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    Orangeburg County, SC Commercial Real Estate for Lease

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    Columbia, SC Greenville, SC Charleston, SC
    24 results
    Retail Space with Drive-Thru
    Contact for pricing
    10,725 SF

    Retail Space with Drive-Thru

    1535 John C Calhoun, Orangeburg, SC

    Former CVS space with drive-thru, outparcel to WalMart.

    • Outparcel to a WalMart Neighborhood Market
    • Former CVS with drive thru, offering ~10,725 SF
    • Located on the hard corner of John C. Calhoun Drive at Stonewall Jackson Street
    • Prominent Pylon Sign with Digital Reader Board
    • Access on John C. Calhoun and Stonewall Jackson
    Updated: Nov 5, 2025
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    High-Traffic Corner Retail Space
    Contact for pricing
    1,800 SF

    High-Traffic Corner Retail Space

    8507 Old State Road, Holly Hill, SC 29059

    1,800 sq ft retail space in high-traffic Holly Hill.

    • High‑traffic corner location at Pine Street and Hwy 176/Old State Road.
    • Exceptional road frontage and visibility.
    • Located across from Piggly Wiggly and V‑Go Gas Station, adjacent to CVS Pharmacy.
    • 1,800 square feet of retail space.
    • Recently updated (within the past 4 years).
    Updated: Mar 3
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    Industrial Outdoor Storage with Office
    $15 SF/Yr

    Industrial Outdoor Storage with Office

    10 acre industrial site with 7,040 SF office.

    625 Five Chop Rd, Orangeburg, SC
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    Orangeburg Warehouse and Distribution Space
    Contact for pricing
    213,093 SF

    Orangeburg Warehouse and Distribution Space

    213,093 SF warehouse and distribution space available for lease.

    821 State Ct, Orangeburg, SC
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    Retail Space Near Walmart
    Contact for pricing
    1,500 SF

    Retail Space Near Walmart

    Retail space available in shadow-anchored shopping center.

    2805-2831 North Rd, Orangeburg, SC
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    16,800 SF Industrial Property For Lease
    $3,000 /Mo

    16,800 SF Industrial Property For Lease

    16,800 SF Industrial Property For Lease

    780 Nottingham St, Orangeburg, SC 29115
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    Retail, Office
    Contact for pricing
    1,250 SF

    Retail, Office

    Retail space · 1,250 SF

    8515 Old State Road, Holly Hill, SC 29059
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    Orangeburg Warehouse Space Available
    Contact for pricing
    50,000 SF

    Orangeburg Warehouse Space Available

    50,000 SF warehouse space available immediately in Orangeburg, South Carolina.

    2850 Magnolia St, Orangeburg, SC
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    Commercial Land in Orangeburg, SC
    Contact for pricing

    Commercial Land in Orangeburg, SC

    2.3 acre site for ground lease or build to suit.

    Orangeburg, SC 29115
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    Retail Space in Orangeburg, SC
    Contact for pricing
    4,625 SF

    Retail Space in Orangeburg, SC

    Retail space available for lease in Orangeburg, South Carolina.

    437 Stonewall Jackson Street Southwest, Orangeburg, SC
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    Industrial Building on 2.19 Acres
    Contact for pricing
    13,593 SF

    Industrial Building on 2.19 Acres

    13,593 SF industrial building with laydown yard near Downtown.

    840 Mill St, Orangeburg, SC
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    Orangeburg Warehouse and Distribution Space
    $3 SF/Yr
    326,536 SF

    Orangeburg Warehouse and Distribution Space

    326,536 SF warehouse/distribution space near I-26.

    2500 Saint Matthews, Orangeburg, SC
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    Orangeburg Flex/Industrial Space Available
    $5 SF/Yr
    60,000 SF

    Orangeburg Flex/Industrial Space Available

    60000 SF flex/industrial space for lease in Orangeburg.

    201 Regional Pkwy, Orangeburg, SC
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    Retail Space in Orangeburg
    Contact for pricing
    524 SF

    Retail Space in Orangeburg

    Retail space available for lease in Orangeburg, SC.

    1350 Grove Park Dr, Orangeburg, SC
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    Orangeburg Warehouse Space Available
    Contact for pricing
    167,000 SF

    Orangeburg Warehouse Space Available

    167,000 SF warehouse space for rent in Orangeburg.

    255 Millenium Dr, Orangeburg, SC
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    Orangeburg Commercial Property for Lease
    Contact for pricing

    Orangeburg Commercial Property for Lease

    Commercial property available for lease in Orangeburg, South Carolina.

    Magnolia Village Parkway @ North Rd (US 178), Orangeburg, SC 29118
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    Industrial Build to Suit Opportunity
    Contact for pricing
    167,000 SF

    Industrial Build to Suit Opportunity

    Industrial build to suit opportunity with ±167,000 SF available.

    147 Millenium Dr, Orangeburg, SC 29115
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    Retail Space on Hwy 178
    Contact for pricing
    11,700 SF

    Retail Space on Hwy 178

    Retail opportunities in high-growth corridor near major retailers.

    2580 North Rd, Orangeburg, SC
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    Retail Space in Grove Park
    Contact for pricing

    Retail Space in Grove Park

    Retail spaces available in a busy Orangeburg shopping center.

    1370 Chestnut St, Orangeburg, SC 29115
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    Orangeburg Office Space Available
    Contact for pricing
    1,829 SF

    Orangeburg Office Space Available

    Office space for rent in Orangeburg, South Carolina.

    1175 Cook Rd, Orangeburg, SC
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    Orangeburg County Warehouse Space Available
    Contact for pricing
    29,250 SF

    Orangeburg County Warehouse Space Available

    Available warehouse space in Orangeburg County, less than 1 mile to I-95.

    8099 Five Chop Rd, Santee, SC
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    Retail Space in Prime Location
    Contact for pricing
    55,000 SF

    Retail Space in Prime Location

    Retail space available in high-traffic Orangeburg shopping center.

    Magnolia Village Parkway @ North Rd (US 178), Orangeburg, SC 29118
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    Restaurant Space Available For Rent
    Contact for pricing
    6,000 SF

    Restaurant Space Available For Rent

    Restaurant and retail spaces available for rent.

    1214 St Matthews Rd NE, Orangeburg, SC 29118
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    Downtown Holly Hill Commercial Space
    Contact for pricing

    Downtown Holly Hill Commercial Space

    Commercial space for lease in renovated historic building.

    8636 Old State Rd, Holly Hill, SC 29059
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    Based on your search, we've compiled 24 Potential Opportunities for your consideration. Besides 24 Active listings in Orangeburg County, SC, we suggest exploring alternatives.

    Orangeburg County, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Orangeburg County, SC with 24 listings featured on our commercial real estate exchange. The current inventory includes 38,357,237,160 square feet of properties with an estimated lease value of $0.00 SF/Yr.

    Estimated lease rates for Commercial real estate in Orangeburg County, SC begin at $0.00 SF/Yr, with an average of $0.00 SF/Yr and extend to $0.00 SF/Yr.
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