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    Florence County, SC Office Spaces for Lease

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    11 properties
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    Special-Use Office Building
    Updated: Jun 19
    Special-Use Office Building

    191 South Cashua Drive, Florence, SC 29501

    Contact for pricing
    2,560 sqft 0.58 AC lot
    Special‑use office building totaling 2,560 SF available September 2026
    Former veterinary office layout suitable for medical, professional, service‑based, or specialty office use
    Located on S Cashua Dr in Florence’s 5 Points commercial district in a high‑traffic area
    On‑site parking includes nine lined spaces in front, with additional parking available at the rear
    Set on a 0.58‑acre lot
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    Class A Office Building
    Updated: Apr 21
    Class A Office Building

    301 W Evans St, Florence, SC 29501

    Contact for pricing
    40,000 sqft
    Class A office building in Florence’s downtown corridor, directly adjacent to the Federal, State, and County Courthouses
    30,000–40,000 SF across 3–4 stories
    High‑capacity elevator and controlled‑access building
    Advanced HVAC and fully customizable tenant interiors
    Brick and stucco exterior with expansive storefront glazing for a downtown streetscape presence
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    Multi-Tenant Retail Office Building
    Multi-Tenant Retail Office Building

    181 S Cashua Dr, Florence, SC 29501

    Contact for pricing
    7,500 sqft 1.83 AC lot

    Shell space with a rear drive-in door, front parking, and monument and above-suite signage options along S Cashua Drive.

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    Three-Story Office Building
    Three-Story Office Building

    186 Dunbarton Drive, Florence, SC 29501

    Contact for pricing
    32,087 sqft

    Three-story office building offering private offices, open workspace, and a ground-floor café-style break room.

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    End-Unit Office Suite
    End-Unit Office Suite

    2843 W Palmetto St, Florence, SC 29501

    Contact for pricing

    Professional space with private offices, reception area, and an on-site restroom in a multi-suite building.

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    Office Building with I-95 Visibility
    Office Building with I-95 Visibility

    2240 North Douglas Street, Florence, SC 29501

    Contact for pricing

    Office building in a professional business park with visibility from I-95 and convenient access to I-20.

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    Modern Office Space For Rent
    Modern Office Space For Rent

    2701 Alex Lee Blvd, Florence, SC 29506

    Contact for pricing
    7,145 sqft

    7,145 SF customizable office space in Florence, SC.

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    Refreshed Office Building For Lease
    Refreshed Office Building For Lease

    620 W Evans St, Florence, SC 29501

    Contact for pricing
    3,000 sqft

    Standalone office building with private parking near Downtown Florence, SC.

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    Established Commercial Complex on Second Loop
    Established Commercial Complex on Second Loop

    1800 2nd Loop Rd, Florence, SC 29501

    Contact for pricing
    2,000 sqft

    Multi-tenant commercial complex with high visibility and convenient access.

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    Florence Commercial Space For Rent
    Florence Commercial Space For Rent

    2843 W Palmetto Street Suite C, Florence, SC 29501

    Contact for pricing

    Commercial space suitable for office, professional, or retail use.

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    Prestigious Office Suites in Florence
    Prestigious Office Suites in Florence

    1831 W Evans St, Florence, SC 29501

    Contact for pricing
    4,453 sqft

    Corporate office suites available for lease in Florence, SC.

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    Based on your search, we've compiled 40 Potential Opportunities for your consideration. Besides 11 Active listings in Florence County, SC, we suggest exploring alternatives. Similar 29 Properties for Sales.

    Similar Spaces for Sale in Florence County, SC

    Consider Similar Space for Sale. We found 29 Spaces matching your search parameters.

    Freestanding Storefront Building
    Freestanding Storefront Building

    205 W Main St, Lake City, SC 29560

    $700,000
    5,410 sqft

    Downtown setting near businesses, banks, restaurants, and public services supports multiple commercial use options.

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    Historic Office Building with Parking
    Historic Office Building with Parking

    248-260 W Evans st., Florence, SC 29501

    $2,700,000
    16,304 sqft 1.47 AC lot

    Historic office building with central air, heat pumps, and over 100 parking spaces in downtown Florence.

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    Wood-Frame Office Building
    Wood-Frame Office Building

    2228 W Palmetto St., Florence, SC 29501

    $225,000
    1,405 sqft 0.31 AC lot

    Wood-frame office building with heat pump heating and central air, positioned on a commercial lot along W Palmetto St.

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    Medical Office Building with 13 Exam Rooms
    Medical Office Building with 13 Exam Rooms

    1706 2nd Loop Rd., Florence, SC 29501

    $1,650,000
    8,291 sqft 1.34 AC lot

    CI-zoned medical office facility with 13 exam rooms, covered patient drop-off, and 62 parking spaces.

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    Historic Downtown Florence Building For Sale
    Historic Downtown Florence Building For Sale

    248,258, and 268 W. Evans St., Florence, SC 29501

    $2,700,000
    16,304 sqft 1.47 AC lot

    16,000 SF historic building in downtown Florence for sale.

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    Historic Downtown Office Building
    Historic Downtown Office Building

    260 W Evans St, Florence, SC 29501

    $2,700,000
    16,000 sqft 1.47 AC lot

    A 16,000-square-foot historic office building with multiple suites, including a law firm and other tenants, plus over 100 parking spaces.

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    Historic Mixed-Use Building in Florence
    Historic Mixed-Use Building in Florence

    248,258, and 268 W. Evans St., Florence, SC 29501

    $2,700,000
    13 sqft

    16,000 sq ft historic building in Downtown Florence for sale.

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    Remodeled Office Building
    Remodeled Office Building

    910 W Evans st, Florence, SC 29501

    $300,000
    2,165 sqft 0.27 AC lot

    Five-room commercial layout with a kitchen, full bathroom, and additional half bath.

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    Office-Warehouse Flex Facility
    Office-Warehouse Flex Facility

    1829 Habersham Square, Florence, SC 29501

    Contact for pricing
    5,000 sqft 0.81 AC lot

    Office space with three private offices and a reception area complements a warehouse with two drive-in doors.

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    Commercial Office Property with Parking
    Commercial Office Property with Parking

    2228 W Palmetto St., Florence, SC 29501

    Contact for pricing
    1,405 sqft

    Office-focused commercial property along a high-traffic corridor, offering visibility, accessibility, and ample on-site parking.

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    Historic Downtown Office Building
    Historic Downtown Office Building

    248-260 W Evans st., Florence, SC 29506

    Contact for pricing
    16,304 sqft 1.47 AC lot

    Historic office building in downtown Florence with multiple tenant suites and over 100 parking spaces.

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    Two-Story Single-Tenant Medical Office
    Two-Story Single-Tenant Medical Office

    1604 E Cheves St, Florence, SC 29506

    Contact for pricing
    16,444 sqft

    Fee simple interest in a purpose-built two-story medical office building, single-tenant and leased to a neurosurgery practice.

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    Freestanding Office Building For Sale
    Freestanding Office Building For Sale

    1221 West Evans Street, Florence, SC 29501

    Contact for pricing
    1,085 sqft

    Leased office building with immediate income potential in Florence.

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    Florence County, SC Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Florence County, SC with 11 listings featured on our commercial real estate exchange. The current inventory includes 98,745 square feet of properties.
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    Featured Florence County Real Estate Agencies

    Realmo connects you with licensed Florence County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Coldwell Banker McMillan and Associates
    419 S.Coit Street Florence, SC 29501
    Phone: 18436017710
    CBFlorence.com

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