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    Seneca, SC

    Seneca, SC Commercial Real Estate for Lease

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    Clemson, SC Westminster, SC Walhalla, SC Pendleton, SC Anderson, SC Salem, SC Fair Play, SC Pickens, SC
    7 properties
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    Seneca Office Space For Lease
    Updated: Mar 28, 2025
    Seneca Office Space For Lease

    865 Old Clemson Highway, Seneca, SC 29678

    $1,500/Mo
    Suitable for various business types, including medical/dental offices.
    Two levels with separate entrances and restrooms, offering flexible leasing options (entire building or individual floors).
    Located in close proximity to Clemson and Seneca.
    Lower level features 3 offices, conference room, and reception area (Lease: $1,750.00 NNN).
    Upper level offers 5 offices and a reception area (Lease: $2,900.00 NNN).
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    Retail Storefront in Shopping Center
    Updated: Jul 27
    Retail Storefront in Shopping Center

    1640 Sandifer Boulevard, Seneca, SC 29678

    Contact for pricing
    2,550 sqft
    Commercial zoning
    About 130 ft of frontage on Sandifer Blvd.
    Located at a signalized shopping center entrance
    Good visibility from Sandifer Blvd.
    Walmart Supercenter averages over 222,000 monthly visitors
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    Main Corridor Office Suite
    Main Corridor Office Suite

    114 Nimmons Circle, Seneca, SC 29678

    Contact for pricing
    1,500 sqft

    Bottom-floor office suite with multiple offices, conference room, reception, two restrooms, and storage, with front parking and signage.

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    Second-Floor Office Suite with Balcony
    Second-Floor Office Suite with Balcony

    202-1510 Blue Ridge Blvd, Seneca, SC 29672

    $3,000/Mo

    Second-floor suite with five private offices, a kitchen area, and two private bathrooms, plus shared lobby access and a balcony.

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    Retail Space with Excellent Signage Visibility
    Retail Space with Excellent Signage Visibility

    1592 Sandifer Blvd, Seneca, SC 29678

    Contact for pricing
    7,250 sqft

    Retail space positioned in the main corridor with strong exposure and signage along Sandifer Blvd.

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    Retail Redevelopment Site
    Retail Redevelopment Site

    1637 Sandifer Blvd, Seneca, SC 29678

    Contact for pricing

    Freestanding retail site with full access along Sandifer Blvd and cross access to Stop-A-Minit.

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    Dominant Power Center For Rent
    Dominant Power Center For Rent

    201 Applewood Center Pl, Seneca, SC 29678

    Contact for pricing
    245,000 sqft

    245,000 SF power center anchored by Belk, Hobby Lobby, etc.

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    Based on your search, we've compiled 45 Potential Opportunities for your consideration. Besides 7 Active listings in Seneca, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 34 Properties for Sales.

    Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Below-Boutique Retail Space
    Below-Boutique Retail Space

    382 College Avenue, Clemson, SC 29631

    $2,800/Mo

    Finished retail space below The Fizz Boutique, previously a coffee shop, available for lease.

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    Industrial Warehouse with Dock Doors
    Industrial Warehouse with Dock Doors

    365 Oconee Business Pkwy, Westminster, SC 29693

    Contact for pricing
    170,417 sqft

    Brand-new 2024 industrial warehouse featuring ESFR sprinklers, reinforced concrete, and multiple dock-high and drive-in loading doors.

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    Retail Suite with Open Layout
    Retail Suite with Open Layout

    1067 Tiger Blvd, Clemson, SC 29631

    Contact for pricing
    1,300 sqft

    1,300 SF retail suite offers a wide-open sales area, rear storage, and two single-stall restrooms.

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    Commercial Land Build-to-Suit Site
    Commercial Land Build-to-Suit Site

    505 S Piedmont St, Westminster, SC 29693

    Contact for pricing

    Rough-graded commercial land along Hwy 123 with two points of full access and utilities available at the property line.

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    Similar Spaces for Sale in Seneca, SC

    Consider Similar Space for Sale. We found 34 Spaces matching your search parameters.

    Downtown Retail Building with Two Units
    Downtown Retail Building with Two Units

    319 Main Street, Seneca, SC 29678

    $1,500,000
    5,500 sqft 0.24 AC lot

    Two fully heated and air-conditioned retail units with private entrances and restrooms, plus street-to-street rear access.

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    Seneca Commercial Building For Sale
    Seneca Commercial Building For Sale

    518 W N 1st Street, Seneca, SC 29678

    $1,695,000
    8,000 sqft 1.01 AC lot

    All brick/concrete building in Seneca, SC with tenant income.

    View details
    Seneca Retail Building For Sale
    Seneca Retail Building For Sale

    12020 North Radio Station Road, Seneca, SC 29678

    $1,399,999
    12,000 sqft 2.42 AC lot

    12,000 SF building with conversion potential in Seneca, SC.

    View details
    Downtown Mixed-Use Commercial Building
    Downtown Mixed-Use Commercial Building

    110 E North 1st St, Seneca, SC 29678

    $429,943
    5,000 sqft

    Two-level commercial building with a prominent street-front location and 2,500 sq ft per floor for flexible uses.

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    Two-Lot Live-Work Development Land
    Two-Lot Live-Work Development Land

    Tract 18/19 S Walnut Street, Seneca, SC 29678

    $265,000
    2.20 AC lot

    Two adjacent lots offer flexible options for a residential build paired with a commercial storefront.

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    General Commercial Retail/Office Building
    General Commercial Retail/Office Building

    615 W N 1st Street, Seneca, SC 29678

    $199,900
    0.23 AC lot

    Open floor plan with two bathrooms and a side storage building, zoned General Commercial in Seneca.

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    Ambulatory Surgery Center and Medical Office
    Ambulatory Surgery Center and Medical Office

    457 E Bypass 123 Building D, Seneca, SC 29678

    Contact for pricing
    10,421 sqft

    Medicare-certified ambulatory surgery center with two laminar flow operating rooms and shared campus medical office building.

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    Unrestricted Subdividable Land Parcel
    Unrestricted Subdividable Land Parcel

    12051 N Radio Station Road, Seneca, SC 29678

    $799,900
    22.18 AC lot

    Unrestricted general-use land offering 22.18 acres and subdividing potential near Seneca.

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    Commercial Building with Open Plan
    Commercial Building with Open Plan

    615 W North 1st St, Seneca, SC 29678

    $214,900

    Own a tenant-occupied commercial building with an open floor plan, two bathrooms, and a recently installed HVAC unit.

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    The Clemson Commercial Lot
    The Clemson Commercial Lot

    189 Seneca Creek Road, Seneca, SC 29678

    $175,000
    84,942 sqft 1.95 AC lot

    1.95 Acres Land, The Clemson Commercial Lot

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    Office Building
    Office Building

    631 By Pass 123, Seneca, SC 29678

    Contact for pricing
    2,400 sqft

    Office building conveniently located right off 123 Bypass, suited for professional and service-based businesses.

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    60 Acres Land 101 Friendship Road Tract B
    60 Acres Land 101 Friendship Road Tract B

    101 Friendship Road, Seneca, SC 29678

    $1,000,000
    2,613,600 sqft 60.00 AC lot

    A convenient 60 acres to everything Clemson

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    Brick Concrete Warehouse Flex Building
    Brick Concrete Warehouse Flex Building

    518 W North 1st St, Seneca, SC 29678

    $1,695,000

    All-brick warehouse flex space with 16-foot ceilings and existing tenants, offering room for another tenant or owner-occupancy.

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    Office Building with Road Frontage
    Office Building with Road Frontage

    11081 N Radio Station Road, Seneca, SC 29678

    $217,000
    0.63 AC lot

    Single-building office asset just outside Seneca city limits with substantial road frontage on Radio Station Road.

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    Prime Commercial Acreage For Sale
    Prime Commercial Acreage For Sale

    1018 E. North 1st Street, Seneca, SC 29678

    $3,500,000
    4.33 AC lot

    4.3 acres in Seneca, SC, ideal for retail or hospitality.

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    Oconee County Land For Sale
    Oconee County Land For Sale

    8006 Keowee School Road, Seneca, SC 29672

    $619,943
    24.70 AC lot

    24.7 acres of unrestricted land near Lake Keowee.

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    Freestanding Office Building
    Freestanding Office Building

    631 By Pass 123, Seneca, SC 29678

    Contact for pricing

    For sale office building at 631 By Pass 123, offering a straightforward setup for professional tenants.

    View details

    Seneca, SC Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Seneca, SC with 7 listings featured on our commercial real estate exchange. The current inventory includes 256,300 square feet of properties.
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    Most Searched ZIP Codes in Seneca, SC

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    • 29672

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