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    Charleston, SC Medical Office Space for Lease

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    Columbia, SC Greenville, SC Spartanburg, SC
    13 results
    West Ashley Medical Office Space
    $22 SF/Yr
    3,000 SF

    West Ashley Medical Office Space

    1027 Physicians Dr, Charleston, SC

    3,000 SF office space in the heart of West Ashley.

    • Prime medical office space in the heart of West Ashley.
    • 3,000 SF of versatile space with customizable floor plan.
    • Anchored by Roper St. Francis Hospital.
    • Hub for numerous ancillary medical offices.
    • Suitable for both medical and general office tenants.
    Updated: Nov 4, 2025
    View details
    Charleston Office Building on East Bay
    $35 SF/Yr
    4,730 SF

    Charleston Office Building on East Bay

    255 East Bay Street, Charleston, SC 29401

    4,730 SF office building in Historic Charleston City Market-area.

    • Prime location in the Historic Charleston City Market area on East Bay Street, near attractions, restaurants, and hotels.
    • ±4,730 SF single‑story office building suitable for various business needs.
    • Six dedicated parking spaces included with the lease.
    • Flexible lease options: 'as is' or potential for long‑term ground lease and redevelopment.
    • Additional parking negotiable, including marked and unmarked spaces.
    Updated: Nov 21, 2025
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    Class A Office Building
    $33 SF/Yr
    34,765 SF

    Class A Office Building

    Class A office building in the heart of West Ashley.

    1014 St. Andrews Blvd, Charleston, SC 29407
    View details
    West Ashley Medical Office Sublease
    $32 SF/Yr
    3,746 SF

    West Ashley Medical Office Sublease

    3,746 SF medical office space available for immediate sublease.

    2270 Ashley Crossing Ln, Charleston, SC
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    West Ashley Medical Office Space
    $34 SF/Yr
    2,500 SF

    West Ashley Medical Office Space

    2,500 SF medical office space available March 1, 2025.

    846 St Andrews Blvd, Charleston, SC
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    Remodeled Office Space Available
    $27 SF/Yr
    1,312 SF

    Remodeled Office Space Available

    Centrally located office suites near St. Francis Hospital.

    1483 Tobias Gadson Blvd, Charleston, SC
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    Office/Medical Space on Saint Andrews
    $33 SF/Yr
    3,698 SF

    Office/Medical Space on Saint Andrews

    Office or medical space available immediately on a major thoroughfare.

    1014 Saint Andrews, Charleston, SC
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    Medical Office Space Sublease Available
    Contact for pricing
    3,746 SF

    Medical Office Space Sublease Available

    Sublease available in West Ashley Medical Center near Roper Hospital.

    2270 Ashley Crossing Dr, Charleston, SC 29414
    View details
    West Ashley Office Space Available
    $17 SF/Yr
    2,078 SF

    West Ashley Office Space Available

    Office space for lease in West Ashley area.

    6 Carriage Ln, Charleston, SC
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    Medical Office Space Available
    $35 SF/Yr
    18,000 SF

    Medical Office Space Available

    Medical office space for rent in Charleston's growing submarket.

    2620 Clements Ferry Rd, Charleston, SC
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    West Ashley Office Space Available
    Contact for pricing
    3,812 SF

    West Ashley Office Space Available

    Office spaces available in central West Ashley from 962-3,812 SF.

    1064 Gardner Rd, Charleston, SC 29407
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    Retail and Medical Office Space
    Contact for pricing

    Retail and Medical Office Space

    Retail and medical office space at Point Hope community.

    State Rd S-8-33, Charleston, SC 29492
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    Medical Office Space Available
    Contact for pricing

    Medical Office Space Available

    Medical office space for lease near Bon Secours Hospital.

    2287 Henry Tecklenburg Dr, Charleston, SC 29414
    View details
    Based on your search, we've compiled 25 Potential Opportunities for your consideration. Besides 13 Active listings in Charleston, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 4 Properties for Sales.

    Explore Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Former Daycare Near Navy Yard
    Contact for pricing
    12,895 SF

    Former Daycare Near Navy Yard

    12,895 SF former daycare near new Navy Yard.

    1910 McMillan Avenue, North Charleston, SC 29405
    View details
    Class A Medical Office Space
    $30 SF/Yr
    1,647 SF

    Class A Medical Office Space

    Premier medical office space near Roper St. Francis Hospital.

    4600 Goer Dr, North Charleston, SC
    View details
    Medical/Professional Office Space Available
    $30 SF/Yr
    4,211 SF

    Medical/Professional Office Space Available

    Single-story office space ready for upfits near new developments.

    2947 Maybank Hwy, Johns Island, SC
    View details
    Maybank Highway Commercial Space
    Contact for pricing
    58,136 SF

    Maybank Highway Commercial Space

    New construction with space for medical, office, or retail.

    Maybank Hwy, Johns Island, SC 29455
    View details

    Explore Similar Spaces for Sale in Charleston, SC

    Consider Similar Space for Sale. We found 4 Spaces matching your search parameters.

    Charleston Medical Property Investment
    $1,895,000

    Charleston Medical Property Investment

    Thriving medical property in Charleston, SC with favorable lease terms.

    2039 Savannah Highway, Charleston, SC 29407
    View details
    Northbridge Executive Park Investment
    $15,968,500
    54,500 SF

    Northbridge Executive Park Investment

    Two-building office campus near Ashley Landing redevelopment.

    1176-1180 Sam Rittenberg Blvd, Charleston, SC
    View details
    West Ashley Freestanding Office Building
    $2,100,000
    9,924 SF

    West Ashley Freestanding Office Building

    Freestanding office building in central West Ashley with ample parking.

    14 Farmfield Road, Charleston, SC 29407
    View details
    Prime Land in West Ashley
    $1,800,000

    Prime Land in West Ashley

    6.32 acres in Charleston, SC, ideal for development.

    Henry Tecklenburg Dr, Charleston, SC 29414
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Commercial Lot For Rent
    $7,500/Mo

    Prime Commercial Lot For Rent

    0.66 acre commercial lot with high visibility.

    Tift Avenue N, Tifton, GA 31794
    View details
    Valdosta Commercial Land For Lease
    Contact for pricing
    43,560 SF

    Valdosta Commercial Land For Lease

    Prime commercial land in high-growth Valdosta corridor, suitable for various uses.

    0 Inner Perimeter Rd & Park Ave., Valdosta, GA 31602
    View details
    Winter Park Mixed-Use Opportunity
    $8,500/Mo
    23,056 SF

    Winter Park Mixed-Use Opportunity

    Double commercial lot in Winter Park, FL, for lease.

    5589 LAKE HOWELL ROAD, Winter Park, FL 32792
    View details
    Highway 72 Corner Lot
    $6,500/Mo
    1,875 SF

    Highway 72 Corner Lot

    1.6 acre commercial lot for rent on Highway 72.

    30472 Highway 72, Madison, AL 35756
    View details

    Charleston, SC Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Charleston, SC with 13 listings featured on our commercial real estate exchange. The current inventory includes 1,916,509,320 square feet of properties with an estimated lease value of $122 SF/Yr.

    Estimated lease rates for Medical Office Space in Charleston, SC begin at $19 SF/Yr, with an average of $24 SF/Yr and extend to $33 SF/Yr.
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    Browse Medical Office Space for Lease Near Charleston, SC

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    Most Searched ZIP Codes in Charleston, SC

    • 29407
    • 29414
    • 29401
    • 29492

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