Medical Space

Greenville, SC Medical Office Space for Lease

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Taylors, SC Greer, SC Mauldin, SC Simpsonville, SC Travelers Rest, SC Piedmont, SC Easley, SC Duncan, SC
6 properties
Medical Office Space For Lease
Updated: Jan 27
Medical Office Space For Lease

10 Enterprise Blvd., Greenville, SC 29615

$25 SF/Yr
45,200 sqft
Prime Location: One block from Prisma Health Patewood Campus & Bon Secours Francis Eastside.
Medical/Healthcare Focus: Ideal office space for medical or healthcare practices.
Flexible Lease Terms: Adaptable lease options to suit tenant needs.
Available Space: 1,634 - 3,297 SF available, offering options for different sized practices.
Renovated Common Areas: Updated and well‑maintained shared spaces.
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Medical Office Space For Lease
Updated: Sep 25, 2025
Medical Office Space For Lease

3535 Pelham Road, Greenville, SC 29615

$13.95 SF/Yr
8,000 sqft
Prime location on Pelham Road corridor in Greenville County.
Convenient access: Less than a mile to I‑85.
Medical office space suitable for various practices.
Flexible space: Can be divided to suit tenant needs.
Features 9 private offices, 2 conference rooms, lobby, and break room.
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Medical Office Space with Marquee Signage
Medical Office Space with Marquee Signage

800 Pelham Rd, Greenville, SC 29615

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Second-generation medical space with existing clinical lab infrastructure and free surface parking near Prisma and Bon Secours.

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Greenville Office/Medical Space For Rent
Greenville Office/Medical Space For Rent

20 Creekview Ct, Greenville, SC 29615

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Office or medical space available in Greenville, SC.

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Eastside Building Near Medical Campuses
Eastside Building Near Medical Campuses

800 Pelham Rd, Greenville, SC 29615

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Full building opportunity on the Eastside, near Prisma Health.

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Greenville Office Space For Rent
Greenville Office Space For Rent

127 Halton Village Cir, Greenville, SC

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5,600 sqft 0.15 AC lot

Flexible office space near Patewood Medical Campus available for rent.

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Based on your search, we've compiled 10 Potential Opportunities for your consideration. Besides 6 Active listings in Greenville, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Turn-Key ADA Accessible Professional Office
Turn-Key ADA Accessible Professional Office

106 Memorial Dr, Greer, SC 29650

$2,200/Mo
1,442 sqft 0.32 AC lot

Newly remodeled office with reception, three private offices, lounge, kitchen, and 10 on-site parking spaces.

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Second-Generation Medical Office
Second-Generation Medical Office

35 Ray E Talley Ct, Simpsonville, SC 29680

Contact for pricing
7,880 sqft

Well-maintained medical and office space in Simpsonville’s retail corridor near I-385 access.

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334,000 SF Office Building For Lease
334,000 SF Office Building For Lease

300 South St, Simpsonville, SC 29681

$19 SF/Yr

334,000 SF Office Building For Lease

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Turn Key Medical Office Space
Turn Key Medical Office Space

100 Constantine Wy, Greer, SC

Contact for pricing
5,000 sqft 0.61 AC lot

New construction medical office space in close proximity to airport.

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Greenville, SC Medical Office Space Lease Rates & Market Statistics

Browse 6 Medical Office Space listings for lease in Greenville, SC on Realmo, a commercial real estate marketplace serving the Greenville area. The current inventory totals 58,800 square feet of properties.

Medical Office Space lease rates in Greenville range from $13.95 SF/Yr at the entry level to $25 SF/Yr at the top of the market, averaging $19.47 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $19.47 SF/Yr, the local average runs 11% below South Carolina's state average of $21.83 SF/Yr.

Greenville accounts for 50% of the 12 medical office space listings currently available across Greenville County, where nearby markets include Simpsonville and Greer. Medical Office Space listings make up 4% of the 147 Office Spaces currently for lease in Greenville, with asking rates averaging $19.47 SF/Yr — 24% below the citywide Office Spaces average of $25.77 SF/Yr. Tenants comparing options may also consider Office Units (99 listings) and Office buildings (39 listings) elsewhere in the Greenville market.

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