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    Pickens County, SC Commercial Real Estate for Lease

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    Greenville, SC Columbia, SC Charleston, SC
    31 results
    Downtown Easley Retail Space
    $2,800/Mo
    2,000 SF

    Downtown Easley Retail Space

    106 N Pendleton Street, Easley, SC 29640

    Retail space in the heart of downtown Easley, South Carolina.

    • Prime downtown Easley location within Doodle Station.
    • Large open area (approximately 1,800 SF) suitable for various uses.
    • Ample parking at the rear of the building.
    • Two handicap accessible parking spaces in the front.
    • Free‑standing building.
    Updated: Oct 24, 2025
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    Premium Office Space in Easley
    $2,250/Mo

    Premium Office Space in Easley

    1818 E Main Street Park, Easley, SC 29640

    Professional office space with excellent visibility and ample parking.

    • Premium office complex with global tenants.
    • Convenient location directly off Hwy 123, close to Hwy 93, I‑85 corridor, Downtown Greenville, Clemson and Powdersville.
    • Ample free onsite parking.
    • Excellent visibility and walkability to restaurants and retail.
    • Versatile floor plans with high ceilings and large open areas.
    Updated: Apr 20
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    Downtown Clemson Retail Space Available
    $2,800/Mo

    Downtown Clemson Retail Space Available

    Retail space in downtown Clemson, formerly a coffee shop.

    382 College Avenue, Clemson, SC 29631
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    Retail Space on Highway 123
    $15 SF/Yr
    1,200 SF

    Retail Space on Highway 123

    Retail space in Easley's trade area with high visibility.

    6811 Calhoun Memorial Hwy, Easley, SC
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    Retail/Office Space For Rent
    Contact for pricing
    1,200 SF

    Retail/Office Space For Rent

    Retail/office space with high visibility and ample parking.

    5208-A Calhoun Memorial Hwy, Easley, SC 29640
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    Easley Town Center Retail Space
    Contact for pricing

    Easley Town Center Retail Space

    Retail space available in a 645,000 SF power center.

    185 Rolling Hills Circle, Easley, SC 29640
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    Remodeled Retail Building on Acreage
    $34 SF/Yr
    1,000 SF

    Remodeled Retail Building on Acreage

    Remodeled 1,000 SF retail building on 0.45 acres.

    5536 Calhoun Memorial Hwy, Easley, SC
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    Freestanding Restaurant Space Available
    $40 SF/Yr
    4,029 SF

    Freestanding Restaurant Space Available

    4,029 SF freestanding restaurant with drive-thru in Clemson, SC.

    1071 Tiger Blvd, Clemson, SC
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    Office Space in Easley, SC
    $13 SF/Yr
    2,589 SF

    Office Space in Easley, SC

    Office space available for lease in Easley, South Carolina.

    810 Powdersville Rd, Easley, SC
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    Easley Office Space Available
    $14 SF/Yr
    2,100 SF

    Easley Office Space Available

    Office space available for lease in Easley, South Carolina.

    836 Powdersville Rd, Easley, SC
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    Easley Office Space Available
    $11 SF/Yr
    3,422 SF

    Easley Office Space Available

    Office space available for rent in Easley, South Carolina.

    109 Fleetwood Dr, Easley, SC
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    Penthouse Office Floor For Rent
    $15 SF/Yr

    Penthouse Office Floor For Rent

    Penthouse office floor in a centrally located professional office complex.

    1818 E Main St, Easley, SC 29640
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    Spacious Office Suite on Main
    Contact for pricing

    Spacious Office Suite on Main

    Functional office suite with natural light and convenient access.

    1814 E Main St, Easley, SC 29640
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    600 Acres Build-to-Suit Opportunity
    Contact for pricing
    4,000,000 SF

    600 Acres Build-to-Suit Opportunity

    Available for rent: build-to-suit industrial space on 600 acres.

    3800 Calhoun Memorial Highway, Easley, SC 29640
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    Downtown Easley Retail Space Available
    Contact for pricing
    2,145 SF

    Downtown Easley Retail Space Available

    Retail suites available in Downtown Easley with courtyard access.

    112 S Pendleton St, Easley, SC 29640
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    Retail Space Near Clemson University
    Contact for pricing
    1,233 SF

    Retail Space Near Clemson University

    Publix-anchored retail space with high visibility near Clemson University.

    1390 Tiger Blvd, Clemson, SC
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    Industrial Property for Lease
    Contact for pricing

    Industrial Property for Lease

    Industrial property available for lease in Easley, South Carolina.

    407 Ross Avenue, Easley, SC 29640
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    Retail Space in High-Traffic Area
    Contact for pricing
    1,396 SF

    Retail Space in High-Traffic Area

    Retail space with strong tenant mix and high visibility.

    6101 Calhoun Memorial Hwy, Easley, SC
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    Mixed-Use Property Near Clemson Campus
    Contact for pricing

    Mixed-Use Property Near Clemson Campus

    Mixed-use property with residential and retail components near Clemson University.

    111 Earle Street, Clemson, SC 29631
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    Versatile Garage/Storage Building for Rent
    Contact for pricing

    Versatile Garage/Storage Building for Rent

    Secure storage and workshop space with easy highway access.

    698 Mount Bethel Road, Sunset, SC 29685
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    Retail/Restaurant Space Near Clemson University
    Contact for pricing
    1,401 SF

    Retail/Restaurant Space Near Clemson University

    Retail/restaurant spaces available in mixed-use student housing project.

    114 Earle St, Clemson, SC
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    Easley Land for Lease
    Contact for pricing
    337,500 SF

    Easley Land for Lease

    Large industrial land parcel available for ground lease or build-to-suit.

    Calhoun Memorial Hwy, Easley, SC
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    Retail/Restaurant Space Near Clemson University
    Contact for pricing
    3,500 SF

    Retail/Restaurant Space Near Clemson University

    Retail/restaurant space with dedicated parking and lake access.

    894 Tiger Blvd, Clemson, SC
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    Land Parcels Near Future C-Store
    Contact for pricing

    Land Parcels Near Future C-Store

    Land parcels available for rent near future C-Store.

    4314 Calhoun Memorial Hwy, Easley, SC
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    Pickens County, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Pickens County, SC with 31 listings featured on our commercial real estate exchange. The current inventory includes 35,921 square feet of properties with an estimated lease value of $179 SF/Yr.

    Estimated lease rates for Commercial real estate in Pickens County, SC begin at $11 SF/Yr, with an average of $19 SF/Yr and extend to $40 SF/Yr.
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