Medical Space

Spartanburg, SC Medical Office Space for Lease

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Drayton, SC Roebuck, SC Boiling Springs, SC Wellford, SC Moore, SC Cowpens, SC Duncan, SC Lyman, SC
Modern Medical Office Space
Updated: Sep 4
Modern Medical Office Space

391 Serpentine Drive, Spartanburg, SC 29303

$1,156/Mo
4,387 sqft
Two available suites: 4,387 SF on the 1st floor and 3,956 SF on the 3rd floor
2nd‑floor surgery room with exhaust system already in place
Adjacent to Spartanburg Regional Medical Hospital
Approximately one mile to I‑585 via Hwy 9
232 on‑site parking spaces, including 29 covered spaces
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Westside Office/Medical Space Available
Updated: Jul 4, 2025
Westside Office/Medical Space Available

225 E Blackstock Rd, Spartanburg, SC

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5,461 sqft 0.94 AC lot
5461 ± sq. ft. office/medical space
Convenient westside location, ½ mile from I‑26
Includes reception, 2 private offices, 5 exam rooms & breakroom
Benefit from a lead lined X‑Ray room
Features 4 restrooms
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Based on your search, we've compiled 11 Potential Opportunities for your consideration. Besides 2 Active listings in Spartanburg, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Turn-Key ADA Accessible Professional Office
Turn-Key ADA Accessible Professional Office

106 Memorial Dr, Greer, SC 29650

$2,200/Mo
1,442 sqft 0.32 AC lot

Newly remodeled office with reception, three private offices, lounge, kitchen, and 10 on-site parking spaces.

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Medical Office Space For Lease
Medical Office Space For Lease

3535 Pelham Road, Greenville, SC 29615

$13.95 SF/Yr
8,000 sqft

Medical office space for lease in Greenville, South Carolina.

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Greenville Office/Medical Space For Rent
Greenville Office/Medical Space For Rent

20 Creekview Ct, Greenville, SC 29615

Contact for pricing

Office or medical space available in Greenville, SC.

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Turn Key Medical Office Space
Turn Key Medical Office Space

100 Constantine Wy, Greer, SC

Contact for pricing
5,000 sqft 0.61 AC lot

New construction medical office space in close proximity to airport.

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Similar Spaces for Sale in Spartanburg, SC

Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

Mixed-Use Property with Detached ADU
Mixed-Use Property with Detached ADU

1586 Skylyn Drive, Spartanburg, SC 29307

$535,000
2,466 sqft 0.59 AC lot

A brick ranch and separate accessory dwelling provide distinct interior spaces and direct access to the Mary Black Rail Trail.

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Medical Office Building
Medical Office Building

1250 John B White Sr Boulevard, Spartanburg, SC 29306

$1,295,000
6,875 sqft

Medical office space offered for sale in Spartanburg.

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Spartanburg Office Building For Sale
Spartanburg Office Building For Sale

130 Dillon Drive, Spartanburg, SC 29307

$1,450,000
7,200 sqft

7,200 SF office building near Spartanburg Medical District.

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Medical/Professional Office Space Available
Medical/Professional Office Space Available

125 Dillon Dr, Spartanburg, SC 29307

Contact for pricing
10,000 sqft 1.30 AC lot

10,000 SF property near Mary Black Regional Hospital.

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Medical Office Space
Medical Office Space

8161 WARREN H ABERNATHY HWY SPARTANBURG SC 29301, Spartanburg, SC 29301

Contact for pricing

Located in West Spartanburg’s commercial corridor alongside medical and drive-through specialty beverage tenancy.

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Spartanburg, SC Medical Office Space Lease Rates & Market Statistics

Explore 2 Medical Office Space listings for lease in Spartanburg, SC on Realmo, a commercial real estate exchange covering the Spartanburg area. The current inventory totals 9,848 square feet of properties.

Medical Office Space lease rates in Spartanburg range from $1,156/Mo at the entry level to $1,156/Mo at the top of the market, averaging $1,156/Mo. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings.

Spartanburg accounts for 50% of the 4 medical office space listings currently available across Spartanburg County, where nearby markets include Boiling Springs and Landrum. Medical Office Space is one of the more limited space types in Spartanburg, with just 2 listings currently available — a scarcity worth factoring into lease negotiations. Also worth a look for tenants weighing alternatives: Office Units (24 listings) and Office buildings (4 listings) elsewhere in the Spartanburg market.

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