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    Columbia, SC
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    Columbia, SC Commercial Real Estate for Lease

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    Cayce, SC West Columbia, SC Lexington, SC
    368 results
    Main Street
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    Turnkey Medical Office Suites
    $20 SF/Yr
    3,742 SF

    Turnkey Medical Office Suites

    4100 N. Main Street, Columbia, SC 29203

    Turnkey suites with exam rooms and plumbing, recently renovated common areas, designed for efficient medical operations.

    • 1987‑built medical office with turnkey suites featuring exam rooms with plumbing
    • Suite 101: ±2,484 SF available 8/1/26
    • Suite 200: ±1,226 SF with reception, 3 exam rooms (with plumbing), 1 private office, and restroom
    • Suite 201: ±2,516 SF with large reception/waiting area, 6 exam rooms (with plumbing), 2 private offices, IT/storage rooms, and restroom
    • Major renovations in 2019 included new roof, building façade, and common area upgrades
    Updated: Jun 2
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    SC, Columbia - Stoneridge Drive
    $129-$7,236/Mo

    SC, Columbia - Stoneridge Drive

    140 Columbia Ave, Columbia, SC 29210

    Workspaces, services and support to help you work better in SC, Columbia - Stoneridge Drive

    • Be part of a vibrant coworking community with dedicated desk or hot desking options in thousands of idyllic locations across the globe
    • Grow in a modern workplace with the added advantage of a benefits program offering exclusive discounts and bespoke procurement support
    • Access Regus' network of workspaces and business lounges as often as you need and take advantage of their exclusive benefits
    • Impress clients, hold memorable workshops, and deliver a winning pitch in Regus' meeting spaces, fully equipped for gatherings of any size
    • Collaborate with like‑minded professionals and enjoy regular networking and community events with a Regus membership
    Updated: Feb 19
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    SC, Columbia - 1501 Main St
    $129-$4,896/Mo

    SC, Columbia - 1501 Main St

    Discover many ways to work your way in SC, Columbia - 1501 Main St

    1501 Main St, Unit 501, Columbia, SC 29201
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    Freestanding Retail Building For Lease
    $14 SF/Yr
    5,000 SF

    Freestanding Retail Building For Lease

    Freestanding retail building in high-traffic area near Dutch Square Mall.

    422 Bush River Road, Columbia, SC 29210
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    Reimagined Class-A Office Space
    $25 SF/Yr
    7,521 SF

    Reimagined Class-A Office Space

    Newly renovated office space in prime downtown location.

    1710 Gervais St., Columbia, SC 29201
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    Columbia Flex Space For Lease
    $12 SF/Yr
    12,550 SF

    Columbia Flex Space For Lease

    Flex space available for lease in Columbia, South Carolina.

    901 Brookwood Drive, Columbia, SC 29201
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    Two-Story Office Building For Rent
    $16 SF/Yr
    3,960 SF

    Two-Story Office Building For Rent

    Two-story office building with flexible layout in central Columbia.

    123 Lawand Dr, Columbia, SC 29210
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    Office Space in Vista District
    $23 SF/Yr
    6,782 SF

    Office Space in Vista District

    Office spaces for lease in Columbia's popular Vista district.

    500 Taylor Street, Columbia, SC 29201
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    Retail Space on High-Traffic Corridor
    $25 SF/Yr
    3,591 SF

    Retail Space on High-Traffic Corridor

    3,500 SF retail space on Taylor St, ample parking.

    1531 Taylor St, Columbia, SC 29201
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    Premier Office Tower with Capitol Views
    $40 SF/Yr
    2,289 SF

    Premier Office Tower with Capitol Views

    Office space in Columbia's premier tower with integrated parking.

    1221 Main Street, Columbia, SC 29201
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    Former Restaurant on Decker Boulevard
    $22 SF/Yr
    4,320 SF

    Former Restaurant on Decker Boulevard

    4,320 SF former restaurant with drive-thru on 1.13 AC.

    2600 Decker Boulevard, Columbia, SC 29206
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    Office Space For Rent
    $20 SF/Yr
    15,000 SF

    Office Space For Rent

    Office suites available in Columbia, between Downtown and Forest Acres.

    3321 Forest Drive, Columbia, SC 29204
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    Historic Arcade Mall Retail Space
    $600/Mo
    39,320 SF

    Historic Arcade Mall Retail Space

    Historic indoor shopping center with high-end finishes in downtown Columbia.

    1332 Main St, Columbia, SC 29201
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    Office Property Near Downtown Columbia
    $17 SF/Yr
    8,181 SF

    Office Property Near Downtown Columbia

    Office and flex spaces available near I-20 and I-26.

    720 Gracern Rd, Columbia, SC
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    Prime Office Space on Devine
    $23 SF/Yr
    12,200 SF

    Prime Office Space on Devine

    Office space for lease in the Devine Street District.

    2422 Devine Street, Columbia, SC 29205
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    Retail Building in Devine Street
    $21 SF/Yr
    4,050 SF

    Retail Building in Devine Street

    Retail or office building with ample parking in the rear.

    2418 Devine Street, Columbia, SC 29205
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    Warehouse with Secured Yard
    $12 SF/Yr
    5,000 SF

    Warehouse with Secured Yard

    5,000 SF warehouse with office and secured yard.

    125 North Shorecrest Drive, Columbia, SC 29209
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    Downtown Columbia Office Space Available
    $21 SF/Yr
    17,594 SF

    Downtown Columbia Office Space Available

    Prime office space for rent in downtown Columbia.

    1333 Main Street, Columbia, SC 29201
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    Columbia Office Building For Lease
    $14 SF/Yr
    16,966 SF

    Columbia Office Building For Lease

    Class B office space with interstate visibility and modern amenities.

    1628 Browning Road, Columbia, SC 29210
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    Devine Street Office Space Available
    $18 SF/Yr
    10,500 SF

    Devine Street Office Space Available

    Office space for lease on highly trafficked Devine Street.

    2442 Devine St., Columbia, SC 29205
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    Class A Office Space Available
    $20 SF/Yr
    35,838 SF

    Class A Office Space Available

    Premium office building with high-tech infrastructure and convenient access.

    1400 Browning Road, Columbia, SC 29210
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    Columbia Office Space For Lease
    $17 SF/Yr
    7,072 SF

    Columbia Office Space For Lease

    High-quality office space in a well-located Columbia area.

    8910 Two Notch Road, Columbia, SC 29223
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    Premier Office Complex in Columbia
    $12 SF/Yr
    20,733 SF

    Premier Office Complex in Columbia

    Centrally located office complex with amenities and interstate visibility.

    300 Arbor Lake Drive, Columbia, SC 29223
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    Columbia, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Columbia, SC with 368 listings featured on our commercial real estate exchange. The current inventory includes 3,269,066 square feet of properties with an estimated lease value of $12,035 /Mo.

    Estimated lease rates for Commercial real estate in Columbia, SC begin at $1.65 SF/Yr, with an average of $58 SF/Yr and extend to $8,000 /Mo.
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    Most Searched ZIP Codes in Columbia, SC

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