Add Listing
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Office
    1
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Price
    Price range
    $
    $
    Size
    Property size / sq.ft.
    AI Search

    Meet Realmo: The Largest Hub
    of Commercial Real     Estate in the US

    Over 1 million active listings and over 150 million property profiles

    Spartanburg County, SC Office Properties & Spaces for Lease

    List
    Map
    Columbia, SC Greenville, SC Charleston, SC
    65 results
    Highway 290 Retail Development Space
    $40 SF/Yr
    9,850 SF

    Highway 290 Retail Development Space

    1723 East Main Street, Duncan, SC 29334

    Retail/office space in growing Duncan market near Highway 290.

    • High traffic location on HWY 290 (±37,500 VPD).
    • Located in a rapidly growing commercial and industrial market.
    • One of the last parcels available for new retail development in the area.
    • Surrounded by high‑paying distribution & manufacturing jobs, residential growth, I‑85, and a Greenville Tech College campus.
    • Join established tenants like McAlisters Deli, Tropical Smoothie Cafe, and AT&T.
    Updated: Jan 27
    View details
    Historic Mill Office Space Available
    $28 SF/Yr
    53,571 SF

    Historic Mill Office Space Available

    1802 Drayton Road, Suite 140B, Spartanburg, SC 29307

    Creative office space in a vibrant mixed-use community.

    • Located in Drayton Mills Marketplace, a successful adaptive‑reuse mixed‑use community.
    • ±3,934 SF office suite with restored historic mill character including exposed brick, high ceilings, and large windows.
    • Walkable access to restaurants, coffee shops, retail, fitness studio, and salons.
    • Connected to Drayton Mills’ trail network for walking, biking, and tenant events.
    • Flexible space suitable for office, creative studio, co‑working, or boutique professional services.
    Updated: Nov 25, 2025
    View details
    Spartanburg Storefront Retail/Office Space
    $15 SF/Yr
    2,046 SF

    Spartanburg Storefront Retail/Office Space

    Renovated 2,046 SF retail/office space in downtown Spartanburg.

    512 E Main St, Spartanburg, SC 29302
    View details
    Premier Office Suite For Rent
    $700 /Mo
    425 SF

    Premier Office Suite For Rent

    Executive office suite in a premier location with ample natural light.

    1451 E Main St, Spartanburg, SC
    View details
    6,000 SF Flex Building I-85
    Contact for pricing
    6,000 SF

    6,000 SF Flex Building I-85

    Flex building with lay-down yard fronting I-85.

    50 Fairview Church Rd, Spartanburg, SC 29303
    View details
    Office Space on Asheville Highway
    $1,900 /Mo
    1,191 SF

    Office Space on Asheville Highway

    Office space for lease with road frontage and ample parking.

    8891 Asheville Hwy, Boiling Springs, SC
    View details
    Westside Office Building For Rent
    $12 SF/Yr
    5,000 SF

    Westside Office Building For Rent

    5,000 sq ft office building in westside location.

    1220 John B White Sr Blvd, Spartanburg, SC
    View details
    Warehouse/Office Space Available For Lease
    $7 SF/Yr
    9,595 SF

    Warehouse/Office Space Available For Lease

    9,595 SF warehouse/office space with fenced laydown yard.

    1611 Union St, Spartanburg, SC
    View details
    Westside Office/Medical Space Available
    $16 SF/Yr
    5,461 SF

    Westside Office/Medical Space Available

    5461± sq ft office/medical space for rent.

    225 E Blackstock Rd, Spartanburg, SC
    View details
    Spartanburg Flex Building For Lease
    Contact for pricing
    6,800 SF

    Spartanburg Flex Building For Lease

    Flex building with office and outdoor storage in Spartanburg.

    440 Southport Commerce Blvd, Spartanburg, SC 29306
    View details
    Office Space for Lease
    $2,500 /Mo
    1,927 SF

    Office Space for Lease

    1,927 SF office space available for lease.

    517 E St John St, Spartanburg, SC
    View details
    Downtown Office Space for Rent
    $23 SF/Yr
    2,500 SF

    Downtown Office Space for Rent

    Prime office space in Spartanburg's revitalized Central Business District.

    101 W Saint John St, Spartanburg, SC
    View details
    Spartanburg Office Space Available
    $11 SF/Yr
    4,000 SF

    Spartanburg Office Space Available

    4,000 sq. ft. office space for rent.

    170 Camelot Dr, Spartanburg, SC
    View details
    Spartanburg Office Space Available
    $25 SF/Yr
    444 SF

    Spartanburg Office Space Available

    Office space available for rent in Spartanburg, South Carolina.

    324 E Saint John St, Spartanburg, SC
    View details
    Class A Office Space
    $21 SF/Yr
    2,963 SF

    Class A Office Space

    Professional office space on Spartanburg's Westside with high visibility.

    1460 John B White Sr Blvd, Spartanburg, SC
    View details
    Renovated Office Space Available
    $20 SF/Yr
    1,500 SF

    Renovated Office Space Available

    Newly renovated office space in a high-visibility location.

    901 S Pine St, Spartanburg, SC
    View details
    Mixed-Use Retail or Office Space
    $25 SF/Yr
    2,382 SF

    Mixed-Use Retail or Office Space

    New retail or office space in redeveloped Startex Mill.

    21 N Main St, Wellford, SC
    View details
    Spartanburg Flex Space For Lease
    $15 SF/Yr
    4,000 SF

    Spartanburg Flex Space For Lease

    Flex space featuring office and warehouse areas, near I-26.

    3211 Reidville Rd, Spartanburg, SC
    View details
    Downtown Spartanburg Retail/Office Space
    $23 SF/Yr
    1,525 SF

    Downtown Spartanburg Retail/Office Space

    Retail or office space with high visibility in downtown.

    178-182 E Main St, Spartanburg, SC
    View details
    Spartanburg Office Space for Lease
    $16 SF/Yr
    1,200 SF

    Spartanburg Office Space for Lease

    Office space available near downtown Spartanburg with on-site parking.

    301 N Pine St, Spartanburg, SC
    View details
    Spartanburg Westside Office Opportunity
    $14 SF/Yr
    6,059 SF

    Spartanburg Westside Office Opportunity

    Office space for rent near I-26 and Downtown Spartanburg.

    347-357 E Blackstock Rd, Spartanburg, SC
    View details
    Spartanburg Office Space Available
    $17 SF/Yr
    3,200 SF

    Spartanburg Office Space Available

    Office space available for lease in Spartanburg, South Carolina.

    229 Magnolia St, Spartanburg, SC
    View details
    Downtown Spartanburg Office Space
    $16 SF/Yr
    1,395 SF

    Downtown Spartanburg Office Space

    Office space in downtown Spartanburg with professional finishes.

    275 E Henry St, Spartanburg, SC
    View details
    Class A Office Suite
    $23 SF/Yr
    2,268 SF

    Class A Office Suite

    Available office suite in Spartanburg's Point West Office Complex.

    775 Spartan Blvd, Spartanburg, SC
    View details

    Spartanburg County, SC Office properties & Spaces Leasing Opportunities Market Analysis

    Explore Office properties & Spaces leasing options in Spartanburg County, SC with 65 listings featured on our commercial real estate exchange. The current inventory includes 459,122,400 square feet of properties with an estimated lease value of $93 SF/Yr.

    Estimated lease rates for Office properties & Spaces in Spartanburg County, SC begin at $3 SF/Yr, with an average of $18 SF/Yr and extend to $39 SF/Yr.
    List
    Map

    Office properties & Spaces by market

    Browse Office properties & Spaces for Lease Near Spartanburg, SC

    Popular Categories

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!