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    Buffalo, NY Medical Office Space for Lease

    32 results
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    Main Street Commercial Space Available
    $2,400 /Mo
    4,620 SF

    Main Street Commercial Space Available

    2290 Main Street, Buffalo, NY 14214

    First floor commercial space on Main Street, Buffalo, NY.

    • High visibility location on busy Main Street corridor.
    • Flexible layout suitable for office, medical, or retail use.
    • Welcoming entrance lobby for a positive first impression.
    • Multiple private office rooms.
    • Easy transition with minimal modifications needed.
    Updated: Feb 28
    View details
    Elmwood Avenue Professional Office Space
    $15 SF/Yr
    7,344 SF

    Elmwood Avenue Professional Office Space

    2555 Elmwood Avenue, Buffalo, NY 14217

    3,000 SF office space in high-traffic Kenmore/Elmwood corridor.

    • High‑visibility location on Elmwood Avenue with strong daily traffic counts.
    • 3,000 SF of flexible office space suitable for various professional uses.
    • On‑site parking for staff and clients.
    • Central air conditioning and forced air natural gas heating.
    • Close proximity to retail, restaurants, and dense residential neighborhoods.
    Updated: Jan 13
    View details
    Spacious Commercial Building, Buffalo, NY
    $499,900
    5,012 SF

    Spacious Commercial Building, Buffalo, NY

    Versatile commercial building with parking, suitable for various businesses.

    1609 Genesee Street, Buffalo, NY 14211
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    West Seneca Medical/Office Space
    $4,000 /Mo
    4,500 SF

    West Seneca Medical/Office Space

    4,500+/- SF medical/office space in high-traffic West Seneca location.

    220 Center Road, West Seneca, NY 14224
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    Medical Office Space For Rent
    $10 SF/Yr
    11,512 SF

    Medical Office Space For Rent

    Medical office space available for lease in Clarence, New York.

    8705 Sheridan Drive, Williamsville, NY 14221
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    Medical/Professional Office Space Available
    $18 SF/Yr
    10,888 SF

    Medical/Professional Office Space Available

    Medical/professional office space for rent in Williamsville, NY.

    1829 Maple Road, Williamsville, NY 14221
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    Kenmore Avenue Retail/Office/Medical Space
    $8 SF/Yr
    12,270 SF

    Kenmore Avenue Retail/Office/Medical Space

    5,600 SF space for lease, suitable for retail/office/medical.

    974-976 Kenmore Ave, Buffalo, NY 14216
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    Medical Office Space Available 2025
    $16 SF/Yr
    20,437 SF

    Medical Office Space Available 2025

    Medical office space available for lease in 2025.

    2733 Wehrle Drive, Williamsville, NY 14221
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    Medical Office Space For Rent
    $16 SF/Yr

    Medical Office Space For Rent

    Medical office space with easy access to major highways.

    2733 Wehrle Drive, Williamsville, NY 14221
    View details
    Niagara Ontario Plaza Leasing Opportunity
    $10 SF/Yr
    43,787 SF

    Niagara Ontario Plaza Leasing Opportunity

    Revitalized commercial hub with high traffic and unmatched accessibility.

    2211 Niagara Street, Buffalo, NY 14207
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    Modern Office/Medical Space Available
    Contact for pricing

    Modern Office/Medical Space Available

    Modern office/medical space with ample parking and excellent accessibility.

    6691 - 6693 Transit Rd., Williamsville, NY 14221, Williamsville, NY 14221
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    Updated Medical/Business Office Space
    Contact for pricing
    11,787 SF

    Updated Medical/Business Office Space

    Updated medical/business office space available for rent.

    897 Delaware Avenue, Buffalo, NY 14209
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    Prime Medical Office Space Available
    Contact for pricing
    18,210 SF

    Prime Medical Office Space Available

    Medical office space near Kenmore Mercy Hospital, ample plumbing.

    1491 Sheridan Dr, Buffalo, NY 14217
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    Updated Medical Space on Abbott
    Contact for pricing

    Updated Medical Space on Abbott

    Updated medical space in South Buffalo's business district.

    306 Abbott Road, Buffalo, NY 14220
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    West Seneca Medical Office Suites
    Contact for pricing
    6,495 SF

    West Seneca Medical Office Suites

    Medical office suites available for lease in West Seneca.

    550 Orchard Park Road, West Seneca, NY 14224
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    Turnkey Medical Office Space
    $15 SF/Yr
    10,000 SF

    Turnkey Medical Office Space

    Well-appointed medical office space with ample parking near downtown.

    Buffalo, NY 14224
    View details
    Delaware Avenue Medical Office Space
    Contact for pricing
    5,868 SF

    Delaware Avenue Medical Office Space

    Medical office space near Allentown and Buffalo's medical campus.

    520 Delaware Ave, Buffalo, NY
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    Medical/Professional Office Building For Rent
    Contact for pricing
    20,000 SF

    Medical/Professional Office Building For Rent

    Two-story, 20,000 SF medical/professional office building in Williamsville.

    52 S Union Rd, Buffalo, NY 14221
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    Medical Office Space Available
    Contact for pricing
    30,000 SF

    Medical Office Space Available

    Medical office suites in downtown Buffalo near medical campus.

    700 Michigan Ave, Buffalo, NY 14203
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    Kenmore Avenue Retail/Office/Medical Space
    $8 SF/Yr
    5,600 SF

    Kenmore Avenue Retail/Office/Medical Space

    Retail, office, or medical space for lease on Kenmore.

    956-976 Kenmore Ave, Buffalo, NY
    View details
    Turnkey Medical Office Space Available
    $15 SF/Yr
    1,744 SF

    Turnkey Medical Office Space Available

    Well-appointed medical office space for rent, 1744 square feet.

    725 Orchard Park Rd, Buffalo, NY
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    Williamsville Medical Office Space Available
    Contact for pricing

    Williamsville Medical Office Space Available

    Well-located medical office space near Millard Fillmore Suburban Hospital.

    1150 Youngs Rd, Buffalo, NY 14221
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    Medical Office Space Near Hospital
    Contact for pricing
    1,400 SF

    Medical Office Space Near Hospital

    Medical office suite with high visibility near Millard Fillmore Hospital.

    1630 Maple Rd, Buffalo, NY 14221
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    First Floor Office Space Available
    Contact for pricing
    1,768 SF

    First Floor Office Space Available

    Office space for rent in excellent location with high visibility.

    4245 Union Rd, Buffalo, NY 14225
    View details

    Buffalo, NY Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Buffalo, NY with 32 listings featured on our commercial real estate exchange. The current inventory includes 1,731,292,200 square feet of properties with an estimated lease value of $60 SF/Yr.

    Estimated lease rates for Medical Office Space in Buffalo, NY begin at $6 SF/Yr, with an average of $12 SF/Yr and extend to $16 SF/Yr.
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    Browse Medical Office Space for Lease Near Buffalo, NY

    Popular Searches in Buffalo, NY

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    Most Searched ZIP Codes in Buffalo, NY

    • 14221
    • 14224
    • 14209
    • 14216
    • 14217
    • 14203
    • 14207
    • 14211
    • 14214
    • 14220
    • 14225

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