Simpsonville, SC Medical Office Space for Rent & Lease

Updated: May 22

Second-Generation Medical Office

35 Ray E Talley Ct, Simpsonville, SC 29680

Contact for pricing

7,880 sqft

7,880 SF medical and office space
Second‑generation configuration
Situated in Simpsonville’s busy retail corridor
Just off Fairview Road
Convenient access to I‑385

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Updated: Jan 21, 2025

334,000 SF Office Building For Lease

300 South St, Simpsonville, SC 29681

$19 SF/Yr

Located in Cotton Mill Place, the historic, early 20th century textile mill transformed into a mixed‑use facility that blends historic charm with modern amenities.
Available Space: ±8,082 sq ft
First Floor (Open Concept): ±7,068 sq ft. Includes a front desk, three individual private rooms, a large open area and two restrooms
Mezzanine: ±1,014 sq ft. Includes three private offices and a breakroom
Outdoor patio space

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Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center

Based on your search, we've compiled 9 Potential Opportunities for your consideration. Besides 2 Active listings in Simpsonville, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 2 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Medical Office Space For Lease

3535 Pelham Road, Greenville, SC 29615

$13.95 SF/Yr

8,000 sqft

Medical office space for lease in Greenville, South Carolina.

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Turn-Key ADA Accessible Professional Office

106 MEMORIAL DR, Greer, SC 29650

Contact for pricing

1,442 sqft 0.32 AC lot

Newly remodeled office with reception, three private offices, lounge, kitchen, and 10 on-site parking spaces.

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Medical Office Space Available

300 Regent Park Ct, Greenville, SC 29607

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Office spaces for healthcare providers near I-385 & Butler Rd.

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Turn Key Medical Office Space

100 Constantine Wy, Greer, SC

Contact for pricing

5,000 sqft 0.61 AC lot

New construction medical office space in close proximity to airport.

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Similar Spaces for Sale in Simpsonville, SC

Consider Similar Space for Sale. We found 2 Spaces matching your search parameters.

Second-Generation Medical Office

35 Ray E Talley Ct, Simpsonville, SC 29680

Contact for pricing

7,880 sqft

Well-maintained medical and office space in Simpsonville’s retail corridor near I-385 access.

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New Retail Space with End Caps

00 Scuffletown Road, Simpsonville, SC 29681

Contact for pricing

Planned retail space offers flexible suite configurations for commercial users.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Prime Development Opportunity in Greenville

39 Airpark Ct, Greenville, SC 29607

Contact for pricing

1.27 AC lot

1.27 acre interstate-visible land for ground lease or build-to-suit.

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Simpsonville, SC Medical Office Space Lease Rates & Market Statistics

Browse 2 Medical Office Space listings for lease in Simpsonville, SC on Realmo, a commercial real estate marketplace serving the Simpsonville area. The current inventory totals 7,880 square feet of properties.

Asking lease rates for Medical Office Space in Simpsonville start at $19 SF/Yr, average $19 SF/Yr, and reach $19 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $19 SF/Yr, the local average runs 13% below South Carolina's state average of $21.73 SF/Yr.

Simpsonville accounts for 12% of the 17 medical office space listings currently available across Greenville County, where nearby markets include Greenville and Greer. Medical Office Space is one of the more limited space types in Simpsonville, with just 2 listings currently available — a scarcity worth factoring into lease negotiations. Also worth a look for tenants weighing alternatives: Office Units (9 listings) and Office buildings (5 listings) elsewhere in the Simpsonville market.