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    Florence County, SC Commercial Real Estate for Lease

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    Greenville, SC Columbia, SC Charleston, SC
    35 results
    Adaptable Office Space in Florence
    $2,900/Mo
    3,100 SF

    Adaptable Office Space in Florence

    720 S Coit St, Florence, SC 29501

    Well-located office building for lease in a desirable professional location.

    • Prime location directly across from Timrod Park and minutes from downtown Florence.
    • Functional layout with multiple private offices, meeting room, and reception area.
    • Ample on‑site parking for employees and visitors.
    • Classic architectural character, hardwood floors, and abundant natural light.
    • Full kitchen and basement storage.
    Updated: May 6
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    Versatile Commercial Space in Florence
    $5,000/Mo
    11,390 SF

    Versatile Commercial Space in Florence

    374 Darlington St., Florence, SC 29501

    Commercial property with bay doors, ideal for automotive or warehouse.

    • Prime Downtown Florence, SC location
    • Multiple bay doors for easy access and operations
    • Versatile space suitable for automotive, warehouse, or service‑related businesses
    • Abundant open space for vehicles, equipment, or flexible use
    • Dedicated office space for administrative functions
    Updated: Oct 11, 2025
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    Retail Spaces in CrossRoads Center
    $18,134/Mo
    95,840 SF

    Retail Spaces in CrossRoads Center

    Retail spaces available in high-traffic Florence commercial corridor.

    2522, 2524, 2528 David H McLeod Blvd, Florence, SC 29501
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    146,270 SF Industrial Warehouse
    Contact for pricing
    146,270 SF

    146,270 SF Industrial Warehouse

    Industrial warehouse with versatile use options and strategic prime location.

    729 White Oak Dr, Johnsonville, SC 29555
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    Florence Flex/Industrial Property for Lease
    Contact for pricing
    4,800 SF

    Florence Flex/Industrial Property for Lease

    4,800 SF flex/industrial building with drive-through capability and outside storage.

    3731 East National Cemetery Road, Florence, SC 29506
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    Retail Space in Lake City
    $12 SF/Yr
    1,200 SF

    Retail Space in Lake City

    Retail spaces available in a busy Lake City shopping center.

    252 Kelley St, Lake City, SC
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    Restaurant Space with Drive-Thru
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    2,700 SF

    Restaurant Space with Drive-Thru

    2,700 SF restaurant space with existing drive-thru.

    1104 Pamplico Highway, Florence, SC 29505
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    Commercial Land for Ground Lease
    Contact for pricing

    Commercial Land for Ground Lease

    2.38 acres available for ground lease in Florence, SC.

    3821 Bancroft Rd, Florence, SC 29501
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    Retail Space in Regional Destination
    $22 SF/Yr
    2,800 SF

    Retail Space in Regional Destination

    Retail space available in premier shopping center, built in 2015.

    112-120 Woody Jones Blvd, Florence, SC
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    Industrial Warehouse with Rail Access
    Contact for pricing
    146,270 SF

    Industrial Warehouse with Rail Access

    146,270 sq ft warehouse for lease near rail line.

    729 White Oak Dr, Johnsonville, SC 29555
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    Commercial Office Space For Rent
    $1,950/Mo
    2,000 SF

    Commercial Office Space For Rent

    Office space available in Shoppes at Celebration shopping center.

    2527 S Cashua Dr, Florence, SC 29501
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    Timmonsville Flex Warehouse Facility
    Contact for pricing
    20,000 SF

    Timmonsville Flex Warehouse Facility

    20,000 SF flex warehouse near I-20 in Timmonsville, SC.

    3324 North Sally Hill Road, Timmonsville, SC 29161
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    Warehouse with Showroom and Yard
    Contact for pricing

    Warehouse with Showroom and Yard

    Single tenant building with showroom, warehouse, and fenced yard.

    511 Irby Street, Florence, SC 29501
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    Retail Space in Regional Destination
    $25 SF/Yr
    2,400 SF

    Retail Space in Regional Destination

    Retail spaces available in premier shopping destination, built in 2015.

    104 Woody Jones Blvd, Florence, SC
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    Modern Office Space For Rent
    $22 SF/Yr
    7,145 SF

    Modern Office Space For Rent

    7,145 SF customizable office space in Florence, SC.

    2701 Alex Lee Blvd, Florence, SC 29506
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    Florence Warehouse in West End
    $90 SF/Yr
    36,360 SF

    Florence Warehouse in West End

    Warehouse in Florence's West End District, near major retailers.

    2295 Hoffmeyer Rd, Florence, SC 29501
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    Retail Space in Florence, SC
    Contact for pricing
    8,000 SF

    Retail Space in Florence, SC

    8,000 SF retail space available for lease.

    2600 David H Mcleod Blvd, Florence, SC
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    Refreshed Office Building For Lease
    $216 SF/Yr
    3,000 SF

    Refreshed Office Building For Lease

    Standalone office building with private parking near Downtown Florence, SC.

    620 W Evans St, Florence, SC 29501
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    New Office Space Available
    $26 SF/Yr
    3,600 SF

    New Office Space Available

    Shell space in a new building, build-out to suit.

    609 2nd Loop Rd, Florence, SC 29505
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    Retail Space in Regional Destination
    $22 SF/Yr
    4,475 SF

    Retail Space in Regional Destination

    Retail spaces available in premier shopping destination near major highways.

    110 Woody Jones Blvd, Florence, SC
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    Prime Land for Lease
    Contact for pricing

    Prime Land for Lease

    Strategically located land parcel with high visibility and access.

    3335 Sneed Rd, Florence, SC
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    Downtown Florence Open Concept Office
    $226 SF/Yr

    Downtown Florence Open Concept Office

    Open concept office space with exceptional visibility in Downtown Florence.

    620 W Evans St, Florence, SC 29501
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    Office/Storage Space For Lease
    $10 SF/Yr
    2,300 SF

    Office/Storage Space For Lease

    Office or storage space with access to I-95 and I-20.

    1092 S Church St, Florence, SC 29506
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    Retail Space in Five Points
    $25 SF/Yr
    2,700 SF

    Retail Space in Five Points

    End-cap retail space in a high-traffic area for lease.

    1939 Hoffmeyer Rd, Florence, SC 29501
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    Florence County, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Florence County, SC with 35 listings featured on our commercial real estate exchange. The current inventory includes 185,213 square feet of properties with an estimated lease value of $536 /Mo.

    Estimated lease rates for Commercial real estate in Florence County, SC begin at $2 SF/Yr, with an average of $33 SF/Yr and extend to $216 SF/Yr.
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