South Carolina Mixed-use properties for Rent & Lease

Updated: Feb 23

Mixed-Use Office Space

413 Main Street S, New Ellenton, SC 29809

$1,100/Mo

840 sqft

840 SF of mixed‑use commercial space
Office‑oriented layout with mixed‑use positioning
NNN lease structure
One bathroom included
Built in 1948

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Updated: Feb 23

Build-Out-Ready Mixed-Use Space

413 Main Street S, New Ellenton, SC 29809

$800/Mo

510 sqft

510 square feet of mixed‑use space
Build‑out‑ready interior configuration
NNN lease structure
Includes a bathroom
1948 construction

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Historic Mixed-Use Building

102 Exchange Street, Pendleton, SC 29670

$3,100/Mo

Restored commercial space occupies a prominent corner on Pendleton’s Town Square near Clemson University.

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Mixed-Use Property in Cayce, SC

528-532 Knox Abbott Dr, Cayce, SC 29033

$825/Mo

7,541 sqft

Mixed-use property suitable for redevelopment, retail, or office use.

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Open-Shell Mixed-Use Space

23b Market Street, Beaufort, SC 29906

$1,600/Mo

As-is unit offers an open-concept layout for office, retail, or restaurant use.

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New Bluffton Flex and Retail

5 Kitties Landing, Bluffton, SC 29910

$25 SF/Yr

8,000 sqft

New flex and retail buildings in the heart of Bluffton.

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Multi-Tenant Office Suite

1510 Whiskey Road #Suite 3, Aiken, SC 29803

$18 SF/Yr

1,303 sqft

Office suite in a multi-tenant property with GB zoning and access along a centrally positioned commercial corridor.

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Ground-Floor Mixed-Use Suites

125 Anderson Hwy, Clemson, SC 29631

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3,391 sqft

Three leasing options within a student housing community accommodate retail, office, restaurant, and service-oriented uses.

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Historic Mill Office Space Available

1802 Drayton Road, Suite 140B, Spartanburg, SC 29307

$16 SF/Yr

53,571 sqft

Creative office space in a vibrant mixed-use community.

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Mixed-Use Retail and Entertainment Center

1740 Towne Centre Way, Mount Pleasant, SC 29464

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3,713 sqft

Towne Centre offers retail and dining alongside Regal Cinemas, Belk, and Hyatt Place.

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New Mixed-Use Retail Space

635 King Street, Charleston, SC 29403

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13,459 sqft

First-floor retail space is planned as part of a new mixed-use development with prominent street frontage.

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Mixed-Use Retail and Office Space

2295 Hoffmeyer Rd, Florence, SC 29501

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7,465 sqft

7,465-square-foot property within a redevelopment featuring retail, office, medical, dining, and lifestyle spaces.

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Renovated Office Suite

137 Calhoun Street Apt A, Charleston, SC 29401

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675 sqft

Open-plan workspace includes a private room, full bath, and quartz counters.

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Spartanburg Flexible Space For Rent

1201 Union, Spartanburg, SC

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34,053 sqft 4.14 AC lot

Flexible space suitable for retail or mixed-use purposes.

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Mixed-Use Development Property

701 Easley Bridge Rd, Greenville, SC 29611

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10,000 sqft

Flexible space options include office, retail, and light industrial uses within a mixed-use campus.

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Mixed-Use Retail and Office Space

21 N Main St, Wellford, SC 29377

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2,286 sqft

Brand-new mixed-use facility offers pre-leasing with options for tenant customization within a redeveloped mill community.

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Adaptive Reuse Mixed-Use Property

1501 King Street, Charleston, SC 29405

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3,345 sqft

Flexible commercial space within a campus combining food, retail, wellness, and office uses around landscaped courtyards.

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Mixed Commercial Space Available

46 Old Wild Horse Road, Hilton Head Island, SC 29926

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1,500 sqft

1,500 sq. ft. space ideal for retail, office, or storage.

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Restaurant or Retail Opportunity

10 Westedge St, Charleston, SC 29403

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3,426 sqft

Ground-floor commercial space offers a patio, grease trap, and adjacency to Publix within a mixed-use development.

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Adaptable Commercial Space Available

441 Hwy 183, Piedmont, SC 29673

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Versatile commercial space suitable for various business types.

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Adaptive Reuse Mixed-Use Campus

1501 King Street, Charleston, SC 29405

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2,227 sqft

A mixed-use campus blending historic warehouse architecture with modern design, with curated outdoor courtyards and gathering areas.

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Redeveloped Mixed-Use Space in Cayce

528-532 Knox Abbott Dr, Cayce, SC 29033

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8,100 sqft

Flexible retail or office space in a growing area.

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Historic Mixed-Use Retail Suites

5359-5369 N Main St, Cowpens, SC 29330

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1,731 sqft

Two retail spaces inside the historic Potter’s Old Store, with apartment units on the upper level, scheduled for completion in fall 2025.

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Planned Mixed-Use Development Opportunity

573 Chapin Rd, Chapin, SC 29036

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Mixed-use development opportunity at Chapin Road and Primrose Lane.

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South Carolina Mixed-use properties Market Trends and Statistics

Explore Mixed-use properties leasing options in South Carolina with 44 listings featured on our commercial real estate exchange. The current inventory includes 379,940 square feet of properties with an estimated lease value of $106.84 SF/Yr.

Estimated lease rates for Mixed-use properties in South Carolina begin at $1.31 SF/Yr, with an average of $15.26 SF/Yr and extend to $25 SF/Yr.