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Columbia, SC

Medical Space

Columbia, SC Medical Office Space for Lease

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Cayce, SC West Columbia, SC Lexington, SC Irmo, SC Blythewood, SC Gaston, SC Swansea, SC Elgin, SC

23 properties

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Turnkey Medical Office Suites

Updated: Jun 2

Turnkey Medical Office Suites

4100 N. Main Street, Columbia, SC 29203

$20 SF/Yr

3,742 sqft

1987‑built medical office with turnkey suites featuring exam rooms with plumbing
Suite 101: ±2,484 SF available 8/1/26
Suite 200: ±1,226 SF with reception, 3 exam rooms (with plumbing), 1 private office, and restroom
Suite 201: ±2,516 SF with large reception/waiting area, 6 exam rooms (with plumbing), 2 private offices, IT/storage rooms, and restroom
Major renovations in 2019 included new roof, building façade, and common area upgrades

Two-Building Office Medical Park

Updated: Jun 29

Two-Building Office Medical Park

3600 Forest Dr, Columbia, SC 29204

$22 SF/Yr

150,000 sqft

Two‑building office/medical park totaling approximately 150,000 RSF (Year built 1973)
Existing tenants include a mix of regional and local medical practices and general office users
Ownership group plans significant building upgrades in 2026, including updated common areas and upgraded building façade improvements
Planned improvements also include upgraded entrances and class A tenant amenities
High visibility from Forest Drive and less than 5 minutes from downtown Columbia

Medical Office Park Buildings

Medical Office Park Buildings

3700 Forest Dr, Columbia, SC 29204

$22 SF/Yr

150,000 sqft

Two office/medical buildings comprise an approximately 150,000 RSF park on Forest Drive.

Medical Office Space with Imaging Rooms

Medical Office Space with Imaging Rooms

74 Polo Rd, Columbia, SC 29223

Contact for pricing

9,975 sqft

Purpose-built medical suite with diagnostic rooms, laboratory space, private offices, and on-site parking.

Medical Office Complex For Rent

Medical Office Complex For Rent

2750 Laurel St., 2601 Laurel St. & 1655 Bernardin Ave., Columbia, SC 29206

$28 SF/Yr

126,002 sqft

Medical office complex in Columbia's Central Business District, renovated.

Move-In Ready Medical Office Suite

Move-In Ready Medical Office Suite

7041 Saint Andrews Rd, Columbia, SC 29212

Contact for pricing

2,752 sqft

Purpose-built clinical space with reception, admin office, multiple operatories, and private suite features for healthcare practices.

Second-Generation Medical Office

Second-Generation Medical Office

100 Jimmy Love Ln, Columbia, SC 29212

Contact for pricing

9,668 sqft

Well-maintained second-generation medical and office space located for convenient access to Interstate 26.

Columbia Office/Medical Space For Lease

Columbia Office/Medical Space For Lease

120 & 122 Highland Center Dr., Columbia, SC 29203

$21 SF/Yr

20,822 sqft

Office and medical space available for lease in Columbia, SC.

Medical Office Space with Exam Rooms

Medical Office Space with Exam Rooms

113-117 Barton Creek Ct, Columbia, SC 29223

Contact for pricing

2,740 sqft

Eight offices or exam rooms support clinical and administrative layouts.

Downtown Medical Office Space

Downtown Medical Office Space

1331 Lady St, Columbia, SC 29201

$25 SF/Yr

Medical office space for lease in downtown Columbia at the corner of Lady Street and Marion Street.

Medical Office Suite with Private Offices

Medical Office Suite with Private Offices

101 Rice Bent Way, Columbia, SC 29229

Contact for pricing

1,500 sqft

Office suite includes five private offices, reception, conference room, break room, and two ADA restrooms.

Retail, Restaurant, or Medical Office

Retail, Restaurant, or Medical Office

2800 Rosewood Dr., Columbia, SC 29205

Contact for pricing

24,000 sqft

Located in a Publix-anchored shopping center with high visibility.

Professional Office Space

Professional Office Space

130 Suber Road, Columbia, SC 29210

$17 SF/Yr

Professionally designed office space with convenient access to I-26 and I-20 in a Columbia business corridor.

Medical Office Space with New Roof

Medical Office Space with New Roof

90 Brighton Hill Rd, Columbia, SC 29223

Contact for pricing

6,564 sqft 1.75 AC lot

Flexible medical office space on a substantial commercial parcel with GC zoning and updated building systems.

Move-in Ready Office Space

Move-in Ready Office Space

144 Leisure Ln, Columbia, SC

Contact for pricing

4,000 sqft 0.68 AC lot

4,000 SF office space for lease in Columbia, SC.

Medical Office Building For Sale

Medical Office Building For Sale

1701 Saint Julian Pl, Columbia, SC 29204

Contact for pricing

14,442 sqft

Medical office building with ample parking near medical campuses.

Move-in Ready Medical Office Space

Move-in Ready Medical Office Space

1538 Main St, Columbia, SC

Contact for pricing

2,466 sqft 0.12 AC lot

Medical office space for lease in Columbia's CBD.

Forest Acres Office Space Available

Forest Acres Office Space Available

4700 Forest Dr, Columbia, SC 29206

Contact for pricing

Office space for rent in the heart of Forest Acres.

Medical Office Space

Medical Office Space

8910 Two Notch Rd, Columbia, SC 29223

Contact for pricing

7,072 sqft

Professional office space available near major interstates and retail centers in northeast Columbia.

Renovated Medical Space Available

Renovated Medical Space Available

1012 Calhoun St, Columbia, SC

Contact for pricing

2,865 sqft 0.52 AC lot

Renovated medical Class A space with convenient access.

Class A Medical Office Building

Class A Medical Office Building

2611 Forest Dr, Columbia, SC 29204

Contact for pricing

5,004 sqft

Medical office building near MUSC Health Columbia Medical Center.

Medical Office Suite with Exam Rooms

Medical Office Suite with Exam Rooms

2113 Adams Grove, Columbia, SC 29203

Contact for pricing

5,000 sqft

Second-floor medical office suite with a central waiting area, nurses station, and multiple exam and procedure rooms.

Class-A Office/Medical Space Available

Class-A Office/Medical Space Available

1074 Pinnacle Point Dr, Columbia, SC

Contact for pricing

3,100 sqft 3.59 AC lot

Class-A office/medical space for lease in Northeast Columbia.

Based on your search, we've compiled 35 Potential Opportunities for your consideration. Besides 23 Active listings in Columbia, SC, we suggest exploring alternatives. Similar 12 Properties for Sales.

Similar Spaces for Sale in Columbia, SC

Consider Similar Space for Sale. We found 12 Spaces matching your search parameters.

Renovated Office Building

Renovated Office Building

8311 Two Notch Road, Columbia, SC 29223

$850,000

5,969 sqft

Multiple private entrances support separate business functions or multi-tenant use.

Columbia, SC Medical Office Space Lease Rates & Market Statistics

Browse 23 Medical Office Space listings for lease in Columbia, SC on Realmo, a commercial real estate marketplace serving the Columbia area. The current inventory totals 551,714 square feet of properties — an average of ~24,000 SF per listing.

Asking lease rates for Medical Office Space in Columbia start at $17 SF/Yr, average $22.14 SF/Yr, and reach $28 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $22.14 SF/Yr is in line with the South Carolina state average.

Medical Office Space listings make up 16% of the 144 Office Spaces currently for lease in Columbia, with asking rates averaging $22.14 SF/Yr — 11% above the citywide Office Spaces average of $19.94 SF/Yr. Tenants comparing options may also consider Office Units (88 listings) and Office buildings (42 listings) elsewhere in the Columbia market.

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