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    York County, SC Medical Office Space for Lease

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    12 properties
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    Spacious Office and Medical Suite
    Updated: May 18
    Spacious Office and Medical Suite

    345 Patricia Lane, Fort Mill, SC 29708

    $29.50 SF/Yr
    8,988 sqft $22,095/Mo
    Expansive 8,988 SF professional office/medical suite.
    Premier location in Fort Mill with unbeatable proximity to I‑77, Gold Hill Road, and Tega Cay.
    Highly functional layout with six massive open rooms (each over 700 square feet).
    Ideal environment within an established park alongside a strong mix of medical tenants.
    Ultimate flexibility for collaborative workspaces, training centers, or large‑scale clinical use.
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    Rock Hill Medical/Office Suites
    Updated: May 18
    Rock Hill Medical/Office Suites

    420 S Herlong Ave, Rock Hill, SC 29732

    $18 SF/Yr
    2,100 sqft $3,150/Mo
    Unbeatable proximity to Piedmont Medical Center
    Located in an established Rock Hill medical complex
    Functional layout easily adaptable for healthcare or professional practices
    Ground‑level suites
    Highly accessible commercial corridor location
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    Medical Office Space For Rent
    Medical Office Space For Rent

    105 Ben Casey Dr, Fort Mill, SC 29708

    $30 SF/Yr
    2,330 sqft $5,825/Mo

    Medical office space in established park, convenient location.

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    Medical/Office Space in Rock Hill
    Medical/Office Space in Rock Hill

    410 S Herlong Ave, Rock Hill, SC 29732

    $18 SF/Yr
    2,598 sqft $3,897/Mo

    Established medical complex with adaptable suites near key locations.

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    Downtown Fort Mill Office Space
    Downtown Fort Mill Office Space

    227 Main St, Fort Mill, SC 29715

    $8 SF/Yr
    125 sqft $83.33/Mo

    Private rooms available within established wellness center in Fort Mill.

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    Medical Office Space For Rent
    Medical Office Space For Rent

    986 Wellness Way, Fort Mill, SC

    $33 SF/Yr
    3,649 sqft $10,034/Mo

    New construction medical office space with connection to hospital.

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    Medical Office on Oakland Avenue
    Medical Office on Oakland Avenue

    356 Oakland Avenue, Rock Hill, SC 29732

    Contact for pricing
    3,600 sqft

    3,600 SF medical office space for lease in Rock Hill.

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    Medical/Professional Office Space Available
    Medical/Professional Office Space Available

    235 S. Herlong Avenue, Rock Hill, SC 29732

    Contact for pricing
    1,200 sqft

    Office space with frontage near Piedmont Medical Center.

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    New Retail/Medical Building For Lease
    New Retail/Medical Building For Lease

    1530 Alexander Love Hwy E, York, SC

    Contact for pricing
    1,694 sqft

    New construction retail/medical building with drive-thru available for lease.

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    Medical Office Space For Lease
    Medical Office Space For Lease

    1000 Wellness Way, Fort Mill, SC 29715

    Contact for pricing

    Medical office space available for lease at 1000 Wellness Way in Fort Mill, SC.

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    Medical Office Space For Rent
    Medical Office Space For Rent

    986 Wellness Wy, Fort Mill, SC 29715

    $28 SF/Yr
    60,000 sqft $140,000/Mo

    Medical office space available in new 60,000 SF building.

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    Class A Medical/Office Development
    Class A Medical/Office Development

    1170 Edgewater Pkwy, Fort Mill, SC 29707

    Contact for pricing
    60,000 sqft

    New medical/office development in Edgewater Corporate Park. Leasing now!

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    Based on your search, we've compiled 24 Potential Opportunities for your consideration. Besides 12 Active listings in York County, SC, we suggest exploring alternatives. Similar 8 Properties for Sales.

    Similar Spaces for Sale in York County, SC

    Consider Similar Space for Sale. We found 8 Spaces matching your search parameters.

    Versatile Commercial Property in Rock Hill
    Versatile Commercial Property in Rock Hill

    166 Dotson Street, Rock Hill, SC 29732

    $1,000,000
    10,479 sqft 1.24 AC lot

    10,479 SF commercial property suitable for various uses.

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    Chiropractic Office Building
    Chiropractic Office Building

    518 North Avenue, Rock Hill, SC 29732

    $850,000
    7,000 sqft

    Former chiropractic clinic offering exam and therapy rooms alongside private offices for flexible medical and office use.

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    Leased Medical Office Building with Ground Lease
    Leased Medical Office Building with Ground Lease

    245-1665 Herlong Ct, Rock Hill, SC 29732

    $3,020,000
    9,572 sqft

    Fully leased medical office building with a Truist Bank ground lease, positioned across from a regional medical center.

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    Freestanding Office Building in Rock Hill
    Freestanding Office Building in Rock Hill

    1601 Ebenezer Road, Rock Hill, SC 29732

    $1,795,000
    7,246 sqft

    7,246 SF commercial building in high-traffic Rock Hill corridor.

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    Herlong Avenue Office/Retail Space
    Herlong Avenue Office/Retail Space

    197 South Herlong Avenue, Rock Hill, SC 29732

    Contact for pricing
    4,827 sqft

    Divisible office/retail space across from Piedmont Medical Center.

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    Lake Wylie Professional Office Condos
    Lake Wylie Professional Office Condos

    252 Latitude Lane Suites 104, 105, & 106, Lake Wylie, SC 29710

    $1,225,000
    3,500 sqft

    Professional/Medical office condos in Lake Wylie, 3500 SF total.

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    Medical Office Condo For Sale
    Medical Office Condo For Sale

    200 S. Herlong Avenue # H, Rock Hill, SC 29732

    $495,000
    2,319 sqft

    Medical office condo located on Piedmont Medical Center campus.

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    Rock Hill Office Condo
    Rock Hill Office Condo

    1033 Bayshore Dr Suite B, Rock Hill, SC 29732

    Contact for pricing
    6,165 sqft

    Office condo in high-demographic area, Rock Hill, South Carolina.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Development Opportunity in Greenville
    Prime Development Opportunity in Greenville

    39 Airpark Ct, Greenville, SC 29607

    Contact for pricing

    1.27 acre interstate-visible land for ground lease or build-to-suit.

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    Prime Commercial Lot For Rent
    Prime Commercial Lot For Rent

    Tift Avenue N, Tifton, GA 31794

    $7,500/Mo

    0.66 acre commercial lot with high visibility.

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    Prime Lexington Outlot Opportunity
    Prime Lexington Outlot Opportunity

    3330 Partner Place, Lexington, KY 40503

    Contact for pricing

    Outlot for ground lease or build-to-suit in South Lexington.

    View details
    Corner Lot on Highway 72
    Corner Lot on Highway 72

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft $32 SF/Yr

    1.7 acre corner lot zoned for commercial, medical, residential.

    View details

    York County, SC Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in York County, SC with 12 listings featured on our commercial real estate exchange. The current inventory includes 79,790 square feet of properties with an estimated lease value of $164.50 SF/Yr.

    Estimated lease rates for Medical Office Space in York County, SC begin at $8 SF/Yr, with an average of $23.50 SF/Yr and extend to $33 SF/Yr.
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