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    South Carolina Commercial Real Estate for Lease

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    Greenville, SC Columbia, SC Charleston, SC
    3,120 listings
    SC, Summerville - 700 Nexton Square Drive
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    Brand-New Medical Office with Exam Rooms
    $10,634/Mo
    3,988 SF
    Brand-New Medical Office with Exam Rooms

    116 Professional Park Dr., Conway, SC 29526

    New brick medical suite with 9 exam rooms, dedicated HVAC for the computer room, and 25 parking spaces.
    • Brand‑new brick medical office space available for lease at Singleton Ridge Professional Business Park
    • 9 exam rooms plus 3 private offices, reception and lobby areas, and a medical technician workspace
    • Includes a laboratory room and a dedicated computer room with dedicated HVAC
    • 3 bathrooms and a laboratory/medical support layout designed for clinical use
    • 25 on‑site parking spaces
    Updated: Jun 5
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    Turnkey Restaurant Space
    $2,500/Mo
    1,078 SF
    Turnkey Restaurant Space

    403 Seaboard St., Myrtle Beach, SC 29577

    Restaurant space with existing equipment that may be available, plus ample on-site parking near major Myrtle Beach destinations.
    • Approximately 1,200 SF of restaurant space available in Myrtle Beach
    • Located near Coastal Grand Mall, Myrtle Beach International Airport, Broadway at the Beach, The Market Common, and Downtown Myrtle Beach
    • Convenient access with less than 1 mile to Highway 501, Highway 17 Bypass, and Robert Grissom Parkway
    • Ample on‑site parking available
    • Existing restaurant equipment may be available for financing
    Updated: May 27
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    Two-Unit Retail Conversion Opportunity
    $2,500/Mo
    2,304 SF
    Two-Unit Retail Conversion Opportunity

    Two storefront units with restaurant conversion-ready features on a high-traffic corridor near I-95.

    225 W Lucas St, Florence, SC 29501

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    Renovated Executive Office Suites Available
    $670/Mo
    2,808 SF
    Renovated Executive Office Suites Available

    Newly renovated office suites in desirable Pawleys Island commercial corridor.

    46 Professional Ln., Pawleys Island, SC 29585

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    Sound-Proof Executive Office Building
    $4,800/Mo
    3,214 SF
    Sound-Proof Executive Office Building

    Single-story office with executive offices, conference rooms, and private paved parking for professional tenants.

    212 Newberry Street NW, Aiken, SC 29801

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    Move-In Ready Second-Floor Office Suite
    $1,000/Mo
    863 SF
    Move-In Ready Second-Floor Office Suite

    Second-floor suite with reception area, two private offices, private restroom, and kitchenette, in a high-visibility office building.

    4717 Highway 17 Bypass, Murrells Inlet, SC 29576

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    Office Suite with Conference Room
    $1,500/Mo
    1,000 SF
    Office Suite with Conference Room

    Suite includes private offices, conference room, and shared lobby with power and water included in a gross lease.

    889 Inlet Square Dr., Murrells Inlet, SC 29576

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    Office Suite with Conference Room
    $2,125/Mo
    1,500 SF
    Office Suite with Conference Room

    Leasable office suite with private conference room, kitchen, and restrooms, with ample on-site parking.

    121 Professional Ln., Pawleys Island, SC 29585

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    Free-Standing Office Building with Reception
    $2,500/Mo
    1,100 SF
    Free-Standing Office Building with Reception

    Well-appointed office layout with reception, four private offices, restrooms, and kitchen area for professional tenants.

    825 1st Ave. N, Surfside Beach, SC 29575

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    Free-Standing Two-Story Office Building
    $7,000/Mo
    9,000 SF
    Free-Standing Two-Story Office Building

    Well-maintained two-story building with dedicated IT and security, offering immediate space for office, education, or assembly use.

    1089 Augusta Road, Warrenville, SC 29851

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    Two-Story Office Building with Parking
    $7,000/Mo
    9,000 SF
    Two-Story Office Building with Parking

    Free-standing two-story office building with on-site parking and flexible interior setup, offering an immediately available section.

    1089 Augusta Road, Warrenville, SC 29851

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    Adaptable Commercial Space in Anderson
    $7,500/Mo
    12,545 SF
    Adaptable Commercial Space in Anderson

    Prime commercial property in Anderson's historic district for diverse ventures.

    200 W Benson Street, Anderson, SC 29624

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    Endcap Retail-Office Suite
    $4,166/Mo
    1,900 SF
    Endcap Retail-Office Suite

    Move-in ready end unit with new HVAC, fresh finishes, and rear access to the parking lot.

    11382 Ocean Hwy., Pawleys Island, SC 29585

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    Freestanding Retail & Office Building
    $24 SF/Yr
    2,640 SF
    Freestanding Retail & Office Building

    High-visibility first-floor suite with an open layout, high ceilings, fire suppression, and ample parking along Sea Island Parkway.

    95 Factory Creek Court, Beaufort, SC 29907

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    Professional Office Space Available
    $3,670/Mo
    1,000 SF
    Professional Office Space Available

    Professional office space for lease in Murrells Inlet, SC.

    5187 Horry Dr., Murrells Inlet, SC 29576

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    Free-Standing Brick Office Building
    $1,950/Mo
    1,494 SF
    Free-Standing Brick Office Building

    Charming office building near downtown Aiken and Interstate 20.

    1598 Columbia Highway, Aiken, SC 29801

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    Renovated Commercial Space in Port Royal
    $3,600/Mo
    1,675 SF
    Renovated Commercial Space in Port Royal

    Versatile, renovated commercial space in a prime Port Royal location.

    1420 Ribaut Road, Port Royal, SC 29935

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    Office Suite with Private Offices
    $2,000/Mo
    1,246 SF
    Office Suite with Private Offices

    Professional office suite features a large waiting room, three private offices, and hardwood floors throughout.

    228 Silver Bluff Road, Aiken, SC 29803

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    Secure Aiken Office Building Available
    $11,000/Mo
    7,000 SF
    Secure Aiken Office Building Available

    Move-in ready office building near Aiken Bypass with ample parking.

    900 Trail Ridge Road, Aiken, SC 29803

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    Warehouse with Office and Roll-Up Doors
    $3,950/Mo
    10,000 SF
    Warehouse with Office and Roll-Up Doors

    Warehouse lease with high ceilings, two large grade-level doors, and an included office area.

    11 Demedicis Boulevard, Warrenville, SC 29851

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    Warehouse with Office and Roll-Up Doors
    $3,950/Mo
    10,000 SF
    Warehouse with Office and Roll-Up Doors

    Warehouse space with 20-foot peak heights and grade-level roll-up doors plus a dedicated office.

    11 Demedicis Boulevard, Warrenville, SC 29851

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    Private Office Space For Lease
    $500/Mo
    Private Office Space For Lease

    Move-in-ready private offices with flexible terms in Myrtle Beach.

    415 79th Ave. N, Myrtle Beach, SC 29572

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    South Carolina Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in South Carolina with 3120 listings featured on our commercial real estate exchange. The current inventory includes 30,202,290 square feet of properties with an estimated lease value of $20,675,279.

    Estimated lease rates for Commercial real estate in South Carolina begin at $0.73 SF/Yr, with an average of $14,377 /Mo and extend to $8,700,000.
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