Advertise
    South Carolina

    Pickens County, SC Commercial Real Estate for Lease

    Notify Me
    List
    Map
    Greenville, SC Columbia, SC Charleston, SC North Charleston, SC Myrtle Beach, SC Spartanburg, SC Rock Hill, SC Summerville, SC
    35 properties
    Sort:
    Freestanding Specialty Property
    Updated: Oct 24, 2025
    Freestanding Specialty Property

    106 N Pendleton Street, Easley, SC 29640

    $2,800/Mo
    Approximately 2,000 SF total building area
    Approximately 1,800 SF open interior area
    2 restrooms, small kitchenette, and storage closet
    Rear parking plus 2 handicap‑accessible spaces at the front
    Concrete flooring and metal construction
    View details
    Finished Coffee Shop Space
    Updated: Jun 12, 2025
    Finished Coffee Shop Space

    382 College Avenue, Clemson, SC 29631

    $2,800/Mo
    Approximately 2100sqf of finished space
    Access from Kieth St
    Located in downtown Clemson
    Positioned beneath The Fizz Boutique
    Formerly occupied by The Grace Coffee Shop
    View details
    Executive Office Units With Flexible Layouts
    Executive Office Units With Flexible Layouts

    1814 E Main Street Park, Easley, SC 29640

    $2,580/Mo

    Professional suites offer open areas, conference or training space, windows, elevators, and on-site parking.

    View details
    Corner End-Cap Retail Space
    Corner End-Cap Retail Space

    1276 Eighteen Mile Rd, Central, SC 29630

    $18 SF/Yr
    2,856 sqft

    Shopping center suite with direct access and signage opportunities for retail, restaurant, or service uses.

    View details
    Office Units with Flexible Floor Plans
    Office Units with Flexible Floor Plans

    1818 E Main Street Park, Easley, SC 29640

    $1,660/Mo

    Multi-floor professional offices offer windows, elevators, and on-site parking.

    View details
    Retail Space with Basement Office
    Retail Space with Basement Office

    6818 Calhoun Memorial, Easley, SC 29640

    $1,350/Mo
    2,500 sqft

    Highway-facing commercial property combines flexible retail frontage with basement offices and on-site parking.

    View details
    Flex Space with Drive-In Doors
    Flex Space with Drive-In Doors

    303 Mossie Smith Rd, Easley, SC 29642

    $4,200/Mo
    3,580 sqft 0.70 AC lot

    Conditioned office space pairs with warehouse capacity for service, storage, and light industrial uses.

    View details
    Renovated Retail Suite
    Renovated Retail Suite

    309 East Main Street, Pickens, SC 29671

    $1,100/Mo
    700 sqft

    Open layout with a private bath, tall ceilings, and abundant natural light.

    View details
    Finished Coffee Shop Space
    Finished Coffee Shop Space

    382 College Avenue Basement Space, Clemson, SC 29631

    $2,800/Mo
    2,100 sqft

    Lower-level commercial space beneath The Fizz Boutique with Kieth St. access.

    View details
    Office Building Adjacent to Hospital
    Office Building Adjacent to Hospital

    201 Richard St, Easley, SC 29640

    Contact for pricing
    4,036 sqft

    Office space available near Prisma Health Baptist Easley Hospital, with repaving and restriping planned for the parking lot.

    View details
    First-Floor Retail and Office Suites
    First-Floor Retail and Office Suites

    125 Anderson Highway, Clemson, SC 29631

    $25 SF/Yr

    Three first-floor suites are available inside a 150-room, 500-bed student housing community on a high-traffic Clemson corridor.

    View details
    Retail Endcap in New Strip Center
    Retail Endcap in New Strip Center

    1298 18 Mile Road, Central, SC 29630

    Contact for pricing
    1,200 sqft

    A three-tenant retail center includes committed Dunkin’ Donuts and Great Clips locations.

    View details
    Freestanding Restaurant with Drive-Thru
    Freestanding Restaurant with Drive-Thru

    5708 Calhoun Memorial Hwy, Easley, SC 29640

    Contact for pricing
    3,625 sqft

    Freestanding restaurant building for lease with a drive-thru window and ample on-site parking.

    View details
    Retail Office Suite with Frontage
    Retail Office Suite with Frontage

    838 Powdersville Rd, Easley, SC 29642

    $14 SF/Yr

    Convenient retail/office suite in Carolina Center with 1,675 feet of road frontage on Powdersville Road.

    View details
    Freestanding Restaurant with Drive-Thru
    Freestanding Restaurant with Drive-Thru

    6205 Calhoun Memorial Hwy, Easley, SC 29642

    Contact for pricing
    3,576 sqft 0.74 AC lot

    Freestanding former restaurant offers a drive-thru, about 50 surface parking spaces, and strong frontage on a high-traffic corridor.

    View details
    Renovated End Cap Retail Suite
    Renovated End Cap Retail Suite

    2037 E Main Street, Easley, SC 29640

    Contact for pricing
    3,300 sqft

    Updated interior and highway exposure accommodate a range of retail or service concepts.

    View details
    Visible Retail Space with Parking
    Visible Retail Space with Parking

    1943 East Main Street, Easley, SC 29640

    $10 SF/Yr

    Flexible interior with natural light and convenient customer access.

    View details
    Office Suite with Boulevard Signage
    Office Suite with Boulevard Signage

    501 Forest Lane, Clemson, SC 29631

    Contact for pricing

    Three private offices support a flexible professional workspace with reception and meeting areas.

    View details
    Retail Space on Highway 123
    Retail Space on Highway 123

    6811 Calhoun Memorial Hwy Ste A, Easley, SC 29640

    $16 SF/Yr

    Retail space in Easley's trade area with high visibility.

    View details
    Private Office Unit
    Private Office Unit

    106 Earle St, Clemson, SC 29631

    Contact for pricing

    Two work areas, storage, a private bathroom, and utilities support flexible day-to-day operations.

    View details
    Retail Space Along Main Corridor
    Retail Space Along Main Corridor

    601 Williams Avenue, Easley, SC 29640

    Contact for pricing
    1.14 AC lot

    Two-building retail offering with available commercial space in Easley’s established shopping corridor.

    View details
    Retail Shopping Center with Parking
    Retail Shopping Center with Parking

    500 Old Greenville Hwy, Clemson, SC 29631

    Contact for pricing
    1,760 sqft 9.49 AC lot

    Retail suites ranging up to 13,802 SF are available within a shopping center in Clemson’s CP2 district.

    View details
    Warehouse Space
    Warehouse Space

    747 & 749 Black Snake Road, Easley, SC 29640

    Contact for pricing

    Warehouse space available for lease in Easley, South Carolina.

    View details
    600 Acres Build-to-Suit Opportunity
    600 Acres Build-to-Suit Opportunity

    3800 Calhoun Memorial Highway, Easley, SC 29640

    Contact for pricing
    4,000,000 sqft 600.00 AC lot

    Available for rent: build-to-suit industrial space on 600 acres.

    View details

    Pickens County, SC Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Pickens County, SC with 35 listings featured on our commercial real estate exchange. The current inventory includes 4,557,493 square feet of properties with an estimated lease value of $138.42.

    Estimated lease rates for Commercial real estate in Pickens County, SC begin at $6.48 SF/Yr, with an average of $15.38 SF/Yr and extend to $25 SF/Yr.
    List
    Map

    Commercial real estate by market

    Browse Commercial real estate for Lease Near Pickens, SC

    Popular Searches in Pickens

    Popular Categories

    Why this one?
    Saved
    Reason not saved — we won't ask again

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!