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    Florence County, SC Commercial Real Estate for Lease

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    55 properties
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    Flex Space with Bay Doors
    Updated: Oct 11, 2025
    Flex Space with Bay Doors

    374 Darlington St., Florence, SC 29501

    $5,000/Mo
    11,390 sqft 1.71 AC lot
    11,390‑square‑foot flex building on 1.71 acres
    Multiple bay doors support vehicle and equipment access
    Front office area for administrative functions
    Restrooms serve staff and visitors
    Built in 1951
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    Flexible Office Unit
    Updated: Jul 26
    Flexible Office Unit

    1604 2nd Loop Rd, Florence, SC 29501

    $2,000/Mo
    1,000 sqft
    Approximately 1,000 square feet of commercial space
    Flexible floor plan for office, medical, retail, or service‑oriented uses
    High‑visibility setting with exposure to local and through traffic
    Convenient access and ample parking
    Located at 1604 2nd Loop Rd, Florence, SC 29501
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    Retail Spaces in CrossRoads Center
    Retail Spaces in CrossRoads Center

    2522, 2524, 2528 David H McLeod Blvd, Florence, SC 29501

    $18,134/Mo
    95,840 sqft

    Retail spaces available in high-traffic Florence commercial corridor.

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    ESFR Distribution Center
    ESFR Distribution Center

    2494 Florence Harllee Boulevard, Florence, SC 29506

    $6.50 SF/Yr
    100,256 sqft

    Industrial facility offers dock access, drive-in loading, and warehouse-scale logistics functionality.

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    Shopping Center Retail Space
    Shopping Center Retail Space

    1945 W Palmetto St, Florence, SC 29501

    Contact for pricing
    4,062 sqft

    Retail space within a multi-tenant center, available for occupancy in 60 days.

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    Flex Warehouse with Showroom
    Flex Warehouse with Showroom

    511 N Irby St, Florence, SC 29501

    $4,500/Mo
    1.09 AC lot

    Single-tenant building with showroom, warehouse space, two rollup doors, and a fully fenced yard on 1.09 acres.

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    Restaurant Space with Drive-Thru
    Restaurant Space with Drive-Thru

    1104 Pamplico Highway, Florence, SC 29505

    Contact for pricing
    2,700 sqft 0.98 AC lot

    2,700 SF restaurant space with existing drive-thru.

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    Special-Use Office Building
    Special-Use Office Building

    191 South Cashua Drive, Florence, SC 29501

    Contact for pricing
    2,560 sqft 0.58 AC lot

    Well-positioned special-use office building with on-site parking and established visibility for medical or professional use.

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    Visible Retail Showroom Suite
    Visible Retail Showroom Suite

    1725 West Palmetto Street, Florence, SC 29501

    Contact for pricing
    1,140 sqft

    Open retail space with storage, restroom, shared parking, and exposure along W. Palmetto Street.

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    Warehouse Space Near Major Freight Corridors
    Warehouse Space Near Major Freight Corridors

    2982 Republic Ave, Florence, SC 29501

    Contact for pricing
    4,460 sqft

    Warehouse space located within minutes of I-95 and I-20 and within half a mile of Route 52.

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    Class A Office Building
    Class A Office Building

    301 W Evans St, Florence, SC 29501

    Contact for pricing
    40,000 sqft

    Class A office building with controlled access, advanced HVAC, and fully customizable interiors across multiple stories.

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    High-Traffic Retail Shopping Center
    High-Traffic Retail Shopping Center

    2522-2530 David H McLeod Blvd, Florence, SC 29501

    Contact for pricing
    43,276 sqft

    Retail space within a high-traffic corridor just off I-20 and I-95 in Florence, SC.

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    Retail Space in Shopping Center
    Retail Space in Shopping Center

    2522-2530 David H McLeod Blvd, Florence, SC 29501

    Contact for pricing
    34,430 sqft

    Retail space located in a high-traffic retail hub along David H McLeod Blvd, just off I-20 and I-95.

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    Multi-Tenant Retail Office Building
    Multi-Tenant Retail Office Building

    181 S Cashua Dr, Florence, SC 29501

    Contact for pricing
    7,500 sqft 1.83 AC lot

    Shell space with a rear drive-in door, front parking, and monument and above-suite signage options along S Cashua Drive.

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    Timmonsville Flex Warehouse Facility
    Timmonsville Flex Warehouse Facility

    3324 North Sally Hill Road, Timmonsville, SC 29161

    Contact for pricing
    20,000 sqft 2.61 AC lot

    20,000 SF flex warehouse near I-20 in Timmonsville, SC.

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    Retail Storefront in Redevelopment Hub
    Retail Storefront in Redevelopment Hub

    2295 Hoffmeyer Rd, Florence, SC 29501

    Contact for pricing
    3,441 sqft

    Retail storefront on Hoffmeyer Rd within an emerging mixed-use retail and lifestyle redevelopment.

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    Mixed-Use Retail and Office Space
    Mixed-Use Retail and Office Space

    2295 Hoffmeyer Rd, Florence, SC 29501

    Contact for pricing
    7,465 sqft

    7,465-square-foot property within a redevelopment featuring retail, office, medical, dining, and lifestyle spaces.

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    Three-Story Office Building
    Three-Story Office Building

    186 Dunbarton Drive, Florence, SC 29501

    Contact for pricing
    32,087 sqft

    Three-story office building offering private offices, open workspace, and a ground-floor café-style break room.

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    Retail Space with High-Traffic Frontage
    Retail Space with High-Traffic Frontage

    2295 Hoffmeyer Rd, Florence, SC 29501

    Contact for pricing
    8,750 sqft

    Retail space in West End District with 18,300+ AADT on Hoffmeyer Rd and combined traffic counts exceeding 30,000 VPD.

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    Light Industrial Warehouse Facility
    Light Industrial Warehouse Facility

    154 Lawson St, Florence, SC 29506

    Contact for pricing
    7,500 sqft 1.52 AC lot

    Light industrial warehouse on a fenced, gated lot with two drive-in doors and covered outdoor storage.

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    End-Unit Office Suite
    End-Unit Office Suite

    2843 W Palmetto St, Florence, SC 29501

    Contact for pricing

    Professional space with private offices, reception area, and an on-site restroom in a multi-suite building.

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    146,270 SF Industrial Warehouse
    146,270 SF Industrial Warehouse

    729 White Oak Dr, Johnsonville, SC 29555

    Contact for pricing
    146,270 sqft

    Industrial warehouse with versatile use options and strategic prime location.

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    Flex Retail-Showroom Warehouse
    Flex Retail-Showroom Warehouse

    2295 Hoffmeyer Rd, Florence, SC 29501

    Contact for pricing
    33,360 sqft

    Flex space with dock-high doors and warehouse clear heights suited for retail, showroom, or distribution uses.

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    Retail Space
    Retail Space

    2201 Hoffmeyer Road, Florence, SC 29501

    Contact for pricing

    Multiple retail configurations are available for lease in Florence.

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    Florence County, SC Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Florence County, SC with 55 listings featured on our commercial real estate exchange. The current inventory includes 1,402,985 square feet of properties with an estimated lease value of $38.04.

    Estimated lease rates for Commercial real estate in Florence County, SC begin at $2.27 SF/Yr, with an average of $9.51 SF/Yr and extend to $24 SF/Yr.
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    Featured Florence County Real Estate Agencies

    Realmo connects you with licensed Florence County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Coldwell Banker McMillan and Associates
    419 S.Coit Street Florence, SC 29501
    Phone: 18436017710
    CBFlorence.com

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