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    Florence, SC

    Florence, SC Commercial Real Estate for Lease

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    49 properties
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    Flex Space with Bay Doors
    Updated: Oct 11, 2025
    Flex Space with Bay Doors

    374 Darlington St., Florence, SC 29501

    $5,000/Mo
    11,390 sqft 1.71 AC lot
    11,390‑square‑foot flex building on 1.71 acres
    Multiple bay doors support vehicle and equipment access
    Front office area for administrative functions
    Restrooms serve staff and visitors
    Built in 1951
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    Flexible Office Unit
    Updated: Jul 26
    Flexible Office Unit

    1604 2nd Loop Rd, Florence, SC 29501

    $2,000/Mo
    1,000 sqft
    Approximately 1,000 square feet of commercial space
    Flexible floor plan for office, medical, retail, or service‑oriented uses
    High‑visibility setting with exposure to local and through traffic
    Convenient access and ample parking
    Located at 1604 2nd Loop Rd, Florence, SC 29501
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    Retail Spaces in CrossRoads Center
    Retail Spaces in CrossRoads Center

    2522, 2524, 2528 David H McLeod Blvd, Florence, SC 29501

    $18,134/Mo
    95,840 sqft

    Retail spaces available in high-traffic Florence commercial corridor.

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    ESFR Distribution Center
    ESFR Distribution Center

    2494 Florence Harllee Boulevard, Florence, SC 29506

    $6.50 SF/Yr
    100,256 sqft

    Industrial facility offers dock access, drive-in loading, and warehouse-scale logistics functionality.

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    Shopping Center Retail Space
    Shopping Center Retail Space

    1945 W Palmetto St, Florence, SC 29501

    Contact for pricing
    4,062 sqft

    Retail space within a multi-tenant center, available for occupancy in 60 days.

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    Warehouse with Showroom and Yard
    Warehouse with Showroom and Yard

    511 N Irby St, Florence, SC 29501

    $4,500/Mo
    1.09 AC lot

    Single tenant building with showroom, warehouse, and fenced yard.

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    Restaurant Space with Drive-Thru
    Restaurant Space with Drive-Thru

    1104 Pamplico Highway, Florence, SC 29505

    Contact for pricing
    2,700 sqft 0.98 AC lot

    2,700 SF restaurant space with existing drive-thru.

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    Special-Use Office Building
    Special-Use Office Building

    191 South Cashua Drive, Florence, SC 29501

    Contact for pricing
    2,560 sqft 0.58 AC lot

    Well-positioned special-use office building with on-site parking and established visibility for medical or professional use.

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    Visible Retail Showroom Suite
    Visible Retail Showroom Suite

    1725 West Palmetto Street, Florence, SC 29501

    Contact for pricing
    1,140 sqft

    Open retail space with storage, restroom, shared parking, and exposure along W. Palmetto Street.

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    Class A Office Building
    Class A Office Building

    301 W Evans St, Florence, SC 29501

    Contact for pricing
    40,000 sqft

    Class A office building with controlled access, advanced HVAC, and fully customizable interiors across multiple stories.

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    High-Traffic Retail Shopping Center
    High-Traffic Retail Shopping Center

    2522-2530 David H McLeod Blvd, Florence, SC 29501

    Contact for pricing
    43,276 sqft

    Retail space within a high-traffic corridor just off I-20 and I-95 in Florence, SC.

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    Retail Space in Shopping Center
    Retail Space in Shopping Center

    2522-2530 David H McLeod Blvd, Florence, SC 29501

    Contact for pricing
    34,430 sqft

    Retail space located in a high-traffic retail hub along David H McLeod Blvd, just off I-20 and I-95.

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    Multi-Tenant Retail Office Building
    Multi-Tenant Retail Office Building

    181 S Cashua Dr, Florence, SC 29501

    Contact for pricing
    7,500 sqft 1.83 AC lot

    Shell space with a rear drive-in door, front parking, and monument and above-suite signage options along S Cashua Drive.

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    Retail Storefront in Redevelopment Hub
    Retail Storefront in Redevelopment Hub

    2295 Hoffmeyer Rd, Florence, SC 29501

    Contact for pricing
    3,441 sqft

    Retail storefront on Hoffmeyer Rd within an emerging mixed-use retail and lifestyle redevelopment.

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    Mixed-Use Retail and Office Space
    Mixed-Use Retail and Office Space

    2295 Hoffmeyer Rd, Florence, SC 29501

    Contact for pricing
    7,465 sqft

    7,465-square-foot property within a redevelopment featuring retail, office, medical, dining, and lifestyle spaces.

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    Three-Story Office Building
    Three-Story Office Building

    186 Dunbarton Drive, Florence, SC 29501

    Contact for pricing
    32,087 sqft

    Three-story office building offering private offices, open workspace, and a ground-floor café-style break room.

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    Retail Space with High-Traffic Frontage
    Retail Space with High-Traffic Frontage

    2295 Hoffmeyer Rd, Florence, SC 29501

    Contact for pricing
    8,750 sqft

    Retail space in West End District with 18,300+ AADT on Hoffmeyer Rd and combined traffic counts exceeding 30,000 VPD.

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    Light Industrial Warehouse Facility
    Light Industrial Warehouse Facility

    154 Lawson St, Florence, SC 29506

    Contact for pricing
    7,500 sqft 1.52 AC lot

    Light industrial warehouse on a fenced, gated lot with two drive-in doors and covered outdoor storage.

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    Flex Retail-Showroom Warehouse
    Flex Retail-Showroom Warehouse

    2295 Hoffmeyer Rd, Florence, SC 29501

    Contact for pricing
    33,360 sqft

    Flex space with dock-high doors and warehouse clear heights suited for retail, showroom, or distribution uses.

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    Retail Space
    Retail Space

    2201 Hoffmeyer Road, Florence, SC 29501

    Contact for pricing

    Multiple retail configurations are available for lease in Florence.

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    Remodeled Retail Space with Signage
    Remodeled Retail Space with Signage

    2221 Pamplico Highway, Florence, SC 29505

    Contact for pricing

    Two remodeled buildings offer retail and office configurations with on-site parking.

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    Office Building with I-95 Visibility
    Office Building with I-95 Visibility

    2240 North Douglas Street, Florence, SC 29501

    Contact for pricing

    Office building in a professional business park with visibility from I-95 and convenient access to I-20.

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    Florence Commercial Space For Rent
    Florence Commercial Space For Rent

    2843 W Palmetto St, Florence, SC 29501

    Contact for pricing

    Commercial space suitable for office, professional, or retail use.

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    Planned Development Outparcel Land
    Planned Development Outparcel Land

    3206 Pine Needles Rd, Florence, SC 29501

    Contact for pricing
    5.00 AC lot

    Land parcel with PD zoning and approximately 850 feet of frontage along Pine Needles Road, with utilities available.

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    Florence, SC Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Florence, SC with 49 listings featured on our commercial real estate exchange. The current inventory includes 1,232,255 square feet of properties with an estimated lease value of $38.04.

    Estimated lease rates for Commercial real estate in Florence, SC begin at $2.27 SF/Yr, with an average of $9.51 SF/Yr and extend to $24 SF/Yr.
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    Popular Searches in Florence, SC

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    Most Searched ZIP Codes in Florence, SC

    • 29501
    • 29505
    • 29506

    Featured Florence Real Estate Agencies

    Realmo connects you with licensed Florence CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Coldwell Banker McMillan and Associates
    419 S.Coit Street Florence, SC 29501
    Phone: 18436017710
    CBFlorence.com

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