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    Simpsonville, SC
    Medical Space

    Simpsonville, SC Medical Office Space for Lease

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    Greenville, SC Fountain Inn, SC Mauldin, SC
    Simpsonville Retail Space For Lease
    Updated: Jul 22, 2025
    Simpsonville Retail Space For Lease

    721 SE Main St, Simpsonville, SC 29681

    Contact for pricing
    7,500 sqft
    Excellent visibility and accessibility off I‑385 and Fairview Rd (high traffic counts).
    Located in a high‑demand, rapidly growing residential area.
    Flexible zoning accommodates retail, medical, and service uses.
    Up to ±7,500 SF of retail space available for lease.
    Space is sub‑dividable.
    View details
    334,000 SF Office Building For Lease
    Updated: Jan 21, 2025
    334,000 SF Office Building For Lease

    300 South St, Simpsonville, SC 29681

    $19 SF/Yr
    Located in Cotton Mill Place, the historic, early 20th century textile mill transformed into a mixed‑use facility that blends historic charm with modern amenities.
    Available Space: ±8,082 sq ft
    First Floor (Open Concept): ±7,068 sq ft. Includes a front desk, three individual private rooms, a large open area and two restrooms
    Mezzanine: ±1,014 sq ft. Includes three private offices and a breakroom
    Outdoor patio space
    View details
    Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center
    Based on your search, we've compiled 10 Potential Opportunities for your consideration. Besides 2 Active listings in Simpsonville, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Two-Story Office Building Available
    Two-Story Office Building Available

    501 Roper Mountain Rd, Greenville, SC

    Contact for pricing
    5,500 sqft

    Two-story office building with ample parking and multiple access points.

    View details
    Turn-Key ADA Accessible Professional Office
    Turn-Key ADA Accessible Professional Office

    106 MEMORIAL DR, Greer, SC 29650

    Contact for pricing
    1,442 sqft

    Newly remodeled office with reception, three private offices, lounge, kitchen, and 10 on-site parking spaces.

    View details
    Turn Key Medical Office Space
    Turn Key Medical Office Space

    100 Constantine Wy, Greer, SC

    $23 SF/Yr
    5,000 sqft · $9,583/Mo

    New construction medical office space in close proximity to airport.

    View details
    Medical Office Space Available
    Medical Office Space Available

    300 Regent Park Ct, Greenville, SC 29607

    Contact for pricing

    Office spaces for healthcare providers near I-385 & Butler Rd.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Development Opportunity in Greenville
    Prime Development Opportunity in Greenville

    39 Airpark Ct, Greenville, SC 29607

    Contact for pricing

    1.27 acre interstate-visible land for ground lease or build-to-suit.

    View details
    Prime Commercial Lot For Rent
    Prime Commercial Lot For Rent

    Tift Avenue N, Tifton, GA 31794

    $7,500/Mo

    0.66 acre commercial lot with high visibility.

    View details
    Corner Lot on Highway 72
    Corner Lot on Highway 72

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft · $32 SF/Yr

    1.7 acre corner lot zoned for commercial, medical, residential.

    View details
    Prime Lexington Outlot Opportunity
    Prime Lexington Outlot Opportunity

    3330 Partner Place, Lexington, KY 40503

    Contact for pricing

    Outlot for ground lease or build-to-suit in South Lexington.

    View details

    Simpsonville, SC Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in Simpsonville, SC with 2 listings featured on our commercial real estate exchange. The current inventory includes 7,500 square feet of properties with an estimated lease value of $19 SF/Yr.

    Estimated lease rates for Medical Office Space in Simpsonville, SC begin at $19 SF/Yr, with an average of $19 SF/Yr and extend to $19 SF/Yr.
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