South Carolina Mixed-use properties for sale

Updated: Oct 13

Corner Mixed-Use Property

900 Main Street S, New Ellenton, SC 29809

$750,000

10,000 sqft 4.51 AC lot

4.51‑acre corner parcel at S Main Street (SC‑19) and Williston Road (US‑278)
Restaurant space of +/-5,320 SF with commercial kitchen, two built‑in bars, dining and event areas
Warehouse of +/-2,080 SF with about 14' eaves and two 10' roll‑up doors
Office/apartment space of +/-1,190 SF and standalone garage apartment of +/-961 SF
Zoned UD (Urban Development) for general and neighborhood commercial, residential, and light manufacturing uses

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Updated: Jul 7

Mixed-Use Property with Storage

4939 Hwy 321, Gaston, SC 29053

$1,150,000

10,775 sqft 1.48 AC lot

10,775‑square‑foot mixed‑use commercial property on 1.48 acres
Fully leased property with auto/shop space, storage units, and a U‑Haul operation
Highway 321 frontage in Gaston with easy access
Multiple commercial buildings with a newer metal roof
Overhead bay doors and illuminated roadside sign

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Two-Story Brick Church

421-425 Hampton Avenue NW, Aiken, SC 29801

$625,000

12,247 sqft 1.16 AC lot

A sanctuary, classrooms, offices and a lower-level kitchen are complemented by an adjacent house.

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Unfinished Two-Story Mixed-Use Building

225 Main Street, Seneca, SC 29678

$850,000

11,160 sqft

Three independently entered commercial areas provide flexibility across two floors in downtown Seneca.

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Mixed-Use Townhome with Commercial Space

2798 Howard Ave., Myrtle Beach, SC 29577

$639,000

2,018 sqft 0.03 AC lot

Street-facing ground-floor flex space sits beneath a three-bedroom residence with a fenced backyard.

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Mixed-Use Property with Metal Buildings

4750 Hwy 17 S, Murrells Inlet, SC 29576

$4,399,000

4,000 sqft 6.24 AC lot

An approved conceptual plan outlines retail, warehouse, storage, and office uses.

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Mixed-Use Townhome with Flex Space

2798 Howard Ave., Myrtle Beach, SC 29577

$639,000

2,018 sqft

A street-facing commercial area with its own full bath sits below the three-bedroom residence.

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Two-Level Mixed-Use Brick Building

233 Main Street, Seneca, SC 29678

$850,000

6,900 sqft

Unfinished interiors and separate access points provide flexibility for a custom commercial buildout.

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Leased 4-Unit Mixed-Use Building

2614 E Highway 76, Marion, SC 29571

$585,000

7,200 sqft 0.85 AC lot

Fully occupied commercial space combines office and retail uses with highway access and rear entry.

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Mixed-Use Property with Restaurant

6196 Edmund Highway, Lexington, SC 29073

$799,000

4,090 sqft 1.65 AC lot

Two improved structures combine an operating restaurant with functional warehouse space on a commercially zoned site.

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Mixed-Use Building with Elevator

186 E Main Street, Spartanburg, SC 29302

$1,449,000

14,464 sqft

Ground-floor retail planning and upper-level studio potential support a mixed-use configuration.

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Two-Story Day Care Center

402 16th Ave. S, Myrtle Beach, SC 29577

$849,000

3,400 sqft 0.28 AC lot

MU-H zoning supports commercial and multifamily-oriented reuse, subject to applicable city requirements and approvals.

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Mixed-Use Property with Metal Building

103 Smith St, Greenwood, SC 29649

$750,000

7,600 sqft

Combination of commercial, residential, and office space with additional land for future development, subject to approvals.

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Mixed-Use Property with Restaurant and Storage

1411 Cherry Road, Rock Hill, SC 29732

$1,200,000

1,800 sqft 0.91 AC lot

Two-building commercial site combines restaurant space with a concrete block self-storage facility.

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Commercial Kitchen Property with Basement

850 Falling Creek Road, Spartanburg, SC 29301

$330,000

1,879 sqft 0.53 AC lot

Commercial property with an open meeting area, kitchen infrastructure, storage, and parking capacity on a half-acre lot.

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Riverfront Mixed-Use Building

155 Montgomery Avenue, Pacolet, SC 29372

$249,900

3,630 sqft

Commercial building combines an air-conditioned storefront, public restroom, storage bays, and upstairs residential living quarters.

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Historic Mixed-Use Property

150 Fairfield St SE, Aiken, SC 29801

$2,500,000

8,070 sqft

Renovated downtown building with office, retail, salon, residential, and annex spaces.

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Riverfront Mixed-Use Property

155 Montgomery Avenue, Pacolet, SC 29372

$249,900

3,630 sqft

Air-conditioned storefront with upstairs living quarters, storage bays, and public water service near a recreational launch.

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Ground-Floor Mixed-Use Suite

284 Meeting St, Charleston, SC 29401

$1,650,000

1,600 sqft

A downtown Charleston commercial unit combines an open interior with dedicated covered parking.

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Brick Mixed-Use Building

25 N Guignard Drive, Sumter, SC 29150

$550,000

4,186 sqft 0.32 AC lot

Flexible commercial space supports office, retail, or barber and beauty uses.

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Mixed-Use Townhome with Commercial Space

25 Market, Beaufort, SC 29906

$615,000

2,160 sqft

A two-bedroom, two-bath residence sits above a ground-floor business area.

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Historic Two-Story Mixed-Use Building

108 Park Street NW, Wagener, SC 29164

$299,950

2,750 sqft 0.03 AC lot

Remodeled interior with separate entrances and updated bathrooms on both levels.

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Mixed-Use Redevelopment Property

114 E. Calhoun Street, Sumter, SC 29150

$2,500,000

36,538 sqft 4.25 AC lot

Former grocery building with substantial acreage and General Commercial zoning.

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Mixed-Use Property with Warehouse

4251 Whiskey Road, Aiken, SC 29803

$1,000,000

3,970 sqft 1.16 AC lot

Two buildings combine warehouse, office, and retail or rental space, with separate driveways from Whiskey Road and Woodvine Road.

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South Carolina Mixed-Use Properties Market Trends and Statistics

Explore 221 mixed-use properties for sale in South Carolina, showcased through 221 active listings on our real estate platform. These investment opportunities span a total of 1,582,784 square feet of properties for sale, with an estimated market value of $228,294,048.

Sale prices for multi use buildings in South Carolina start at $50,000, averaging $1,521,960, and reaching up to $16,500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.