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    Pickens County, SC Commercial Real Estate for Lease

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    Columbia, SC Greenville, SC Charleston, SC
    30 results
    Downtown Clemson Retail Space Available
    $2,800 /Mo

    Downtown Clemson Retail Space Available

    382 College Avenue, Clemson, SC 29631

    Retail space in downtown Clemson, formerly a coffee shop.

    • Prime downtown Clemson location.
    • Approximately 2100 sqf. of finished space.
    • Accessible from Kieth St.
    • Central heating and cooling.
    • Durable brick construction.
    Updated: Jun 12, 2025
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    Easley Retail Leasing Opportunity
    $10 SF/Yr
    16,528 SF

    Easley Retail Leasing Opportunity

    1943 East Main Street, Easley, SC 29640

    Turnkey retail space with high visibility and ample parking.

    • Turnkey retail space ready for immediate occupancy.
    • High‑visibility location at the gateway to Downtown Easley with ± 15,300 VPD.
    • Abundant on‑site parking available.
    • Open, spacious floor plan with high ceilings and ample lighting.
    • Multiple signage opportunities available.
    Updated: Nov 26, 2025
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    Easley Town Center Retail Space
    Contact for pricing

    Easley Town Center Retail Space

    Retail space available in a 645,000 SF power center.

    185 Rolling Hills Circle, Easley, SC 29640
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    Retail Space on Highway 123
    $15 SF/Yr
    1,200 SF

    Retail Space on Highway 123

    Retail space in Easley's trade area with high visibility.

    6811 Calhoun Memorial Hwy, Easley, SC
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    Freestanding Restaurant Space Available
    $40 SF/Yr
    4,029 SF

    Freestanding Restaurant Space Available

    4,029 SF freestanding restaurant with drive-thru in Clemson, SC.

    1071 Tiger Blvd, Clemson, SC
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    Spacious Office Suite on Main
    Contact for pricing

    Spacious Office Suite on Main

    Functional office suite with natural light and convenient access.

    1814 E Main St, Easley, SC 29640
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    Office Space in Easley, SC
    $13 SF/Yr
    2,589 SF

    Office Space in Easley, SC

    Office space available for lease in Easley, South Carolina.

    810 Powdersville Rd, Easley, SC
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    Mixed-Use Property Near Clemson Campus
    Contact for pricing

    Mixed-Use Property Near Clemson Campus

    Mixed-use property with residential and retail components near Clemson University.

    111 Earle Street, Clemson, SC 29631
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    Easley Office Space Available
    $11 SF/Yr
    3,422 SF

    Easley Office Space Available

    Office space available for rent in Easley, South Carolina.

    109 Fleetwood Dr, Easley, SC
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    Remodeled Retail Building on Acreage
    $34 SF/Yr
    1,000 SF

    Remodeled Retail Building on Acreage

    Remodeled 1,000 SF retail building on 0.45 acres.

    5536 Calhoun Memorial Hwy, Easley, SC
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    Retail Space Near Clemson University
    Contact for pricing
    1,233 SF

    Retail Space Near Clemson University

    Publix-anchored retail space with high visibility near Clemson University.

    1390 Tiger Blvd, Clemson, SC
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    Penthouse Office Floor For Rent
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    Penthouse Office Floor For Rent

    Penthouse office floor in a centrally located professional office complex.

    1818 E Main St, Easley, SC 29640
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    Industrial Property for Lease
    Contact for pricing

    Industrial Property for Lease

    Industrial property available for lease in Easley, South Carolina.

    407 Ross Avenue, Easley, SC 29640
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    600 Acres Build-to-Suit Opportunity
    Contact for pricing
    4,000,000 SF

    600 Acres Build-to-Suit Opportunity

    Available for rent: build-to-suit industrial space on 600 acres.

    3800 Calhoun Memorial Highway, Easley, SC 29640
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    Easley Office Space Available
    $14 SF/Yr
    2,100 SF

    Easley Office Space Available

    Office space available for lease in Easley, South Carolina.

    836 Powdersville Rd, Easley, SC
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    Downtown Easley Retail Space Available
    Contact for pricing
    2,145 SF

    Downtown Easley Retail Space Available

    Retail suites available in Downtown Easley with courtyard access.

    112 S Pendleton St, Easley, SC 29640
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    Retail Space in High-Traffic Area
    Contact for pricing
    1,396 SF

    Retail Space in High-Traffic Area

    Retail space with strong tenant mix and high visibility.

    6101 Calhoun Memorial Hwy, Easley, SC
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    Land Parcels Near Future C-Store
    Contact for pricing

    Land Parcels Near Future C-Store

    Land parcels available for rent near future C-Store.

    4314 Calhoun Memorial Hwy, Easley, SC
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    Retail/Restaurant Space Near Clemson University
    Contact for pricing
    1,401 SF

    Retail/Restaurant Space Near Clemson University

    Retail/restaurant spaces available in mixed-use student housing project.

    114 Earle St, Clemson, SC
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    Easley Land for Lease
    Contact for pricing
    337,500 SF

    Easley Land for Lease

    Large industrial land parcel available for ground lease or build-to-suit.

    Calhoun Memorial Hwy, Easley, SC
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    Retail/Restaurant Space Near Clemson University
    Contact for pricing
    3,500 SF

    Retail/Restaurant Space Near Clemson University

    Retail/restaurant space with dedicated parking and lake access.

    894 Tiger Blvd, Clemson, SC
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    Retail Space in West End
    Contact for pricing
    1,800 SF

    Retail Space in West End

    Retail spaces available in high-traffic Easley location.

    504 W Main St, Easley, SC 29640
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    Commercial Land for Lease
    Contact for pricing

    Commercial Land for Lease

    Land available for ground lease or build to suit.

    Calhoun Memorial Hwy, Easley, SC 29640
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    Commercial Land Near Walmart
    Contact for pricing

    Commercial Land Near Walmart

    0.93 acre commercial land for rent, anchored by Walmart.

    2641 Gentry Memorial Hwy, Pickens, SC
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    Pickens County, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Pickens County, SC with 30 listings featured on our commercial real estate exchange. The current inventory includes 190,379,502,720 square feet of properties with an estimated lease value of $10 SF/Yr.

    Estimated lease rates for Commercial real estate in Pickens County, SC begin at $10 SF/Yr, with an average of $10 SF/Yr and extend to $10 SF/Yr.
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