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    Florence County, SC Commercial Real Estate for Lease

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    40 properties
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    Two-Unit Retail Conversion Opportunity
    Updated: May 10
    Two-Unit Retail Conversion Opportunity

    225 W Lucas St, Florence, SC 29501

    $2,500/Mo
    2,304 sqft
    Two‑unit commercial property built in 1983 at 225 W Lucas St (front) and 223 W Lucas St (rear), Florence, SC 29501
    Front unit currently a convenience store and includes natural gas access, a commercial hood vent, take‑out window, and seating area for restaurant conversion
    Rear unit has a liquor store permit application underway (223 W Lucas St), positioning dual revenue streams on one site
    Property sits on the US‑52/Lucas Street Corridor with an average daily traffic count of 24,700 vehicles
    Located just minutes from I‑95 and surrounded by 5,000+ hotel rooms
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    Industrial Flex Building with Bay Doors
    Updated: Oct 11, 2025
    Industrial Flex Building with Bay Doors

    374 Darlington St., Florence, SC 29501

    $5,000/Mo
    11,390 sqft
    Year built: 1951
    Downtown Florence, SC commercial property with multiple bay doors
    Versatile open space suitable for vehicle, equipment, or flexible commercial use
    Front office space plus restrooms for staff and clients
    Rent listed at $5,000/month
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    146,270 SF Industrial Warehouse
    146,270 SF Industrial Warehouse

    729 White Oak Dr, Johnsonville, SC 29555

    $146,270 SF/Yr
    146,270 sqft

    Industrial warehouse with versatile use options and strategic prime location.

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    Flex Warehouse with Showroom
    Flex Warehouse with Showroom

    511 N Irby St, Florence, SC 29501

    $4,500/Mo

    Single-tenant building with showroom, warehouse space, two rollup doors, and a fully fenced yard on 1.09 acres.

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    Restaurant Space with Drive-Thru
    Restaurant Space with Drive-Thru

    1104 Pamplico Highway, Florence, SC 29505

    Contact for pricing
    2,700 sqft

    2,700 SF restaurant space with existing drive-thru.

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    Special-Use Office Building
    Special-Use Office Building

    191 South Cashua Drive, Florence, SC 29501

    Contact for pricing
    2,560 sqft

    Well-positioned special-use office building with on-site parking and established visibility for medical or professional use.

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    Florence Flex/Industrial Property for Lease
    Florence Flex/Industrial Property for Lease

    3731 East National Cemetery Road, Florence, SC 29506

    Contact for pricing
    4,800 sqft

    4,800 SF flex/industrial building with drive-through capability and outside storage.

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    Timmonsville Flex Warehouse Facility
    Timmonsville Flex Warehouse Facility

    3324 North Sally Hill Road, Timmonsville, SC 29161

    Contact for pricing
    20,000 sqft

    20,000 SF flex warehouse near I-20 in Timmonsville, SC.

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    Retail Space in Regional Destination
    Retail Space in Regional Destination

    112-120 Woody Jones Blvd, Florence, SC

    $22 SF/Yr
    2,800 sqft

    Retail space available in premier shopping center, built in 2015.

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    Medical Office Building Near MUSC
    Medical Office Building Near MUSC

    1929 Mountain Laurel Court, Florence, SC

    Contact for pricing
    7,950 sqft

    Medical office building near MUSC campus with ample parking.

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    Versatile Office Space Available
    Versatile Office Space Available

    420 W Cheves St, Florence, SC 29501

    $1,400/Mo
    1,500 sqft

    Approximately 1,500 sq ft office space for rent.

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    Commercial Office Space For Rent
    Commercial Office Space For Rent

    2527 S Cashua Dr, Florence, SC 29501

    $1,950/Mo
    2,000 sqft

    Office space available in Shoppes at Celebration shopping center.

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    Downtown Florence Mixed-Use Space
    Downtown Florence Mixed-Use Space

    127 W Evans St, Florence, SC 29501

    $25 SF/Yr
    1,800 sqft

    Prime mixed-use space in Downtown Florence Historic District.

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    Office Building with I-95 Visibility
    Office Building with I-95 Visibility

    2240 North Douglas Street, Florence, SC 29501

    Contact for pricing

    Office building in a professional business park with visibility from I-95 and convenient access to I-20.

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    Warehouse with Showroom and Yard
    Warehouse with Showroom and Yard

    511 Irby Street, Florence, SC 29501

    Contact for pricing

    Single tenant building with showroom, warehouse, and fenced yard.

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    Retail Space in Regional Destination
    Retail Space in Regional Destination

    104 Woody Jones Blvd, Florence, SC

    $25 SF/Yr
    2,400 sqft

    Retail spaces available in premier shopping destination, built in 2015.

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    Modern Office Space For Rent
    Modern Office Space For Rent

    2701 Alex Lee Blvd, Florence, SC 29506

    $22 SF/Yr
    7,145 sqft

    7,145 SF customizable office space in Florence, SC.

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    Refreshed Office Building For Lease
    Refreshed Office Building For Lease

    620 W Evans St, Florence, SC 29501

    $216 SF/Yr
    3,000 sqft

    Standalone office building with private parking near Downtown Florence, SC.

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    Refreshed Office Building For Lease
    Refreshed Office Building For Lease

    620 W Evans Street, Florence, SC 29501

    $4,500/Mo
    3,000 sqft

    Standalone office building near Downtown Florence with private parking.

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    Retail Space in Lake City
    Retail Space in Lake City

    252 Kelley St, Lake City, SC

    Contact for pricing
    1,200 sqft

    Retail spaces available in a busy Lake City shopping center.

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    Retail Space at Claussen Shops
    Retail Space at Claussen Shops

    2332 Pamplico Hwy, Florence, SC 29505

    $16 SF/Yr
    3,600 sqft

    Grocery-anchored retail space for lease with ample parking.

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    Retail Space in Florence, SC
    Retail Space in Florence, SC

    2600 David H Mcleod Blvd, Florence, SC

    Contact for pricing
    8,000 sqft

    8,000 SF retail space available for lease.

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    Renovated Retail Space on US-52
    Renovated Retail Space on US-52

    1611 S Irby St, Florence, SC 29505

    Contact for pricing
    22,800 sqft

    Anchor suite in renovated shopping center with high visibility.

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    Retail Space in Five Points
    Retail Space in Five Points

    1939 Hoffmeyer Rd, Florence, SC 29501

    $25 SF/Yr
    2,700 sqft

    End-cap retail space in a high-traffic area for lease.

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    Florence County, SC Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Florence County, SC with 40 listings featured on our commercial real estate exchange. The current inventory includes 212,367 square feet of properties with an estimated lease value of $146,749.

    Estimated lease rates for Commercial real estate in Florence County, SC begin at $3 SF/Yr, with an average of $8,152 /Mo and extend to $146,270.
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