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    Buffalo, NY Mixed-use Properties for Lease

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    Amherst, NY Cheektowaga, NY Tonawanda, NY
    7 listings
    Elmwood Village Mixed-Use Building
    Contact for pricing
    20,000 SF
    Elmwood Village Mixed-Use Building

    448 Elmwood Ave, Buffalo, NY

    20,000 SF mixed-use building in Elmwood Village, Buffalo, NY.
    • Located in the Elmwood Village at the corner of Bryant Street
    • Luxury two bedroom two bath apartments on 2nd and 3rd floors
    • Retail opportunities on first floor
    • Gated Covered Parking available for apartments
    • 20,000 SF Mixed Use building
    Updated: Nov 26, 2025
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    New Retail Space in Buffalo
    $267 SF/Yr
    700 SF
    New Retail Space in Buffalo

    386 Grant St, Buffalo, NY 14213

    Brand new 700 sqft retail space in vibrant neighborhood.
    • Brand new 700 sqft retail space in a high‑visibility location on Buffalo's vibrant West Side.
    • Rent includes heating, cooling, water, and one off‑street parking space.
    • Modern design with 14 ft ceilings, exposed ductwork, polished concrete floors, and oversized storefront glass.
    • Delivered as a vanilla box, ready for customization with new HVAC, electrical service, and ADA restroom.
    • Part of a new mixed‑use building with high‑end apartments, geothermal heating/cooling, and solar panels.
    Updated: Aug 19, 2024
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    Eastern Hills Town Center Opportunity
    Contact for pricing
    50,000 SF
    Eastern Hills Town Center Opportunity

    Mixed-use development with office, retail, and residential spaces.

    4545 Transit Rd, Buffalo, NY

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    Historic Mixed-Use Building Renovation
    $8 SF/Yr
    Historic Mixed-Use Building Renovation

    Renovated mixed-use building with retail, office, warehouse, and apartments.

    222 Chicago St, Buffalo, NY 14204

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    Renovated Mixed-Use Building on Michigan
    $19 SF/Yr
    Renovated Mixed-Use Building on Michigan

    Recently renovated mixed-use building with office and apartment spaces.

    270 Michigan Ave, Buffalo, NY 14203

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    Niagara Street Mixed-Use Complex
    Contact for pricing
    Niagara Street Mixed-Use Complex

    Renovated mixed-use complex with high ceilings and signage opportunities.

    1088 Niagara St, Buffalo, NY 14213

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    Historic Landmark Mixed-Use Property
    Contact for pricing
    Historic Landmark Mixed-Use Property

    Unique commercial and residential spaces in restored historic building.

    1115 Main Rd, Buffalo, NY 14209

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    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 7 Active listings in Buffalo, NY, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 65 Properties for Sales.

    Mixed-use properties for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Waterfront Mixed-Use Opportunity in Mayville
    $825,000 SF/Yr
    5,500 SF
    Waterfront Mixed-Use Opportunity in Mayville

    Landmark property with mixed-use potential on Chautauqua Lake.

    188 S Erie Street, Mayville, NY 14757

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    Waterfront Mixed-Use Opportunity in Mayville
    $6,950/Mo
    5,500 SF
    Waterfront Mixed-Use Opportunity in Mayville

    Landmark waterfront property with mixed-use potential on Chautauqua Lake.

    188 S Erie Street, Mayville, NY 14757

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    Renovated Mixed-Use Live/Work Property
    $699,000 SF/Yr
    5,004 SF
    Renovated Mixed-Use Live/Work Property

    Front residence-style space with flexible rooms plus a rear carriage house with an established tenant in place since 2021.

    9060 Main Street, Clarence, NY 14031

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    Mixed-Use Property in Clarence, NY
    $599,900 SF/Yr
    Mixed-Use Property in Clarence, NY

    Versatile mixed-use property with income potential in Clarence, NY.

    9060 Main St, Clarence, NY 14031

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    Similar Spaces for Sale in Buffalo, NY

    Consider Similar Space for Sale. We found 65 Spaces matching your search parameters.

    Five-Unit Mixed-Use Building
    $699,900
    3,641 SF
    Five-Unit Mixed-Use Building

    Fully renovated five-unit mix of office and retail/studio spaces with on-site parking and multiple private entrances.

    4444 Main Street, Buffalo, NY 14226

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    Flexible Mixed-Use Building
    $519,999
    6,119 SF
    Flexible Mixed-Use Building

    A 1930-built multi-space building with parking and Harlem Road frontage, suited for office, retail, or service use.

    1113- 1125 Harlem Road, Buffalo, NY 14227

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    Flexible Retail Office Building
    $519,999
    6,119 SF
    Flexible Retail Office Building

    Mixed-use flexible building with frontage on Harlem Road and ample on-site parking for office, retail, or service uses.

    1113- 1125 Harlem Road, Buffalo, NY 14227

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    Mixed-Use Building with Retail Spaces
    $425,000
    6,787 SF
    Mixed-Use Building with Retail Spaces

    Affordable mixed-use building with ample parking, featuring ground-floor commercial space and two second-floor apartments.

    2895 Seneca Street, West Seneca, NY 14224

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    Mixed-Use Building in West Seneca
    $425,000
    6,787 SF
    Mixed-Use Building in West Seneca

    Mixed-use building with commercial spaces and apartments, fully rented.

    2895 Seneca Street, West Seneca, NY 14224

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    Mixed-Use Building with Restaurant Space
    $115,000
    2,676 SF
    Mixed-Use Building with Restaurant Space

    First-floor storefront/restaurant space with an upper residential apartment, offering flexible live-work or tenant options.

    1269 Fillmore Avenue, Buffalo, NY 14211

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    Mixed-Use Building with Street-Level Shop
    $199,999
    4,320 SF
    Mixed-Use Building with Street-Level Shop

    Three residential units above a street-level barbershop, offering flexibility for owner occupancy or rental income.

    130 Crocker Street, Buffalo, NY 14212

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    Brick Mixed-Use Building
    $340,000
    4,554 SF
    Brick Mixed-Use Building

    Mixed-use property with a vacant retail storefront and two apartments, supported by 2024 roof and plumbing updates.

    577 Ontario Street, Buffalo, NY 14207

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    Mixed-Use Building with Medical Space
    $399,000
    4,620 SF
    Mixed-Use Building with Medical Space

    Leased lower commercial space plus a two-bedroom apartment creates immediate rental income and flexible on-site professional use.

    2290 Main Street, Buffalo, NY 14214

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    Versatile Mixed-Use Investment Opportunity
    $259,900
    4,002 SF
    Versatile Mixed-Use Investment Opportunity

    Mixed-use property with commercial space and remodeled residential unit.

    543 S Park Avenue, Buffalo, NY 14204

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    Mixed-Use Building with Updated Retail
    $225,000
    4,275 SF
    Mixed-Use Building with Updated Retail

    Three-unit mixed-use building with updated retail space and apartments.

    662 Hertel Avenue, Buffalo, NY 14207

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    Mixed-Use Two-Family with Office
    $775,000
    4,662 SF
    Mixed-Use Two-Family with Office

    Two-family property with a first-floor office and an upstairs 3-bedroom, 2-bath residence plus off-street parking.

    615 Elmwood Avenue, Buffalo, NY 14222

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    Mixed-Use Property Near Larkin Square
    $249,000
    3,408 SF
    Mixed-Use Property Near Larkin Square

    Mixed-use property with recent improvements, near Larkin Square.

    995 Exchange Street, Buffalo, NY 14210

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    Mixed-Use Building with Vacant Storefronts
    $449,900
    4,515 SF
    Mixed-Use Building with Vacant Storefronts

    Two vacant storefronts and four updated 1-bedroom apartments offer leasing flexibility on Seneca Street.

    2096 Seneca Street, Buffalo, NY 14210

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    Mixed-Use Property Near New Development
    $259,900
    4,002 SF
    Mixed-Use Property Near New Development

    Investment opportunity near new apartments, suitable for various businesses.

    543 S Park Avenue, Buffalo, NY 14204

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    Brick Mixed-Use Building with Storefronts
    $199,000
    6,100 SF
    Brick Mixed-Use Building with Storefronts

    Brick mixed-use building with two storefront entrances, multiple residential units, and a high-ceiling basement for storage or future planning.

    696 Genesee Street, Buffalo, NY 14211

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    Mixed-Use Property in Buffalo, NY
    $149,000
    4,160 SF
    Mixed-Use Property in Buffalo, NY

    Versatile mixed-use property with established bar/restaurant and residential income.

    1263 Clinton Street, Buffalo, NY 14206

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Harrisburg Redevelopment Site For Rent
    Contact for pricing
    11,000 SF
    Harrisburg Redevelopment Site For Rent

    5.85-acre redevelopment site approved for 92 residential units.

    2150 Herr Street, Harrisburg, PA 17103

    View details
    Prime Commercial Land in Schenectady
    $23 SF/Yr
    22,240 SF
    Prime Commercial Land in Schenectady

    High-visibility commercial land suitable for retail, office, or mixed-use development.

    120 Erie Boulevard, Schenectady, NY 12305

    View details
    Prime Land in Jarrettsville Corridor
    Contact for pricing
    Prime Land in Jarrettsville Corridor

    1.55 acre parcel in Jarrettsville's business corridor.

    1753, Jarrettsville, MD 21084

    View details
    Prime Downtown Lot For Lease
    $2,100/Mo
    Prime Downtown Lot For Lease

    0.17 acre lot in downtown Pittsfield for lease.

    95 Union St, Pittsfield, MA 1201

    View details

    Buffalo, NY Mixed-use properties Market Trends and Statistics

    Explore Mixed-use properties leasing options in Buffalo, NY with 7 listings featured on our commercial real estate exchange. The current inventory includes 700 square feet of properties with an estimated lease value of $267 SF/Yr.

    Estimated lease rates for Mixed-use properties in Buffalo, NY begin at $267 SF/Yr, with an average of $267 SF/Yr and extend to $267 SF/Yr.
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    Most Searched ZIP Codes in Buffalo, NY

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