Medical Space

North Charleston, SC Medical Office Space for Lease

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Charleston, SC Summerville, SC Hanahan, SC Goose Creek, SC Ladson, SC Wando, SC Johns Island, SC Mount Pleasant, SC
12 properties
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Medical Office and Wellness Space
Updated: Jul 14
Medical Office and Wellness Space

2409 Mall Dr, North Charleston, SC 29406

$8,333/Mo
8,333 sqft 1.21 AC lot
8,333‑SF commercial space with a flexible, reconfigurable interior layout
High‑ceiling open area for tenant customization based on operational needs
Located on 1.21 acres with ample free surface parking
Positioned along a highly trafficked commercial corridor in North Charleston
Within walking distance of the future Roper Hospital System campus (est. delivery in three years)
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Full-Floor Medical Office Suite
Updated: Jun 11
Full-Floor Medical Office Suite

4969 Centre Pointe Drive # 100, North Charleston, SC 29418

Contact for pricing
10,363 sqft
Full‑floor medical office suite available January 1, 2027 at 4969 Centre Pointe Drive
Suite 100 offers 10,363 RSF and has expansion potential by an additional 3,000 SF
Expansion allows up to 21,000 SF total for the suite
Offered at a full‑service rate of $36.00 per RSF
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Flex Space with Roll-Up Door
Flex Space with Roll-Up Door

2409 Mall Drive # B, North Charleston, SC 29406

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8,333 sqft 1.21 AC lot

Customizable conditioned flex suite with multiple restrooms, high ceilings, and ample free parking along a high-traffic corridor.

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First-Generation Office and Medical Suites
First-Generation Office and Medical Suites

8471 Dorchester Road, North Charleston, SC 29420

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6,500 sqft

Flexible, suite-divisible two-story space on a busy commercial corridor with landlord-provided shell build-out.

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Medical Office Suite
Medical Office Suite

3210 Landmark Drive, North Charleston, SC 29418

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1,880 sqft

Move-in ready OB-GYN medical space with strong visibility, signage, and ample parking for healthcare practices.

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End-Cap Office Suite
End-Cap Office Suite

2431 Aviation Avenue # 709, North Charleston, SC 29406

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6,127 sqft

Professional workspace combines enclosed offices with open-plan area and abundant natural light.

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Office Unit with X-Ray Room
Office Unit with X-Ray Room

3841 Rivers Avenue, North Charleston, SC 29405

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3,361 sqft

Configured for professional operations with reception, conference rooms, kitchen, and an executive suite.

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North Charleston Office Space Available
North Charleston Office Space Available

2070 Northbrook Blvd, North Charleston, SC

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1,664 sqft 6.44 AC lot

Office space for rent in North Rivers Business Center.

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Medical Office Condo End Cap
Medical Office Condo End Cap

5401 Netherby Lane Ste 601, North Charleston, SC 29420

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End cap medical office condo with private offices, conference space, and parking within a professional park.

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Updated Freestanding Office Building
Updated Freestanding Office Building

2132 Dorchester Road, North Charleston, SC 29405

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Updated commercial space includes private offices, a kitchen, restroom, and surface parking.

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Medical Office Suite with Exam Rooms
Medical Office Suite with Exam Rooms

2891 Tricom Street Ste B, North Charleston, SC 29406

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Suite includes reception, two exam rooms/offices, an open work area, and two bathrooms on an NNN basis.

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Free-Standing Medical Office Suite
Free-Standing Medical Office Suite

9133 Timber Street Suite A, North Charleston, SC 29406

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Free-standing medical office suite with reception, offices, bathrooms, and a breakroom for lease on an NNN basis.

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Based on your search, we've compiled 24 Potential Opportunities for your consideration. Besides 12 Active listings in North Charleston, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 8 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Renovating Office Park Suites
Renovating Office Park Suites

15 Gamecock Ave, Charleston, SC 29407

$2,500/Mo
3,625 sqft

Two office suites are available within Orange Grove Office Park with ongoing renovations and quick access to I-26.

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West Ashley Medical Office Sublease
West Ashley Medical Office Sublease

2270 Ashley Crossing Ln, Charleston, SC

Contact for pricing
3,746 sqft 8.99 AC lot

3,746 SF medical office space available for immediate sublease.

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Turnkey Dental Office Sublease Opportunity
Turnkey Dental Office Sublease Opportunity

9403 Hwy 78 # 201, Ladson, SC 29456

Contact for pricing

Sublease opportunity for a turnkey dental office in Ladson.

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Build-to-Suit Four-Floor Medical Office
Build-to-Suit Four-Floor Medical Office

9403 Hwy 78, Ladson, SC 29456

Contact for pricing
42,000 sqft

Conceptual four-floor tilt-up medical office build-to-suit with flexible terms and a parking ratio of 7:1,000.

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Similar Spaces for Sale in North Charleston, SC

Consider Similar Space for Sale. We found 8 Spaces matching your search parameters.

Freestanding Medical Center
Freestanding Medical Center

2690 Lake Park Dr, North Charleston, SC 29406

Contact for pricing
12,772 sqft 2.51 AC lot

Clinical layout includes operating rooms, procedure rooms, and pre- and post-operative areas.

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Office Redevelopment Opportunity
Office Redevelopment Opportunity

3841 Rivers Avenue, North Charleston, SC 29405

Contact for pricing
5,161 sqft

Two-building office property with multiple private offices, conference areas, and an X-ray room.

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Freestanding Office Building
Freestanding Office Building

4425 Belle Oaks Drive, North Charleston, SC 29405

Contact for pricing
6,793 sqft

The building is presented for office, medical, or flex-type use and includes on-site parking.

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Light Industrial Flex Buildings
Light Industrial Flex Buildings

3605 Meeting Street Road, North Charleston, SC 29405

Contact for pricing
7,726 sqft 0.64 AC lot

Two freestanding light industrial buildings total about 7,726 SF on roughly 0.64 acres, zoned M-1 and currently delivered vacant.

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Dorchester Road Office Space Available
Dorchester Road Office Space Available

7880-7890 Dorchester Rd, North Charleston, SC

Contact for pricing
6,600 sqft 0.67 AC lot

High-traffic location with flexible spaces for professional uses.

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North Charleston Medical Office Building
North Charleston Medical Office Building

3800 Faber Place Drive, North Charleston, SC 29405

Contact for pricing
4,345 sqft

Commercial property suitable for medical or professional office use.

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Former Day Care Facility
Former Day Care Facility

1910 Mcmillan Avenue, North Charleston, SC 29405

Contact for pricing
12,895 sqft

Former daycare totaling 12,895 SF, positioned just outside the Navy Yard redevelopment project in North Charleston.

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NNN Medical Office Building
NNN Medical Office Building

8720 Dorchester Rd., North Charleston, SC 29420

Contact for pricing

100% occupied NNN medical office with in-house lab and imaging facilities, and 11+ years remaining on the lease.

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North Charleston, SC Medical Office Space Lease Rates & Market Statistics

Explore 12 Medical Office Space listings for lease in North Charleston, SC on Realmo, a commercial real estate exchange covering the North Charleston area. The current inventory totals 46,561 square feet of properties — an average of ~3,900 SF per listing.

Medical Office Space lease rates in North Charleston range from $12 SF/Yr at the entry level to $12 SF/Yr at the top of the market, averaging $12 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $12 SF/Yr, the local average runs 44% below South Carolina's state average of $21.59 SF/Yr.

Within Charleston County, most North Charleston medical office space listings are located in and around Charleston, with additional options across the city. Medical Office Space listings make up 13% of the 92 Office Spaces currently for lease in North Charleston, with asking rates averaging $12 SF/Yr — 45% below the citywide Office Spaces average of $21.64 SF/Yr. Also worth a look for tenants weighing alternatives: Office Units (70 listings) and Office buildings (16 listings) elsewhere in the North Charleston market.

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