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    Spartanburg, SC Medical Office Space for Lease

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    Boiling Springs, SC Roebuck, SC Wellford, SC
    Premier Medical Office Space Available
    $20 SF/Yr
    7,039 SF

    Premier Medical Office Space Available

    1650 Skylyn Drive, Spartanburg, SC 29307

    Class A medical office space in Spartanburg's prime location.

    • Premier Class A medical office space, strategically located on the Mary Black campus, unique to the Spartanburg market.
    • On‑site wellness amenity suite featuring a fitness gym, swimming pool, and smoothie bar exclusively for building tenants.
    • Lower NNN fees than comparable properties.
    • Direct access to the Drayton Mills Trail and proximity to the vibrant Drayton Mills mixed‑use development.
    • Abundant parking.
    Updated: Mar 7
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    Westside Office/Medical Space Available
    $16 SF/Yr
    5,461 SF

    Westside Office/Medical Space Available

    225 E Blackstock Rd, Spartanburg, SC

    5461± sq ft office/medical space for rent.

    • 5461 ± sq. ft. office/medical space
    • Convenient westside location, ½ mile from I‑26
    • Includes reception, 2 private offices, 5 exam rooms & breakroom
    • Benefit from a lead lined X‑Ray room
    • Features 4 restrooms
    Updated: Jul 4, 2025
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    Spartanburg Medical Office Space Available
    Contact for pricing
    3,000 SF

    Spartanburg Medical Office Space Available

    Medical office space for lease with ample parking.

    478-480 Floyd Rd, Spartanburg, SC
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    Class A Medical Office Space
    Contact for pricing

    Class A Medical Office Space

    Premier medical office space with wellness amenities and convenient location.

    1650 Skylyn Dr, Spartanburg, SC 29307
    View details
    Based on your search, we've compiled 19 Potential Opportunities for your consideration. Besides 4 Active listings in Spartanburg, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 7 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Medical Office Space For Lease
    $13 SF/Yr
    8,000 SF

    Medical Office Space For Lease

    Medical office space for lease in Greenville, South Carolina.

    3535 Pelham Road, Greenville, SC 29615
    View details
    Turnkey Healthcare Suite Available
    Contact for pricing

    Turnkey Healthcare Suite Available

    Ready-to-occupy medical suite with excellent visibility and accessibility.

    2709 Pelham Road, Greenville, SC 29615
    View details
    Turn Key Medical Office Space
    $23 SF/Yr
    5,000 SF

    Turn Key Medical Office Space

    New construction medical office space in close proximity to airport.

    100 Constantine Wy, Greer, SC
    View details
    Land Available For Development
    Contact for pricing

    Land Available For Development

    Land available for ground lease or build to suit.

    13435 E Wade Hampton Blvd, Greer, SC 29651
    View details

    Similar Spaces for Sale in Spartanburg, SC

    Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

    Spartanburg Office Building For Sale
    $1,810,000
    7,200 SF
    Spartanburg Office Building For Sale

    7,200 SF office building near Spartanburg Medical District.

    130 Dillon Drive, Spartanburg, SC 29307

    View details
    Medical/Professional Office Space Available
    $775,000
    10,000 SF
    Medical/Professional Office Space Available

    10,000 SF property near Mary Black Regional Hospital.

    125 Dillon Dr, Spartanburg, SC 29307

    View details
    Medical Office Space Available
    $430,000
    4,645 SF
    Medical Office Space Available

    4,645 SF medical office space for lease.

    1241 Boiling Springs Rd, Spartanburg, SC

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    Spartanburg Medical/Office Building For Sale
    $825,000
    9,594 SF
    Spartanburg Medical/Office Building For Sale

    9,594 SF medical/office building near downtown Spartanburg.

    1770 Skylyn Dr, Spartanburg, SC

    View details
    Professional Office/Medical Pads For Sale
    $150,000
    3,500 SF
    Professional Office/Medical Pads For Sale

    Two office/medical pads with utilities, parking, and infrastructure included.

    108 Burton St, Spartanburg, SC

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    11,058 SF Office Building For Sale
    Contact for pricing
    11,058 SF
    11,058 SF Office Building For Sale

    11,058 SF fantastic medical investment opportunity

    480 Floyd Rd, Spartanburg, SC 29307

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    Versatile Commercial Building Near Hospital
    $845,000
    11,925 SF
    Versatile Commercial Building Near Hospital

    Adaptable commercial building suitable for medical, retail, or storage use.

    200 Dillon Cir, Spartanburg, SC 29307

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Commercial Lot For Rent
    $7,500/Mo

    Prime Commercial Lot For Rent

    0.66 acre commercial lot with high visibility.

    Tift Avenue N, Tifton, GA 31794
    View details
    Corner Lot on Highway 72
    $5,000/Mo
    1,875 SF

    Corner Lot on Highway 72

    1.7 acre corner lot zoned for commercial, medical, residential.

    30472 Highway 72, Madison, AL 35756
    View details
    Valdosta Commercial Land For Lease
    Contact for pricing
    43,560 SF

    Valdosta Commercial Land For Lease

    Prime commercial land in high-growth Valdosta corridor, suitable for various uses.

    Inner Perimeter Rd & Park Ave., Valdosta, GA 31602
    View details
    WINTER PARK Land Lease Opportunity
    $8,500/Mo
    23,056 SF

    WINTER PARK Land Lease Opportunity

    Commercial land lease opportunity in Winter Park, Florida.

    5589 LAKE HOWELL ROAD, Winter Park, FL 32792
    View details

    Spartanburg, SC Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Spartanburg, SC with 4 listings featured on our commercial real estate exchange. The current inventory includes 12,500 square feet of properties with an estimated lease value of $36 SF/Yr.

    Estimated lease rates for Medical Office Space in Spartanburg, SC begin at $16 SF/Yr, with an average of $18 SF/Yr and extend to $20 SF/Yr.
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