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    South Carolina Medical Office Space for Lease

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    Greenville, SC Columbia, SC Charleston, SC North Charleston, SC Myrtle Beach, SC Spartanburg, SC Rock Hill, SC Summerville, SC
    127 properties
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    Medical Office Space with Multiple Offices
    Updated: Jul 31
    Medical Office Space with Multiple Offices

    407 N Salem Avenue, Sumter, SC 29150

    $7,337/Mo
    7,337 sqft 1.13 AC lot
    7,337‑square‑foot medical office property
    Layout includes numerous rooms, offices, and storage areas
    1.13‑acre site at 407 N Salem Avenue, Sumter, SC 29150
    Brick and block construction with tile and carpet flooring
    Central air conditioning and heat pump heating
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    New Mixed-Use Space
    Updated: Sep 8
    New Mixed-Use Space

    5100 Highway 17 Bypass, Murrells Inlet, SC 29576

    $3,125/Mo
    2,500 sqft 1.90 AC lot
    2,500 SF available within a 12,000 SF mixed‑use building
    Can be configured as two 1,250 SF suites or one 2,500 SF space
    Direct exposure on Highway 17 Bypass with approximately 36,700 vehicles per day
    1.9‑acre site with ample parking
    Projected completion March 2027
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    Dental Medical Office Suite
    Dental Medical Office Suite

    417 W Cheves Street, Florence, SC 29501

    $3,000/Mo
    1,850 sqft

    The layout includes operatories, laboratory space, reception areas, and a private office.

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    Medical Office Space with Drop-Off Area
    Medical Office Space with Drop-Off Area

    230 Giles Dr, Boiling Springs, SC 29316

    $6,730/Mo
    6,730 sqft 1.25 AC lot

    Private offices, shared work areas, and a dedicated vehicle drop-off area provide a flexible existing layout.

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    Medical Office Suite in Professional Park
    Medical Office Suite in Professional Park

    710 21st Ave. N, Myrtle Beach, SC 29577

    $1,166/Mo
    560 sqft 0.16 AC lot

    The space is part of a multi-building office park with medical and professional units.

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    Renovated Medical Office Suite
    Renovated Medical Office Suite

    4310 Highway 17 Business, Murrells Inlet, SC 29576

    $8,000/Mo
    3,557 sqft 3.00 AC lot

    Recently renovated Class A space with shared patient amenities, dedicated elevators, and services included in the lease package.

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    Medical Office Suite
    Medical Office Suite

    710 21st Ave. N, Myrtle Beach, SC 29577

    $2,410/Mo
    1,157 sqft 0.16 AC lot

    A medical and professional office unit is available within a multi-building office park.

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    Modern Medical Office Space
    Modern Medical Office Space

    391 Serpentine Drive, Spartanburg, SC 29303

    $1,156/Mo
    4,387 sqft

    Modern medical suites with patient-care areas, elevator access, on-site parking, and proximity to Spartanburg Regional Medical Hospital.

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    New Brick Medical Office Space
    New Brick Medical Office Space

    116 Professional Park Dr., Conway, SC 29526

    $10,634/Mo
    3,988 sqft 0.78 AC lot

    Clinical rooms, private offices, laboratory space, and dedicated HVAC support a ready-to-lease configuration.

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    Renovated Office Units with Elevator
    Renovated Office Units with Elevator

    5000 Woodside Executive Court, Aiken, SC 29803

    $4,810/Mo
    2,540 sqft

    Two available office configurations offer reception, private rooms, a kitchenette, conference space, storage, and on-site parking.

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    Medical Office Space with Clinical Upfit
    Medical Office Space with Clinical Upfit

    2320 Cosgrove Avenue, North Charleston, SC 29405

    $24 SF/Yr
    4,935 sqft 0.31 AC lot

    Plumbing and medical connections remain throughout the building, alongside on-site parking.

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    Renovated Office Suite
    Renovated Office Suite

    5000 Woodside Executive Court, Aiken, SC 29803

    $4,810/Mo
    2,540 sqft 5.36 AC lot

    Second-floor space includes a kitchenette, reception area, conference room, storage, and six office or treatment rooms.

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    Office Unit with Build-Out Opportunity
    Office Unit with Build-Out Opportunity

    148 Waterloo Street SW, Aiken, SC 29801

    $3,772/Mo
    1,886 sqft

    Unfinished office suite offering flexible planning for general or medical office use within a multi-tenant building.

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    New Medical Office Suites
    New Medical Office Suites

    5100 Highway 17, Murrells Inlet, SC 29576

    $3,125/Mo
    2,500 sqft

    New construction with adaptable suite layouts, on-site parking, and direct exposure along a heavily traveled commercial corridor.

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    Medical Office Suite with Shower
    Medical Office Suite with Shower

    1264 Ribaut Road, Beaufort, SC 29902

    $2,845/Mo
    0.01 AC lot

    Flexible professional suite includes private offices, a data room, plumbing, and accessible entry.

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    Turnkey Medical Office Space
    Turnkey Medical Office Space

    53 Persimmon Street, Bluffton, SC 29910

    $33 SF/Yr
    0.10 AC lot

    Fully built-out premises support medical, healthcare, and professional office operations.

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    Renovated Medical Office Suite
    Renovated Medical Office Suite

    5000 Woodside Executive Ct, Aiken, SC 29803

    $4,278/Mo
    2,540 sqft 8.00 AC lot

    Newly renovated second-floor suite with kitchenette, conference room, six rooms, and private reception and bathroom.

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    Two-Story Office Suite with Patio
    Two-Story Office Suite with Patio

    277 Willbrook Blvd, Pawleys Island, SC 29585

    $25 SF/Yr
    2,420 sqft

    Office suite with exam rooms, reception space, three restrooms, and a covered pond-facing patio.

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    Two-Story Office Units
    Two-Story Office Units

    2591 N Fraser St, Georgetown, SC 29440

    $1,540/Mo
    1,232 sqft

    Flexible professional office configuration with private rooms, reception areas, storage, parking, and modified gross lease structure.

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    Office Unit Near Medical Center
    Office Unit Near Medical Center

    1504 North Fant Street, Anderson, SC 29621

    $11 SF/Yr
    3,015 sqft

    On-site parking serves this office space along the N Fant Street corridor.

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    Medical Office Suite with Flexible Layout
    Medical Office Suite with Flexible Layout

    302-1264 Ribaut Road, Beaufort, SC 29902

    $2,845/Mo
    1,484 sqft

    Professional suite with private offices, a data room, plumbing capacity, and access to an established healthcare-oriented complex.

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    Renovating Office Park Suites
    Renovating Office Park Suites

    15 Gamecock Ave, Charleston, SC 29407

    $2,500/Mo
    3,625 sqft

    Two office suites are available within Orange Grove Office Park with ongoing renovations and quick access to I-26.

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    Build-to-Suit Office Suite
    Build-to-Suit Office Suite

    148 Waterloo Street Sw Suite 5, Aiken, SC 29801

    $3,772/Mo
    1,886 sqft

    Cold and dark suite offers 1,886 sf for buildout as general or medical office space in a multi-tenant building.

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    Flexible Office Unit
    Flexible Office Unit

    1604 2nd Loop Rd, Florence, SC 29501

    $1,800/Mo
    1,000 sqft

    Commercial space with adaptable layout, parking, and access for office, medical, retail, or service businesses.

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    South Carolina Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in South Carolina with 127 listings featured on our commercial real estate exchange. The current inventory includes 1,137,544 square feet of properties with an estimated lease value of $1,087.

    Estimated lease rates for Medical Office Space in South Carolina begin at $6.16 SF/Yr, with an average of $21.75 SF/Yr and extend to $37 SF/Yr.
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