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    Columbia, SC Medical Office Space for Lease

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    22 properties
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    Turnkey Medical Office Suites
    Updated: Jun 2
    Turnkey Medical Office Suites

    4100 N. Main Street, Columbia, SC 29203

    $20 SF/Yr
    3,742 sqft
    1987‑built medical office with turnkey suites featuring exam rooms with plumbing
    Suite 101: ±2,484 SF available 8/1/26
    Suite 200: ±1,226 SF with reception, 3 exam rooms (with plumbing), 1 private office, and restroom
    Suite 201: ±2,516 SF with large reception/waiting area, 6 exam rooms (with plumbing), 2 private offices, IT/storage rooms, and restroom
    Major renovations in 2019 included new roof, building façade, and common area upgrades
    View details
    Medical Office Complex For Rent
    Updated: Nov 24, 2025
    Medical Office Complex For Rent

    2601 Laurel St, Columbia, SC

    $28 SF/Yr
    1,797 sqft
    Located in Columbia Central Business District
    Adjacent to the Providence/LifePoint Health campus
    126,002 RSF medical office building complex
    Parking ratio of 5 spaces per 1,000 SF
    Customized suites available up to 14,189 RSF
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    Medical Office Complex For Rent
    Medical Office Complex For Rent

    2750 Laurel St., 2601 Laurel St. & 1655 Bernardin Ave., Columbia, SC 29206

    $28 SF/Yr
    126,002 sqft

    Medical office complex in Columbia's Central Business District, renovated.

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    Standalone Office Building Suite
    Standalone Office Building Suite

    300 Rice Meadow Way, Columbia, SC

    $22 SF/Yr
    4,000 sqft

    Office suite with reception, offices, bathrooms, and break room.

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    Move-in Ready Office Space
    Move-in Ready Office Space

    144 Leisure Ln, Columbia, SC

    $15 SF/Yr
    4,000 sqft

    4,000 SF office space for lease in Columbia, SC.

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    Columbia Office/Medical Space For Lease
    Columbia Office/Medical Space For Lease

    120 & 122 Highland Center Dr., Columbia, SC 29203

    $21 SF/Yr
    20,822 sqft

    Office and medical space available for lease in Columbia, SC.

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    Move-In Ready Medical Office Suite
    Move-In Ready Medical Office Suite

    7041 Saint Andrews Road, Columbia, SC 29212

    Contact for pricing
    2,752 sqft

    Purpose-built clinical space with reception, admin office, multiple operatories, and private suite features for healthcare practices.

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    Office Suite in Medical Corridor
    Office Suite in Medical Corridor

    3634 Sunset Blvd, W, Columbia, SC

    $19 SF/Yr
    3,566 sqft

    Office suite with private offices near Lexington Medical Center.

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    Move-in Ready Medical Office Space
    Move-in Ready Medical Office Space

    1538 Main St, Columbia, SC

    $20 SF/Yr
    2,466 sqft

    Medical office space for lease in Columbia's CBD.

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    Retail, Restaurant, or Medical Office
    Retail, Restaurant, or Medical Office

    2800 Rosewood Dr., Columbia, SC 29205

    Contact for pricing
    24,000 sqft

    Located in a Publix-anchored shopping center with high visibility.

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    Medical/Office Space Near Veterans Hospital
    Medical/Office Space Near Veterans Hospital

    200 Byron Rd, Columbia, SC

    $10 SF/Yr
    800 sqft

    800 SF medical/office space with ample parking, easy access.

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    Highland Center Office Space Available
    Highland Center Office Space Available

    122 Highland Center Dr, Columbia, SC

    $21 SF/Yr
    7,000 sqft

    Office and medical space available for lease in Columbia.

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    Class A Medical Office Space
    Class A Medical Office Space

    1600 Lake Murray Blvd, Columbia, SC 29212

    Contact for pricing

    Highly visible medical office location in Irmo, South Carolina.

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    New Mixed-Use Building For Lease
    New Mixed-Use Building For Lease

    1514 Brentwood Dr, Columbia, SC 29206

    $33 SF/Yr
    14,660 sqft

    New mixed-use building in thriving retail corridor available for lease.

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    Forest Acres Office Space Available
    Forest Acres Office Space Available

    4700 Forest Dr, Columbia, SC

    $17 SF/Yr
    4,106 sqft

    Office space for rent in the heart of Forest Acres.

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    Medical Office Space For Rent
    Medical Office Space For Rent

    710 Rabon Rd, Columbia, SC 29203

    $28 SF/Yr

    Professional second-floor medical office space in Columbia, SC.

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    Class-A Office/Medical Space Available
    Class-A Office/Medical Space Available

    1074 Pinnacle Point Dr, Columbia, SC

    $22.50 SF/Yr
    3,100 sqft

    Class-A office/medical space for lease in Northeast Columbia.

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    Renovated Medical Space Available
    Renovated Medical Space Available

    1012 Calhoun St, Columbia, SC

    Contact for pricing
    2,865 sqft

    Renovated medical Class A space with convenient access.

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    Class A Medical Office Building
    Class A Medical Office Building

    2611 Forest Dr, Columbia, SC 29204

    Contact for pricing
    5,004 sqft

    Medical office building near MUSC Health Columbia Medical Center.

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    Renovated Medical Office Space Available
    Renovated Medical Office Space Available

    1777 St Julian Pl, Columbia, SC 29204

    $25 SF/Yr
    10,000 sqft

    Newly renovated medical office space for lease in Columbia, SC.

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    Medical Office Building For Lease
    Medical Office Building For Lease

    1706 St Julian Pl, Columbia, SC 29204

    Contact for pricing
    12,395 sqft

    12,395 SF medical office building available for lease.

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    Retail, Restaurant, or Medical Office
    Retail, Restaurant, or Medical Office

    2800 Rosewood Dr, Columbia, SC 29205

    Contact for pricing

    Located in Publix-anchored shopping center with high visibility.

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    Based on your search, we've compiled 38 Potential Opportunities for your consideration. Besides 22 Active listings in Columbia, SC, we suggest exploring alternatives. Similar 16 Properties for Sales.

    Similar Spaces for Sale in Columbia, SC

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    Renovated Multi-Tenant Commercial Suite
    Renovated Multi-Tenant Commercial Suite

    3201 Broad River Road, Columbia, SC 29210

    $250,000
    1,138 sqft 0.50 AC lot

    Renovated in 2014 with multiple tenant suites, including a medical spa and aviation instruction academy.

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    Move-In Ready Office Building
    Move-In Ready Office Building

    7193 Saint Andrews Road, Columbia, SC 29212

    $699,000
    3,500 sqft 0.41 AC lot

    Well-maintained office building with reception, private offices, conference room, and on-site storage.

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    Columbia, SC Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in Columbia, SC with 22 listings featured on our commercial real estate exchange. The current inventory includes 206,061 square feet of properties with an estimated lease value of $301.50 /Mo.

    Estimated lease rates for Medical Office Space in Columbia, SC begin at $10 SF/Yr, with an average of $21.54 SF/Yr and extend to $33 SF/Yr.
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