Hilton Head Island, SC Commercial Real Estate for Lease

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Multiple Office Solutions at SC, Hilton Head - Office Park Road. Contact us today to book a tour!
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Light Industrial Flex Suites
Updated: Jul 24
Light Industrial Flex Suites

12 Cardinal Rd, Hilton Head Island, SC 29926

$2,100/Mo
5,090 sqft
12 Cardinal Road offers mid‑island light industrial flex space with Units A and B available for lease.
Unit A includes 2,990 SF of warehouse, office, and mezzanine space with roll‑up doors, shared loading dock, drive‑in door, and full HVAC.
Unit B includes 2,100 SF of warehouse and office space with a drive‑in door and shared dock access.
Both units have 3‑phase power and can be leased together for a combined total of 5,090 SF.
Each suite features loading access with roll‑up doors and a shared fenced yard.
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End-Cap Flex Space
Updated: Aug 24
End-Cap Flex Space

A-4 Mathews Ct, Hilton Head Island, SC 29926

$18.50 SF/Yr
1,614 sqft
1,614‑square‑foot end‑cap suite in the Mathews Court center
CC zoning allows a broad range of permitted uses
Wide‑open interior with office, fitting rooms, storage room, and restroom
Adjacent to Sea Turtle Marketplace
Port Royal Plaza is directly across the street
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Light Industrial Flex Suites
Light Industrial Flex Suites

12 Cardinal Rd, Hilton Head Island, SC 29926

$2,100/Mo
7,127 sqft

Flex space suites with warehouse-and-office layouts, roll-up doors, dock access, and a shared fenced yard.

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Large-Format Retail Space
Large-Format Retail Space

Z-435 William Hilton Pkwy, Hilton Head Island, SC 29928

$9 SF/Yr
16,000 sqft

Open-plan commercial premises with locker rooms, showers, private offices, HVAC, and shared parking.

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Conditioned Flex Warehouse Building
Conditioned Flex Warehouse Building

16 Finch St, Hilton Head Island, SC 29926

$22 SF/Yr
8,495 sqft 1.12 AC lot

Fully conditioned warehouse with epoxy flooring, spray foam insulation, two office areas, and a loading door.

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Flex Space with Loading Dock
Flex Space with Loading Dock

4-11 Mathews Dr, Hilton Head Island, SC 29926

$18 SF/Yr
3,500 sqft

Mixed-use flex space suites include a back loading dock and pull-up door, available immediately.

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Office Space with High-End Finishes
Office Space with High-End Finishes

386 Spanish Wells Rd, Unit B-3, Hilton Head Island, SC 29926

$3,000/Mo
2,175 sqft

Office space featuring high-end finishes in a desirable location.

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North End Office Spaces
North End Office Spaces

100 Exchange Street, Hilton Head Island, SC 29926

$22.50 SF/Yr
4,335 sqft

North end office spaces for lease in Hilton Head.

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Conditioned Flex Space
Conditioned Flex Space

136 Beach City Rd, Hilton Head Island, SC 29926

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1,663 sqft

Climate-controlled office, showroom, and warehouse areas provide a flexible commercial configuration with an on-site restroom.

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Medical Building on Hilton Head
Medical Building on Hilton Head

4101 Main St, Suite E & F, Hilton Head Island, SC 29926

$17 SF/Yr

Stand-alone medical building for lease on Hilton Head Island.

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Open Showroom with Glassfront Doors
Open Showroom with Glassfront Doors

Hilton Head Island, SC 29926

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2,218 sqft

Open showroom layout with natural light and ramped storefront access.

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Flexible-Layout Office Suite
Flexible-Layout Office Suite

Hilton Head Island, SC 29928

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1,250 sqft

Immediately available office accommodation with private rooms, reception space, a conference-room option, and shared lobby access.

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Class A Office Suites Available
Class A Office Suites Available

2 Park Lane, Hilton Head Island, SC 29928

$18 SF/Yr

Functional office spaces in updated building with covered parking.

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Renovated First-Floor Office Suite
Renovated First-Floor Office Suite

8 Lafayette Pl, Hilton Head Island, SC 29926

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3,025 sqft

Recently updated workspace with reception, private offices, conference room, kitchenette, and lobby access.

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Functional Office Spaces For Rent
Functional Office Spaces For Rent

2 Park Rd, Hilton Head Island, SC

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1,792 sqft 1.82 AC lot

Updated building with covered parking and a great location.

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Mixed Commercial Space Available
Mixed Commercial Space Available

11 Mathews Drive #4, Hilton Head Island, SC 29026

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3,500 sqft

Commercial space suitable for retail, office, or storage.

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Office Suite with Reception and Conference Room
Office Suite with Reception and Conference Room

23B Shelter Cove Ln, Hilton Head Island, SC 29928

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4,920 sqft

Office suite ready for occupancy with reception, multiple offices, and a conference room in a mid-island Shelter Cove location.

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Mixed Commercial Space Available
Mixed Commercial Space Available

46 Old Wild Horse Road, Hilton Head Island, SC 29926

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1,500 sqft

1,500 sq. ft. space ideal for retail, office, or storage.

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Office Suite with Reception
Office Suite with Reception

23B Shelter Cove Ln, Hilton Head Island, SC 29928

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7,268 sqft

Office suite features a reception area, multiple offices, and flexible open work or meeting space.

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Medical Office Suites
Medical Office Suites

25 Hospital Center Blvd, Hilton Head Island, SC 29926

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2,774 sqft

Three-story medical pavilion offers multiple suite layouts for lease, connected by breezeway to Hilton Head Hospital.

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Former IHOP on William Hilton
Former IHOP on William Hilton

439 William Hilton Pkwy, Hilton Head Island, SC 29926

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Freestanding 5,172 SF building in high-traffic retail corridor.

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Ground-Floor Medical Office Suite
Ground-Floor Medical Office Suite

23 Main St, Hilton Head Island, SC 29926

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750 sqft

Ground-floor medical office suite in a high-profile building with ample on-site parking.

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Industrial Land for Outdoor Storage
Industrial Land for Outdoor Storage

326 Spanish Wells Rd, Hilton Head Island, SC 29926

$4,200/Mo

Industrial land offers laydown-yard and outdoor storage use, with fencing and shipping containers available by arrangement.

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Retail Space in Shelter Cove
Retail Space in Shelter Cove

50 Shelter Cove Lane, Hilton Head Island, SC 29928

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Retail space available within Shelter Cove Shopping and Entertainment area.

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Hilton Head Island, SC Commercial real estate Market Trends and Statistics

Explore Commercial real estate leasing options in Hilton Head Island, SC with 27 listings featured on our commercial real estate exchange. The current inventory includes 135,503 square feet of properties with an estimated lease value of $150.04.

Estimated lease rates for Commercial real estate in Hilton Head Island, SC begin at $3.54 SF/Yr, with an average of $15 SF/Yr and extend to $22.50 SF/Yr.
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