Medical Space

Hilton Head Island, SC Medical Office Space for Lease

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Bluffton, SC Bluffton, GA Port Royal, SC Cross, SC Beaufort, SC Ridgeland, SC Hardeeville, SC Tybee Island, GA
Medical Building on Hilton Head
Updated: Mar 5
Medical Building on Hilton Head

4101 Main St, Suite E & F, Hilton Head Island, SC 29926

$17 SF/Yr
Stand‑alone medical building, ideal for medical or wellness users.
Prime location on Main Street, North End of Hilton Head Island, with easy access to Highway 278.
Convenient access to Hilton Head Hospital and surrounding professional area.
Ground‑floor layout with multiple exam rooms, waiting area, and private offices.
Plumbing in place for additional exam or treatment rooms.
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Medical Office Suites
Updated: Mar 28, 2025
Medical Office Suites

25 Hospital Center Blvd, Hilton Head Island, SC 29926

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2,774 sqft
Medical office suites for lease in a three‑story medical pavilion on Hilton Head Island
Eight suites available, each with varying layouts suited to multiple medical uses
Property is adjacent to and connected via breezeway to Hilton Head Hospital
Current tenants include Hilton Head Regional Physicians Network, Hilton Head Cardiology, and Hilton Head Health System
Also includes tenants such as Optim Orthopedics, radiation oncology center for St. Joseph's Candler, and Cora Physical Therapy
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Ground-Floor Medical Office Suite
Ground-Floor Medical Office Suite

23 Main St, Hilton Head Island, SC 29926

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750 sqft

Ground-floor medical office suite in a high-profile building with ample on-site parking.

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Based on your search, we've compiled 16 Potential Opportunities for your consideration. Besides 3 Active listings in Hilton Head Island, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 9 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Medical Office Suite with Private Offices
Medical Office Suite with Private Offices

1264 Ribaut Road, Beaufort, SC 29902

$2,845/Mo
0.01 AC lot

Open work area, data room, shower, and existing plumbing support varied professional uses.

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Office/Medical Suite
Office/Medical Suite

1264 Ribaut Rd, Beaufort, SC 29902

Contact for pricing
1,484 sqft

Suite offers a large open work area, two offices, data room, and one bathroom, plus washer/dryer hookups.

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Single-Story Retail Office Medical Building
Single-Story Retail Office Medical Building

128 Bluffton Rd, Bluffton, SC 29910

Contact for pricing
2,730 sqft

Pre-leasing is underway for a single-story retail, office, and medical building with a planned Fall 2026 delivery.

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Single-Story Medical Office Retail
Single-Story Medical Office Retail

128 Bluffton Rd, Bluffton, SC 29910

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2,655 sqft

Pre-leasing single-story retail and office building planned for delivery in Fall 2026.

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Similar Spaces for Sale in Hilton Head Island, SC

Consider Similar Space for Sale. We found 9 Spaces matching your search parameters.

Two-Story Office Building with Elevator
Two-Story Office Building with Elevator

1044 William Hilton Pkwy, Hilton Head Island, SC 29928

$2,200,000
10,017 sqft

Flexible layout with private offices, training areas, storage, and kitchenette or breakroom spaces.

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Stand Alone Medical Office Building
Stand Alone Medical Office Building

4101 Main St, Suite E & F, Hilton Head Island, SC 29926

$1,348,000
3,600 sqft

Stand-alone medical building on Hilton Head Island, ready for occupancy.

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Medical Office Suite Near Hospital
Medical Office Suite Near Hospital

23 Main Street, Suite 101-A, Hilton Head Island, SC 29926

Contact for pricing
750 sqft

Ground floor medical office suite near Hilton Head Hospital.

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Medical Office Suite with Exam Rooms
Medical Office Suite with Exam Rooms

23 Main St, Hilton Head Island, SC 29926

Contact for pricing
1,213 sqft

Medical office suite near Hilton Head Hospital with reception, waiting area, restroom, and multiple exam rooms.

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Medical Office Suite Near Hospital
Medical Office Suite Near Hospital

23 Main Street, Suite 101-A, Hilton Head Island, SC 29926

Contact for pricing
1,500 sqft

Ground floor medical office suite available near Hilton Head Hospital.

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Hilton Head Office/Medical Space
Hilton Head Office/Medical Space

23 Main Street, Suite 303, Hilton Head Island, SC 29926

$375,000

Office/Medical space for sale near Hilton Head Hospital.

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Medical Office Suites For Sale
Medical Office Suites For Sale

25 Hospital Center Boulevard, Hilton Head Island, SC 29926

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Medical office suites available in prestigious Hilton Head medical complex.

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Medical Office Suites Near Hospital
Medical Office Suites Near Hospital

25 Hospital Center Boulevard, Hilton Head Island, SC 29926

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Medical office suites for lease adjacent to Hilton Head Hospital.

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Leased Medical Office Development
Leased Medical Office Development

19 Moss Creek Village, Hilton Head Island, SC 29926

Contact for pricing

Medical office development offers 100% occupancy, including tenants such as St. Joseph/Candler Hyperbaric and Wound Care.

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Hilton Head Island, SC Medical Office Space Lease Rates & Market Statistics

Browse 3 Medical Office Space listings for lease in Hilton Head Island, SC on Realmo, a commercial real estate marketplace serving the Hilton Head Island area. The current inventory totals 3,524 square feet of properties.

Asking lease rates for Medical Office Space in Hilton Head Island start at $17 SF/Yr, average $17 SF/Yr, and reach $17 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. At $17 SF/Yr, the local average runs 23% below South Carolina's state average of $22.04 SF/Yr.

Hilton Head Island accounts for 30% of the 10 medical office space listings currently available across Beaufort County, where nearby markets include Bluffton and Beaufort. Medical Office Space is one of the more limited space types in Hilton Head Island, with just 3 listings currently available — a scarcity worth factoring into lease negotiations. Tenants comparing options may also consider Office Units (15 listings) elsewhere in the Hilton Head Island market.

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