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    South Carolina Office Spaces for Lease

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    Greenville, SC Columbia, SC Charleston, SC North Charleston, SC Spartanburg, SC Rock Hill, SC Myrtle Beach, SC Summerville, SC
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    Multi-Tenant Office Building
    Multi-Tenant Office Building

    1124 Park West Boulevard #Executive Suites, Mount Pleasant, SC 29466

    Contact for pricing

    Move-in-ready suites in a modern, multi-tenant office building with first- and second-floor options.

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    Access-Controlled Office and Retail Suites
    Access-Controlled Office and Retail Suites

    5 Lake Carolina Way, Columbia, SC 29229

    $1,500/Mo
    2,560 sqft

    First-floor suites include office and former salon retail space with ample parking in a controlled-access building.

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    Warehouse Office Suite with Drive-In
    Warehouse Office Suite with Drive-In

    7349 Peppermill Parkway, North Charleston, SC 29418

    $14 SF/Yr

    Warehouse and office suite with a lobby, three offices, one restroom, and a drive-in door available May 1, 2026.

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    Class A Office Building
    Class A Office Building

    140 Wildewood Park Dr, Columbia, SC 29223

    Contact for pricing

    Class A office space offering flexible lease terms and abundant on-site parking for day-to-day operations.

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    Office and Warehouse Unit
    Office and Warehouse Unit

    63 Schinger Avenue, Ridgeland, SC 29936

    Contact for pricing

    Office and warehouse space for lease with two offices, a break room, and a large warehouse.

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    Turn Key Medical Office Space
    Turn Key Medical Office Space

    100 Constantine Wy, Greer, SC

    $23 SF/Yr
    5,000 sqft

    New construction medical office space in close proximity to airport.

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    Class A Office Suite
    Class A Office Suite

    775 Spartan Blvd, Spartanburg, SC

    Contact for pricing
    2,268 sqft

    Available office suite in Spartanburg's Point West Office Complex.

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    Freestanding Single Tenant Office Building
    Freestanding Single Tenant Office Building

    260 S Pleasantburg Dr, Greenville, SC 29607

    $10 SF/Yr

    Single tenant office building with multiple offices and storage.

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    Downtown Florence Mixed-Use Space
    Downtown Florence Mixed-Use Space

    127 W Evans St, Florence, SC 29501

    $25 SF/Yr
    1,800 sqft

    Prime mixed-use space in Downtown Florence Historic District.

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    Downtown Medical Office Space
    Downtown Medical Office Space

    1331 Lady St, Columbia, SC 29201

    Contact for pricing

    Medical office space for lease in downtown Columbia at the corner of Lady Street and Marion Street.

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    Multi-Tenant Office Building For Rent
    Multi-Tenant Office Building For Rent

    2231 Devine Street, Columbia, SC 29205

    $17 SF/Yr

    Three-story office building in the Devine Street corridor.

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    Piedmont Office Unit For Rent
    Piedmont Office Unit For Rent

    104 Commons Blvd Unit A, Piedmont, SC 29673

    Contact for pricing
    1,400 sqft

    Office unit for rent with highway and interstate access.

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    Second-Floor Office Suite with Balcony
    Second-Floor Office Suite with Balcony

    202-1510 Blue Ridge Blvd, Seneca, SC 29672

    $3,000/Mo

    Second-floor suite with five private offices, a kitchen area, and two private bathrooms, plus shared lobby access and a balcony.

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    Flex Warehouse Office Suite
    Flex Warehouse Office Suite

    111 Northway Road, Columbia, SC 29201

    Contact for pricing

    Flexible flex warehouse unit with a roll-up door and an office with restroom, with units that can be combined.

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    Clements Ferry Road Office Units
    Clements Ferry Road Office Units

    2414 Clements Ferry Rd, Charleston, SC 29492

    $20 SF/Yr
    1,010 sqft

    Office units for rent near Daniel Island, Charleston, SC.

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    Office Warehouse Flex Building
    Office Warehouse Flex Building

    2209 Mechanic Street, Charleston, SC 29405

    Contact for pricing

    Flex-style office warehouse building offering combined work and storage space on approximately 1.1 acres.

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    Office Space with Renovations
    Office Space with Renovations

    31 Cessna Court, Greenville, SC

    Contact for pricing
    5,240 sqft

    Office space for rent with ongoing interior and exterior renovations.

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    Office Space For Rent
    Office Space For Rent

    111 Millport Circle, Greenville, SC 29607

    Contact for pricing
    30,941 sqft

    Office space available for lease in Greenville, South Carolina.

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    North Myrtle Beach Office Space
    North Myrtle Beach Office Space

    1639 Hwy 17 S, North Myrtle Beach, SC 29582

    $16 SF/Yr

    Office space for rent in North Myrtle Beach, SC.

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    Renovated Flex/Showroom Space For Rent
    Renovated Flex/Showroom Space For Rent

    3294 Ashley Phosphate Road # 1d, North Charleston, SC 29418

    $18 SF/Yr

    Recently renovated office, flex, and showroom facility with excellent visibility.

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    Multi-Use Office with Warehouse Space
    Multi-Use Office with Warehouse Space

    770 Augusta Road, Edgefield, SC 29824

    Contact for pricing

    Three-floor office with wood finishes and meeting rooms, plus warehouse space and a pavilion by the pond.

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    First-Floor Retail and Office Suites
    First-Floor Retail and Office Suites

    125 Anderson Highway, Clemson, SC 29631

    $25 SF/Yr

    Three first-floor suites are available inside a 150-room, 500-bed student housing community on a high-traffic Clemson corridor.

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    Charleston Adaptive Reuse Project Space
    Charleston Adaptive Reuse Project Space

    1503 King Street, Charleston, SC

    Contact for pricing
    2,985 sqft

    Historic warehouse architecture with modern design in Charleston's NoMo district.

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    Ladys Island Retail/Office/Restaurant Space
    Ladys Island Retail/Office/Restaurant Space

    95 Factory Crk Ct, Beaufort, SC 29907

    $24 SF/Yr

    Retail, office, or restaurant space available on Ladys Island.

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