vehicles per day
1.9‑acre site with ample parking
Projected completion March 2027

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Updated: Feb 23

Mixed-Use Office Property

413 Main Street S, New Ellenton, SC 29809

$1,100/Mo

840 sqft

840 square feet of mixed‑use office space
NNN lease structure
Bathroom included
Constructed in 1948
Located at 413 Main Street S, New Ellenton, SC 29809

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Build-Out-Ready Mixed-Use Space

413 Main Street S, New Ellenton, SC 29809

Triple net (NNN)

$800/Mo

510 sqft Built 1948

Compact office or mixed-use space in New Ellenton with an NNN lease structure.

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Oceanfront End-Cap Retail Space

700 N Ocean Blvd, Myrtle Beach, SC 29577

$27 SF/Yr

4,251 sqft Built 2025

Ground-floor retail suite with an oceanfront patio and sidewalk access to the boardwalk.

Oceanfront outdoor patio Sidewalk connectivity to oceanfront boardwalk

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Mixed-Use Building with Monument Signage

22 Sams Point Way, Beaufort, SC 29907

Triple net (NNN)

$26 SF/Yr

Single tenant 3,526 sqft Built 1988 2-story

A standalone property offers a two-level layout and buildout flexibility for office or retail occupancy.

Monument signage Dedicated parking

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Mixed-Use Property with Loading Dock

11 Mathews Drive, Hilton Head Island, SC 29926

Triple net (NNN)

$18 SF/Yr

1,500 sqft Built 1981 1 acre

Commercially zoned space includes a loading dock and rear pull-up door.

Loading dock Pull up door in the back

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Mixed-Use Storefront Space

742 Main St. Unit: Arts & Innovation Distric, Myrtle Beach, SC 29577

$1,597/Mo

1,277 sqft Built 1929

The interior combines two offices, an open showroom area, and one restroom.

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Rivers Avenue Renovated Flex Space

5640 Rivers Ave, Charleston, SC 29406

$18 SF/Yr

4,420 sqft Built 1990

Renovated flex space available on highly traveled retail strip.

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Mixed-Use Property with Retail Space

807 Gervais St, Columbia, SC 29201

Triple net (NNN) Vista Neighborhood Association

Contact for pricing

3,054 sqft

Retail and office suites feature showroom glazing, coffered metal ceilings, and original hardwood flooring.

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Mixed-Use Property in Cayce, SC

528-532 Knox Abbott Dr, Cayce, SC 29033

$825/Mo

7,541 sqft

Mixed-use property suitable for redevelopment, retail, or office use.

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Historic Mixed-Use Space

102 Exchange Street Basement, Pendleton, SC 29670

$3,100/Mo

Multi-tenant Built 1910

Road access

Basement commercial space offered as a shell for tenant upfit.

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Downtown Mixed-Use Space with Parking

1203 Main St., Conway, SC 29526

$3,338/Mo

1,535 sqft

Road access DT

The downtown space offers professional interiors and a dedicated private parking lot.

Private parking lot Prominent Main Street frontage Excellent visibility Pedestrian traffic

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New Bluffton Flex and Retail

5 Kitties Landing, Bluffton, SC 29910

$25 SF/Yr

8,000 sqft

New flex and retail buildings in the heart of Bluffton.

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Renovated Storefront Retail Space

2295 Hoffmeyer Road - Storefront B, Florence, SC 29501

Contact for pricing

Multi-tenant 7,405 sqft

Highway access

A renovated retail suite includes new HVAC, sprinkler protection, and access to on-site parking.

107 parking spaces Sprinklered New HVAC Lush landscaping

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Retail Space Near Interstate Access

3710 Pelham Ct, Greenville, SC 29615

Contact for pricing

1,500 sqft

Highway access

Retail space within a multi-building retail and office setting, near dining and fitness businesses.

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Mixed-Use Development on Highway 41

1031 & 1039 Hwy 41, Mount Pleasant, SC 29466

$28 SF/Yr

16,000 sqft

Multi-building mixed-use development with retail and office space.

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Historic Mixed-Use Building

127 W Evans Street, Florence, SC 29501

$3,266/Mo

1,568 sqft Built 1925

Two restrooms serve a space suited to retail, restaurant, or coffee shop use.

Two restrooms

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Five-Story Mixed-Use Building

111 E Main St, Spartanburg, SC 29306

Triple net (NNN)

Contact for pricing

5,691 sqft 5-story

Planned redevelopment combines apartments with ground-floor retail and restaurant space.

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Mixed-Use Retail Unit

720 Highway 17 Business #Unit C, Surfside Beach, SC 29575

$2,500/Mo

1,754 sqft

Highway access Road access

HC-zoned space offers an open retail area, work and storage space, a kitchenette, and a restroom.

Hardwood flooring Open work/storage area Kitchenette Restroom

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Mixed-Use Retail Storefront

2295 Hoffmeyer Road - Storefront C, Florence, SC 29501

$4,688/Mo

3,750 sqft Built 1979

Renovated commercial space offers new HVAC, sprinkler protection, and flexible build-out options within a multi-use development.

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Office Units with Flexible Sizes

61 Broad St, Charleston, SC 29401

Charlestowne

Contact for pricing

4–8 people 1,230 sqft

Office units are offered in multiple configurations within a building that maintains separate access for residential floors.

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Ground-Floor Mixed-Use Suite

284 Meeting Street # 101, Charleston, SC 29401

Silver Hill/Magnolia

Contact for pricing

1,600 sqft

An open interior with HVAC and two restrooms supports office or retail use.

Two restrooms HVAC Beautiful mahogany storefront

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Office/Retail Suite Near I-26

2470 Mall Drive # G, North Charleston, SC 29406

Full service Centre Pointe

Contact for pricing

980 sqft

Highway access

The full-service arrangement excludes internet and janitorial service.

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Industrial-Character Mixed-Use Property

31 Victor St, Greenville, SC 29609

Triple net (NNN)

Contact for pricing

30,000 sqft brick-and-beam

Redeveloped industrial space accommodates retail, food and beverage, office, and residential uses alongside outdoor amenities.

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South Carolina Mixed-use properties Market Trends and Statistics

Explore Mixed-use properties leasing options in South Carolina with 62 listings featured on our commercial real estate exchange. The current inventory includes 230,133 square feet of properties with an estimated lease value of $459.63.

Estimated lease rates for Mixed-use properties in South Carolina begin at $1.31 SF/Yr, with an average of $19.15 SF/Yr and extend to $45 SF/Yr.