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    Spartanburg County, SC Commercial Real Estate for Lease

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    Greenville, SC Columbia, SC Charleston, SC
    256 results
    Premier Medical Office Space Available
    $20 SF/Yr
    7,039 SF
    Premier Medical Office Space Available

    1650 Skylyn Drive, Spartanburg, SC 29307

    Class A medical office space in Spartanburg's prime location.
    • Premier Class A medical office space, strategically located on the Mary Black campus, unique to the Spartanburg market.
    • On‑site wellness amenity suite featuring a fitness gym, swimming pool, and smoothie bar exclusively for building tenants.
    • Lower NNN fees than comparable properties.
    • Direct access to the Drayton Mills Trail and proximity to the vibrant Drayton Mills mixed‑use development.
    • Abundant parking.
    Updated: Mar 7
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    Restaurant Space in Drayton Mills
    $29 SF/Yr
    6,979 SF
    Restaurant Space in Drayton Mills

    1802 Drayton Road Suite I, Spartanburg, SC 29307

    Second-generation restaurant space in a historic mixed-use development.
    • Second‑generation restaurant space significantly reduces startup costs and time to opening.
    • Located at the entrance to the vibrant Drayton Mills mixed‑use development.
    • ±6,979 SF space within a fully restored historic mill environment.
    • High ceilings, exposed brick, large windows, and authentic mill character.
    • Located within Drayton Mills live‑work campus with 500+ residents and consistent daily foot traffic.
    Updated: Mar 5
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    Highway 290 Retail Development Space
    $40 SF/Yr
    9,850 SF
    Highway 290 Retail Development Space

    Retail/office space in growing Duncan market near Highway 290.

    1723 East Main Street, Duncan, SC 29334

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    Spartanburg Automotive Shop For Lease
    $11 SF/Yr
    2,000 SF
    Spartanburg Automotive Shop For Lease

    2,000 SF automotive shop or light industrial space available.

    51A Dexter Rd, Spartanburg, SC 29303

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    Spartanburg Storefront Retail/Office Space
    $15 SF/Yr
    2,046 SF
    Spartanburg Storefront Retail/Office Space

    Renovated 2,046 SF retail/office space in downtown Spartanburg.

    512 E Main St, Spartanburg, SC 29302

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    New Retail Development on Highway 9
    $38 SF/Yr
    3,189 SF
    New Retail Development on Highway 9

    New retail spaces available for lease in Boiling Springs, SC.

    2221 Boiling Springs Rd, Boiling Springs, SC

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    6,000 SF Flex Building I-85
    Contact for pricing
    6,000 SF
    6,000 SF Flex Building I-85

    Flex building with lay-down yard fronting I-85.

    50 Fairview Church Rd, Spartanburg, SC 29303

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    Move-in Ready Furnished Office Space
    $20 SF/Yr
    Move-in Ready Furnished Office Space

    Recently renovated, fully furnished office building in a prime location.

    792 John B White Sr Boulevard, Spartanburg, SC 29306

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    Spartanburg Retail Suites For Lease
    Contact for pricing
    74,481 SF
    Spartanburg Retail Suites For Lease

    Retail suites available in a high-traffic Spartanburg shopping center.

    2199 Southport Road, Spartanburg, SC 29302

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    Historic Mill Office Space Available
    $28 SF/Yr
    53,571 SF
    Historic Mill Office Space Available

    Creative office space in a vibrant mixed-use community.

    1802 Drayton Road, Suite 140B, Spartanburg, SC 29307

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    Premier Office Suite For Rent
    $700/Mo
    425 SF
    Premier Office Suite For Rent

    Executive office suite in a premier location with ample natural light.

    1451 E Main St, Spartanburg, SC

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    Retail Space in Booming Area
    $17 SF/Yr
    1,200 SF
    Retail Space in Booming Area

    Retail space in a thriving business park with high visibility.

    110 Rainbow Lake Rd, Boiling Springs, SC

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    Duncan Development Opportunity For Rent
    $5,670/Mo
    Duncan Development Opportunity For Rent

    4.2 AC development opportunity in Duncan, SC, near I-85.

    Apple Valley Road, Duncan, SC 29334

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    Industrial Space Near I-85
    $4 SF/Yr
    333,500 SF
    Industrial Space Near I-85

    241,100 SF industrial space with highway access near I-85.

    5950 N Main St, Cowpens, SC 29330

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    Industrial Space in Duncan, SC
    $8 SF/Yr
    28,000 SF
    Industrial Space in Duncan, SC

    28,000 SF industrial space for lease near I-85.

    925 Berry Shoals Rd, Duncan, SC 29334

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    Spartanburg Outdoor Storage Opportunity
    $4,000/Mo
    Spartanburg Outdoor Storage Opportunity

    4.38 AC outdoor storage lot for lease in Spartanburg.

    220 West Lanford Street |, Spartanburg, SC 29302

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    Retail Space with Highway Access
    $22 SF/Yr
    4,500 SF
    Retail Space with Highway Access

    4,500 SF retail space with flexible terms and visibility.

    2799 Reidville Rd, Spartanburg, SC

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    Freestanding Building with Drive-Thru
    Contact for pricing
    Freestanding Building with Drive-Thru

    Freestanding building with drive-thru in Duncan, South Carolina.

    1548 E Main St, Duncan, SC 29334

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    Industrial Facility Near Future Greenway
    Contact for pricing
    Industrial Facility Near Future Greenway

    Well-maintained industrial facility suitable for manufacturing, warehousing, or distribution.

    1090 South Shamrock Avenue, Landrum, SC 29356

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    Industrial Space in Apple Valley
    Contact for pricing
    75,320 SF
    Industrial Space in Apple Valley

    Industrial space for lease with excellent access to I-85.

    231-233 Apple Valley Rd, Duncan, SC 29334

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    Office Space on Asheville Highway
    $1,900/Mo
    1,191 SF
    Office Space on Asheville Highway

    Office space for lease with road frontage and ample parking.

    8891 Asheville Hwy, Boiling Springs, SC

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    Spartanburg Office Space Available
    $25 SF/Yr
    444 SF
    Spartanburg Office Space Available

    Office space available for rent in Spartanburg, South Carolina.

    324 E Saint John St, Spartanburg, SC

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    Renovated Office Space Available
    $20 SF/Yr
    1,500 SF
    Renovated Office Space Available

    Newly renovated office space in a high-visibility location.

    901 S Pine St, Spartanburg, SC

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    Retail Space in Westgate Mall
    $12 SF/Yr
    1,837 SF
    Retail Space in Westgate Mall

    Retail space available for lease in Westgate Mall.

    210-220 Westgate Mall Dr, Spartanburg, SC

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    Spartanburg County, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Spartanburg County, SC with 256 listings featured on our commercial real estate exchange. The current inventory includes 5,093,037 square feet of properties with an estimated lease value of $42,607.

    Estimated lease rates for Commercial real estate in Spartanburg County, SC begin at $3 SF/Yr, with an average of $383 /Mo and extend to $17,010 /Mo.
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