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    South Carolina Mixed-use Properties for Sale

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    Columbia, SC Greenville, SC Spartanburg, SC
    180 listings
    Adaptable Commercial Property on Highway
    $925,000
    8,700 SF
    Adaptable Commercial Property on Highway

    6114 HWY 76, Pendleton, SC 29670

    Warehouse and office buildings with high traffic frontage on Highway.
    • High‑traffic location on HWY 76 with 15k‑22k vehicles per day
    • 7200+\/- sqft warehouse with 14x14 garage door and framed office/restroom/storage spaces
    • 1500+\/- sqft office building with 4 offices, conference room, waiting room, and 2 restrooms (1 handicap accessible)
    • Convenient access to I‑85 (less than 4 miles) and central location to Anderson, Clemson, and Pendleton
    • Two access points: HWY 76 and Circle St
    Updated: May 22
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    Redevelopment Opportunity in Beaufort, SC
    $2,495,000
    6,500 SF
    Redevelopment Opportunity in Beaufort, SC

    12 Neil Road, Beaufort, SC 29906

    Rare mixed-use redevelopment site with high visibility and trail access.
    • Rare 2.69‑acre redevelopment opportunity in a dynamic area.
    • Prominent visibility and access from two major thoroughfares (Hwy 21).
    • Frontage along the rapidly growing Spanish Moss Trail.
    • Existing curb cut on Hwy 21 providing immediate access.
    • Includes a 5,500 SF live/work building and a 1,000 SF modular building.
    Updated: Apr 1
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    Versatile Commercial Property, Cleveland SC
    $650,000
    3,355 SF
    Versatile Commercial Property, Cleveland SC

    Two well-maintained buildings on 1.89 acres with mountain views.

    4033 Geer Highway, Cleveland, SC 29635

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    Mixed-Use Site in Beaufort, SC
    $2,250,000
    6,273 SF
    Mixed-Use Site in Beaufort, SC

    Mixed-use site with redevelopment potential in a promising corridor.

    8 Neil Road, Beaufort, SC 29906

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    Five-Building Mixed-Use Portfolio
    $1,022,000
    13,900 SF
    Five-Building Mixed-Use Portfolio

    Five-building portfolio offering flexible retail, office, and mixed-use configurations on a compact site.

    2725 Cleveland Street, Elloree, SC 29047

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    Versatile Commercial Property on Edmund Highway
    $799,000
    4,090 SF
    Versatile Commercial Property on Edmund Highway

    Commercial property with restaurant and warehouse in Lexington, SC.

    6196 Edmund Highway, Lexington, SC 29073

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    Prime Greenville Commercial Corner Lot
    $1,400,000
    10,000 SF
    Prime Greenville Commercial Corner Lot

    High-visibility mixed-use property near downtown Greenville with development potential.

    Poinsett Highway, Greenville, SC 29609

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    Versatile Commercial Flex Property
    $799,900
    6,000 SF
    Versatile Commercial Flex Property

    6,000 sq ft commercial flex property in thriving district.

    463 Calhoun, Greenwood, SC 29646

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    Versatile Industrial and Commercial Complex
    $1,800,000
    70,000 SF
    Versatile Industrial and Commercial Complex

    73,000 sq ft Mullins complex for distribution, manufacturing, storage.

    122 E Laurel St, Mullins, SC 29574

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    Historic Charleston Mixed-Use Building
    $2,650,000
    4,923 SF
    Historic Charleston Mixed-Use Building

    Three-story mixed-use building in Charleston's historic commercial corridor.

    59 Broad Street, Charleston, SC 29401

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    Prime Greenville Commercial Corner Lot
    $1,400,000
    5,000 SF
    Prime Greenville Commercial Corner Lot

    High-visibility corner lot near downtown Greenville, ideal for development.

    Poinsett Highway, Greenville, SC 29609

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    Prime Land in Greenville, SC
    $1,800,000
    2,500 SF
    Prime Land in Greenville, SC

    11+/- acre property ideal for development in a growing corridor.

    3900 Highway 153, Greenville, SC 29611

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    Historic Aiken Mixed-Use Property
    $2,500,000
    8,070 SF
    Historic Aiken Mixed-Use Property

    Unique mixed-use property in downtown Aiken with income potential.

    150 Fairfield Street SE, Aiken, SC 29801

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    Versatile Commercial Opportunity in Columbia
    $550,000
    3,960 SF
    Versatile Commercial Opportunity in Columbia

    Prime commercial site with existing structure and redevelopment potential.

    123 Lawand Drive, Columbia, SC 29210

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    Mixed-Use Property in Lexington, SC
    $850,000
    10,000 SF
    Mixed-Use Property in Lexington, SC

    Mixed-use property with retail, residential, and warehouse units.

    2040 S Lake Drive, Lexington, SC 29072

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    Prime Commercial Property in Ridgeland
    $1,300,000
    13,000 SF
    Prime Commercial Property in Ridgeland

    13,000+ sq ft in central Ridgeland, suitable for various uses.

    668 Green Street, Ridgeland, SC 29936

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    Highway-Frontage Commercial Land Opportunity
    $1,999,900
    5.04 Acres
    Highway-Frontage Commercial Land Opportunity

    A 5+ acre HC-zoned site with more than 780 feet of Hwy 17 frontage and strong daily visibility.

    116 Hwy 17 S, Little River, SC 29566

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    Mixed-Use Corner Property with NNN Retail
    $4,695,000
    4,253 SF
    Mixed-Use Corner Property with NNN Retail

    Newly constructed 2024 mixed-use property with a leased ground-floor retail space and an operating luxury short-term rental above.

    651 King Street, Charleston, SC 29403

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    Marsh-Front Mixed-Use Commercial Building
    $425,000
    0.32 Acres
    Marsh-Front Mixed-Use Commercial Building

    Cement block commercial building with marsh views and ample parking along a heavily traveled corridor.

    Saint Helena Island, SC 29920

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    Commercial Opportunity in Beaufort, SC
    $1,400,000
    13,000 SF
    Commercial Opportunity in Beaufort, SC

    Mixed-use property with warehouse, residential units, and commercial potential.

    494 Laurel Bay Road, Beaufort, SC 29906

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    Renovated Mixed-Use Building
    $600,000
    Renovated Mixed-Use Building

    Two occupied levels with ADA-compliant facilities and street-facing balcony, located on a highly visible Beaufort corridor.

    609 Carteret Street, Beaufort, SC 29902

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    Historic Edgefield Commercial Opportunity
    $549,000
    6,000 SF
    Historic Edgefield Commercial Opportunity

    Dual income property in historic downtown Edgefield.

    303 Main Street, Edgefield, SC 29824

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    Historic Coca-Cola Plant Opportunity
    $275,000
    8,000 SF
    Historic Coca-Cola Plant Opportunity

    Historic building with modern potential, suitable for various commercial uses.

    100 Lightsey Street, Hampton, SC 29924

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    Inman Commercial Property For Sale
    $1,350,000
    7,500 SF
    Inman Commercial Property For Sale

    2.75 acre commercial property with 7,500 SF building.

    1385 Meadow Farm Road, Inman, SC 29349

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    South Carolina Mixed-Use Properties Market Trends and Statistics

    Explore 180 mixed-use properties for sale in South Carolina, showcased through 180 active listings on our real estate platform. These investment opportunities span a total of 2,525,450 square feet of properties for sale, with an estimated market value of $193,721,249.

    Sale prices for multi use buildings in South Carolina start at $79,000, averaging $1,714,347, and reaching up to $18,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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