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    Spartanburg County, SC Office Spaces for Lease

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    36 properties
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    Renovated Furnished Office Units
    Updated: Jun 21
    Renovated Furnished Office Units

    792 John B White Sr Boulevard, Spartanburg, SC 29306

    $2,808/Mo
    0.56 AC lot
    1,230‑square‑foot furnished office property
    Recently renovated with updated lighting, LVP, carpet, and contemporary finishes
    Flexible office layout with central heating and central air
    0.56‑acre site with parking lot and porch
    Access to Interstate 26 and Interstate 85
    View details
    Medical Office Space with Drop-Off Area
    Updated: Sep 26
    Medical Office Space with Drop-Off Area

    230 Giles Dr, Boiling Springs, SC 29316

    $6,730/Mo
    6,730 sqft 1.25 AC lot
    6,730 SF building on approximately 1.25 acres
    Existing layout includes lobby, kitchen, private offices, multipurpose areas, storage, and restrooms
    Approximately 25 paved parking spaces, with additional parking available
    Dedicated drive‑thru/drop‑off/delivery area and covered patio
    Near Hwy 9, I‑85, and I‑26 in Boiling Springs
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    Modern Medical Office Space
    Modern Medical Office Space

    391 Serpentine Drive, Spartanburg, SC 29303

    $1,156/Mo
    4,387 sqft

    Modern medical suites with patient-care areas, elevator access, on-site parking, and proximity to Spartanburg Regional Medical Hospital.

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    Industrial Flex Space with Two Buildings
    Industrial Flex Space with Two Buildings

    113 Ian Ct, Spartanburg, SC 29306

    $12,500/Mo
    12,500 sqft 1.95 AC lot

    Two-building property combines office areas with warehouse space for flexible business operations.

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    Corner Medical Office Building
    Corner Medical Office Building

    108 W Rutherford St, Landrum, SC 29356

    $2,500/Mo
    2,400 sqft

    All-brick medical building offers exam rooms, multiple lobbies, and private parking lot access to two city streets.

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    Flex Space with Conditioned Warehouse
    Flex Space with Conditioned Warehouse

    1095 Southport Rd, Spartanburg, SC 29306

    $8 SF/Yr
    24,000 sqft

    Industrial property combining office accommodation with conditioned warehouse and manufacturing space.

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    Highway 290 Retail Development Space
    Highway 290 Retail Development Space

    1723 East Main Street, Duncan, SC 29334

    $40 SF/Yr
    9,850 sqft

    Retail/office space in growing Duncan market near Highway 290.

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    Spartanburg Storefront Retail/Office Space
    Spartanburg Storefront Retail/Office Space

    512 E Main St, Spartanburg, SC 29302

    $15 SF/Yr
    2,046 sqft

    Renovated 2,046 SF retail/office space in downtown Spartanburg.

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    Office Units with Dual Frontage
    Office Units with Dual Frontage

    846 WO Ezell Blvd, Spartanburg, SC 29301

    Contact for pricing
    3,120 sqft

    B4-zoned commercial space near downtown with exposure along two public streets.

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    Mixed-Use Marketplace with Restaurant Space
    Mixed-Use Marketplace with Restaurant Space

    1802 Drayton Road, Drayton, SC 29333

    $16 SF/Yr

    Lease offerings include creative offices, a second-generation restaurant, and event space.

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    Historic Office Building for Rent
    Historic Office Building for Rent

    571 East Main Street, Spartanburg, SC 29302

    Contact for pricing
    4,688 sqft 0.48 AC lot

    Renovated historic building with multiple rooms, suited for professional office use, with street parking available.

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    Class A Office Suite
    Class A Office Suite

    149B West Main Street, Spartanburg, SC 29306

    $30 SF/Yr

    Class A suite with private offices and flexible configuration, featuring top-floor views in downtown Morgan Square.

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    Historic Spartanburg Mixed-Use Retail Space
    Historic Spartanburg Mixed-Use Retail Space

    174 E Main St, Spartanburg, SC 29306

    Contact for pricing
    4,709 sqft

    Retail space available in historic mixed-use building in downtown Spartanburg.

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    Office Suite with Testing Facility
    Office Suite with Testing Facility

    105 Corporate Dr, Spartanburg, SC 29303

    Contact for pricing
    1,350 sqft

    Move-in-ready office suite with testing facility and a floor plan that can be modified to fit your operation.

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    Mixed-Use Retail or Office Space
    Mixed-Use Retail or Office Space

    21 N Main St, Wellford, SC

    Contact for pricing
    2,382 sqft 26.65 AC lot

    New retail or office space in redeveloped Startex Mill.

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    Office Suite on Main Street
    Office Suite on Main Street

    1948 E Main St, Spartanburg, SC 29307

    Contact for pricing

    Office space on the East Main Street corridor with on-site parking for customers and employees.

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    Westside Office/Medical Space Available
    Westside Office/Medical Space Available

    225 E Blackstock Rd, Spartanburg, SC

    Contact for pricing
    5,461 sqft 0.94 AC lot

    5461± sq ft office/medical space for rent.

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    Mixed-Use Building with Outdoor Area
    Mixed-Use Building with Outdoor Area

    500 W Main St, Spartanburg, SC 29301

    Contact for pricing
    10,992 sqft

    Built in 1916 and renovated 2023–2024, featuring retail, restaurant, office, and entertainment space plus large rear outdoor area.

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    Renovated Historic Mixed-Use Building
    Renovated Historic Mixed-Use Building

    500 W Main St, Spartanburg, SC 29301

    Contact for pricing
    4,388 sqft

    Historic building renovated 2023–2024 with retail, restaurant, office, and entertainment space plus ample parking.

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    Renovated Office Building with Parking
    Renovated Office Building with Parking

    500 W Main St, Spartanburg, SC 29301

    Contact for pricing
    5,061 sqft

    Office component in a mixed-use building renovated 2023–2024 with ample parking and multiple ingress/egress options.

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    Three-Level Professional Office Building
    Three-Level Professional Office Building

    291 S. Pine Street, Spartanburg, SC 29301

    Contact for pricing

    Professional office building with three levels, multiple conference rooms, outdoor patio, and on-site parking for 38 vehicles.

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    Spartanburg Office Space For Rent
    Spartanburg Office Space For Rent

    135 West Main Street, Spartanburg, SC

    Contact for pricing
    1,700 sqft 0.08 AC lot

    Office space available for rent in Spartanburg, SC.

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    Office Space on Asheville Highway
    Office Space on Asheville Highway

    8891 Asheville Hwy, Boiling Springs, SC

    Contact for pricing
    1,191 sqft 0.68 AC lot

    Office space for lease with road frontage and ample parking.

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    Office Suites in Spartanburg
    Office Suites in Spartanburg

    900 S Pine St, Spartanburg, SC

    Contact for pricing
    1,218 sqft 0.68 AC lot

    Office suites available in Spartanburg near downtown and amenities.

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    Spartanburg County, SC Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Spartanburg County, SC with 36 listings featured on our commercial real estate exchange. The current inventory includes 155,555 square feet of properties with an estimated lease value of $145.50.

    Estimated lease rates for Office Spaces in Spartanburg County, SC begin at $8 SF/Yr, with an average of $18.19 SF/Yr and extend to $40 SF/Yr.
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    Featured Spartanburg County Real Estate Agencies

    Realmo connects you with licensed Spartanburg County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Keller Williams Realty Spartanburg Partners
    1707 John B White Sr Blvd, Suite E Spartanburg, SC 29301
    Phone: 18645746000
    www.kwspartanburg.com
    Century 21 Blackwell & Co.
    2260 Boiling Springs Road Boiling Springs, SC 29316
    Phone: 18645960322
    www.century21blackwell.com
    Better Homes and Gardens Young & Company
    8291 Warren H. Abernathy Highway Spartanburg, SC 29301
    Phone: 19706605323
    bhgyoung.com
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