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    Pickens County, SC Commercial Real Estate for Lease

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    46 properties
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    Freestanding Specialty Property
    Updated: Oct 24, 2025
    Freestanding Specialty Property

    106 N Pendleton Street, Easley, SC 29640

    $2,800/Mo
    Approximately 2,000 SF total building area
    Approximately 1,800 SF open interior area
    2 restrooms, small kitchenette, and storage closet
    Rear parking plus 2 handicap‑accessible spaces at the front
    Concrete flooring and metal construction
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    Finished Coffee Shop Space
    Updated: Jun 12, 2025
    Finished Coffee Shop Space

    382 College Avenue, Clemson, SC 29631

    $2,800/Mo
    Approximately 2100sqf of finished space
    Access from Kieth St
    Located in downtown Clemson
    Positioned beneath The Fizz Boutique
    Formerly occupied by The Grace Coffee Shop
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    Executive Office Units With Flexible Layouts
    Executive Office Units With Flexible Layouts

    1814 E Main Street Park, Easley, SC 29640

    $2,780/Mo

    Professional suites offer open areas, conference or training space, windows, elevators, and on-site parking.

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    Corner End-Cap Retail Space
    Corner End-Cap Retail Space

    1276 Eighteen Mile Rd, Central, SC 29630

    $18 SF/Yr
    2,856 sqft

    Shopping center suite with direct access and signage opportunities for retail, restaurant, or service uses.

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    Office Units with Flexible Floor Plans
    Office Units with Flexible Floor Plans

    1818 E Main Street Park, Easley, SC 29640

    $1,795/Mo

    Multi-floor professional offices offer windows, elevators, and on-site parking.

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    Retail Space with Basement Office
    Retail Space with Basement Office

    6818 Calhoun Memorial, Easley, SC 29640

    $1,350/Mo
    2,500 sqft

    Highway-facing commercial property combines flexible retail frontage with basement offices and on-site parking.

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    Retail Space with New HVAC
    Retail Space with New HVAC

    6811 Calhoun Memorial Hwy Ste A, Easley, SC 29640

    $16 SF/Yr
    1,200 sqft

    Available retail suite with NNN lease structure, on-site parking, signage options, and access from both sides of the property.

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    Renovated Retail Suite
    Renovated Retail Suite

    309 East Main Street, Pickens, SC 29671

    $1,100/Mo
    700 sqft

    Open layout with a private bath, tall ceilings, and abundant natural light.

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    Freestanding Restaurant with Drive-Thru
    Freestanding Restaurant with Drive-Thru

    5708 Calhoun Memorial Hwy, Easley, SC 29640

    $3,625/Mo
    3,625 sqft

    Freestanding restaurant building for lease with a drive-thru window and ample on-site parking.

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    Finished Coffee Shop Space
    Finished Coffee Shop Space

    382 College Avenue Basement Space, Clemson, SC 29631

    $2,800/Mo
    2,100 sqft

    Lower-level commercial space beneath The Fizz Boutique with Kieth St. access.

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    Ground-Floor Mixed-Use Suites
    Ground-Floor Mixed-Use Suites

    125 Anderson Hwy, Clemson, SC 29631

    Contact for pricing
    3,391 sqft

    Three leasing options within a student housing community accommodate retail, office, restaurant, and service-oriented uses.

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    First-Floor Retail and Office Suites
    First-Floor Retail and Office Suites

    125 Anderson Highway, Clemson, SC 29631

    $25 SF/Yr

    Three first-floor suites are available inside a 150-room, 500-bed student housing community on a high-traffic Clemson corridor.

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    Easley’s Carolina Center Shopping Center
    Easley’s Carolina Center Shopping Center

    838 Powdersville Rd Ste M, Easley, SC 29642

    $14 SF/Yr

    Suite M is part of a shopping center built in 1997 along Powdersville Road.

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    Retail Office Suite with Frontage
    Retail Office Suite with Frontage

    838 Powdersville Road, Easley, SC 29642

    $14 SF/Yr

    Convenient retail/office suite in Carolina Center with 1,675 feet of road frontage on Powdersville Road.

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    Freestanding Restaurant with Drive-Thru
    Freestanding Restaurant with Drive-Thru

    6205 Calhoun Memorial Hwy, Easley, SC 29642

    Contact for pricing
    3,576 sqft 0.74 AC lot

    Freestanding former restaurant offers a drive-thru, about 50 surface parking spaces, and strong frontage on a high-traffic corridor.

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    Office Building Adjacent to Hospital
    Office Building Adjacent to Hospital

    201 Richard St, Easley, SC 29640

    Contact for pricing
    4,036 sqft

    Office space available near Prisma Health Baptist Easley Hospital, with repaving and restriping planned for the parking lot.

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    Retail/Office Space For Rent
    Retail/Office Space For Rent

    5208-A Calhoun Memorial Hwy, Easley, SC 29640

    Contact for pricing
    1,200 sqft

    Retail/office space with high visibility and ample parking.

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    Visible Retail Space with Parking
    Visible Retail Space with Parking

    1943 East Main Street, Easley, SC 29640

    $10 SF/Yr

    Flexible interior with natural light and convenient customer access.

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    Retail or Office Suite
    Retail or Office Suite

    5823 Calhoun Memorial Highway, Easley, SC 29640

    Contact for pricing
    1,211 sqft

    Suite 1A provides flexible retail or office space within a highly visible shopping center with ample parking.

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    Office Suite with Boulevard Signage
    Office Suite with Boulevard Signage

    501 Forest Lane, Clemson, SC 29631

    Contact for pricing

    Three private offices support a flexible professional workspace with reception and meeting areas.

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    Private Office Unit
    Private Office Unit

    106 Earle St, Clemson, SC 29631

    Contact for pricing

    Two work areas, storage, a private bathroom, and utilities support flexible day-to-day operations.

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    Warehouse with Drive-In Doors
    Warehouse with Drive-In Doors

    161 Hunter Rd, Pickens, SC 29671

    Contact for pricing
    22,000 sqft 10.00 AC lot

    Flex warehouse space includes 13 drive-in doors, variable clear heights, office space, and optional leased yard.

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    Retail Shopping Center with Parking
    Retail Shopping Center with Parking

    500 Old Greenville Hwy, Clemson, SC 29631

    Contact for pricing
    1,760 sqft 9.49 AC lot

    Retail suites ranging up to 13,802 SF are available within a shopping center in Clemson’s CP2 district.

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    Retail Space on Highway 123
    Retail Space on Highway 123

    6811 Calhoun Memorial Hwy, Easley, SC

    Contact for pricing
    1,200 sqft 0.90 AC lot

    Retail space in Easley's trade area with high visibility.

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    Pickens County, SC Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Pickens County, SC with 46 listings featured on our commercial real estate exchange. The current inventory includes 4,942,709 square feet of properties with an estimated lease value of $143.86.

    Estimated lease rates for Commercial real estate in Pickens County, SC begin at $10 SF/Yr, with an average of $15.98 SF/Yr and extend to $25 SF/Yr.
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