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    Columbia, SC Medical Office Space for Lease

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    Cayce, SC West Columbia, SC Lexington, SC
    20 results
    Two-Story Office Building For Rent
    $16 SF/Yr
    3,960 SF

    Two-Story Office Building For Rent

    123 Lawand Dr, Columbia, SC 29210

    Two-story office building with flexible layout in central Columbia.

    • Excellent central Columbia location with easy access to I‑20/I‑26 interchange.
    • Highly functional and flexible layout suitable for various business uses (office, medical, professional services).
    • Potential to function as up to three separate office suites, accommodating single or multiple tenants.
    • ±3,960 SF two‑story masonry office building.
    • Move‑in‑ready condition.
    Updated: Mar 20
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    Columbia Office/Medical Space For Lease
    $21 SF/Yr
    20,822 SF

    Columbia Office/Medical Space For Lease

    120 & 122 Highland Center Dr., Columbia, SC 29203

    Office and medical space available for lease in Columbia, SC.

    • Ready‑to‑occupancy, fully constructed 4,028 SF medical office space available.
    • Flexible space options ranging from 1,450 SF to 7,000 SF.
    • Prime location at the intersection of Hard Scrabble Road and Farrow Road in Northeast Columbia.
    • Convenient access to I‑77, MUSC, and Clemson Road.
    • Divisible contiguous space allows for customized layouts.
    Updated: Nov 26, 2025
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    Medical Office Complex For Rent
    $28 SF/Yr
    126,002 SF

    Medical Office Complex For Rent

    Medical office complex in Columbia's Central Business District, renovated.

    2750 Laurel St., 2601 Laurel St. & 1655 Bernardin Ave., Columbia, SC 29206
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    Standalone Office Building Suite
    $22 SF/Yr
    4,000 SF

    Standalone Office Building Suite

    Office suite with reception, offices, bathrooms, and break room.

    300 Rice Meadow Way, Columbia, SC
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    Move-in Ready Office Space
    $15 SF/Yr
    4,000 SF

    Move-in Ready Office Space

    4,000 SF office space for lease in Columbia, SC.

    144 Leisure Ln, Columbia, SC
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    Move-in Ready Medical Office Space
    $20 SF/Yr
    2,466 SF

    Move-in Ready Medical Office Space

    Medical office space for lease in Columbia's CBD.

    1538 Main St, Columbia, SC
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    Retail, Restaurant, or Medical Office
    Contact for pricing
    24,000 SF

    Retail, Restaurant, or Medical Office

    Located in a Publix-anchored shopping center with high visibility.

    2800 Rosewood Dr., Columbia, SC 29205
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    Office Suite in Medical Corridor
    $19 SF/Yr
    3,566 SF

    Office Suite in Medical Corridor

    Office suite with private offices near Lexington Medical Center.

    3634 Sunset Blvd, W, Columbia, SC
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    Medical/Office Space Near Veterans Hospital
    $10 SF/Yr
    800 SF

    Medical/Office Space Near Veterans Hospital

    800 SF medical/office space with ample parking, easy access.

    200 Byron Rd, Columbia, SC
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    Class A Medical Office Space
    Contact for pricing

    Class A Medical Office Space

    Highly visible medical office location in Irmo, South Carolina.

    1600 Lake Murray Blvd, Columbia, SC 29212
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    Highland Center Office Space Available
    $21 SF/Yr
    7,000 SF

    Highland Center Office Space Available

    Office and medical space available for lease in Columbia.

    122 Highland Center Dr, Columbia, SC
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    Medical Office Complex For Rent
    $28 SF/Yr
    1,797 SF

    Medical Office Complex For Rent

    Medical office complex in Columbia's Central Business District.

    2601 Laurel St, Columbia, SC
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    New Mixed-Use Building For Lease
    $33 SF/Yr
    14,660 SF

    New Mixed-Use Building For Lease

    New mixed-use building in thriving retail corridor available for lease.

    1514 Brentwood Dr, Columbia, SC 29206
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    Forest Acres Office Space Available
    $17 SF/Yr
    4,106 SF

    Forest Acres Office Space Available

    Office space for rent in the heart of Forest Acres.

    4700 Forest Dr, Columbia, SC
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    Medical Office Space For Rent
    $28 SF/Yr

    Medical Office Space For Rent

    Professional second-floor medical office space in Columbia, SC.

    710 Rabon Rd, Columbia, SC 29203
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    Renovated Medical Space Available
    Contact for pricing
    2,865 SF

    Renovated Medical Space Available

    Renovated medical Class A space with convenient access.

    1012 Calhoun St, Columbia, SC
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    Class-A Office/Medical Space Available
    $22 SF/Yr
    3,100 SF

    Class-A Office/Medical Space Available

    Class-A office/medical space for lease in Northeast Columbia.

    1074 Pinnacle Point Dr, Columbia, SC
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    Class A Medical Office Building
    Contact for pricing
    5,004 SF

    Class A Medical Office Building

    Medical office building near MUSC Health Columbia Medical Center.

    2611 Forest Dr, Columbia, SC 29204
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    Medical Office Building For Lease
    Contact for pricing
    12,395 SF

    Medical Office Building For Lease

    12,395 SF medical office building available for lease.

    1706 St Julian Pl, Columbia, SC 29204
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    Retail, Restaurant, or Medical Office
    Contact for pricing

    Retail, Restaurant, or Medical Office

    Located in Publix-anchored shopping center with high visibility.

    2800 Rosewood Dr, Columbia, SC 29205
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    Based on your search, we've compiled 42 Potential Opportunities for your consideration. Besides 20 Active listings in Columbia, SC, we suggest exploring alternatives. Similar 22 Properties for Sales.

    Similar Spaces for Sale in Columbia, SC

    Consider Similar Space for Sale. We found 22 Spaces matching your search parameters.

    Renovated Commercial Building in Columbia
    $250,000
    1,138 SF
    Renovated Commercial Building in Columbia

    Multi-tenant property suitable for retail, medical, or aviation businesses.

    3201 Broad River Road, Columbia, SC 29210

    View details
    Freestanding Medical Office Investment
    $1,250,000
    3,200 SF
    Freestanding Medical Office Investment

    Freestanding medical office building for sale in Northeast Columbia.

    131 Wildewood Park Drive, Columbia, SC 29223

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    High-Visibility Business/Office Center For Sale
    $2,250,000
    15,593 SF
    High-Visibility Business/Office Center For Sale

    Office/retail building with high visibility and customer parking.

    7358 Garners Ferry, Columbia, SC 29209

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    High-Traffic Commercial Center with Suites
    $2,150,000
    15,593 SF
    High-Traffic Commercial Center with Suites

    Highly visible commercial center with 41 suites in Columbia, SC.

    7358 Garners Ferry, Columbia, SC 29209

    View details

    Columbia, SC Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Columbia, SC with 20 listings featured on our commercial real estate exchange. The current inventory includes 247,863 square feet of properties with an estimated lease value of $310 /Mo.

    Estimated lease rates for Medical Office Space in Columbia, SC begin at $10 SF/Yr, with an average of $20 SF/Yr and extend to $33 SF/Yr.
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