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    Florence County, SC Office Spaces for Lease

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    13 properties
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    Medical Office Building Near MUSC
    Updated: Nov 25, 2025
    Medical Office Building Near MUSC

    1929 Mountain Laurel Court, Florence, SC

    Contact for pricing
    7,950 sqft
    Prime location at the MUSC campus entrance.
    Ample parking with space for up to 50 vehicles and a covered portico.
    Functional layout featuring 15 exam rooms, lab, nurses stations, and administrative offices.
    Renovated in 2015.
    Brick and glass storefront façade offering exceptional curb appeal.
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    Versatile Office Space Available
    Updated: Oct 4, 2024
    Versatile Office Space Available

    420 W Cheves St, Florence, SC 29501

    $1,400/Mo
    1,500 sqft $11.20 SF/Yr
    Central location at 420 C W Cheves St.
    Approximately 1,500 sq ft of flexible office space.
    Suitable for various business types (office, consulting, studio, retail).
    Refreshed floors.
    Easy access to local amenities and public transportation.
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    Commercial Office Space For Rent
    Commercial Office Space For Rent

    2527 S Cashua Dr, Florence, SC 29501

    $1,950/Mo
    2,000 sqft $11.70 SF/Yr

    Office space available in Shoppes at Celebration shopping center.

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    Special-Use Office Building
    Special-Use Office Building

    191 South Cashua Drive, Florence, SC 29501

    Contact for pricing
    2,560 sqft

    Well-positioned special-use office building with on-site parking and established visibility for medical or professional use.

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    Downtown Florence Mixed-Use Space
    Downtown Florence Mixed-Use Space

    127 W Evans St, Florence, SC 29501

    $25 SF/Yr
    1,800 sqft $3,750/Mo

    Prime mixed-use space in Downtown Florence Historic District.

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    Refreshed Office Building For Lease
    Refreshed Office Building For Lease

    620 W Evans Street, Florence, SC 29501

    $4,500/Mo
    3,000 sqft $18 SF/Yr

    Standalone office building near Downtown Florence with private parking.

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    Refreshed Office Building For Lease
    Refreshed Office Building For Lease

    620 W Evans St, Florence, SC 29501

    $216 SF/Yr
    3,000 sqft $54,000/Mo

    Standalone office building with private parking near Downtown Florence, SC.

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    Office Building with I-95 Visibility
    Office Building with I-95 Visibility

    2240 North Douglas Street, Florence, SC 29501

    Contact for pricing

    Office building in a professional business park with visibility from I-95 and convenient access to I-20.

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    Modern Office Space For Rent
    Modern Office Space For Rent

    2701 Alex Lee Blvd, Florence, SC 29506

    $22 SF/Yr
    7,145 sqft $13,099/Mo

    7,145 SF customizable office space in Florence, SC.

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    Established Commercial Complex on Second Loop
    Established Commercial Complex on Second Loop

    1800 2nd Loop Rd, Florence, SC 29501

    Contact for pricing
    2,000 sqft

    Multi-tenant commercial complex with high visibility and convenient access.

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    Florence Commercial Space For Rent
    Florence Commercial Space For Rent

    2843 W Palmetto Street Suite C, Florence, SC 29501

    Contact for pricing

    Commercial space suitable for office, professional, or retail use.

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    Downtown Florence Flex Office Warehouse
    Downtown Florence Flex Office Warehouse

    312 Railroad Ave, Florence, SC 29506

    $7.89 SF/Yr
    9,880 sqft $6,496/Mo

    Flex office warehouse space for lease in downtown Florence.

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    Prestigious Office Suites in Florence
    Prestigious Office Suites in Florence

    1831 W Evans St, Florence, SC 29501

    $25 SF/Yr
    4,453 sqft $9,277/Mo

    Corporate office suites available for lease in Florence, SC.

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    Based on your search, we've compiled 37 Potential Opportunities for your consideration. Besides 13 Active listings in Florence County, SC, we suggest exploring alternatives. Similar 20 Properties for Sales.

    Similar Spaces for Sale in Florence County, SC

    Consider Similar Space for Sale. We found 20 Spaces matching your search parameters.

    Medical Office Building with Parking
    Medical Office Building with Parking

    1706 2nd Loop Rd., Florence, SC 29501

    $1,650,000
    8,291 sqft 1.34 AC lot

    Turnkey medical office facility featuring 13 exam rooms, X-ray room, and 62 parking spaces.

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    Historic Downtown Office Building
    Historic Downtown Office Building

    248-260 W Evans st., Florence, SC 29501

    $2,700,000
    16,304 sqft 1.47 AC lot

    Historic office building with multiple suites and ample on-site parking in downtown Florence.

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    Office Property with Parking
    Office Property with Parking

    2228 W Palmetto St., Florence, SC 29501

    $250,000
    1,405 sqft 0.31 AC lot

    Office space on a 0.31-acre lot with parking and strong visibility along W Palmetto St in Florence.

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    Remodeled Medical Office Building
    Remodeled Medical Office Building

    910 W Evans st, Florence, SC 29501

    $300,000
    2,165 sqft 0.27 AC lot

    Turnkey, fully rebuilt office suite with treatment-room style spaces, new HVAC, and updated plumbing and electrical.

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    Historic Downtown Office Building
    Historic Downtown Office Building

    260 W Evans St, Florence, SC 29501

    $2,700,000
    16,000 sqft 1.47 AC lot

    A 16,000-square-foot historic office building with multiple suites, including a law firm and other tenants, plus over 100 parking spaces.

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    Commercial Office Property with Parking
    Commercial Office Property with Parking

    2228 W Palmetto St., Florence, SC 29501

    $250,000
    1,405 sqft

    Office-focused commercial property along a high-traffic corridor, offering visibility, accessibility, and ample on-site parking.

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    McLeod Physician Associates For Sale
    McLeod Physician Associates For Sale

    1540 American Dr, Florence, SC

    $1,384,320
    2,666 sqft 0.59 AC lot

    2,666 SF medical office in Florence, SC for sale.

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    Downtown Florence Business Technology Center
    Downtown Florence Business Technology Center

    187 E Evans St, Florence, SC

    $12,000,000
    119,567 sqft 3.29 AC lot

    Office building in downtown Florence with investment and value-add potential.

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    Historic Downtown Florence Building For Sale
    Historic Downtown Florence Building For Sale

    248,258, and 268 W. Evans St., Florence, SC 29501

    $2,700,000
    16,304 sqft 1.47 AC lot

    16,000 SF historic building in downtown Florence for sale.

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    Office/Retail Conversion Opportunity
    Office/Retail Conversion Opportunity

    2901 W Palmetto Street, Florence, SC 29501

    $400,000
    2,600 sqft 1.60 AC lot

    2600 SF residence on 1.6 acres, suitable for conversion.

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    Stand-Alone Office Building For Sale
    Stand-Alone Office Building For Sale

    215 John St, Lake City, SC

    $250,000
    1,722 sqft 0.29 AC lot

    Stand-alone office building with immediate occupancy in Lake City, SC.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Land Lease Opportunity in Waxhaw
    Land Lease Opportunity in Waxhaw

    5325 Waxhaw Marvin Road, Waxhaw, NC 28173

    $8,000/Mo

    5.341-acre commercial land for lease in a high-growth area.

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    Waterfront Commercial Land Parcel
    Waterfront Commercial Land Parcel

    Old Bridge Street, Jacksonville, NC 28540

    $4,500/Mo

    Commercially zoned waterfront parcel with deep water frontage and bulkhead, located within city limits.

    View details
    Commercial Land Build-to-Suit Opportunity
    Commercial Land Build-to-Suit Opportunity

    2683 Henderson Drive, Jacksonville, NC 28546

    $4,000/Mo
    2,400 sqft $20 SF/Yr

    Commercial land available for build-to-suit in Jacksonville, NC.

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    Prime Development Opportunity in Greenville
    Prime Development Opportunity in Greenville

    39 Airpark Ct, Greenville, SC 29607

    Contact for pricing

    1.27 acre interstate-visible land for ground lease or build-to-suit.

    View details

    Florence County, SC Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Florence County, SC with 13 listings featured on our commercial real estate exchange. The current inventory includes 32,778 square feet of properties with an estimated lease value of $336.79 /Mo.

    Estimated lease rates for Office Spaces in Florence County, SC begin at $7.89 SF/Yr, with an average of $42.10 SF/Yr and extend to $216 SF/Yr.
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