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    Pickens County, SC Commercial Real Estate for Lease

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    28 properties
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    Downtown Easley Retail Space
    Updated: Oct 24, 2025
    Downtown Easley Retail Space

    106 N Pendleton Street, Easley, SC 29640

    $2,800/Mo
    2,000 sqft
    Prime downtown Easley location within Doodle Station.
    Large open area (approximately 1,800 SF) suitable for various uses.
    Ample parking at the rear of the building.
    Two handicap accessible parking spaces in the front.
    Free‑standing building.
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    Below-Boutique Retail Space
    Updated: Jun 12, 2025
    Below-Boutique Retail Space

    382 College Avenue, Clemson, SC 29631

    $2,800/Mo
    Approx. 2,100 SF of finished space
    Former Grace Coffee Shop location, currently below The Fizz Boutique
    Accessible from Kieth St
    Brick construction with tile flooring
    Central heating and central air conditioning
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    Professional Office Suites with Elevators
    Professional Office Suites with Elevators

    1814 E Main Street Park, Easley, SC 29640

    $4,995/Mo

    Executive-style office suites with elevators, abundant windows, and high-ceiling layouts in a well-parked professional complex.

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    Retail Space on Highway 123
    Retail Space on Highway 123

    6811 Calhoun Memorial Hwy, Easley, SC

    $15 SF/Yr
    1,200 sqft

    Retail space in Easley's trade area with high visibility.

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    Executive Park Office Suite
    Executive Park Office Suite

    1818 E Main Street Park, Easley, SC 29640

    $2,585/Mo

    Premium suite within a professional office complex with elevators, high ceilings, and ample onsite parking.

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    Retail/Office Space For Rent
    Retail/Office Space For Rent

    5208-A Calhoun Memorial Hwy, Easley, SC 29640

    Contact for pricing
    1,200 sqft

    Retail/office space with high visibility and ample parking.

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    First-Floor Retail and Office Suites
    First-Floor Retail and Office Suites

    125 Anderson Highway, Clemson, SC 29631

    $25 SF/Yr

    Three first-floor suites are available inside a 150-room, 500-bed student housing community on a high-traffic Clemson corridor.

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    Office Space in Easley, SC
    Office Space in Easley, SC

    810 Powdersville Rd, Easley, SC

    $13 SF/Yr
    2,589 sqft

    Office space available for lease in Easley, South Carolina.

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    Easley Office Space Available
    Easley Office Space Available

    109 Fleetwood Dr, Easley, SC

    $11 SF/Yr
    3,422 sqft

    Office space available for rent in Easley, South Carolina.

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    Penthouse Office Floor For Rent
    Penthouse Office Floor For Rent

    1818 E Main St, Easley, SC 29640

    $15 SF/Yr

    Penthouse office floor in a centrally located professional office complex.

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    600 Acres Build-to-Suit Opportunity
    600 Acres Build-to-Suit Opportunity

    3800 Calhoun Memorial Highway, Easley, SC 29640

    Contact for pricing
    4,000,000 sqft

    Available for rent: build-to-suit industrial space on 600 acres.

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    Retail Space Near Clemson University
    Retail Space Near Clemson University

    1390 Tiger Blvd, Clemson, SC

    Contact for pricing
    1,233 sqft

    Publix-anchored retail space with high visibility near Clemson University.

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    Easley Town Center Retail Space
    Easley Town Center Retail Space

    185 Rolling Hills Circle, Easley, SC 29640

    Contact for pricing

    Retail space available in a 645,000 SF power center.

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    Downtown Easley Retail Space Available
    Downtown Easley Retail Space Available

    112 S Pendleton St, Easley, SC 29640

    Contact for pricing
    2,145 sqft

    Retail suites available in Downtown Easley with courtyard access.

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    Industrial Property for Lease
    Industrial Property for Lease

    407 Ross Avenue, Easley, SC 29640

    Contact for pricing

    Industrial property available for lease in Easley, South Carolina.

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    Versatile Garage/Storage Building for Rent
    Versatile Garage/Storage Building for Rent

    698 Mount Bethel Road, Sunset, SC 29685

    Contact for pricing

    Secure storage and workshop space with easy highway access.

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    Mixed-Use Property Near Clemson Campus
    Mixed-Use Property Near Clemson Campus

    111 Earle Street, Clemson, SC 29631

    Contact for pricing

    Mixed-use property with residential and retail components near Clemson University.

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    Retail/Restaurant Space Near Clemson University
    Retail/Restaurant Space Near Clemson University

    114 Earle St, Clemson, SC

    Contact for pricing
    1,401 sqft

    Retail/restaurant spaces available in mixed-use student housing project.

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    Easley Land for Lease
    Easley Land for Lease

    Calhoun Memorial Hwy, Easley, SC

    Contact for pricing
    337,500 sqft

    Large industrial land parcel available for ground lease or build-to-suit.

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    Land Parcels Near Future C-Store
    Land Parcels Near Future C-Store

    4314 Calhoun Memorial Hwy, Easley, SC

    Contact for pricing

    Land parcels available for rent near future C-Store.

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    Retail Space in Pickens, SC
    Retail Space in Pickens, SC

    2700 Gentry Memorial Hwy, Pickens, SC 29671

    Contact for pricing
    16,188 sqft

    Retail spaces available within a shopping center.

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    Medical Office Building For Rent
    Medical Office Building For Rent

    109 Fleetwood Dr, Easley, SC 29640

    $11 SF/Yr
    18,631 sqft

    Medical office building offering approximately 18,631 square feet for lease.

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    Retail Space in Easley, SC
    Retail Space in Easley, SC

    5156 Calhoun Memorial Hwy, Easley, SC 29640

    $16 SF/Yr

    Retail space for rent with high traffic and ample parking.

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    Commercial Land for Lease
    Commercial Land for Lease

    Calhoun Memorial Hwy, Easley, SC 29640

    Contact for pricing

    Land available for ground lease or build to suit.

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    Pickens County, SC Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Pickens County, SC with 28 listings featured on our commercial real estate exchange. The current inventory includes 28,792 square feet of properties with an estimated lease value of $90.80 SF/Yr.

    Estimated lease rates for Commercial real estate in Pickens County, SC begin at $11 SF/Yr, with an average of $15.13 SF/Yr and extend to $24 SF/Yr.
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