Columbia, SC Medical Office Space for Lease

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38 properties

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Updated: Jun 2

Turnkey Medical Office Suites

4100 N. Main Street, Columbia, SC 29203

$20 SF/Yr

3,742 sqft

1987‑built medical office with turnkey suites featuring exam rooms with plumbing
Suite 101: ±2,484 SF available 8/1/26
Suite 200: ±1,226 SF with reception, 3 exam rooms (with plumbing), 1 private office, and restroom
Suite 201: ±2,516 SF with large reception/waiting area, 6 exam rooms (with plumbing), 2 private offices, IT/storage rooms, and restroom
Major renovations in 2019 included new roof, building façade, and common area upgrades

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Updated: Jun 29

Two-Building Office Medical Park

3600 Forest Dr, Columbia, SC 29204

$22 SF/Yr

150,000 sqft

Two‑building office/medical park totaling approximately 150,000 RSF (Year built 1973)
Existing tenants include a mix of regional and local medical practices and general office users
Ownership group plans significant building upgrades in 2026, including updated common areas and upgraded building façade improvements
Planned improvements also include upgraded entrances and class A tenant amenities
High visibility from Forest Drive and less than 5 minutes from downtown Columbia

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Medical Office Park Buildings

3700 Forest Dr, Columbia, SC 29204

$22 SF/Yr

150,000 sqft

Two office/medical buildings comprise an approximately 150,000 RSF park on Forest Drive.

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Medical Office Space with Imaging Rooms

74 Polo Rd, Columbia, SC 29223

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9,975 sqft

Purpose-built medical suite with diagnostic rooms, laboratory space, private offices, and on-site parking.

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Medical Office Complex For Rent

2750 Laurel St., 2601 Laurel St. & 1655 Bernardin Ave., Columbia, SC 29206

$28 SF/Yr

126,002 sqft

Medical office complex in Columbia's Central Business District, renovated.

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Move-In Ready Medical Office Suite

7041 Saint Andrews Road, Columbia, SC 29212

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2,752 sqft

Purpose-built clinical space with reception, admin office, multiple operatories, and private suite features for healthcare practices.

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Second-Generation Medical Office

100 Jimmy Love Ln, Columbia, SC 29212

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9,668 sqft

Well-maintained second-generation medical and office space located for convenient access to Interstate 26.

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Medical Office Suite

7041 Saint Andrews Rd, Columbia, SC 29212

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2,752 sqft

Purpose-built clinical layout suited to medical, dental, and specialty healthcare operations.

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Second-Generation Medical Office

100 Jimmy Love Ln, Columbia, SC 29212

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9,668 sqft

Well-maintained second-generation medical and office space with quick interstate access.

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Columbia Office/Medical Space For Lease

120 & 122 Highland Center Dr., Columbia, SC 29203

$21 SF/Yr

20,822 sqft

Office and medical space available for lease in Columbia, SC.

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Medical Office Space with Exam Rooms

113-117 Barton Creek Ct, Columbia, SC 29223

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2,740 sqft

Eight offices or exam rooms support clinical and administrative layouts.

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Downtown Medical Office Space

1331 Lady St, Columbia, SC 29201

$25 SF/Yr

Medical office space for lease in downtown Columbia at the corner of Lady Street and Marion Street.

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Medical Office Building

110 Atrium Way, Columbia, SC 29223

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4,900 sqft

Approximately 4,900 SF medical office building available for lease off Two Notch Rd.

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Medical Office Suite with Private Offices

101 Rice Bent Way, Columbia, SC 29229

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1,500 sqft

Office suite includes five private offices, reception, conference room, break room, and two ADA restrooms.

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Retail, Restaurant, or Medical Office

2800 Rosewood Dr., Columbia, SC 29205

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24,000 sqft

Located in a Publix-anchored shopping center with high visibility.

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Medical/Professional Office Suite

3145 Carlisle St, Columbia, SC 29205

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1,463 sqft

Office suite offers a private office and conference room layout with parking and TI allowance included for interior upfit.

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Medical Office Space with New Roof

90 Brighton Hill Rd, Columbia, SC 29223

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6,564 sqft 1.75 AC lot

Flexible medical office space on a substantial commercial parcel with GC zoning and updated building systems.

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Fully Plumbed Medical Office Suites

1701 Saint Julian Pl, Columbia, SC 29204

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14,442 sqft

Medical office space fully plumbed for medical use, offering multiple suite options with 60 parking spots.

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Move-in Ready Office Space

144 Leisure Ln, Columbia, SC

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4,000 sqft 0.68 AC lot

4,000 SF office space for lease in Columbia, SC.

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Medical Office Space

8910 Two Notch Road, Columbia, SC 29223

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Professional office space available near major interstates and retail centers in northeast Columbia.

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Medical Office Space with On-Site Parking

4100 N Main St, Columbia, SC 29203

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1,226 sqft

Primarily configured for clinical and medical uses, with the flexibility to support traditional office needs and on-site parking.

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Second-Generation Medical Office Building

100 Jimmy Love Ln, Columbia, SC 29212

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Medical office building with existing exam and clinical areas, delivering vacant and ready for medical-related occupancy.

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Medical Office Building For Sale

1701 Saint Julian Pl, Columbia, SC

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14,442 sqft 0.87 AC lot

Medical office building with ample parking near medical campuses.

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Medical Office Corner Suite

2901-2903 Millwood Ave, Columbia, SC 29205

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4,200 sqft

Corner office suite with reception, open workspace, conference rooms, private offices, and seven off-street parking spaces.

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Columbia, SC Medical Office Space Lease Rates & Market Statistics

Browse 38 Medical Office Space listings for lease in Columbia, SC on Realmo, a commercial real estate marketplace serving the Columbia area. The current inventory totals 612,709 square feet of properties — an average of ~16,100 SF per listing.

Asking lease rates for Medical Office Space in Columbia start at $20 SF/Yr, average $23 SF/Yr, and reach $28 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $23 SF/Yr, the local average runs 6% above South Carolina's state average of $21.78 SF/Yr.

Medical Office Space listings make up 17% of the 228 Office Spaces currently for lease in Columbia, with asking rates averaging $23 SF/Yr — 16% above the citywide Office Spaces average of $19.79 SF/Yr. Tenants comparing options may also consider Office Units (134 listings) and Office buildings (67 listings) elsewhere in the Columbia market.

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