Clemson, SC Commercial Real Estate for Lease

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Seneca, SC Pendleton, SC Central, SC Anderson, SC Liberty, SC Pickens, SC Easley, SC Walhalla, SC

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Updated: Jun 12, 2025

Finished Coffee Shop Space

382 College Avenue, Clemson, SC 29631

$2,800/Mo

Approximately 2100sqf of finished space
Access from Kieth St
Located in downtown Clemson
Positioned beneath The Fizz Boutique
Formerly occupied by The Grace Coffee Shop

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Updated: Jul 21

Finished Coffee Shop Space

382 College Avenue Basement Space, Clemson, SC 29631

$2,800/Mo

2,100 sqft

Approximately 2,100 square feet of finished space
Located beneath The Fizz Boutique
Accessible from Kieth St.
382 College Avenue address in downtown Clemson
Previously operated as The Grace Coffee Shop

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First-Floor Retail and Office Suites

125 Anderson Highway, Clemson, SC 29631

$25 SF/Yr

Three first-floor suites are available inside a 150-room, 500-bed student housing community on a high-traffic Clemson corridor.

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Office Suite with Boulevard Signage

501 Forest Lane, Clemson, SC 29631

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Three private offices support a flexible professional workspace with reception and meeting areas.

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Private Office Unit

106 Earle St, Clemson, SC 29631

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Two work areas, storage, a private bathroom, and utilities support flexible day-to-day operations.

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Retail Shopping Center with Parking

500 Old Greenville Hwy, Clemson, SC 29631

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1,760 sqft 9.49 AC lot

Retail suites ranging up to 13,802 SF are available within a shopping center in Clemson’s CP2 district.

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Retail Shopping Center Space

500 Old Greenville Hwy, Clemson, SC 29631

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893 sqft 9.49 AC lot

Retail space is available in a shopping center with free onsite parking in Clemson’s CP2 zoning.

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Shopping Center Lease Space

500 Old Greenville Hwy, Clemson, SC 29631

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4,680 sqft

Lease space is available near Clemson University for retail shopping center use.

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Mixed-Use Property Near Clemson Campus

111 Earle Street, Clemson, SC 29631

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Mixed-use property with residential and retail components near Clemson University.

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Retail/Restaurant Space Near Clemson University

114 Earle St, Clemson, SC

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1,401 sqft 3.28 AC lot

Retail/restaurant spaces available in mixed-use student housing project.

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Retail Suite with Open Layout

1067 Tiger Blvd, Clemson, SC 29631

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1,300 sqft

1,300 SF retail suite offers a wide-open sales area, rear storage, and two single-stall restrooms.

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Retail Space Near Clemson University

107 Canoy Ln, Clemson, SC 29631

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Retail space on high-traffic corridor near Clemson University.

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Based on your search, we've compiled 29 Potential Opportunities for your consideration. Besides 12 Active listings in Clemson, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 13 Properties for Sales.

Commercial real estate for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Historic Storefront Space

104 Exchange Street, Pendleton, SC 29670

$3,500/Mo

One-level commercial space includes an annex and access to an adjacent garden courtyard.

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Open-Concept Retail Space

117-125 N Mechanic St, Pendleton, SC 29670

Contact for pricing

1,405 sqft

Managed retail space with an open layout, restroom, and optional additional storage.

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Flex Building with Drive-In Door

1725 Wells Hwy, Seneca, SC 29678

Contact for pricing

6,000 sqft 5.00 AC lot

Metal flex building combines conditioned office space with warehouse functionality on a 5-acre commercial site.

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End Cap Retail Space

1085 Old Clemson Highway, Seneca, SC 29672

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1,200 sqft

End-cap retail space available for lease near Clemson University.

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Similar Spaces for Sale in Clemson, SC

Consider Similar Space for Sale. We found 13 Spaces matching your search parameters.

Multi-Tenant Retail Building

203 Pendleton Road, Clemson, SC 29631

$1,500,000

7,000 sqft 0.88 AC lot

Multi-tenant retail building with ample parking and an unfinished basement, located on highly visible Pendleton Road.

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Multi-Tenant Retail Building

203 Pendleton Road, Clemson, SC 29631

$1,500,000

0.88 AC lot

Commercial property with an unfinished basement and a flexible multi-tenant configuration.

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Commercial Building on Highway 123

990 Tiger Blvd, Clemson, SC 29631

$1,349,990

6,000 sqft 0.48 AC lot

6000 sq ft commercial building with ample parking.

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Finished Coffee Shop Space

382 College Avenue, Basement space, Clemson, SC 29631

Contact for pricing

2,100 sqft

Finished commercial space with access from Kieth Street and prior coffee shop use.

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Absolute NNN Ground Lease Site

118 Pinnacle St, Clemson, SC 29631

$2,887,000

15-year absolute NNN corporate ground lease with zero landlord maintenance or expense responsibilities in the Clemson University trade area.

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Multi-Tenant Retail Center

379 Old Greenville Highway, Clemson, SC 29631

Contact for pricing

10,006 sqft 1.09 AC lot

Freestanding center combines retail and office suites with brick construction, glass storefronts, and a monument sign.

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Fitness Center Building

990 Tiger Boulevard, Clemson, SC 29631

$1,349,990

0.48 AC lot

Commercial facility with concrete flooring, central HVAC, and on-site parking.

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Ground-Floor Retail and Office Suites

125 Anderson Highway, Clemson, SC 29631

Contact for pricing

Three ground-level suites are available within a 2017 student housing community on Clemson’s primary corridor.

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Clemson Land for Development

76 Highway, Clemson, SC 29631

$1,299,774

7.66 AC lot

7+ acres of land near Clemson University.

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NNN Drive-Thru Pharmacy & Fuel

680 Old Greenville Highway, Clemson, SC 29631

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NNN leased property with a drive-thru pharmacy and detached six-pump fueling station under a Walmart-guaranteed lease.

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Commercial Land Available

Central (, Clemson, SC 29630

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Commercial land for sale in Clemson, SC.

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Ready-to-Build Commercial Land Site

201 Frontage Rd, Clemson, SC 29631

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Level, graded commercial site with stormwater retention in place at a corner intersection.

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Clemson, SC Commercial real estate Market Trends and Statistics

Explore Commercial real estate leasing options in Clemson, SC with 12 listings featured on our commercial real estate exchange. The current inventory includes 12,134 square feet of properties with an estimated lease value of $41.

Estimated lease rates for Commercial real estate in Clemson, SC begin at $16 SF/Yr, with an average of $20.50 SF/Yr and extend to $25 SF/Yr.

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