Seneca, SC Commercial real estate for Rent & Lease

$1,700/Mo

712 SF

Seneca Retail/Office Space Available

1109 Jennings Ave Unit A, Seneca, SC 29768

Retail/office space for lease in Seneca, SC. Renovated and visible.

Located at one of the busiest intersections in Seneca, SC, offering incredible visibility.
Rent includes all utilities ($1,700/month).
Recently renovated with new lights, new paint, and concrete floors.
Ample parking available.
Lots of natural light.

Updated: Mar 5

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$1,500/Mo

Seneca Office Space For Lease

865 Old Clemson Highway, Seneca, SC 29678

Two-level office building suitable for various businesses, near Clemson.

Suitable for various business types, including medical/dental offices.
Two levels with separate entrances and restrooms, offering flexible leasing options (entire building or individual floors).
Located in close proximity to Clemson and Seneca.
Lower level features 3 offices, conference room, and reception area (Lease: $1,750.00 NNN).
Upper level offers 5 offices and a reception area (Lease: $2,900.00 NNN).

Updated: Mar 28, 2025

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$11 SF/Yr

7,250 SF

Retail Property on Main Corridor

Retail property with excellent visibility and heavy traffic.

1592 Sandifer Blvd, Seneca, SC

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$15 SF/Yr

4,800 SF

Seneca Office/Retail Space Available

Office and retail spaces for lease in Seneca, South Carolina.

12019 North Radio Station Rd, Seneca, SC

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Retail Opportunity Near Walmart

Retail space available for lease, GL, or build-to-suit.

1637 Sandifer Blvd, Seneca, SC

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16,000 SF

Restaurant Space Near Oconee Medical

1,600 SF 2nd Gen Restaurant Space Available For Rent.

201-273 Applewood Center Pl, Seneca, SC

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Land Near Oconee Medical Center

Commercial land for rent near medical center and Clemson University.

15516 Wells Hwy, Seneca, SC

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1,600 SF

Retail Space Near Oconee Medical

Retail space available near Oconee Medical Center and Clemson University.

101 Applewood Center Pl, Seneca, SC

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$25 SF/Yr

245,000 SF

Dominant Power Center For Rent

245,000 SF power center anchored by Belk, Hobby Lobby, etc.

201 Applewood Center Pl, Seneca, SC 29678

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Based on your search, we've compiled 45 Potential Opportunities for your consideration. Besides 9 Active listings in Seneca, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 32 Properties for Sales.

Commercial real estate for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

$2,200/Mo

Move-In Ready Office Suite

Well maintained office space with multiple private offices, reception, and breakroom, plus unfinished basement for expansion.

111 N Earle Street, Walhalla, SC 29691

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$2,800/Mo

Below-Boutique Retail Space

Finished retail space below The Fizz Boutique, previously a coffee shop, available for lease.

382 College Avenue, Clemson, SC 29631

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$2,000/Mo

Remodeled Restaurant Space on Main

Prime restaurant property in a high-traffic, growing tourist area.

100 -102 W Main Street, Walhalla, SC 29691

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Retail/Restaurant Space Near Clemson University

Contact for pricing

3,500 SF

Retail/Restaurant Space Near Clemson University

Retail/restaurant space with dedicated parking and lake access.

894 Tiger Blvd, Clemson, SC

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Similar Spaces for Sale in Seneca, SC

Consider Similar Space for Sale. We found 32 Spaces matching your search parameters.

$1,695,000

8,000 SF

Seneca Commercial Building For Sale

All brick/concrete building in Seneca, SC with tenant income.

518 W N 1st Street, Seneca, SC 29678

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$224,900

0.23 Acres

Open Floor Plan Commercial Building

Commercial building in Seneca with an open layout, two bathrooms, and a newly installed HVAC unit.

615 W N 1st Street, Seneca, SC 29678

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$1,399,999

12,000 SF

Seneca Retail Building For Sale

12,000 SF building with conversion potential in Seneca, SC.

12020 North Radio Station Road, Seneca, SC 29678

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$545,000

2.65 Acres

Prime Commercial Land Opportunity

2.65-acre commercial parcel in high-growth area, ideal for development.

1800 Sandifer Boulevard, Seneca, SC 29678

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Turn-Key Restaurant Franchise Opportunity

$1,900,000

0.78 Acres

Turn-Key Restaurant Franchise Opportunity

Turn-key national franchise restaurant with real estate for sale.

1053 By Pass 123 Bypass, Seneca, SC 29678

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$490,000

9,650 SF

Two Warehouses Near Clemson

Two warehouse buildings totaling 9,650 SF on one acre.

306 By Pass 123, Seneca, SC

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$49,900

0.50 Acres

Seneca Land in Prime Location

Buildable lot in downtown Seneca near lakes and amenities.

S Fairplay Street, Seneca, SC 29678

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$395,000

0.99 Acres

Commercial Lot Near Wells Highway

0.99-acre commercial lot with high visibility and easy access.

Corner of Wells Hwy. & Return Church Rd. Highway, Seneca, SC 29678

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$250,000

0.63 Acres

Freestanding Office Building

Original radio station facility offers strong road frontage and redevelopment flexibility for investors or business operators.

11081 N Radio Station Road, Seneca, SC 29678

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$1,695,000

Brick Concrete Warehouse Flex Building

All-brick warehouse flex space with 16-foot ceilings and existing tenants, offering room for another tenant or owner-occupancy.

518 W North 1st St, Seneca, SC 29678

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$1,399,999

12,000 SF

Seneca Retail Building For Sale

12,000 SF building with conversion potential in Seneca, SC.

12020 N Radio Station Rd, Seneca, SC 29678

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$599,000

2,400 SF

Seneca Office Space For Sale

Office space conveniently located off Bypass 123 in Seneca, SC.

631 By Pass 123, Seneca, SC

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$1,900,000

102.70 Acres

Land with Highway Frontage

Commercial land with highway and state road frontage.

125 Armstrong Road, Seneca, SC 29678

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$250,000

0.63 Acres

Commercial Land on Radio Station Road

Commercial land with building on busy Radio Station Road.

11081 N Radio Station Road, Seneca, SC 29678

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$2,049,000

NNN Bank Building

For sale NNN bank building with corporate ABS structure in Seneca, SC.

1313 Sandifer Boulevard, Seneca, SC 29678

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