Add Listing
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Space Uses
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    • Hospitality
    • Sports & Entertainment
    • Specialty
    Rent
    Rent / SF / Yr
    $
    $
    Rent / Mo
    $
    $
    Size
    Property size / sq.ft.

    Meet Realmo: The Largest Hub
    of Commercial Real     Estate in the US

    Over 1 million active listings and over 150 million property profiles

    Seneca, SC Commercial Real Estate for Lease

    Notify Me
    List
    Map
    Columbia, SC Greenville, SC Charleston, SC
    13 results
    Seneca Office Space For Lease
    $1,500/Mo

    Seneca Office Space For Lease

    865 Old Clemson Highway, Seneca, SC 29678

    Two-level office building suitable for various businesses, near Clemson.

    • Suitable for various business types, including medical/dental offices.
    • Two levels with separate entrances and restrooms, offering flexible leasing options (entire building or individual floors).
    • Located in close proximity to Clemson and Seneca.
    • Lower level features 3 offices, conference room, and reception area (Lease: $1,750.00 NNN).
    • Upper level offers 5 offices and a reception area (Lease: $2,900.00 NNN).
    Updated: Mar 28, 2025
    View details
    Office Space Near Clemson
    $4,000/Mo

    Office Space Near Clemson

    865 Old Clemson Highway, Seneca, SC 29678

    Two-level office building suitable for various businesses, near Clemson.

    • Close proximity to Clemson and Seneca
    • Suitable for various business types and offices
    • Potential conversion to medical or dental office
    • Two levels with separate entrances
    • Multiple offices and restrooms on each level
    Updated: Mar 28, 2025
    View details
    Office Space in Seneca, SC
    $2,500/Mo

    Office Space in Seneca, SC

    Commercial office space available for lease in Seneca, South Carolina.

    865 Old Clemson Highway, Seneca, SC 29678
    View details
    Seneca Retail/Office Space Available
    $1,700/Mo
    712 SF

    Seneca Retail/Office Space Available

    Retail/office space for lease in Seneca, SC. Renovated and visible.

    1109 Jennings Ave Unit A, Seneca, SC 29768
    View details
    Retail Space Near Clemson University
    $21 SF/Yr
    43,000 SF

    Retail Space Near Clemson University

    End-cap retail space with drive-thru potential near Clemson University.

    1085 Old Clemson Highway, Seneca, SC 29672
    View details
    Retail Opportunity Near Walmart
    Contact for pricing

    Retail Opportunity Near Walmart

    Retail space available for lease near Walmart and hospital.

    Seneca, SC 29678
    View details
    Retail Property on Main Corridor
    $11 SF/Yr
    7,250 SF

    Retail Property on Main Corridor

    Retail property with excellent visibility and heavy traffic.

    1592 Sandifer Blvd, Seneca, SC
    View details
    Retail Opportunity Near Walmart
    Contact for pricing

    Retail Opportunity Near Walmart

    Retail space available for lease, GL, or build-to-suit.

    1637 Sandifer Blvd, Seneca, SC
    View details
    Seneca Office/Retail Space Available
    $15 SF/Yr
    4,800 SF

    Seneca Office/Retail Space Available

    Office and retail spaces for lease in Seneca, South Carolina.

    12019 North Radio Station Rd, Seneca, SC
    View details
    Restaurant Space Near Oconee Medical
    Contact for pricing
    16,000 SF

    Restaurant Space Near Oconee Medical

    1,600 SF 2nd Gen Restaurant Space Available For Rent.

    201-273 Applewood Center Pl, Seneca, SC
    View details
    Land Near Oconee Medical Center
    Contact for pricing

    Land Near Oconee Medical Center

    Commercial land for rent near medical center and Clemson University.

    15516 Wells Hwy, Seneca, SC
    View details
    Retail Space Near Oconee Medical
    Contact for pricing
    1,600 SF

    Retail Space Near Oconee Medical

    Retail space available near Oconee Medical Center and Clemson University.

    101 Applewood Center Pl, Seneca, SC
    View details
    Dominant Power Center For Rent
    Contact for pricing
    245,000 SF

    Dominant Power Center For Rent

    245,000 SF power center anchored by Belk, Hobby Lobby, etc.

    201 Applewood Center Pl, Seneca, SC 29678
    View details
    Based on your search, we've compiled 48 Potential Opportunities for your consideration. Besides 13 Active listings in Seneca, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 31 Properties for Sales.

    Explore Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Move-in Ready Office Space
    $2,200/Mo

    Move-in Ready Office Space

    Well-maintained office space in established professional park, ready for occupancy.

    111 N Earle Street, Walhalla, SC 29691
    View details
    Downtown Clemson Retail Space Available
    $2,800/Mo

    Downtown Clemson Retail Space Available

    Retail space in downtown Clemson, formerly a coffee shop.

    382 College Avenue, Clemson, SC 29631
    View details
    Remodeled Restaurant Space on Main
    $2,000/Mo

    Remodeled Restaurant Space on Main

    Prime restaurant property in a high-traffic, growing tourist area.

    100 -102 W Main Street, Walhalla, SC 29691
    View details
    Retail/Restaurant Space Near Clemson University
    Contact for pricing
    3,500 SF

    Retail/Restaurant Space Near Clemson University

    Retail/restaurant space with dedicated parking and lake access.

    894 Tiger Blvd, Clemson, SC
    View details

    Explore Similar Spaces for Sale in Seneca, SC

    Consider Similar Space for Sale. We found 31 Spaces matching your search parameters.

    Commercial Building in Seneca, SC
    $249,900
    0.23 Acres

    Commercial Building in Seneca, SC

    Commercial building with open floor plan suitable for various businesses.

    615 W N 1st Street, Seneca, SC 29678
    View details
    Seneca Land in Prime Location
    $49,900
    0.50 Acres

    Seneca Land in Prime Location

    Buildable lot in downtown Seneca near lakes and amenities.

    S Fairplay Street, Seneca, SC 29678
    View details
    Seneca Retail/Warehouse Opportunity
    $1,800,000
    1.01 Acres

    Seneca Retail/Warehouse Opportunity

    All brick/concrete building with existing tenants and expansion potential.

    518 W N 1st Street, Seneca, SC 29678
    View details
    Prime Commercial Land Opportunity
    $545,000
    2.65 Acres

    Prime Commercial Land Opportunity

    2.65-acre commercial parcel in high-growth area, ideal for development.

    1800 Sandifer Boulevard, Seneca, SC 29678
    View details
    Commercial Land in Seneca, SC
    $275,000
    2.50 Acres

    Commercial Land in Seneca, SC

    2.5-acre commercial lot in Seneca, ready for development.

    13000 S Radio Station Road, Seneca, SC 29678
    View details
    Turn-Key Restaurant Franchise Opportunity
    $1,900,000
    0.78 Acres

    Turn-Key Restaurant Franchise Opportunity

    Turn-key national franchise restaurant with real estate for sale.

    1053 By Pass 123 Bypass, Seneca, SC 29678
    View details
    Commercial Lot Near Wells Highway
    $395,000
    0.99 Acres

    Commercial Lot Near Wells Highway

    0.99-acre commercial lot with high visibility and easy access.

    Corner of Wells Hwy. & Return Church Rd. Highway, Seneca, SC 29678
    View details
    Two Warehouses Near Clemson
    $490,000
    9,650 SF

    Two Warehouses Near Clemson

    Two warehouse buildings totaling 9,650 SF on one acre.

    306 By Pass 123, Seneca, SC
    View details
    Seneca Retail Building For Sale
    $1,399,999
    12,000 SF

    Seneca Retail Building For Sale

    12,000 SF building with conversion potential in Seneca, SC.

    12020 North Radio Station Road, Seneca, SC 29678
    View details
    Seneca Automotive Service Property
    $125,000

    Seneca Automotive Service Property

    Automotive service property near downtown Seneca with four bays.

    919 E S 6th Street, Seneca, SC 29678
    View details
    Corner Lot in Seneca
    $325,000
    1.29 Acres

    Corner Lot in Seneca

    1.29 acre corner lot zoned for commercial use.

    911 E. North 1st Street Street, Seneca, SC 29678
    View details

    Seneca, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Seneca, SC with 13 listings featured on our commercial real estate exchange. The current inventory includes 55,762 square feet of properties with an estimated lease value of $76 SF/Yr.

    Estimated lease rates for Commercial real estate in Seneca, SC begin at $11 SF/Yr, with an average of $19 SF/Yr and extend to $28 SF/Yr.
    List
    Map

    Browse Commercial real estate for Lease Near Seneca, SC

    Popular Searches in Seneca, SC

    Popular Categories

    Most Searched ZIP Codes in Seneca, SC

    • 29678
    • 29672
    • 29768

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!