Advertise
    Florence, SC

    Florence, SC Commercial Real Estate for Lease

    Notify Me
    List
    Map
    Darlington, SC Timmonsville, SC Hawthorne, FL Hartsville, SC Marion, SC Lake City, SC Dillon, SC
    39 properties
    Sort:
    Two-Unit Retail Conversion Opportunity
    Updated: May 10
    Two-Unit Retail Conversion Opportunity

    225 W Lucas St, Florence, SC 29501

    $2,500/Mo
    2,304 sqft
    Two‑unit commercial property built in 1983 at 225 W Lucas St (front) and 223 W Lucas St (rear), Florence, SC 29501
    Front unit currently a convenience store and includes natural gas access, a commercial hood vent, take‑out window, and seating area for restaurant conversion
    Rear unit has a liquor store permit application underway (223 W Lucas St), positioning dual revenue streams on one site
    Property sits on the US‑52/Lucas Street Corridor with an average daily traffic count of 24,700 vehicles
    Located just minutes from I‑95 and surrounded by 5,000+ hotel rooms
    View details
    Industrial Flex Building with Bay Doors
    Updated: Oct 11, 2025
    Industrial Flex Building with Bay Doors

    374 Darlington St., Florence, SC 29501

    $5,000/Mo
    11,390 sqft
    Year built: 1951
    Downtown Florence, SC commercial property with multiple bay doors
    Versatile open space suitable for vehicle, equipment, or flexible commercial use
    Front office space plus restrooms for staff and clients
    Rent listed at $5,000/month
    View details
    Restaurant Space with Drive-Thru
    Restaurant Space with Drive-Thru

    1104 Pamplico Highway, Florence, SC 29505

    Contact for pricing
    2,700 sqft

    2,700 SF restaurant space with existing drive-thru.

    View details
    Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center
    Special-Use Office Building
    Special-Use Office Building

    191 South Cashua Drive, Florence, SC 29501

    Contact for pricing
    2,560 sqft

    Well-positioned special-use office building with on-site parking and established visibility for medical or professional use.

    View details
    Florence Flex/Industrial Property for Lease
    Florence Flex/Industrial Property for Lease

    3731 East National Cemetery Road, Florence, SC 29506

    Contact for pricing
    4,800 sqft

    4,800 SF flex/industrial building with drive-through capability and outside storage.

    View details
    Retail Space in Regional Destination
    Retail Space in Regional Destination

    112-120 Woody Jones Blvd, Florence, SC

    $22 SF/Yr
    2,800 sqft

    Retail space available in premier shopping center, built in 2015.

    View details
    Multi-Tenant Retail Office Building
    Multi-Tenant Retail Office Building

    181 S Cashua Dr, Florence, SC 29501

    Contact for pricing
    7,500 sqft

    Shell space with a rear drive-in door, front parking, and monument and above-suite signage options along S Cashua Drive.

    View details
    Medical Office Building Near MUSC
    Medical Office Building Near MUSC

    1929 Mountain Laurel Court, Florence, SC

    Contact for pricing
    7,950 sqft

    Medical office building near MUSC campus with ample parking.

    View details
    Versatile Office Space Available
    Versatile Office Space Available

    420 W Cheves St, Florence, SC 29501

    $1,400/Mo
    1,500 sqft

    Approximately 1,500 sq ft office space for rent.

    View details
    Commercial Office Space For Rent
    Commercial Office Space For Rent

    2527 S Cashua Dr, Florence, SC 29501

    $1,950/Mo
    2,000 sqft

    Office space available in Shoppes at Celebration shopping center.

    View details
    Flex Warehouse with Showroom
    Flex Warehouse with Showroom

    511 N Irby St, Florence, SC 29501

    $4,500/Mo

    Single-tenant building with showroom, warehouse space, two rollup doors, and a fully fenced yard on 1.09 acres.

    View details
    Downtown Florence Mixed-Use Space
    Downtown Florence Mixed-Use Space

    127 W Evans St, Florence, SC 29501

    $25 SF/Yr
    1,800 sqft

    Prime mixed-use space in Downtown Florence Historic District.

    View details
    Refreshed Office Building For Lease
    Refreshed Office Building For Lease

    620 W Evans Street, Florence, SC 29501

    $4,500/Mo
    3,000 sqft

    Standalone office building near Downtown Florence with private parking.

    View details
    Office Building with I-95 Visibility
    Office Building with I-95 Visibility

    2240 North Douglas Street, Florence, SC 29501

    Contact for pricing

    Office building in a professional business park with visibility from I-95 and convenient access to I-20.

    View details
    Warehouse with Showroom and Yard
    Warehouse with Showroom and Yard

    511 Irby Street, Florence, SC 29501

    Contact for pricing

    Single tenant building with showroom, warehouse, and fenced yard.

    View details
    Retail Space in Regional Destination
    Retail Space in Regional Destination

    104 Woody Jones Blvd, Florence, SC

    $25 SF/Yr
    2,400 sqft

    Retail spaces available in premier shopping destination, built in 2015.

    View details
    Modern Office Space For Rent
    Modern Office Space For Rent

    2701 Alex Lee Blvd, Florence, SC 29506

    $22 SF/Yr
    7,145 sqft

    7,145 SF customizable office space in Florence, SC.

    View details
    Refreshed Office Building For Lease
    Refreshed Office Building For Lease

    620 W Evans St, Florence, SC 29501

    $216 SF/Yr
    3,000 sqft

    Standalone office building with private parking near Downtown Florence, SC.

    View details
    Retail Space at Claussen Shops
    Retail Space at Claussen Shops

    2332 Pamplico Hwy, Florence, SC 29505

    $16 SF/Yr
    3,600 sqft

    Grocery-anchored retail space for lease with ample parking.

    View details
    Retail Space in Florence, SC
    Retail Space in Florence, SC

    2600 David H Mcleod Blvd, Florence, SC

    Contact for pricing
    8,000 sqft

    8,000 SF retail space available for lease.

    View details
    Retail Space in Five Points
    Retail Space in Five Points

    1939 Hoffmeyer Rd, Florence, SC 29501

    $25 SF/Yr
    2,700 sqft

    End-cap retail space in a high-traffic area for lease.

    View details
    Retail Space in Regional Destination
    Retail Space in Regional Destination

    110 Woody Jones Blvd, Florence, SC

    $22 SF/Yr
    4,475 sqft

    Retail spaces available in premier shopping destination near major highways.

    View details
    Renovated Retail Space on US-52
    Renovated Retail Space on US-52

    1611 S Irby St, Florence, SC 29505

    Contact for pricing
    22,800 sqft

    Anchor suite in renovated shopping center with high visibility.

    View details
    Industrial Distribution Warehouse
    Industrial Distribution Warehouse

    2982 Republic Ave, Florence, SC 29501

    Contact for pricing

    Distribution and warehouse space available for rent at 2982 Republic Ave in Florence, SC.

    View details

    Florence, SC Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Florence, SC with 39 listings featured on our commercial real estate exchange. The current inventory includes 55,017 square feet of properties with an estimated lease value of $468.46 /Mo.

    Estimated lease rates for Commercial real estate in Florence, SC begin at $5.27 SF/Yr, with an average of $31.23 SF/Yr and extend to $216 SF/Yr.
    List
    Map

    Popular Searches in Florence, SC

    Popular Categories

    Most Searched ZIP Codes in Florence, SC

    • 29501
    • 29506
    • 29505

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!