Medical Space

Greenville, SC Medical Office Space for Lease

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Taylors, SC Greer, SC Mauldin, SC Simpsonville, SC Travelers Rest, SC Duncan, SC Piedmont, SC Easley, SC
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Medical Office Space For Lease
Updated: Jan 27
Medical Office Space For Lease

10 Enterprise Blvd., Greenville, SC 29615

$26.50 SF/Yr
45,200 sqft
Prime Location: One block from Prisma Health Patewood Campus & Bon Secours Francis Eastside.
Medical/Healthcare Focus: Ideal office space for medical or healthcare practices.
Flexible Lease Terms: Adaptable lease options to suit tenant needs.
Available Space: 1,634 - 3,297 SF available, offering options for different sized practices.
Renovated Common Areas: Updated and well‑maintained shared spaces.
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Medical Office Space For Lease
Updated: Sep 25, 2025
Medical Office Space For Lease

3535 Pelham Road, Greenville, SC 29615

$13.95 SF/Yr
8,000 sqft
Prime location on Pelham Road corridor in Greenville County.
Convenient access: Less than a mile to I‑85.
Medical office space suitable for various practices.
Flexible space: Can be divided to suit tenant needs.
Features 9 private offices, 2 conference rooms, lobby, and break room.
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Medical Office Building in Medical Park
Medical Office Building in Medical Park

10 Memorial Medical Drive, Greenville, SC 29605

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7,000 sqft

Medical office building in Memorial Medical Park near I-185, offering space for healthcare practices or related offices.

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Medical Office Space with Marquee Signage
Medical Office Space with Marquee Signage

800 Pelham Rd, Greenville, SC 29615

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Second-generation medical space with existing clinical lab infrastructure and free surface parking near Prisma and Bon Secours.

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Greenville Office/Medical Space For Rent
Greenville Office/Medical Space For Rent

20 Creekview Ct, Greenville, SC

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1,005 sqft 1.17 AC lot

Office or medical space available in Greenville, SC.

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Lower-Level Office Suite with Lab Room
Lower-Level Office Suite with Lab Room

1405 Grove Road, Greenville, SC 29605

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Lower-level suite with private offices, conference room, and lab/work room for medical or professional operations.

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Eastside Building Near Medical Campuses
Eastside Building Near Medical Campuses

800 Pelham Rd, Greenville, SC 29615

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Full building opportunity on the Eastside, near Prisma Health.

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Medical Office Space Near Hospital
Medical Office Space Near Hospital

1200 W Faris Rd, Greenville, SC 29605

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4,232 sqft

Stand-alone building ideal for medical use near Greenville Memorial.

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Greenville Office Space For Rent
Greenville Office Space For Rent

127 Halton Village Cir, Greenville, SC

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5,600 sqft 0.15 AC lot

Flexible office space near Patewood Medical Campus available for rent.

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Based on your search, we've compiled 19 Potential Opportunities for your consideration. Besides 9 Active listings in Greenville, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Turn-Key ADA Accessible Professional Office
Turn-Key ADA Accessible Professional Office

106 MEMORIAL DR, Greer, SC 29650

Contact for pricing
1,442 sqft 0.32 AC lot

Newly remodeled office with reception, three private offices, lounge, kitchen, and 10 on-site parking spaces.

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Medical Office Space
Medical Office Space

634 Fairview Road, Simpsonville, SC 29680

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Established healthcare setting with SC-418 frontage, I-385 connectivity, and more than 120 medical providers within 3 miles.

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334,000 SF Office Building For Lease
334,000 SF Office Building For Lease

300 South St, Simpsonville, SC 29681

$19 SF/Yr

334,000 SF Office Building For Lease

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Turn Key Medical Office Space
Turn Key Medical Office Space

100 Constantine Wy, Greer, SC

Contact for pricing
5,000 sqft 0.61 AC lot

New construction medical office space in close proximity to airport.

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Similar Spaces for Sale in Greenville, SC

Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

Absolute NNN Dental Office
Absolute NNN Dental Office

1173 Ashmore Bridge Rd, Greenville, SC 29605

Contact for pricing
4,200 sqft

Newly delivered dental office offered on an Absolute NNN basis with a long-term lease and corporate guarantee.

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Medical Office with Parking
Medical Office with Parking

21 Memorial Medical Dr, Greenville, SC 29605

Contact for pricing
3,400 sqft 0.50 AC lot

Former dermatology practice with dedicated parking near I-85 and Faris Road.

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Medical Office Building with Rental Income
Medical Office Building with Rental Income

9 Hawthorne Park Court, Greenville, SC 29605

Contact for pricing

Medical office building for sale with a current tenant, Brio Internal Medicine, and rental income through September 2021.

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Single-Tenant Medical Office Building
Single-Tenant Medical Office Building

13 Edgewood Dr, Greenville, SC 29605

Contact for pricing

Fully leased orthopedic outpatient clinic building used by Prisma Health.

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Medical Office Sale Leaseback
Medical Office Sale Leaseback

24 Memorial Medical Dr, Greenville, SC 29605

Contact for pricing

Healthcare workspace offered in Greenville County through a sale-leaseback structure.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Prime Development Opportunity in Greenville
Prime Development Opportunity in Greenville

39 Airpark Ct, Greenville, SC 29607

Contact for pricing
1.27 AC lot

1.27 acre interstate-visible land for ground lease or build-to-suit.

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Greenville, SC Medical Office Space Lease Rates & Market Statistics

Browse 9 Medical Office Space listings for lease in Greenville, SC on Realmo, a commercial real estate marketplace serving the Greenville area. The current inventory totals 71,037 square feet of properties.

Medical Office Space lease rates in Greenville range from $13.95 SF/Yr at the entry level to $26.50 SF/Yr at the top of the market, averaging $20.22 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $20.22 SF/Yr, the local average runs 9% below South Carolina's state average of $22.33 SF/Yr.

Greenville accounts for 56% of the 16 medical office space listings currently available across Greenville County, where nearby markets include Simpsonville and Greer. Medical Office Space listings make up 5% of the 189 Office Spaces currently for lease in Greenville, with asking rates averaging $20.22 SF/Yr — 16% below the citywide Office Spaces average of $24.10 SF/Yr. Tenants comparing options may also consider Office Units (123 listings) and Office buildings (51 listings) elsewhere in the Greenville market.

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