Buffalo, NY Office space for Rent & Lease

Harlem Road Commercial Leasing Opportunity

$1.00 SF/Yr

11,760 SF

Harlem Road Commercial Leasing Opportunity

3435 Harlem Rd, Buffalo, NY 14225

High-visibility office spaces available for lease on Harlem Road.

High‑visibility location on Harlem Road.
Flexible layouts suitable for office, professional services, or retail.
Ample parking on both sides of the building.
Restrooms on each floor.
Convenient access to major roadways.

Updated: Mar 2

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$2,400 / Mo

4,620 SF

Main Street Commercial Space Available

2290 Main St, Buffalo, NY 14214

First floor commercial space on Main Street, Buffalo, NY.

High visibility location on busy Main Street corridor.
Flexible layout suitable for office, medical, or retail use.
Welcoming entrance lobby for a positive first impression.
Multiple private office rooms.
Easy transition with minimal modifications needed.

Updated: Feb 28

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$2,450 / Mo

1,842 SF

West Seneca Commercial Office Space

1,842.50 sq ft office space in prime West Seneca location.

4085 Seneca St, Buffalo, NY 14224

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$14 SF/Yr

8,196 SF

West Seneca Office Space Available

1900 sqft office space with 6-8 offices near Buffalo.

51 N America Dr, Buffalo, NY 14224

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Elmwood Avenue Professional Office Space

$15 SF/Yr

7,344 SF

Elmwood Avenue Professional Office Space

3,000 SF office space in high-traffic Kenmore/Elmwood corridor.

2555 Elmwood Ave, Buffalo, NY 14217

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$2,500 / Mo

1,242 SF

Elmwood Avenue Commercial Space

Prime commercial space in high-traffic Buffalo business corridor, available 2026.

513 Elmwood Ave, Buffalo, NY 14222

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Renovated Commercial Space with Warehouse

$11 SF/Yr

9,635 SF

Renovated Commercial Space with Warehouse

Adaptable retail, office, and warehouse space in high-visibility location.

4336 Bailey Ave, Buffalo, NY 14226

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Tonawanda Street Commercial Space Available

$400 / Mo

3,036 SF

Tonawanda Street Commercial Space Available

Office or retail space with included utilities on Tonawanda Street.

868 Tonawanda St, Buffalo, NY 14207

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$1,000 / Mo

13,323 SF

Versatile Commercial Space Available

Bright commercial space with private offices and updated bathroom.

2195 Sheridan Ste 203 Dr, Buffalo, NY 14223

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$600 / Mo

13,323 SF

Adaptable Commercial Unit in Buffalo

Versatile commercial space with open office and private room.

2195 Sheridan Ste 204 Dr, Buffalo, NY 14223

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$2,100 / Mo

1,050 SF

Prime Commercial Space on Elmwood

High-traffic Buffalo location ideal for retail, office, or service-based operations.

515 Elmwood Ave, Buffalo, NY 14222

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$1,250 / Mo

5,196 SF

Professional Office Suites For Lease

Six individual office suites available in two professional buildings.

932 French Rd, Buffalo, NY 14227

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$17 SF/Yr

82,667 SF

Buffalo Office Suites For Rent

Office suites available for lease in Buffalo, New York.

200 John James Audubon Pkwy, Buffalo, NY 14228

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$8 SF/Yr

29,129 SF

Buffalo Office and Warehouse Space

Office and warehouse space available in Buffalo, New York.

501 Amherst St, Buffalo, NY 14207

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$1,250 / Mo

1,665 SF

Office Space in Buffalo, NY

Office space available for lease in Buffalo, New York.

1109 Harlem Rd, Buffalo, NY 14227

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$2,100 / Mo

17,360 SF

Downtown Buffalo Office Space Available

Downtown Buffalo office space in well-maintained building near Metro Rail.

487 Fl St, Buffalo, NY 14203

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$15 SF/Yr

151,938 SF

Buffalo Office Space For Rent

Available office space in a professional building near medical corridor.

921 Main St, Buffalo, NY 14203

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$1,050,000

12,200 SF

Mixed-Use Building Near Medical Campus

Highly visible mixed-use building with restaurant, office, and redevelopment potential.

1412 Main St, Buffalo, NY 14209

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Kenmore Avenue Retail/Office/Medical Space

$8 SF/Yr

12,270 SF

Kenmore Avenue Retail/Office/Medical Space

5,600 SF space for lease, suitable for retail/office/medical.

974-976 Kenmore Ave, Buffalo, NY 14216

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$1,950 / Mo

3,680 SF

Office Space with 24-Hour Security

Office space with private offices, conference room, and 24-hour security.

79 Perry St, Buffalo, NY 14203

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$3,000 / Mo

1,500 SF

Former Service Station on Route 5

Former service station suitable for automotive, retail, restaurant, or office.

3233 Lake Shore Rd, Blasdell, NY 14219

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$20 SF/Yr

5,294 SF

Renovated Office Space on Main

Tastefully renovated office space in a prime Clarence location.

8828 Main St, Williamsville, NY 14221

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$15 SF/Yr

4,000 SF

Elmwood Avenue Second Floor Office

Second floor office space in desirable Elmwood Avenue location.

423 Elmwood Ave, Buffalo, NY 14222

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$12 SF/Yr

8,500 SF

Downtown Buffalo Office Suites

Well-appointed office suites available for immediate occupancy in downtown Buffalo.

360 Delaware Ave, Buffalo, NY 14202

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Buffalo, NY Office space Leasing Opportunities Market Analysis

Explore Office space leasing options in Buffalo, NY with 257 listings featured on our commercial real estate exchange. The current inventory includes 61,163,205,840 square feet of properties with an estimated lease value of $1,341 /Mo.

Estimated lease rates for Office space in Buffalo, NY begin at $0.54 SF/Yr, with an average of $14 SF/Yr and extend to $57 SF/Yr.

Buffalo, NY Office Space for Lease

Harlem Road Commercial Leasing Opportunity

High-visibility office spaces available for lease on Harlem Road.

Main Street Commercial Space Available

First floor commercial space on Main Street, Buffalo, NY.

West Seneca Commercial Office Space

West Seneca Office Space Available

Elmwood Avenue Professional Office Space

Elmwood Avenue Commercial Space

Renovated Commercial Space with Warehouse

Tonawanda Street Commercial Space Available

Versatile Commercial Space Available

Adaptable Commercial Unit in Buffalo

Prime Commercial Space on Elmwood

Professional Office Suites For Lease

Buffalo Office Suites For Rent

Buffalo Office and Warehouse Space

Office Space in Buffalo, NY

Downtown Buffalo Office Space Available

Buffalo Office Space For Rent

Mixed-Use Building Near Medical Campus

Kenmore Avenue Retail/Office/Medical Space

Office Space with 24-Hour Security

Former Service Station on Route 5

Renovated Office Space on Main

Elmwood Avenue Second Floor Office

Downtown Buffalo Office Suites

Buffalo, NY Office space Leasing Opportunities Market Analysis

Browse Office space for Lease Near Buffalo, NY

Popular Searches in Buffalo, NY

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Buffalo, NY Office Space for Lease

Harlem Road Commercial Leasing Opportunity

High-visibility office spaces available for lease on Harlem Road.

Main Street Commercial Space Available

First floor commercial space on Main Street, Buffalo, NY.

West Seneca Commercial Office Space

West Seneca Office Space Available

Elmwood Avenue Professional Office Space

Elmwood Avenue Commercial Space

Renovated Commercial Space with Warehouse

Tonawanda Street Commercial Space Available

Versatile Commercial Space Available

Adaptable Commercial Unit in Buffalo

Prime Commercial Space on Elmwood

Professional Office Suites For Lease

Buffalo Office Suites For Rent

Buffalo Office and Warehouse Space

Office Space in Buffalo, NY

Downtown Buffalo Office Space Available

Buffalo Office Space For Rent

Mixed-Use Building Near Medical Campus

Kenmore Avenue Retail/Office/Medical Space

Office Space with 24-Hour Security

Former Service Station on Route 5

Renovated Office Space on Main

Elmwood Avenue Second Floor Office

Downtown Buffalo Office Suites

Buffalo, NY Office space Leasing Opportunities Market Analysis

Browse Office space for Lease Near Buffalo, NY

Popular Searches in Buffalo, NY

Popular Categories

Most Searched ZIP Codes in Buffalo, NY

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