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    South Carolina Medical Office Space for Lease

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    Columbia, SC Greenville, SC Charleston, SC
    134 results
    Professional Office Space Available
    $3,670 /Mo
    2,000 SF

    Professional Office Space Available

    5187 Horry Dr., Murrells Inlet, SC 29576

    Office space for lease in Murrells Inlet, SC.

    • Prime location in the heart of Murrells Inlet with convenient access to Highway 17 Business and Bypass.
    • Flexible space options: 3,000 SF total, divisible into 1,000 SF and 2,000 SF suites.
    • Well‑designed 2,000 SF suite with reception area, conference room, and executive offices.
    • Tenant Improvement (TI) Allowance available for customization and upfit.
    • Ample on‑site parking and monument signage for excellent visibility.
    Updated: Mar 27
    View details
    Professional Office Space Available
    $3,670 /Mo
    1,000 SF

    Professional Office Space Available

    5187 Horry Dr., Murrells Inlet, SC 29576

    Office space for lease in Murrells Inlet, South Carolina.

    • Prime location in Murrells Inlet with easy access to Highway 17 Business and Bypass.
    • Flexible space options: 3,000 SF total, divisible into 1,000 SF and 2,000 SF suites.
    • The 2,000 SF suite features a reception area, conference room, and executive offices with quality finishes.
    • Ample on‑site parking and monument signage for excellent visibility.
    • Tenant Improvement (TI) Allowance available for customization.
    Updated: Mar 27
    View details
    Lady's Island Versatile Office Space
    $3,600 /Mo

    Lady's Island Versatile Office Space

    Well-conditioned office space ideal for medical, wellness, or traditional office.

    27 Kemmerlin Lane, Beaufort, SC 29907
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    Aiken Office/Medical Space Available
    $4,810 /Mo
    2,540 SF

    Aiken Office/Medical Space Available

    Office and medical suites available for sublease in Aiken, SC.

    5000 Woodside Executive Court, Aiken, SC 29803
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    Aiken Office Space for Rent
    $4,810 /Mo
    2,540 SF

    Aiken Office Space for Rent

    Renovated office space suitable for medical or administrative uses.

    5000 Woodside Executive Court unit: 5230, Aiken, SC 29803
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    Murrells Inlet Office Space
    $2,187 /Mo
    1,250 SF

    Murrells Inlet Office Space

    Multi-tenant office/retail/medical building with 1,250 SF available 4/1/26.

    637 Bellamy Ave., Murrells Inlet, SC 29576
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    Class A Office Space
    $3,400 /Mo

    Class A Office Space

    Professional office suite for rent in Anderson, SC.

    2315 N Main Street, Anderson, SC 29621
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    Medical Office in Woodside Village
    $6,378 /Mo
    2,639 SF

    Medical Office in Woodside Village

    Stand-alone medical office in a live, work, play community.

    210 High Gate Loop, Aiken, SC 29803
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    Versatile Commercial Space For Rent
    $4,500 /Mo

    Versatile Commercial Space For Rent

    Two-story commercial building with flexible space and high visibility.

    8 Celadon Drive unit: A&B, Beaufort, SC 29907
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    Medical/Professional Office Near Conway Hospital
    $6,251 /Mo
    5,246 SF

    Medical/Professional Office Near Conway Hospital

    Medical/professional office building near Conway Medical Center with customizable space.

    8028 Myrtle Trace Dr., Conway, SC 29526
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    Class A Office Suites Available
    $4,360 /Mo
    1,539 SF

    Class A Office Suites Available

    Premium office suites in a Class A development for lease.

    4559 Oleander Dr., Myrtle Beach, SC 29577
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    Myrtle Beach Office Space For Rent
    $3,000 /Mo
    2,340 SF

    Myrtle Beach Office Space For Rent

    2340 sq ft commercial space perfect for medical or professional office.

    8210 Devon Ct., Myrtle Beach, SC 29572
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    Aiken Office Space For Lease
    $3,772 /Mo
    1,886 SF

    Aiken Office Space For Lease

    New build-out opportunity for office or medical space in Aiken.

    148 Waterloo Street SW unit: Suite 5, Aiken, SC 29801
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    Pawleys Island Professional Office Space
    $3,632 /Mo
    1,981 SF

    Pawleys Island Professional Office Space

    Versatile office space in high-visibility Pawleys Island location.

    38 Blackgum Rd., Pawleys Island, SC 29585
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    Seneca Office Space For Lease
    $1,500 /Mo

    Seneca Office Space For Lease

    Two-level office building suitable for various businesses, near Clemson.

    865 Old Clemson Highway, Seneca, SC 29678
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    Turn-Key Medical Office Space
    $22 SF/Yr
    8,300 SF

    Turn-Key Medical Office Space

    8,300 SF medical office in Surfside Beach, South Carolina.

    1945 Glenns Bay Road, Surfside Beach, SC 29575
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    Office Space Near Clemson
    $4,000 /Mo

    Office Space Near Clemson

    Two-level office building suitable for various businesses, near Clemson.

    865 Old Clemson Highway, Seneca, SC 29678
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    Two-Story Office Building For Rent
    $16 SF/Yr
    3,960 SF

    Two-Story Office Building For Rent

    Two-story office building with flexible layout in central Columbia.

    123 Lawand Dr, Columbia, SC 29210
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    West Columbia Office/Medical Suite
    $18 SF/Yr
    12,000 SF

    West Columbia Office/Medical Suite

    Office/medical suite for lease near Lexington Medical Hospital.

    3618 Sunset Blvd., West Columbia, SC 29169
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    Medical Office Space For Lease
    $20 SF/Yr
    7,659 SF

    Medical Office Space For Lease

    Medical office space in prime healthcare corridor location.

    161 Medical Circle, West Columbia, SC 29169
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    Class A Medical Office Building
    $28 SF/Yr
    14,084 SF

    Class A Medical Office Building

    Renovated medical/office building with ample parking in Mt. Pleasant.

    1200 Innovation Way, Mount Pleasant, SC 29466
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    Highway 170 Retail/Office/Medical Space
    $36 SF/Yr

    Highway 170 Retail/Office/Medical Space

    Retail, office, or medical space for lease on Highway 170.

    48 Terrace Drive, Okatie, SC 29909
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    Bluffton Office/Medical Suites Available
    $28 SF/Yr
    3,870 SF

    Bluffton Office/Medical Suites Available

    Class A office and medical suites for rent in Bluffton.

    2 WESTBURY PKWY, Bluffton, SC
    View details
    Medical Building on Hilton Head
    $22 SF/Yr

    Medical Building on Hilton Head

    Stand-alone medical building for lease on Hilton Head Island.

    4101 Main St, Suite E & F, Hilton Head Island, SC 29926
    View details

    South Carolina Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in South Carolina with 134 listings featured on our commercial real estate exchange. The current inventory includes 18,046,071,310 square feet of properties with an estimated lease value of $874 /Mo.

    Estimated lease rates for Medical Office Space in South Carolina begin at $0.67 SF/Yr, with an average of $20 SF/Yr and extend to $44 SF/Yr.
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