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    Charleston, SC Medical Office Space for Lease

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    11 properties
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    Single-Story Office Building
    Updated: Jun 2
    Single-Story Office Building

    255 East Bay Street, Charleston, SC 29401

    $35 SF/Yr
    4,730 sqft
    4,730 SF single‑story office building in City of Charleston’s GB (General Business) zoning
    Currently leased to Roper Physician Partners; tenant will vacate with notice
    6 parking spaces included with the lease; 19 marked spaces in front, 2 marked spaces on Pinckney St, and 2 unmarked spaces in the rear
    Landlord will consider leasing “as is,” long‑term ground lease, and redevelopment
    Lease rate listed at $35/SF NNN
    View details
    West Ashley Medical Office Sublease
    Updated: May 9, 2025
    West Ashley Medical Office Sublease

    2270 Ashley Crossing Ln, Charleston, SC

    $32 SF/Yr
    3,746 sqft
    Prime location across from Roper St. Francis Hospital in West Ashley, ideal for healthcare providers
    3,746 SF of first‑floor space available immediately at West Ashley Medical Center
    Ample parking and excellent visibility at a main entrance
    $32.00 Full Service lease
    Tenant improvement allowance available for qualified tenants
    View details
    Renovating Office Park Suites
    Renovating Office Park Suites

    15 Gamecock Avenue Ste B, Charleston, SC 29407

    Contact for pricing
    3,625 sqft

    Two office suites are available within Orange Grove Office Park with ongoing renovations and quick access to I-26.

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    Remodeled Office Space Available
    Remodeled Office Space Available

    1483 Tobias Gadson Blvd, Charleston, SC

    $27 SF/Yr
    1,312 sqft

    Centrally located office suites near St. Francis Hospital.

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    Medical Office Space Available
    Medical Office Space Available

    2620 Clements Ferry Rd, Charleston, SC

    $35 SF/Yr
    18,000 sqft

    Medical office space for rent in Charleston's growing submarket.

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    Two-Story Freestanding Office Building
    Two-Story Freestanding Office Building

    2125 Charlie Hall Boulevard #First Floor, Charleston, SC 29414

    Contact for pricing

    Entire first floor is available in a centrally located, medically oriented freestanding office building with ample parking.

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    Office/Medical Space on Saint Andrews
    Office/Medical Space on Saint Andrews

    1014 Saint Andrews, Charleston, SC

    $33.75 SF/Yr
    3,698 sqft

    Office or medical space available immediately on a major thoroughfare.

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    West Ashley Office Space Available
    West Ashley Office Space Available

    1064 Gardner Rd, Charleston, SC 29407

    $24 SF/Yr
    3,812 sqft

    Office spaces available in central West Ashley from 962-3,812 SF.

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    West Ashley Medical Office Space
    West Ashley Medical Office Space

    846 St Andrews Blvd, Charleston, SC

    $34 SF/Yr
    2,500 sqft

    2,500 SF medical office space available March 1, 2025.

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    Medical Office Space Available
    Medical Office Space Available

    2287 Henry Tecklenburg Dr, Charleston, SC 29414

    $24 SF/Yr

    Medical office space for lease near Bon Secours Hospital.

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    Retail and Medical Office Space
    Retail and Medical Office Space

    State Rd S-8-33, Charleston, SC 29492

    Contact for pricing

    Retail and medical office space at Point Hope community.

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    Based on your search, we've compiled 20 Potential Opportunities for your consideration. Besides 11 Active listings in Charleston, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 1 Properties for Sales.

    Medical Office Space for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Mount Pleasant Retail/Office/Medical Space
    Mount Pleasant Retail/Office/Medical Space

    1123 Queensborough Boulevard, Mount Pleasant, SC 29464

    $30 SF/Yr
    3,949 sqft

    3,949 SF space ideal for retail, office, or medical.

    View details
    Medical Office and Wellness Space
    Medical Office and Wellness Space

    2409 Mall Dr, North Charleston, SC 29406

    $8,333/Mo
    8,333 sqft

    Reconfigurable interior with high-ceiling open area and ample free surface parking on a major North Charleston corridor.

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    Dental-To-Medical Office Suite
    Dental-To-Medical Office Suite

    1065-C Johnnie Dodds Blvd, Mount Pleasant, SC 29464

    Contact for pricing
    1,500 sqft

    Turn-key office currently set up for dental use, positioned across from a major hospital with convenient highway access.

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    Flex Space with Roll-Up Door
    Flex Space with Roll-Up Door

    2409 Mall Drive # B, North Charleston, SC 29406

    Contact for pricing
    8,333 sqft

    Customizable conditioned flex suite with multiple restrooms, high ceilings, and ample free parking along a high-traffic corridor.

    View details

    Similar Spaces for Sale in Charleston, SC

    Consider Similar Space for Sale. We found 1 Spaces matching your search parameters.

    Northbridge Executive Park Investment
    Northbridge Executive Park Investment

    1176-1180 Sam Rittenberg Blvd, Charleston, SC

    $15,968,500
    54,500 sqft 3.25 AC lot

    Two-building office campus near Ashley Landing redevelopment.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Development Opportunity in Greenville
    Prime Development Opportunity in Greenville

    39 Airpark Ct, Greenville, SC 29607

    Contact for pricing

    1.27 acre interstate-visible land for ground lease or build-to-suit.

    View details
    Prime Commercial Lot For Rent
    Prime Commercial Lot For Rent

    Tift Avenue N, Tifton, GA 31794

    $7,500/Mo

    0.66 acre commercial lot with high visibility.

    View details
    WINTER PARK Land Lease Opportunity
    WINTER PARK Land Lease Opportunity

    5589 LAKE HOWELL ROAD, Winter Park, FL 32792

    $8,500/Mo
    23,056 sqft

    Commercial land lease opportunity in Winter Park, Florida.

    View details
    Corner Lot on Highway 72
    Corner Lot on Highway 72

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft

    1.7 acre corner lot zoned for commercial, medical, residential.

    View details

    Charleston, SC Medical Office Space Market Trends and Statistics

    Explore Medical Office Space leasing options in Charleston, SC with 11 listings featured on our commercial real estate exchange. The current inventory includes 37,798 square feet of properties with an estimated lease value of $220.75 SF/Yr.

    Estimated lease rates for Medical Office Space in Charleston, SC begin at $24 SF/Yr, with an average of $31.54 SF/Yr and extend to $35 SF/Yr.
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    Most Searched ZIP Codes in Charleston, SC

    • 29407
    • 29414
    • 29401
    • 29492

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