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    Florence County, SC Commercial Real Estate for Lease

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    25 properties
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    Restaurant Space with Driveway Access
    Updated: Sep 21
    Restaurant Space with Driveway Access

    3751 W Palmetto St, Florence, SC 29501

    $7,000/Mo
    4,190 sqft 1.00 AC lot
    4,190 SF restaurant space on a 1‑acre property
    Triple‑net lease structure
    Two driveway entrances and road frontage
    17,800 vehicles daily on US‑76
    36,300 vehicles daily on I‑95
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    Restaurant Space with Two Driveways
    Updated: Sep 21
    Restaurant Space with Two Driveways

    3751 W Palmetto St., Florence, SC 29501

    $7,000/Mo
    4,190 sqft 1.00 AC lot
    4,190 SF restaurant space available for lease
    1‑acre site with road frontage and on‑site parking
    Two driveway entrances support property access
    Triple‑net lease structure
    Just off I‑95 Exit 157
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    Dental Medical Office Suite
    Dental Medical Office Suite

    417 W Cheves Street, Florence, SC 29501

    $3,000/Mo
    1,850 sqft

    The layout includes operatories, laboratory space, reception areas, and a private office.

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    Restaurant Space Near I-95
    Restaurant Space Near I-95

    3751 W Palmetto St, Florence, SC 29501

    $7,000/Mo
    4,190 sqft

    Two driveway connections and on-site parking support customer access.

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    Office Building Near City Center
    Office Building Near City Center

    129 S Coit Street, Florence, SC 29501

    $1,400/Mo
    1,320 sqft

    A 1,320-square-foot office property built in 1959, positioned adjacent to City Center.

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    Flexible Office Unit
    Flexible Office Unit

    1604 2nd Loop Rd, Florence, SC 29501

    $1,800/Mo
    1,000 sqft

    Commercial space with adaptable layout, parking, and access for office, medical, retail, or service businesses.

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    Flex Space with Warehouse Shop
    Flex Space with Warehouse Shop

    120 W Freight Rd, Florence, SC 29501

    $16,500/Mo
    7,920 sqft 3.50 AC lot

    Office, showroom, and service-area improvements support a range of commercial operations.

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    ESFR Distribution Center
    ESFR Distribution Center

    2494 Florence Harllee Boulevard, Florence, SC 29506

    $6.50 SF/Yr
    100,256 sqft

    Industrial facility offers dock access, drive-in loading, and warehouse-scale logistics functionality.

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    Renovated Storefront Retail Space
    Renovated Storefront Retail Space

    2295 Hoffmeyer Road - Storefront B, Florence, SC 29501

    Contact for pricing
    7,405 sqft

    A renovated retail suite includes new HVAC, sprinkler protection, and access to on-site parking.

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    Shopping Center Retail Space
    Shopping Center Retail Space

    1945 W Palmetto St, Florence, SC 29501

    Contact for pricing
    4,062 sqft

    Retail space within a multi-tenant center, available for occupancy in 60 days.

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    Drive-Through Restaurant with Walk-Up Window
    Drive-Through Restaurant with Walk-Up Window

    1245 South Irby Street, Florence, SC 29505

    Contact for pricing
    734 sqft 0.50 AC lot

    The existing food-service building includes outdoor seating and on-site parking along a commercial corridor.

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    High-Traffic Retail Shopping Center
    High-Traffic Retail Shopping Center

    2522-2530 David H McLeod Blvd, Florence, SC 29501

    Contact for pricing
    43,276 sqft

    Retail space within a high-traffic corridor just off I-20 and I-95 in Florence, SC.

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    Retail Space in Shopping Center
    Retail Space in Shopping Center

    2522-2530 David H McLeod Blvd, Florence, SC 29501

    Contact for pricing
    34,430 sqft

    Retail space located in a high-traffic retail hub along David H McLeod Blvd, just off I-20 and I-95.

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    Medical Office with Four Operatories
    Medical Office with Four Operatories

    417 West Cheves Street, Florence, SC 29501

    Contact for pricing
    1,850 sqft

    A patient reception area, laboratory, private office, break room, and two restrooms support a functional clinical layout.

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    Character Office Unit
    Character Office Unit

    201 Graham Street, Florence, SC 29501

    Contact for pricing

    Historic office layout with private rooms, conference space, reception, and kitchenette.

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    Renovated Mixed-Use Storefront
    Renovated Mixed-Use Storefront

    2295 Hoffmeyer Road - Storefront A, Florence, SC 29501

    Contact for pricing

    Flexible commercial space combines a two-level office component with adaptable interior area and dock access.

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    146,270 SF Industrial Warehouse
    146,270 SF Industrial Warehouse

    729 White Oak Dr, Johnsonville, SC 29555

    Contact for pricing
    146,270 sqft

    Industrial warehouse with versatile use options and strategic prime location.

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    Flex Retail-Showroom Warehouse
    Flex Retail-Showroom Warehouse

    2295 Hoffmeyer Rd, Florence, SC 29501

    Contact for pricing
    33,360 sqft

    Flex space with dock-high doors and warehouse clear heights suited for retail, showroom, or distribution uses.

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    Florence Commercial Space For Rent
    Florence Commercial Space For Rent

    2843 W Palmetto St, Florence, SC 29501

    Contact for pricing

    Commercial space suitable for office, professional, or retail use.

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    Planned Development Outparcel Land
    Planned Development Outparcel Land

    3206 Pine Needles Rd, Florence, SC 29501

    Contact for pricing
    5.00 AC lot

    Land parcel with PD zoning and approximately 850 feet of frontage along Pine Needles Road, with utilities available.

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    Industrial Distribution Warehouse
    Industrial Distribution Warehouse

    2982 Republic Ave, Florence, SC 29501

    Contact for pricing

    Distribution and warehouse space available for rent at 2982 Republic Ave in Florence, SC.

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    Retail Space in Florence, SC
    Retail Space in Florence, SC

    2600 David H Mcleod Blvd, Florence, SC

    Contact for pricing
    8,000 sqft 4.31 AC lot

    8,000 SF retail space available for lease.

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    Modern Office Space For Rent
    Modern Office Space For Rent

    2701 Alex Lee Blvd, Florence, SC 29506

    Contact for pricing
    7,145 sqft

    7,145 SF customizable office space in Florence, SC.

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    Updated Strip Mall Suite
    Updated Strip Mall Suite

    1811 S Irby Suite 107, Florence, SC 29505

    Contact for pricing

    Open commercial space with refreshed interior finishes and plaza access from Attwood.

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    Florence County, SC Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Florence County, SC with 25 listings featured on our commercial real estate exchange. The current inventory includes 411,448 square feet of properties with an estimated lease value of $120.44.

    Estimated lease rates for Commercial real estate in Florence County, SC begin at $6.50 SF/Yr, with an average of $17.21 SF/Yr and extend to $21.60 SF/Yr.
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    Featured Florence County Real Estate Agencies

    Realmo connects you with licensed Florence County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Coldwell Banker McMillan and Associates
    419 S.Coit Street Florence, SC 29501
    Phone: 18436017710
    CBFlorence.com
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