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    Florence, SC
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    Florence, SC Commercial Real Estate for Lease

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    Darlington, SC Timmonsville, SC Hartsville, SC
    32 results
    Two-Unit Retail Conversion Opportunity
    $2,500/Mo
    2,304 SF
    Two-Unit Retail Conversion Opportunity

    225 W Lucas St, Florence, SC 29501

    Two storefront units with restaurant conversion-ready features on a high-traffic corridor near I-95.
    • Two‑unit commercial property built in 1983 at 225 W Lucas St (front) and 223 W Lucas St (rear), Florence, SC 29501
    • Front unit currently a convenience store and includes natural gas access, a commercial hood vent, take‑out window, and seating area for restaurant conversion
    • Rear unit has a liquor store permit application underway (223 W Lucas St), positioning dual revenue streams on one site
    • Property sits on the US‑52/Lucas Street Corridor with an average daily traffic count of 24,700 vehicles
    • Located just minutes from I‑95 and surrounded by 5,000+ hotel rooms
    Updated: May 10
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    Office Building with Private Offices
    $2,900/Mo
    3,100 SF
    Office Building with Private Offices

    720 S Coit St, Florence, SC 29501

    Functional office layout with hardwood floors, meeting room, kitchen, basement storage, and on-site parking for client-facing operations.
    • +/-3,600 SF office building for lease with a functional layout and multiple private offices
    • Dedicated meeting room plus receptionist area for client‑facing operations
    • Classic interior character with hardwood floors and carpet flooring; abundant natural light
    • Heat pump heating and central air conditioning
    • Full kitchen and basement with additional storage; covered rear area for extra storage or utility use
    Updated: May 6
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    Industrial Flex Building with Bay Doors
    $5,000/Mo
    11,390 SF
    Industrial Flex Building with Bay Doors

    Flexible industrial space with multiple bay doors and front office area for vehicle, equipment, and service operations.

    374 Darlington St., Florence, SC 29501

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    Retail Spaces in CrossRoads Center
    $18,134/Mo
    95,840 SF
    Retail Spaces in CrossRoads Center

    Retail spaces available in high-traffic Florence commercial corridor.

    2522, 2524, 2528 David H McLeod Blvd, Florence, SC 29501

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    Florence Flex/Industrial Property for Lease
    Contact for pricing
    4,800 SF
    Florence Flex/Industrial Property for Lease

    4,800 SF flex/industrial building with drive-through capability and outside storage.

    3731 East National Cemetery Road, Florence, SC 29506

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    Restaurant Space with Drive-Thru
    Contact for pricing
    2,700 SF
    Restaurant Space with Drive-Thru

    2,700 SF restaurant space with existing drive-thru.

    1104 Pamplico Highway, Florence, SC 29505

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    Commercial Land for Ground Lease
    Contact for pricing
    Commercial Land for Ground Lease

    2.38 acres available for ground lease in Florence, SC.

    3821 Bancroft Rd, Florence, SC 29501

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    Retail Space in Regional Destination
    $22 SF/Yr
    2,800 SF
    Retail Space in Regional Destination

    Retail space available in premier shopping center, built in 2015.

    112-120 Woody Jones Blvd, Florence, SC

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    Commercial Office Space For Rent
    $1,950/Mo
    2,000 SF
    Commercial Office Space For Rent

    Office space available in Shoppes at Celebration shopping center.

    2527 S Cashua Dr, Florence, SC 29501

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    Warehouse with Showroom and Yard
    Contact for pricing
    Warehouse with Showroom and Yard

    Single tenant building with showroom, warehouse, and fenced yard.

    511 Irby Street, Florence, SC 29501

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    Retail Space in Regional Destination
    $25 SF/Yr
    2,400 SF
    Retail Space in Regional Destination

    Retail spaces available in premier shopping destination, built in 2015.

    104 Woody Jones Blvd, Florence, SC

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    Modern Office Space For Rent
    $22 SF/Yr
    7,145 SF
    Modern Office Space For Rent

    7,145 SF customizable office space in Florence, SC.

    2701 Alex Lee Blvd, Florence, SC 29506

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    Florence Warehouse in West End
    $90 SF/Yr
    36,360 SF
    Florence Warehouse in West End

    Warehouse in Florence's West End District, near major retailers.

    2295 Hoffmeyer Rd, Florence, SC 29501

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    Retail Space in Florence, SC
    Contact for pricing
    8,000 SF
    Retail Space in Florence, SC

    8,000 SF retail space available for lease.

    2600 David H Mcleod Blvd, Florence, SC

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    Refreshed Office Building For Lease
    $216 SF/Yr
    3,000 SF
    Refreshed Office Building For Lease

    Standalone office building with private parking near Downtown Florence, SC.

    620 W Evans St, Florence, SC 29501

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    New Office Space Available
    $26 SF/Yr
    3,600 SF
    New Office Space Available

    Shell space in a new building, build-out to suit.

    609 2nd Loop Rd, Florence, SC 29505

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    Retail Space in Regional Destination
    $22 SF/Yr
    4,475 SF
    Retail Space in Regional Destination

    Retail spaces available in premier shopping destination near major highways.

    110 Woody Jones Blvd, Florence, SC

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    Prime Land for Lease
    Contact for pricing
    Prime Land for Lease

    Strategically located land parcel with high visibility and access.

    3335 Sneed Rd, Florence, SC

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    Downtown Florence Open Concept Office
    $226 SF/Yr
    Downtown Florence Open Concept Office

    Open concept office space with exceptional visibility in Downtown Florence.

    620 W Evans St, Florence, SC 29501

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    Office/Storage Space For Lease
    $10 SF/Yr
    2,300 SF
    Office/Storage Space For Lease

    Office or storage space with access to I-95 and I-20.

    1092 S Church St, Florence, SC 29506

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    Retail Space in Five Points
    $25 SF/Yr
    2,700 SF
    Retail Space in Five Points

    End-cap retail space in a high-traffic area for lease.

    1939 Hoffmeyer Rd, Florence, SC 29501

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    Laydown Yard For Lease
    $0.39 SF/Yr
    Laydown Yard For Lease

    0.85 acre fenced laydown yard in Florence, SC.

    1927 E Palmetto St, Florence, SC 29506

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    New Warehouse Space Available
    Contact for pricing
    11,250 SF
    New Warehouse Space Available

    New warehouse with flexible space in established industrial park.

    Broughton Blvd, Florence, SC 29501

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    Established Commercial Complex on Second Loop
    Contact for pricing
    2,000 SF
    Established Commercial Complex on Second Loop

    Multi-tenant commercial complex with high visibility and convenient access.

    1800 2nd Loop Rd, Florence, SC 29501

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    Florence, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Florence, SC with 32 listings featured on our commercial real estate exchange. The current inventory includes 184,013 square feet of properties with an estimated lease value of $524 /Mo.

    Estimated lease rates for Commercial real estate in Florence, SC begin at $2 SF/Yr, with an average of $34 SF/Yr and extend to $216 SF/Yr.
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