West Seneca, NY Commercial Real Estate for Lease

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350 properties
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Buffalo - North Towns
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Medical Office with Exam Rooms
Updated: Jun 11
Medical Office with Exam Rooms

4085 Seneca Street, Buffalo, NY 14224

$2,850/Mo
1,900 sqft
Office or medical space layout with four exam rooms plus a waiting room and dedicated billing office
Handicap accessible with an accessible approach ramp
Central air cooling and forced‑air natural gas heating
Public water and public sewer
Flat roof; building built in 1967
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Private Office in Shared Suite
Updated: Apr 14
Private Office in Shared Suite

625 W Ferry, Buffalo, NY 14222

$1,600/Mo
2,000 sqft
Private office in a 2,000+ SF shared space at Parish Commons (2nd floor) in Elmwood Village
Office size is 18' x 12', suited for 1–2 people
High‑end finishes with large windows for natural light
Central air cooling and natural gas heating
Includes utilities and internet in the rent
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Restaurant Building with Outdoor Patio
Restaurant Building with Outdoor Patio

2711 S Park Avenue, Buffalo, NY 14218

$349,998/Mo
7,338 sqft

Restaurant building offered for rent with a full basement and a large outdoor patio connected to a nearby pocket park.

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Retail Building with High-Visibility Frontage
Retail Building with High-Visibility Frontage

3146 North Bailey Avenue, Buffalo, NY 14226

$12 SF/Yr
5,712 sqft

Flexible former Rent-A-Center space with prominent frontage, strong roadway access, and rear parking for customer and service needs.

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Turn-Key Restaurant and Warehouse
Turn-Key Restaurant and Warehouse

898 Genesee Street, Buffalo, NY 14211

$5,000/Mo
10,908 sqft

Turn-key restaurant with equipment and furnishings pairs with warehouse space featuring a loading/unloading door.

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Two-Story Office Building
Two-Story Office Building

3686 Seneca Street, Buffalo, NY 14224

$219,900/Mo
2,603 sqft

Two-story office building with kitchenette, reception, conference room, five private offices, two bathrooms, and 10 on-site parking spaces.

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Historic Office Suite with Reception
Historic Office Suite with Reception

1109 Delaware Avenue, Buffalo, NY 14209

$750/Mo
1,200 sqft

Third-floor suite features three private offices, a reception area, and a full bathroom with included maintenance services.

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Corner Retail Building with Parking
Corner Retail Building with Parking

2990 Seneca Street, West Seneca, NY 14224

$2,995/Mo
2,298 sqft

A 1979-built commercial retail building with ample paved parking, street signage, and corner-lot access.

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Renovated Retail and Office Space
Renovated Retail and Office Space

18 Abbott Road, Buffalo, NY 14220

$1,800/Mo
1,220 sqft

Renovated storefront suite with private restrooms, kitchenette, and onsite parking for retail or professional use.

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First-Floor Office Suite with Offices
First-Floor Office Suite with Offices

5900 Main Street, Buffalo, NY 14221

$2,500/Mo
1,500 sqft

A turnkey first-floor suite with reception, conference room, and three private offices plus shared workspace.

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Retail Storefront with Exposed Brick
Retail Storefront with Exposed Brick

220 Lexington Ave, Buffalo, NY 14222

$26.08 SF/Yr
1,000 sqft

Retail storefront for rent featuring exposed brick walls in a walkable area with established nearby co-tenants.

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Professional Office Space with Parking
Professional Office Space with Parking

2555 Elmwood Avenue, Buffalo, NY 14217

$15/Mo
7,344 sqft

Well-maintained office space with central air, private offices, flexible open areas, and on-site parking.

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Retail Specialty Suite
Retail Specialty Suite

1109 Harlem Rd Ste 1, Buffalo, NY 14227

$450/Mo
1,701 sqft

Ground-floor suite within a specialty property, with remeasured square footage noted to differ from tax records.

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Prime Retail Space on Bailey
Prime Retail Space on Bailey

3115 Bailey Ave, Buffalo, NY 14215

$10 SF/Yr
7,100 sqft

7,100+/- SF retail space in high-traffic commercial district.

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Warehouse with Loading Dock
Warehouse with Loading Dock

4336 Bailey Avenue, Buffalo, NY 14226

$11/Mo
9,635 sqft

Fully renovated in 2024, offering a warehouse with a 28-foot loading dock and adaptable retail/office space.

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Retail Space in Buffalo, NY
Retail Space in Buffalo, NY

1109 Harlem Rd Ste 2, Buffalo, NY 14227

$1,250/Mo
1,665 sqft

Retail space available for lease in Buffalo, New York.

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West Seneca Medical/Office Space
West Seneca Medical/Office Space

220 Center Road, West Seneca, NY 14224

$4,000/Mo
4,500 sqft

4,500+/- SF medical/office space in high-traffic West Seneca location.

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Commercial Space in Buffalo, NY
Commercial Space in Buffalo, NY

1109 Harlem Rd Ste 3, Buffalo, NY 14227

$800/Mo
600 sqft

Commercial space available for rent in Buffalo, New York.

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Renovated Commercial Building For Lease
Renovated Commercial Building For Lease

1492 Southwestern Blvd., West Seneca, NY 14224

$78,000 SF/Yr
7,800 sqft

Extensively upgraded 7,800 SF commercial building with recent capital improvements.

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All-Inclusive Office Suites
All-Inclusive Office Suites

200 John James Audubon Parkway, Buffalo, NY 14228

$17/Mo
82,667 sqft

Office suites with gross rent that includes janitorial service and onsite management, plus ample free parking.

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Corner Office Building for Lease
Corner Office Building for Lease

2060 Sheridan Drive, Buffalo, NY 14223

$16 SF/Yr
12,000 sqft

Two-story office building with multiple tenant options and ample parking.

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Professional Office Suite with Private Offices
Professional Office Suite with Private Offices

51 N America Drive, Buffalo, NY 14224

$14/Mo
8,196 sqft

Single-story office suite with multiple private rooms, open areas, two restrooms, and dedicated parking.

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Broadway Corner Opportunity
Broadway Corner Opportunity

756 Broadway Street, Buffalo, NY 14212

$2,000/Mo
5,475 sqft

Two-story building with vacant lot for lease.

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Brick Warehouse with Garage Bays
Brick Warehouse with Garage Bays

1433 Niagara Street, Buffalo, NY 14213

$675,000/Mo
4,744 sqft

Two-building warehouse site includes a two-story brick structure and a two-bay one-story cinder block garage.

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West Seneca, NY Commercial real estate Market Trends and Statistics

Explore Commercial real estate leasing options in West Seneca, NY with 350 listings featured on our commercial real estate exchange. The current inventory includes 1,569,411 square feet of properties with an estimated lease value of $2,300,076.

Estimated lease rates for Commercial real estate in West Seneca, NY begin at $0.90 SF/Yr, with an average of $17,692 /Mo and extend to $675,000.
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