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    Bluffton, SC Medical Office Space for Lease

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    Columbia, SC Greenville, SC Charleston, SC
    Highway 170 Retail/Office/Medical Space
    $36 SF/Yr

    Highway 170 Retail/Office/Medical Space

    48 Terrace Drive, Okatie, SC 29909

    Retail, office, or medical space for lease on Highway 170.

    • Excellent visibility directly on Highway 170.
    • Located in a brand new development, The Terrace at Okatie Crossings.
    • Strategic location between Bluffton and Beaufort, near Highway 278 Interchange.
    • Suitable for retail, office, or medical use.
    • Surrounded by significant residential and commercial growth, including Sun City.
    Updated: Mar 5
    View details
    Bluffton Office/Medical Suites Available
    $28 SF/Yr
    3,870 SF

    Bluffton Office/Medical Suites Available

    2 WESTBURY PKWY, Bluffton, SC

    Class A office and medical suites for rent in Bluffton.

    • Class "A" office/medical suite in a premier Bluffton office complex.
    • Former bank branch (3,870 SF) featuring two drive‑through lanes, an ATM lane, and a full safe.
    • Rent includes property taxes, property insurance, common area maintenance, power, and water.
    • Easily accessible via Highway 278 or Bluffton Parkway via Buck Island Road.
    • Professional office suites available (1,524 - 1,740 SF) with varying layouts.
    Updated: Nov 24, 2025
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    Bluffton Retail/Office/Medical Building
    $35 SF/Yr

    Bluffton Retail/Office/Medical Building

    Pre-leasing single-story retail/office/medical building in the heart of Bluffton.

    128 Bluffton Road, 29910, SC, Bluffton, SC 29910
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    Okatie Outpatient Surgery Center Shell
    Contact for pricing
    1,556 SF

    Okatie Outpatient Surgery Center Shell

    Shell space available in Okatie Outpatient Surgery Center.

    40-48 Okatie Center Blvd S, Okatie, SC
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    Based on your search, we've compiled 19 Potential Opportunities for your consideration. Besides 4 Active listings in Bluffton, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 7 Properties for Sales.

    Explore Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Lady's Island Versatile Office Space
    $3,600 /Mo

    Lady's Island Versatile Office Space

    Well-conditioned office space ideal for medical, wellness, or traditional office.

    27 Kemmerlin Lane, Beaufort, SC 29907
    View details
    Versatile Commercial Space For Rent
    $4,500 /Mo

    Versatile Commercial Space For Rent

    Two-story commercial building with flexible space and high visibility.

    8 Celadon Drive unit: A&B, Beaufort, SC 29907
    View details
    Medical Building on Hilton Head
    $22 SF/Yr

    Medical Building on Hilton Head

    Stand-alone medical building for lease on Hilton Head Island.

    4101 Main St, Suite E & F, Hilton Head Island, SC 29926
    View details
    Medical Suites in Hilton Head
    Contact for pricing

    Medical Suites in Hilton Head

    Medical suites for lease in Hilton Head's medical district.

    25 Hospital Center Blvd, Hilton Head Island, SC 29926
    View details

    Explore Similar Spaces for Sale in Bluffton, SC

    Consider Similar Space for Sale. We found 7 Spaces matching your search parameters.

    Leased Medical Space For Sale
    $647,111

    Leased Medical Space For Sale

    100% leased medical space with new long-term lease.

    14 Oak Forest Road, Bluffton, SC 29910
    View details
    Leased Medical Space For Sale
    $628,148

    Leased Medical Space For Sale

    100% leased medical space with new 5-year lease.

    14 Oak Forest Road, Bluffton, SC 29910
    View details
    Leased Medical Space For Sale
    $1,609,481

    Leased Medical Space For Sale

    100% leased medical space with new long-term lease.

    14 Oak Forest Road, Bluffton, SC 29910
    View details
    Highway 278 Frontage Office Building
    Contact for pricing
    8,800 SF

    Highway 278 Frontage Office Building

    Class A office/medical building on Highway 278 in Bluffton.

    5 Buck Island Rd, Bluffton, SC 29910
    View details
    Two-Story Office Building For Sale
    $2,200,000

    Two-Story Office Building For Sale

    Multi-tenant office building in Bluffton, SC with income.

    10 Plantation Park Dr, Bluffton, SC 29910
    View details
    Bluffton Office/Medical Building For Sale
    Contact for pricing
    17,525 SF

    Bluffton Office/Medical Building For Sale

    Class A office/medical building fronting Highway 278 in Bluffton.

    5 Buck Island Rd, Bluffton, SC 29910
    View details
    Medical Office Suites For Sale
    $2,861,037
    6,808 SF

    Medical Office Suites For Sale

    Four medical office suites totaling 6808 sqft for sale.

    14 Oak Forest Rd, Bluffton, SC 29910
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Commercial Lot For Rent
    $7,500 /Mo

    Prime Commercial Lot For Rent

    0.66 acre commercial lot with high visibility.

    Tift Avenue N, Tifton, GA 31794
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    Valdosta Commercial Land For Lease
    Contact for pricing
    43,560 SF

    Valdosta Commercial Land For Lease

    Prime commercial land in high-growth Valdosta corridor, suitable for various uses.

    0 Inner Perimeter Rd & Park Ave., Valdosta, GA 31602
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    Winter Park Mixed-Use Opportunity
    $8,500 /Mo
    23,056 SF

    Winter Park Mixed-Use Opportunity

    Double commercial lot in Winter Park, FL, for lease.

    5589 LAKE HOWELL ROAD, Winter Park, FL 32792
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    Highway 72 Corner Lot
    $6,500 /Mo
    1,875 SF

    Highway 72 Corner Lot

    1.6 acre commercial lot for rent on Highway 72.

    30472 Highway 72, Madison, AL 35756
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    Bluffton, SC Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Bluffton, SC with 4 listings featured on our commercial real estate exchange. The current inventory includes 168,577,200 square feet of properties with an estimated lease value of $28 SF/Yr.

    Estimated lease rates for Medical Office Space in Bluffton, SC begin at $28 SF/Yr, with an average of $28 SF/Yr and extend to $28 SF/Yr.
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