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    Spartanburg County, SC Commercial Real Estate for Lease

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    Columbia, SC Greenville, SC Charleston, SC
    268 results
    Premier Medical Office Space Available
    $20 SF/Yr
    7,039 SF

    Premier Medical Office Space Available

    1650 Skylyn Drive, Spartanburg, SC 29307

    Class A medical office space in Spartanburg's prime location.

    • Premier Class A medical office space, strategically located on the Mary Black campus, unique to the Spartanburg market.
    • On‑site wellness amenity suite featuring a fitness gym, swimming pool, and smoothie bar exclusively for building tenants.
    • Lower NNN fees than comparable properties.
    • Direct access to the Drayton Mills Trail and proximity to the vibrant Drayton Mills mixed‑use development.
    • Abundant parking.
    Updated: Mar 7
    View details
    Restaurant Space in Drayton Mills
    $29 SF/Yr
    6,979 SF

    Restaurant Space in Drayton Mills

    1802 Drayton Road Suite I, Spartanburg, SC 29307

    Second-generation restaurant space in a historic mixed-use development.

    • Second‑generation restaurant space significantly reduces startup costs and time to opening.
    • Located at the entrance to the vibrant Drayton Mills mixed‑use development.
    • ±6,979 SF space within a fully restored historic mill environment.
    • High ceilings, exposed brick, large windows, and authentic mill character.
    • Located within Drayton Mills live‑work campus with 500+ residents and consistent daily foot traffic.
    Updated: Mar 5
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    Highway 290 Retail Development Space
    $40 SF/Yr
    9,850 SF

    Highway 290 Retail Development Space

    Retail/office space in growing Duncan market near Highway 290.

    1723 East Main Street, Duncan, SC 29334
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    Spartanburg Automotive Shop For Lease
    $11 SF/Yr
    2,000 SF

    Spartanburg Automotive Shop For Lease

    2,000 SF automotive shop or light industrial space available.

    51A Dexter Rd, Spartanburg, SC 29303
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    New Retail Development on Highway 9
    $38 SF/Yr
    3,189 SF

    New Retail Development on Highway 9

    New retail spaces available for lease in Boiling Springs, SC.

    2221 Boiling Springs Rd, Boiling Springs, SC
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    Historic Mill Office Space Available
    $28 SF/Yr
    53,571 SF

    Historic Mill Office Space Available

    Creative office space in a vibrant mixed-use community.

    1802 Drayton Road, Suite 140B, Spartanburg, SC 29307
    View details
    Spartanburg Storefront Retail/Office Space
    $15 SF/Yr
    2,046 SF

    Spartanburg Storefront Retail/Office Space

    Renovated 2,046 SF retail/office space in downtown Spartanburg.

    512 E Main St, Spartanburg, SC 29302
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    Boiling Springs Outdoor Storage Lot
    $3,000/Mo

    Boiling Springs Outdoor Storage Lot

    10.60 AC outdoor storage lot for lease, Boiling Springs.

    201 Giles Dr, Boiling Springs, SC 29316
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    New Industrial Facility For Rent
    $12 SF/Yr
    11,900 SF

    New Industrial Facility For Rent

    New industrial facility in Spartanburg's logistics hub, ideal for warehousing.

    470 Old Greenville Rd, Spartanburg, SC 29301
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    Premier Office Suite For Rent
    $700/Mo
    425 SF

    Premier Office Suite For Rent

    Executive office suite in a premier location with ample natural light.

    1451 E Main St, Spartanburg, SC
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    Duncan Development Opportunity For Rent
    $5,670/Mo

    Duncan Development Opportunity For Rent

    4.2 AC development opportunity in Duncan, SC, near I-85.

    Apple Valley Road, Duncan, SC 29334
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    6,000 SF Flex Building I-85
    Contact for pricing
    6,000 SF

    6,000 SF Flex Building I-85

    Flex building with lay-down yard fronting I-85.

    50 Fairview Church Rd, Spartanburg, SC 29303
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    Spartanburg Retail Suites For Lease
    Contact for pricing
    74,481 SF

    Spartanburg Retail Suites For Lease

    Retail suites available in a high-traffic Spartanburg shopping center.

    2199 Southport Road, Spartanburg, SC 29302
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    Industrial Space in Duncan, SC
    $8 SF/Yr
    28,000 SF

    Industrial Space in Duncan, SC

    28,000 SF industrial space for lease near I-85.

    925 Berry Shoals Rd, Duncan, SC 29334
    View details
    Spartanburg Outdoor Storage Opportunity
    $4,000/Mo

    Spartanburg Outdoor Storage Opportunity

    4.38 AC outdoor storage lot for lease in Spartanburg.

    220 West Lanford Street |, Spartanburg, SC 29302
    View details
    Industrial Space Near I-85
    $4 SF/Yr
    333,500 SF

    Industrial Space Near I-85

    241,100 SF industrial space with highway access near I-85.

    5950 N Main St, Cowpens, SC 29330
    View details
    Spartanburg Warehouse Space Available
    $9 SF/Yr
    8,000 SF

    Spartanburg Warehouse Space Available

    Warehouse space for lease with easy access to major routes.

    480 Old Greenville Rd, Spartanburg, SC 29301
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    Duncan Warehouse Space Available
    $8 SF/Yr
    3,600 SF

    Duncan Warehouse Space Available

    Warehouse space featuring a dock door and office.

    140 Congress Blvd, Duncan, SC
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    Freestanding Building with Drive-Thru
    Contact for pricing

    Freestanding Building with Drive-Thru

    Freestanding building with drive-thru in Duncan, South Carolina.

    1548 E Main St, Duncan, SC 29334
    View details
    Prime Retail Space on Main
    $22 SF/Yr
    2,073 SF

    Prime Retail Space on Main

    High-traffic retail suites in downtown Spartanburg with ample parking.

    435 E Main St, Spartanburg, SC
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    Retail Space with Highway Access
    $22 SF/Yr
    4,500 SF

    Retail Space with Highway Access

    4,500 SF retail space with flexible terms and visibility.

    2799 Reidville Rd, Spartanburg, SC
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    Industrial Facility Near Future Greenway
    Contact for pricing

    Industrial Facility Near Future Greenway

    Well-maintained industrial facility suitable for manufacturing, warehousing, or distribution.

    1090 South Shamrock Avenue, Landrum, SC 29356
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    Industrial Space in Apple Valley
    Contact for pricing
    75,320 SF

    Industrial Space in Apple Valley

    Industrial space for lease with excellent access to I-85.

    231-233 Apple Valley Rd, Duncan, SC 29334
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    Office Space on Asheville Highway
    $1,900/Mo
    1,191 SF

    Office Space on Asheville Highway

    Office space for lease with road frontage and ample parking.

    8891 Asheville Hwy, Boiling Springs, SC
    View details

    Spartanburg County, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Spartanburg County, SC with 268 listings featured on our commercial real estate exchange. The current inventory includes 715,522,222,800 square feet of properties with an estimated lease value of $0.00 SF/Yr.

    Estimated lease rates for Commercial real estate in Spartanburg County, SC begin at $0.00 SF/Yr, with an average of $0.00 SF/Yr and extend to $0.00 SF/Yr.
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