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    Spartanburg County, SC Office Spaces for Lease

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    Greenville, SC Columbia, SC Charleston, SC
    67 results
    Premier Medical Office Space Available
    $20 SF/Yr
    7,039 SF
    Premier Medical Office Space Available

    1650 Skylyn Drive, Spartanburg, SC 29307

    Class A medical office space in Spartanburg's prime location.
    • Premier Class A medical office space, strategically located on the Mary Black campus, unique to the Spartanburg market.
    • On‑site wellness amenity suite featuring a fitness gym, swimming pool, and smoothie bar exclusively for building tenants.
    • Lower NNN fees than comparable properties.
    • Direct access to the Drayton Mills Trail and proximity to the vibrant Drayton Mills mixed‑use development.
    • Abundant parking.
    Updated: Mar 7
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    Highway 290 Retail Development Space
    $40 SF/Yr
    9,850 SF
    Highway 290 Retail Development Space

    1723 East Main Street, Duncan, SC 29334

    Retail/office space in growing Duncan market near Highway 290.
    • High traffic location on HWY 290 (±37,500 VPD).
    • Located in a rapidly growing commercial and industrial market.
    • One of the last parcels available for new retail development in the area.
    • Surrounded by high‑paying distribution & manufacturing jobs, residential growth, I‑85, and a Greenville Tech College campus.
    • Join established tenants like McAlisters Deli, Tropical Smoothie Cafe, and AT&T.
    Updated: Jan 27
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    Spartanburg Storefront Retail/Office Space
    $15 SF/Yr
    2,046 SF
    Spartanburg Storefront Retail/Office Space

    Renovated 2,046 SF retail/office space in downtown Spartanburg.

    512 E Main St, Spartanburg, SC 29302

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    6,000 SF Flex Building I-85
    Contact for pricing
    6,000 SF
    6,000 SF Flex Building I-85

    Flex building with lay-down yard fronting I-85.

    50 Fairview Church Rd, Spartanburg, SC 29303

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    Move-in Ready Furnished Office Space
    $20 SF/Yr
    Move-in Ready Furnished Office Space

    Recently renovated, fully furnished office building in a prime location.

    792 John B White Sr Boulevard, Spartanburg, SC 29306

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    Historic Mill Office Space Available
    $28 SF/Yr
    53,571 SF
    Historic Mill Office Space Available

    Creative office space in a vibrant mixed-use community.

    1802 Drayton Road, Suite 140B, Spartanburg, SC 29307

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    Premier Office Suite For Rent
    $700/Mo
    425 SF
    Premier Office Suite For Rent

    Executive office suite in a premier location with ample natural light.

    1451 E Main St, Spartanburg, SC

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    Office Space on Asheville Highway
    $1,900/Mo
    1,191 SF
    Office Space on Asheville Highway

    Office space for lease with road frontage and ample parking.

    8891 Asheville Hwy, Boiling Springs, SC

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    Spartanburg Office Space Available
    $25 SF/Yr
    444 SF
    Spartanburg Office Space Available

    Office space available for rent in Spartanburg, South Carolina.

    324 E Saint John St, Spartanburg, SC

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    Renovated Office Space Available
    $20 SF/Yr
    1,500 SF
    Renovated Office Space Available

    Newly renovated office space in a high-visibility location.

    901 S Pine St, Spartanburg, SC

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    Mixed-Use Retail or Office Space
    $25 SF/Yr
    2,382 SF
    Mixed-Use Retail or Office Space

    New retail or office space in redeveloped Startex Mill.

    21 N Main St, Wellford, SC

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    Westside Office Building For Rent
    $12 SF/Yr
    5,000 SF
    Westside Office Building For Rent

    5,000 sq ft office building in westside location.

    1220 John B White Sr Blvd, Spartanburg, SC

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    Downtown Spartanburg Retail/Office Space
    $23 SF/Yr
    1,525 SF
    Downtown Spartanburg Retail/Office Space

    Retail or office space with high visibility in downtown.

    178-182 E Main St, Spartanburg, SC

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    Spartanburg Office Space for Lease
    $16 SF/Yr
    1,200 SF
    Spartanburg Office Space for Lease

    Office space available near downtown Spartanburg with on-site parking.

    301 N Pine St, Spartanburg, SC

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    Spartanburg Flex Building For Lease
    Contact for pricing
    6,800 SF
    Spartanburg Flex Building For Lease

    Flex building with office and outdoor storage in Spartanburg.

    440 Southport Commerce Blvd, Spartanburg, SC 29306

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    Downtown Spartanburg Office Space
    $16 SF/Yr
    1,395 SF
    Downtown Spartanburg Office Space

    Office space in downtown Spartanburg with professional finishes.

    275 E Henry St, Spartanburg, SC

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    Class A Office Suite
    $23 SF/Yr
    2,268 SF
    Class A Office Suite

    Available office suite in Spartanburg's Point West Office Complex.

    775 Spartan Blvd, Spartanburg, SC

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    Westside Office/Medical Space Available
    $16 SF/Yr
    5,461 SF
    Westside Office/Medical Space Available

    5461± sq ft office/medical space for rent.

    225 E Blackstock Rd, Spartanburg, SC

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    Office Space For Lease
    $15 SF/Yr
    2,400 SF
    Office Space For Lease

    Office space available for lease near Boiling Springs and Lake Bowen.

    7770 Hwy 9, Inman, SC

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    Office Suites in Spartanburg
    $18 SF/Yr
    1,218 SF
    Office Suites in Spartanburg

    Office suites available in Spartanburg near downtown and amenities.

    900 S Pine St, Spartanburg, SC

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    Office Space for Lease
    $2,500/Mo
    1,927 SF
    Office Space for Lease

    1,927 SF office space available for lease.

    517 E St John St, Spartanburg, SC

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    Downtown Office Space for Rent
    $23 SF/Yr
    2,500 SF
    Downtown Office Space for Rent

    Prime office space in Spartanburg's revitalized Central Business District.

    101 W Saint John St, Spartanburg, SC

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    Spartanburg Office Space Available
    $11 SF/Yr
    4,000 SF
    Spartanburg Office Space Available

    4,000 sq. ft. office space for rent.

    170 Camelot Dr, Spartanburg, SC

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    Class A Office Space
    $21 SF/Yr
    2,963 SF
    Class A Office Space

    Professional office space on Spartanburg's Westside with high visibility.

    1460 John B White Sr Blvd, Spartanburg, SC

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    Spartanburg County, SC Office Spaces Leasing Opportunities Market Analysis

    Explore Office Spaces leasing options in Spartanburg County, SC with 67 listings featured on our commercial real estate exchange. The current inventory includes 217,431 square feet of properties with an estimated lease value of $901 /Mo.

    Estimated lease rates for Office Spaces in Spartanburg County, SC begin at $3 SF/Yr, with an average of $19 SF/Yr and extend to $69 SF/Yr.
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