Add Listing
    Charleston, SC
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    1
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Rent
    Rent
    $
    $
    Size
    Property Size / SF

    Charleston, SC Medical Office Space for Lease

    Notify Me
    List
    Map
    Wando, SC Mt Pleasant, SC North Charleston, SC
    14 results
    West Ashley Office Space Available
    $24 SF/Yr
    2,652 SF
    West Ashley Office Space Available

    1064 Gardner Road, Charleston, SC 29407

    Office spaces for lease in central West Ashley location.
    • Convenient central West Ashley location.
    • Landlord willing to improve/upfit space to fit tenant's needs.
    • Rates start at $24/sf gross (includes maintenance, cam, taxes, insurance).
    • Beautiful courtyard for tenants to enjoy.
    • Perfect for medical, corporate, or general office use.
    Updated: May 4
    View details
    Office Suites in Orange Grove Park
    $2,500/Mo
    1,625 SF
    Office Suites in Orange Grove Park

    15 Gamecock Ave, Charleston, SC 29407

    Two professionally oriented office suites with ongoing renovations in a West Ashley office park setting.
    • Orange Grove Office Park West Ashley office leasing opportunity with two available suites
    • Unit 1A: ±720 SF available August 2026, office suite for professional use
    • Unit B: ±3,625 SF available late Summer/Fall 2026, leased at $28/SF NNN
    • Zoning: LB (Limited Business) for the City of Charleston
    • Conveniently located just off Sam Rittenberg with immediate access to I‑26
    Updated: Jun 2
    View details
    Single-Story Office Building
    $35 SF/Yr
    4,730 SF
    Single-Story Office Building

    Centrally located office building with flexible lease terms and included parking to support medical or professional users.

    255 East Bay Street, Charleston, SC 29401

    View details
    West Ashley Medical Office Space
    $22 SF/Yr
    3,000 SF
    West Ashley Medical Office Space

    3,000 SF office space in the heart of West Ashley.

    1027 Physicians Dr, Charleston, SC

    View details
    West Ashley Medical Office Sublease
    $32 SF/Yr
    3,746 SF
    West Ashley Medical Office Sublease

    3,746 SF medical office space available for immediate sublease.

    2270 Ashley Crossing Ln, Charleston, SC

    View details
    Remodeled Office Space Available
    $27 SF/Yr
    1,312 SF
    Remodeled Office Space Available

    Centrally located office suites near St. Francis Hospital.

    1483 Tobias Gadson Blvd, Charleston, SC

    View details
    Move-in Ready Office Space Available
    Contact for pricing
    795 SF
    Move-in Ready Office Space Available

    Office space for lease on Folly Rd corridor.

    354 Folly Road # 2 ##2, Charleston, SC 29412

    View details
    West Ashley Medical Office Space
    $34 SF/Yr
    2,500 SF
    West Ashley Medical Office Space

    2,500 SF medical office space available March 1, 2025.

    846 St Andrews Blvd, Charleston, SC

    View details
    Office/Medical Space on Saint Andrews
    $33 SF/Yr
    3,698 SF
    Office/Medical Space on Saint Andrews

    Office or medical space available immediately on a major thoroughfare.

    1014 Saint Andrews, Charleston, SC

    View details
    Medical Office Space Available
    $35 SF/Yr
    18,000 SF
    Medical Office Space Available

    Medical office space for rent in Charleston's growing submarket.

    2620 Clements Ferry Rd, Charleston, SC

    View details
    West Ashley Office Space Available
    $17 SF/Yr
    2,078 SF
    West Ashley Office Space Available

    Office space for lease in West Ashley area.

    6 Carriage Ln, Charleston, SC

    View details
    West Ashley Office Space Available
    $24 SF/Yr
    3,812 SF
    West Ashley Office Space Available

    Office spaces available in central West Ashley from 962-3,812 SF.

    1064 Gardner Rd, Charleston, SC 29407

    View details
    Medical Office Space Available
    $24 SF/Yr
    Medical Office Space Available

    Medical office space for lease near Bon Secours Hospital.

    2287 Henry Tecklenburg Dr, Charleston, SC 29414

    View details
    Retail and Medical Office Space
    Contact for pricing
    Retail and Medical Office Space

    Retail and medical office space at Point Hope community.

    State Rd S-8-33, Charleston, SC 29492

    View details
    Based on your search, we've compiled 27 Potential Opportunities for your consideration. Besides 14 Active listings in Charleston, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Former Daycare Near Navy Yard
    Contact for pricing
    12,895 SF
    Former Daycare Near Navy Yard

    12,895 SF former daycare near new Navy Yard.

    1910 McMillan Avenue, North Charleston, SC 29405

    View details
    Class A Medical Office Space
    $30 SF/Yr
    1,647 SF
    Class A Medical Office Space

    Premier medical office space near Roper St. Francis Hospital.

    4600 Goer Dr, North Charleston, SC

    View details
    Medical/Professional Office Space Available
    $30 SF/Yr
    4,211 SF
    Medical/Professional Office Space Available

    Single-story office space ready for upfits near new developments.

    2947 Maybank Hwy, Johns Island, SC

    View details
    Maybank Highway Commercial Space
    $40 SF/Yr
    58,136 SF
    Maybank Highway Commercial Space

    New construction with space for medical, office, or retail.

    Maybank Hwy, Johns Island, SC 29455

    View details

    Similar Spaces for Sale in Charleston, SC

    Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

    Charleston Medical Property Investment
    $1,895,000
    Charleston Medical Property Investment

    Thriving medical property in Charleston, SC with favorable lease terms.

    2039 Savannah Highway, Charleston, SC 29407

    View details
    Free-Standing Office Building
    $895,000
    5,000 SF
    Free-Standing Office Building

    A flexible office layout offers private offices, open bullpen space, and exam-ready rooms for medical or legal use.

    4476 Leeds Place West, Charleston, SC 29405

    View details
    Freestanding Mixed-Use Retail/Office
    $500,000
    1,330 SF
    Freestanding Mixed-Use Retail/Office

    Freestanding two-story building with flexible office, medical office, or retail use.

    154 Cannon Street, Charleston, SC 29403

    View details
    Northbridge Executive Park Investment
    $15,968,500
    54,500 SF
    Northbridge Executive Park Investment

    Two-building office campus near Ashley Landing redevelopment.

    1176-1180 Sam Rittenberg Blvd, Charleston, SC

    View details
    Prime Land in West Ashley
    $1,800,000
    6.32 Acres
    Prime Land in West Ashley

    6.32 acres in Charleston, SC, ideal for development.

    Henry Tecklenburg Dr, Charleston, SC 29414

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Development Opportunity in Greenville
    Contact for pricing
    Prime Development Opportunity in Greenville

    1.27 acre interstate-visible land for ground lease or build-to-suit.

    39 Airpark Ct, Greenville, SC 29607

    View details
    Prime Commercial Lot For Rent
    $7,500/Mo
    Prime Commercial Lot For Rent

    0.66 acre commercial lot with high visibility.

    Tift Avenue N, Tifton, GA 31794

    View details
    Valdosta Commercial Land For Lease
    Contact for pricing
    43,560 SF
    Valdosta Commercial Land For Lease

    Prime commercial land in high-growth Valdosta corridor, suitable for various uses.

    Inner Perimeter Rd & Park Ave., Valdosta, GA 31602

    View details
    WINTER PARK Land Lease Opportunity
    $8,500/Mo
    23,056 SF
    WINTER PARK Land Lease Opportunity

    Commercial land lease opportunity in Winter Park, Florida.

    5589 LAKE HOWELL ROAD, Winter Park, FL 32792

    View details

    Charleston, SC Medical Office Space Leasing Opportunities Market Analysis

    Explore Medical Office Space leasing options in Charleston, SC with 14 listings featured on our commercial real estate exchange. The current inventory includes 47,153 square feet of properties with an estimated lease value of $302 /Mo.

    Estimated lease rates for Medical Office Space in Charleston, SC begin at $17 SF/Yr, with an average of $27 SF/Yr and extend to $35 SF/Yr.
    List
    Map

    Browse Medical Office Space for Lease Near Charleston, SC

    Popular Searches in Charleston, SC

    Popular Categories

    Most Searched ZIP Codes in Charleston, SC

    • 29407
    • 29401
    • 29412
    • 29414
    • 29492

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!