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    South Carolina Mixed-use Properties for Lease

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    Greenville, SC Columbia, SC Charleston, SC
    43 listings
    Turn-Key Office/Mixed-Use Space
    $1,100/Mo
    840 SF
    Turn-Key Office/Mixed-Use Space

    413 Main Street S, New Ellenton, SC 29809

    Move-in ready office or mixed-use space available on an NNN lease in downtown New Ellenton.
    • Turn key and move in ready condition
    • Office/mixed use space
    • Located in the heart of New Ellenton
    • NNN Lease
    • Year Built: 1948
    Updated: Feb 23
    View details
    Ground Floor Office Suite
    $2,100/Mo
    1,150 SF
    Ground Floor Office Suite

    8 Celadon Drive, Beaufort, SC 29907

    Ground floor suite with private offices and utilities included, ideal for small teams needing dedicated work space.
    • Ground floor location with 1150 sq ft open floor plan.
    • Rent includes water, trash, HOA, insurance, and property taxes.
    • Two private offices, half‑bath, and utility room/kitchenette included.
    • Concrete and wood flooring.
    • Heat pump for both heating and cooling.
    Updated: Nov 1, 2025
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    Build-Out Ready Office/Mixed-Use Space
    $800/Mo
    510 SF
    Build-Out Ready Office/Mixed-Use Space

    Build-out ready office and mixed-use space available on a NNN lease in New Ellenton.

    413 Main Street S, New Ellenton, SC 29809

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    Da Gullah Way Mixed-Use Unit
    $3,329/Mo
    1,598 SF
    Da Gullah Way Mixed-Use Unit

    Prime mixed-use space in desirable Pawleys Island location.

    71 Da Gullah Way, Pawleys Island, SC 29585

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    Light-Filled Town Center Retail Suite
    $2,500/Mo
    1,440 SF
    Light-Filled Town Center Retail Suite

    Spacious commercial suite in a mixed-use town center setting, well suited for a variety of storefront uses.

    20 Market Street, Beaufort, SC 29906

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    New Bluffton Flex and Retail
    $25 SF/Yr
    8,000 SF
    New Bluffton Flex and Retail

    New flex and retail buildings in the heart of Bluffton.

    5 Kitties Landing, Bluffton, SC 29910

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    Textile Mill Lofts in Greenville
    $20 SF/Yr
    2,035 SF
    Textile Mill Lofts in Greenville

    Live, work, and play spaces with industrial architecture.

    201 Smythe Street, Greenville, SC 29611

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    Mixed-Use Property in Cayce, SC
    $825/Mo
    7,541 SF
    Mixed-Use Property in Cayce, SC

    Mixed-use property suitable for redevelopment, retail, or office use.

    528-532 Knox Abbott Dr, Cayce, SC 29033

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    Myrtle Beach Mixed-Use Office Space
    $21 SF/Yr
    4,135 SF
    Myrtle Beach Mixed-Use Office Space

    Office space in vibrant Myrtle Beach district with live-work-play lifestyle.

    1101 Johnson Ave, Myrtle Beach, SC

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    Historic Mill Office Space Available
    $28 SF/Yr
    53,571 SF
    Historic Mill Office Space Available

    Creative office space in a vibrant mixed-use community.

    1802 Drayton Road, Suite 140B, Spartanburg, SC 29307

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    New Mixed-Use Development Space
    Contact for pricing
    8,093 SF
    New Mixed-Use Development Space

    First-generation office and retail space in Greenville, SC.

    20 Liberty Lane, Greenville, SC 29607

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    Historic Greer Mill Mixed-Use Space
    Contact for pricing
    5,000 SF
    Historic Greer Mill Mixed-Use Space

    Vibrant mixed-use community with retail, restaurant, and office opportunities.

    300 Connecticut Avenue, Greer, SC 29650

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    Class-A Mixed-Use Development For Rent
    Contact for pricing
    15,000 SF
    Class-A Mixed-Use Development For Rent

    New mixed-use development with commercial and residential spaces available for rent.

    351 Meeting Street, West Columbia, SC 29169

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    Spartanburg Flexible Space For Rent
    $8 SF/Yr
    34,053 SF
    Spartanburg Flexible Space For Rent

    Flexible space suitable for retail or mixed-use purposes.

    1201 Union, Spartanburg, SC

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    Updated Mixed-Use Commercial Space
    Contact for pricing
    2,201 SF
    Updated Mixed-Use Commercial Space

    Updated mixed-use space with parking and high-speed internet in Columbia.

    746 Harden St., Columbia, SC 29205

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    New Mixed-Use Suites Available
    Contact for pricing
    1,262 SF
    New Mixed-Use Suites Available

    New commercial spaces for lease in mixed-use development.

    50 Tanner Rd, Greenville, SC 29607

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    Historic Mixed-Use Building on Main
    Contact for pricing
    64,799 SF
    Historic Mixed-Use Building on Main

    Mixed-use building in Columbia's Central Business District.

    1350 Main Street, Columbia, SC 29201

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    Retail Space on Forest Drive
    Contact for pricing
    1,920 SF
    Retail Space on Forest Drive

    Retail space available in mixed-use development on Forest Drive.

    4609 Forest Dr, Columbia, SC

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    Adaptable Commercial Space Available
    Contact for pricing
    Adaptable Commercial Space Available

    Versatile commercial space suitable for various business types.

    441 Hwy 183, Piedmont, SC 29673

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    Mixed-Use Destination Retail Space
    Contact for pricing
    2,245 SF
    Mixed-Use Destination Retail Space

    Retail space in a mixed-use destination with shops and restaurants.

    1596 Palmetto Grande Dr, Mt Pleasant, SC

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    Rivers Avenue Renovated Flex Space
    Contact for pricing
    4,420 SF
    Rivers Avenue Renovated Flex Space

    Renovated flex space available on highly traveled retail strip.

    5640 Rivers Ave, Charleston, SC 29406

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    Design-Forward Mixed-Use Campus Retail Space
    Contact for pricing
    4,238 SF
    Design-Forward Mixed-Use Campus Retail Space

    Retail space available in Charleston's emerging NoMo district.

    804 Meeting St, Charleston, SC

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    Mixed Commercial Space Available
    Contact for pricing
    1,500 SF
    Mixed Commercial Space Available

    1,500 sq. ft. space ideal for retail, office, or storage.

    46 Old Wild Horse Road, Hilton Head Island, SC 29926

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    Class A Office Space
    $43 SF/Yr
    Class A Office Space

    Office space in mixed-use center with retail and residential.

    New Riverside Vlg Wy, Bluffton, SC 29910

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    South Carolina Mixed-use properties Market Trends and Statistics

    Explore Mixed-use properties leasing options in South Carolina with 43 listings featured on our commercial real estate exchange. The current inventory includes 132,802 square feet of properties with an estimated lease value of $235 SF/Yr.

    Estimated lease rates for Mixed-use properties in South Carolina begin at $1.31 SF/Yr, with an average of $19 SF/Yr and extend to $33 SF/Yr.
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