Erie County, NY Medical Office Space for sale

Updated: Jul 23

Mixed-Use Property with Medical Office

6575 Transit Road, East Amherst, NY 14051

$950,000

3,330 sqft 1.00 AC lot

3,330‑square‑foot mixed‑use building on 1 acre
88 feet of frontage on Transit Road
Lower‑level medical office includes reception, kitchenette, three private rooms or offices, and a half bath
Upper residence has three bedrooms and a kitchen renovated in 2023
16 front parking spaces, with additional room at the rear

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Updated: May 21

Accessible Two-Story Office Building

1609 Genesee Street, Buffalo, NY 14211

$499,900

5,012 sqft 0.43 AC lot

5,012 SF two‑story brick office building on a 0.43‑acre lot
Valid Certificate of Occupancy with flexible office and multipurpose layouts
Full elevator, wheelchair ramp, and wide hallways for accessible circulation
Four bathrooms, with two on each floor, plus dedicated laundry areas
Oversized parking lot with 25+ spaces and multiple entry points

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Mixed-Use Property with Office

3723 Seneca Street, Buffalo, NY 14224

$359,900

3,472 sqft 0.38 AC lot

Two-level commercial property combines a physician’s office with an upstairs apartment and on-site parking.

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Medical Office Building

2084 Sheridan Dr, Buffalo, NY 14223

$599,900

4,500 sqft 0.38 AC lot

One-story medical office property with three suites, basement storage, and on-site parking along Sheridan Drive.

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Mixed-Use Property with Dental Office

484 Ontario Street, Buffalo, NY 14207

$179,900

4,785 sqft 0.08 AC lot

Operating dental office with an upstairs three-bedroom apartment and updated building systems.

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Mixed-Use Live-Work Property

11881 Broadway Street, Alden, NY 14004

$324,900

2,444 sqft 0.60 AC lot

Combines residential living space with a dedicated commercial area along Broadway in Alden.

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Gutted Mixed-Use Property

2746 Main Street, Buffalo, NY 14214

$250,000

2,241 sqft 0.22 AC lot

Interior is cleared for a buyer-directed commercial, residential, or mixed-use layout.

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Adjoining Medical Office Suites

8600 Sheridan Drive, Clarence, NY 14221

$1,500,000

5,792 sqft 1.10 AC lot

Three bright adjoining office suites offer separate entrances and private bathrooms with ample on-site parking.

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Three-Story Office Building

1281 Union Road, West Seneca, NY 14224

$799,900

4,855 sqft

Elevator service reaches every level, supporting accessible circulation for occupants and visitors.

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Main Street Commercial Property

305 Main Street, Aurora, NY 14052

$574,900

4,212 sqft

Highly visible commercial property with flexible use options.

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Two-Story Office Building

1176 Main St, Buffalo, NY 14209

$1,400,000

22,228 sqft 0.58 AC lot

N-1C-zoned property with Main Street frontage and public transportation access.

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Remodeled Office Building in East Amherst

6483 Transit Rd, East Amherst, NY 14051

$699,999

3,112 sqft 0.35 AC lot

Remodeled 3,112 SF office building in a medical park.

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Live-Work Property with Office

11881 Broadway St, Alden, NY 14004

$324,900

2,444 sqft

The property combines residential living space with a dedicated commercial area configured for office use.

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Medical Office Building with Adjacent Lot

3083 William Street, Cheektowaga, NY 14227

$499,000

7,404 sqft

Partially leased healthcare property includes additional land for expansion or parking.

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Medical Office with Upstairs Apartment

484 Ontario St, Buffalo, NY 14207

$179,900

4,785 sqft

Operating dental office with a separate three-bedroom apartment and multiple recent building-system updates.

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Mixed-Use Office and Residential Duplex

2533 Sheridan Dr, Buffalo, NY 14150

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4,380 sqft

High-visibility property with first-floor medical or professional office space and second-floor office or two residential units.

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Medical Office Building with Adjacent Lot

3083 William Street, Buffalo, NY 14227

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6,400 sqft

Partially leased medical-focused office building with an adjacent developable parcel for expansion or additional parking.

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Medical Office with Exam Rooms

4085 Seneca Street, West Seneca, NY 14224

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1,900 sqft

Configured for medical or professional service use with patient-facing and administrative areas.

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Medical Office/Retail Building

6140 Transit Rd, Depew, NY 14043

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5,520 sqft

Medical office/retail building in C-2 Shopping Center District on a high-traffic corridor near a new O’Reilly Auto Parts.

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Medical/Professional Office Plaza

6199 Transit Rd, Depew, NY 14043

Contact for pricing

16,763 sqft 1.00 AC lot

Retail and office plaza offering 161 feet of frontage along Transit Road with prominent parking and pylon signage.

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Updated Office Unit with Private Offices

1161 Abbott Road, Buffalo, NY 14220

Contact for pricing

3,458 sqft

Renovated professional space combines a practical office layout with accessible entry, on-site parking, and Abbott Road exposure.

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Medical Office with Dental Buildout

476 Hertel Ave, Buffalo, NY 14207

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3,685 sqft 0.40 AC lot

Medical office space featuring a dental buildout and parking.

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Renovated Historic Office Building

1131 Broadway, Buffalo, NY 14212

$850,000

Multi-floor office property with central HVAC, elevator service, and parking for 30 vehicles.

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Live-Work Building with Separate Office Entrance

3405 North Buffalo Street, Orchard Park, NY 14127

$789,900

Single-story live-work property combines ADA-compatible office space with a 4-bedroom residence and 11 on-site parking spaces.

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Erie County, NY Medical Office Space Market Trends and Statistics

Explore 72 medical office space for sale in Erie County, NY, showcased through 38 active listings on our real estate platform. These investment opportunities span a total of 213,644 square feet of properties for sale, with an estimated market value of $13,000,676.

Sale prices for medical spaces in Erie County, NY start at $179,900, averaging $619,079, and reaching up to $1,500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.