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    Columbia, SC Medical Office Space for Lease

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    Greenville, SC Charleston, SC Spartanburg, SC
    24 results
    Two-Story Office Building For Rent
    $16 SF/Yr
    3,960 SF

    Two-Story Office Building For Rent

    123 Lawand Dr, Columbia, SC 29210

    Two-story office building with flexible layout in central Columbia.

    • Excellent central Columbia location with easy access to I‑20/I‑26 interchange.
    • Highly functional and flexible layout suitable for various business uses (office, medical, professional services).
    • Potential to function as up to three separate office suites, accommodating single or multiple tenants.
    • ±3,960 SF two‑story masonry office building.
    • Move‑in‑ready condition.
    Updated: Mar 20
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    Downtown Columbia Office Space Available
    $17 SF/Yr
    8,584 SF

    Downtown Columbia Office Space Available

    1901 Gadsden Street, Columbia, SC 29201

    Office spaces for lease in downtown Columbia, South Carolina.

    • Prime downtown Columbia location near the Governor's Mansion.
    • Free rear surface parking.
    • Suitable for professional or medical office tenants.
    • Available space ranging from ±1500 - 4,340 SF on the 2nd floor.
    • Market tenant improvement allowance available.
    Updated: Nov 26, 2025
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    Columbia Office/Medical Space For Lease
    $21 SF/Yr
    20,822 SF

    Columbia Office/Medical Space For Lease

    Office and medical space available for lease in Columbia, SC.

    120 & 122 Highland Center Dr., Columbia, SC 29203
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    Medical Office Complex For Rent
    $28 SF/Yr
    126,002 SF

    Medical Office Complex For Rent

    Medical office complex in Columbia's Central Business District, renovated.

    2750 Laurel St., 2601 Laurel St. & 1655 Bernardin Ave., Columbia, SC 29206
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    Standalone Office Building Suite
    $22 SF/Yr
    4,000 SF

    Standalone Office Building Suite

    Office suite with reception, offices, bathrooms, and break room.

    300 Rice Meadow Way, Columbia, SC
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    Move-in Ready Office Space
    $15 SF/Yr
    4,000 SF

    Move-in Ready Office Space

    4,000 SF office space for lease in Columbia, SC.

    144 Leisure Ln, Columbia, SC
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    Retail, Restaurant, or Medical Office
    Contact for pricing
    24,000 SF

    Retail, Restaurant, or Medical Office

    Located in a Publix-anchored shopping center with high visibility.

    2800 Rosewood Dr., Columbia, SC 29205
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    Renovated Medical Office Space Available
    $25 SF/Yr
    43,000 SF

    Renovated Medical Office Space Available

    10,000 SF renovated medical office space for lease.

    1777 St. Julian Place, Columbia, SC 29204
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    Move-in Ready Medical Office Space
    $15 SF/Yr
    2,466 SF

    Move-in Ready Medical Office Space

    Medical office space for lease in Columbia's CBD.

    1538 Main St, Columbia, SC
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    9,000 SF Office Building For Lease
    $8 SF/Yr

    9,000 SF Office Building For Lease

    9,000 SF Office Building For Lease +$8/sqft

    110 Sparkman Dr, Columbia, SC 29209
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    Office Suite in Medical Corridor
    $19 SF/Yr
    3,566 SF

    Office Suite in Medical Corridor

    Office suite with private offices near Lexington Medical Center.

    3634 Sunset Blvd, W, Columbia, SC
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    Medical/Office Space Near Veterans Hospital
    $10 SF/Yr
    800 SF

    Medical/Office Space Near Veterans Hospital

    800 SF medical/office space with ample parking, easy access.

    200 Byron Rd, Columbia, SC
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    Highland Center Office Space Available
    $21 SF/Yr
    7,000 SF

    Highland Center Office Space Available

    Office and medical space available for lease in Columbia.

    122 Highland Center Dr, Columbia, SC
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    Medical Office Complex For Rent
    $28 SF/Yr
    1,797 SF

    Medical Office Complex For Rent

    Medical office complex in Columbia's Central Business District.

    2601 Laurel St, Columbia, SC
    View details
    Forest Acres Office Space Available
    $17 SF/Yr
    4,106 SF

    Forest Acres Office Space Available

    Office space for rent in the heart of Forest Acres.

    4700 Forest Dr, Columbia, SC
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    Renovated Medical Space Available
    Contact for pricing
    2,865 SF

    Renovated Medical Space Available

    Renovated medical Class A space with convenient access.

    1012 Calhoun St, Columbia, SC
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    Class A Medical Office Building
    Contact for pricing
    5,004 SF

    Class A Medical Office Building

    Medical office building near MUSC Health Columbia Medical Center.

    2611 Forest Dr, Columbia, SC 29204
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    Medical Office Space For Rent
    Contact for pricing

    Medical Office Space For Rent

    Professional second-floor medical office space in Columbia, SC.

    710 Rabon Rd, Columbia, SC 29203
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    New Mixed-Use Building For Lease
    Contact for pricing
    14,660 SF

    New Mixed-Use Building For Lease

    New mixed-use building in thriving retail corridor available for lease.

    1514 Brentwood Dr, Columbia, SC 29206
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    Class-A Office/Medical Space Available
    $22 SF/Yr
    3,100 SF

    Class-A Office/Medical Space Available

    Class-A office/medical space for lease in Northeast Columbia.

    1074 Pinnacle Point Dr, Columbia, SC
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    Renovated Medical Office Space Available
    Contact for pricing
    10,000 SF

    Renovated Medical Office Space Available

    Newly renovated medical office space for lease in Columbia, SC.

    1777 St Julian Pl, Columbia, SC 29204
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    Medical Office Building For Lease
    Contact for pricing
    12,395 SF

    Medical Office Building For Lease

    12,395 SF medical office building available for lease.

    1706 St Julian Pl, Columbia, SC 29204
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    Retail Shopping Center Space Available
    Contact for pricing
    23,595 SF

    Retail Shopping Center Space Available

    Retail, office, medical, or educational uses in Columbia, SC.

    2012 Harden St, Columbia, SC 29204
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    Medical Office Suite For Lease
    Contact for pricing

    Medical Office Suite For Lease

    Second floor medical office suite available for lease.

    2113 Adams Grove Rd, Columbia, SC 29203
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    Based on your search, we've compiled 24 Potential Opportunities for your consideration. Besides 24 Active listings in Columbia, SC, we suggest exploring alternatives.

    Columbia, SC Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Columbia, SC with 24 listings featured on our commercial real estate exchange. The current inventory includes 638,154,000 square feet of properties with an estimated lease value of $38 SF/Yr.

    Estimated lease rates for Medical Office Space in Columbia, SC begin at $8 SF/Yr, with an average of $12 SF/Yr and extend to $15 SF/Yr.
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    Browse Medical Office Space for Lease Near Columbia, SC

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    Most Searched ZIP Codes in Columbia, SC

    • 29204
    • 29203
    • 29206
    • 29201
    • 29205
    • 29209
    • 29210

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