Seneca, SC Commercial Real Estate for Lease

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Westminster, SC Clemson, SC Walhalla, SC Pendleton, SC Anderson, SC Central, SC Salem, SC Fair Play, SC

11 properties

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Updated: Aug 15

Flex Space with Showroom

879 By Pass 123 Highway Includes 710 Seneca Dr, Seneca, SC 29678

$4,000/Mo

3,264 sqft

Two buildings provide 4,704 SF of combined commercial space
1,440 SF building includes showroom, office, break room, and two bathrooms
3,264 SF Service/Garage Industrial building supports service‑oriented use
169 feet of road frontage along US By Pass 123
Located at the traffic light intersection of Mountain View Drive and Seneca Drive

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Updated: Aug 6

Upper-Level Office Unit

205 Stork Way Upper Unit, Seneca, SC 29678

$1,300/Mo

1,800 sqft

1800+ SF upper‑level office unit
Separate entry door accessed from the stairway
Open floor plan with cubicles allowed
Kitchenette or break room and full bathroom
New luxury vinyl plank flooring and closet storage

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Main Corridor Office Suite

114 Nimmons Circle, Seneca, SC 29678

$1,600/Mo

1,500 sqft

Bottom-floor office suite with multiple offices, conference room, reception, two restrooms, and storage, with front parking and signage.

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Office Units With Suite Options

402 Cane Creek Landing Road, Seneca, SC 29672

$26.26-$74.38 SF/Yr

Flexible leasing includes private offices, floor suites, and full-building occupancy with shared conference and reception areas.

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Retail Storefront in Shopping Center

1640 Sandifer Boulevard, Seneca, SC 29678

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2,550 sqft

Storefront suite in a signalized shopping center entrance with about 130 feet of frontage on Sandifer Blvd.

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End Cap Retail Space

1085 Old Clemson Highway, Seneca, SC 29672

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1,200 sqft

End-cap retail space available for lease near Clemson University.

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Built-Out Medical Office Suite

205 Central Park Ln, Seneca, SC 29678

$17.50 SF/Yr

Fully built-out suite with clinical rooms, reception, conference space, and staff amenities.

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Furnished Office Unit

10 Accountants Circle, Seneca, SC 29678

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Professional suite with nearby restroom, break room access, parking, and optional office furnishings.

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Second-Floor Office Suite with Balcony

202-1510 Blue Ridge Blvd, Seneca, SC 29672

$3,000/Mo

Second-floor suite with five private offices, a kitchen area, and two private bathrooms, plus shared lobby access and a balcony.

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Retail Redevelopment Site

1637 Sandifer Blvd, Seneca, SC 29678

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1.83 AC lot

Freestanding retail site with full access along Sandifer Blvd and cross access to Stop-A-Minit.

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Commercial Land Outparcel

285 Applewood Center Pl, Seneca, SC 29678

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4,000 sqft

Build-to-suit or ground-lease options are available within a Belk-anchored shopping center.

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Based on your search, we've compiled 54 Potential Opportunities for your consideration. Besides 11 Active listings in Seneca, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 39 Properties for Sales.

Commercial real estate for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Office Suite with Showroom

2345 Sandifer Boulevard Suite E, Westminster, SC 29693

$1,185/Mo

1,584 sqft

Vacant office space offers private workrooms, a break area, and access to shared kitchen facilities.

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Finished Coffee Shop Space

382 College Avenue, Clemson, SC 29631

$2,800/Mo

Finished commercial space with access from Kieth St in downtown Clemson.

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Retail Suite with Open Layout

1067 Tiger Blvd, Clemson, SC 29631

Contact for pricing

1,300 sqft

1,300 SF retail suite offers a wide-open sales area, rear storage, and two single-stall restrooms.

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Commercial Land Build-to-Suit Site

505 S Piedmont St, Westminster, SC 29693

Contact for pricing

1.23 AC lot

Rough-graded commercial land along Hwy 123 with two points of full access and utilities available at the property line.

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Similar Spaces for Sale in Seneca, SC

Consider Similar Space for Sale. We found 39 Spaces matching your search parameters.

Dual-Storefront Restaurant Property

124 And 118 N Townville Street Ye Ole Restaurant, Seneca, SC 29678

$799,000

5,772 sqft

Two storefront spaces provide restaurant, confectionery, and banquet-room functionality for food and event operations.

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Mixed-Use Property With Two Buildings

879 By Pass 123 Highway, includes 710 Seneca Drive, Seneca, SC 29678

$677,000

3,264 sqft

Two-building commercial offering with retail, office, and industrial improvements along an established Seneca business corridor.

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Downtown Retail Building with Two Units

319 Main Street, Seneca, SC 29678

$1,500,000

5,500 sqft 0.24 AC lot

Two fully heated and air-conditioned retail units with private entrances and restrooms, plus street-to-street rear access.

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Two-Story Storefront Property

110 E N 1st Street, Seneca, SC 29678

$429,943

5,000 sqft

Downtown setting near shops, restaurants, and community events.

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Five-Office Professional Office Suite

C-528 By Pass 123, Seneca, SC 29678

$375,000

1,290 sqft

Move-in-ready workspace includes reception, kitchenette, and an ADA-accessible restroom.

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Updated Self-Service Car Wash

1469 Blue Ridge Boulevard 1471 Blue Ridge Blvd, Seneca, SC 29672

$895,000

0.58 AC lot

Automotive property with a customer waiting office, support buildings, and covered maintenance storage across a commercial site.

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Professional Office Suite

528 ByPass 123, Seneca, SC 29678

$375,000

1,290 sqft

Flexible professional workspace with private offices, reception, kitchenette, and an ADA-accessible restroom.

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Unrestricted Subdividable Land Parcel

12051 N Radio Station Road, Seneca, SC 29678

$799,900

22.18 AC lot

Unrestricted general-use land offering 22.18 acres and subdividing potential near Seneca.

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Brick Flex Building

518 W N 1st Street, Seneca, SC 29678

$1,695,000

1.01 AC lot

All-brick and concrete flex property with existing tenants and additional space for occupancy or leasing.

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Downtown Mixed-Use Commercial Building

110 E North 1st St, Seneca, SC 29678

$429,943

5,000 sqft

Two-level commercial building with a prominent street-front location and 2,500 sq ft per floor for flexible uses.

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Two-Lot Live-Work Development Land

Tract 18/19 S Walnut Street, Seneca, SC 29678

$265,000

2.20 AC lot

Two adjacent lots offer flexible options for a residential build paired with a commercial storefront.

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Medical Office Building

685 S. Oak Street, Seneca, SC 29678

Contact for pricing

4,200 sqft

Established medical office property with a lease renewal option and convenient access to Seneca, Clemson, and US-123.

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Self-Storage Facility with Outdoor Storage

195 Meade Street, Seneca, SC 29672

$750,000

0.85 AC lot

Fenced property with electronic gate access and a small building offering potential office or additional storage use.

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Seneca, SC Commercial real estate Market Trends and Statistics

Explore Commercial real estate leasing options in Seneca, SC with 11 listings featured on our commercial real estate exchange. The current inventory includes 14,314 square feet of properties with an estimated lease value of $154.32.

Estimated lease rates for Commercial real estate in Seneca, SC begin at $8.67 SF/Yr, with an average of $25.72 SF/Yr and extend to $74.38 SF/Yr.

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