Medical Space

Bluffton, SC Medical Office Space for Lease

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Turnkey Medical Office Space
Updated: Sep 18
Turnkey Medical Office Space

53 Persimmon Street, Bluffton, SC 29910

$33 SF/Yr
0.10 AC lot
3,445 SF medical and professional office space
Existing medical‑office buildout with tile flooring
Central air conditioning and electric heat
Parking lot with accessible approach and ramp
Public water and public sewer service
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Office Suites with Highway Frontage
Updated: Jun 3
Office Suites with Highway Frontage

2 Westbury Park Way, Bluffton, SC 29910

$32 SF/Yr
3,870 sqft
2002‑built office property fronting Hwy 278 (Fording Island Road) with 250'+ highway frontage
2 suites available: 1,790 SF and 3,870 SF (total 5,660 SF)
Bluffton side of Hwy 278 with easy access to major thoroughfares
Ample on‑site parking for employees and visitors
Existing tenant mix includes medical, professional, institutional, and local tenants
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Single-Story Retail Office Medical Building
Single-Story Retail Office Medical Building

128 Bluffton Rd, Bluffton, SC 29910

Contact for pricing
2,730 sqft

Pre-leasing is underway for a single-story retail, office, and medical building with a planned Fall 2026 delivery.

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Single-Story Medical Office Retail
Single-Story Medical Office Retail

128 Bluffton Rd, Bluffton, SC 29910

Contact for pricing
2,655 sqft

Pre-leasing single-story retail and office building planned for delivery in Fall 2026.

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Class A Office Medical Building
Class A Office Medical Building

5 Buck Island Rd, Bluffton, SC 29910

Contact for pricing
17,525 sqft

Class A office and medical building with floor-to-ceiling windows and an interior elevator at a highway intersection.

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Based on your search, we've compiled 15 Potential Opportunities for your consideration. Besides 5 Active listings in Bluffton, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 6 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Medical Office Suite with Shower
Medical Office Suite with Shower

1264 Ribaut Road, Beaufort, SC 29902

$2,845/Mo
0.01 AC lot

Flexible professional suite includes private offices, a data room, plumbing, and accessible entry.

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Medical Suites in Hilton Head
Medical Suites in Hilton Head

25 Hospital Center Blvd, Hilton Head Island, SC 29926

Contact for pricing
2,424 sqft

Medical office suites for lease in prestigious medical complex.

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Medical Building on Hilton Head
Medical Building on Hilton Head

4101 Main St, Suite E & F, Hilton Head Island, SC 29926

$17 SF/Yr

Stand-alone medical building for lease on Hilton Head Island.

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Office/Medical Suite
Office/Medical Suite

1264 Ribaut Rd, Beaufort, SC 29902

Contact for pricing
1,484 sqft

Suite offers a large open work area, two offices, data room, and one bathroom, plus washer/dryer hookups.

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Similar Spaces for Sale in Bluffton, SC

Consider Similar Space for Sale. We found 6 Spaces matching your search parameters.

Built-Out Medical Office Space
Built-Out Medical Office Space

53 Persimmons Street STE 105, Bluffton, SC 29910

Contact for pricing
3,445 sqft

Existing medical-office improvements support healthcare and professional occupancy, subject to the current lease and landlord approval.

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Leased Medical Office Space
Leased Medical Office Space

53 Persimmons Street, Bluffton, SC 29910

$1,395,000

A long-term medical tenant occupies the property under a lease with annual rent increases.

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Highway 278 Frontage Office Building
Highway 278 Frontage Office Building

5 Buck Island Rd, Bluffton, SC 29910

Contact for pricing
8,800 sqft

Class A office/medical building on Highway 278 in Bluffton.

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Medical Office with CT Scanner
Medical Office with CT Scanner

14 Oak Forest Road, Bluffton, SC 29910

$1,600,000

Renovated in 2024, the suite combines imaging equipment with exam, laboratory, and patient-support areas.

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Bluffton Office/Medical Building For Sale
Bluffton Office/Medical Building For Sale

5 Buck Island Rd, Bluffton, SC 29910

Contact for pricing
17,525 sqft

Class A office/medical building fronting Highway 278 in Bluffton.

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Built-Out Medical Office Space
Built-Out Medical Office Space

53 Persimmons Street, Bluffton, SC 29910

Contact for pricing

Existing professional improvements support medical, healthcare, and other office uses with limited additional build-out needs.

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Bluffton, SC Medical Office Space Lease Rates & Market Statistics

Explore 5 Medical Office Space listings for lease in Bluffton, SC on Realmo, a commercial real estate exchange covering the Bluffton area. The current inventory totals 26,780 square feet of properties.

Asking lease rates for Medical Office Space in Bluffton start at $32 SF/Yr, average $32.50 SF/Yr, and reach $33 SF/Yr at the top of the market. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $32.50 SF/Yr is 49% above the South Carolina state average of $21.75 SF/Yr.

Bluffton accounts for 45% of the 11 medical office space listings currently available across Beaufort County, where nearby markets include Beaufort and Hilton Head Island. Medical Office Space listings make up 50% of the 10 Office Spaces currently for lease in Bluffton, with asking rates in line with the citywide Office Spaces average. Also worth a look for tenants weighing alternatives: Office Units (6 listings) elsewhere in the Bluffton market.

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