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    Anderson County, SC Commercial Real Estate for Lease

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    Columbia, SC Greenville, SC Charleston, SC
    88 results
    Historic Pendleton Bank Retail Space
    $3,500 /Mo

    Historic Pendleton Bank Retail Space

    104 Exchange Street, Pendleton, SC 29670

    Renovated retail space in historic Pendleton Town Square.

    • Located on the charming Pendleton Town Square, near Clemson University.
    • Historic 1910 building, formerly the Pendleton Bank, undergoing complete renovation.
    • Approximately 1,550 sq ft of space including an extended annex.
    • Historic renovation to restore authenticity while incorporating modern standards.
    • Opportunity to take advantage of historic tax credits for upfit with early commitment.
    Updated: Feb 17
    View details
    Class A Office Space
    $3,400 /Mo

    Class A Office Space

    2315 N Main Street, Anderson, SC 29621

    Professional office suite for rent in Anderson, SC.

    • Prime Main Street location ideal for high‑visibility professional business.
    • Class A office building with included maintenance, electric, and water.
    • Versatile 2,800 sq ft suite suitable for medical or professional use.
    • Functional layout with five private offices, open floor plan, two restrooms, and a kitchen area.
    • Includes a welcoming reception area and large parking space.
    Updated: Nov 13, 2025
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    Downtown Anderson Commercial Space For Rent
    $1,150 /Mo

    Downtown Anderson Commercial Space For Rent

    Versatile 1,300 SF space in historic downtown Anderson.

    122 W Whitner Street, Anderson, SC 29624
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    Turnkey Restaurant Space in Iva
    $2,150 /Mo
    2,700 SF

    Turnkey Restaurant Space in Iva

    Move-in ready restaurant space with high visibility and convenient access.

    624 East Front Street, Iva, SC 29655
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    Flex Building with Office, Warehouse
    $4,000 /Mo
    3,200 SF

    Flex Building with Office, Warehouse

    Flex building with office and warehouse space for lease.

    109 Old Denver Road, Anderson, SC 29625
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    Historic Building in Pendleton Square
    $3,100 /Mo

    Historic Building in Pendleton Square

    Iconic building in a vibrant town square near Clemson.

    102 Exchange Street, Pendleton, SC 29670
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    Miracle Mile Commercial Building
    $9 SF/Yr
    4,000 SF

    Miracle Mile Commercial Building

    Approximately 4000 SF building for lease with high visibility.

    102 Miracle Mile Dr, Anderson, SC 29621
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    Renovated Office Building For Rent
    $1,300 /Mo
    1,300 SF

    Renovated Office Building For Rent

    Renovated office building with versatile space for rent.

    1311 South Murray Avenue, Anderson, SC 29624
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    Office Space Near Downtown Anderson
    $1,300 /Mo
    900 SF

    Office Space Near Downtown Anderson

    Office suite with three private offices, reception, and kitchenette.

    1214 North Main Street, Anderson, SC 29621
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    Downtown Anderson Flex Space Available
    $1,800 /Mo
    2,750 SF

    Downtown Anderson Flex Space Available

    Flex space for lease in downtown Anderson near redevelopments.

    114-118 Tribble St, Anderson, SC 29625
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    Modern Office Space Available
    $500 /Mo

    Modern Office Space Available

    Updated office space with 9 offices, conference room, and breakroom.

    521 N Mcduffie St, Anderson, SC 29621
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    Industrial Building in Anderson, SC
    $5,500 /Mo

    Industrial Building in Anderson, SC

    Industrial building suitable for wholesale distribution in Anderson, SC.

    1821 S McDuffie Street, Anderson, SC 29624
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    Retail Spaces Available For Lease
    $4 SF/Yr
    9,500 SF

    Retail Spaces Available For Lease

    Retail spaces for lease at 505-511 Sayre Street.

    505-511 Sayre Street, Anderson, SC 29624
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    Retail Space in Whitehall Commons
    $13 SF/Yr
    1,200 SF

    Retail Space in Whitehall Commons

    Retail or office space available in a high-traffic area.

    1486 Pearman Dairy Road, Anderson, SC 29625
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    Warehouse Building Near Anderson Airport
    $9 SF/Yr
    4,960 SF

    Warehouse Building Near Anderson Airport

    4960 SF warehouse space available for lease near airport.

    3226 Highway 24, Anderson, SC 29626
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    Downtown Anderson Retail Space Available
    $5,000 /Mo

    Downtown Anderson Retail Space Available

    Retail space available for lease in downtown Anderson, SC.

    151 E Church St, Anderson, SC 29624
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    Office Space Near Clemson Blvd
    $4,500 /Mo

    Office Space Near Clemson Blvd

    Strategically located office space off Anderson's premier commercial corridor.

    120 East West Parkway, Anderson, SC 29621
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    Retail Space Available for Lease
    $1,810 /Mo

    Retail Space Available for Lease

    Retail space available for lease in Anderson, South Carolina.

    2507 Whitehall Avenue, Anderson, SC 29621
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    Subdividable Manufacturing and Distribution Space
    $4 SF/Yr
    386,000 SF

    Subdividable Manufacturing and Distribution Space

    Approximately 386,000 sq ft available for lease near I-85.

    2415 Hwy 81, Anderson, SC 29621
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    Renovated Office/Retail Space Available
    $15 SF/Yr
    1,200 SF

    Renovated Office/Retail Space Available

    Newly renovated 1,200 SF office/retail space for lease.

    1207 Whitehall Road, Anderson, SC 29625
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    Former Sears Box in Mall
    Contact for pricing
    90,750 SF

    Former Sears Box in Mall

    90,750 SF retail space in Anderson Mall available for lease.

    3101 N Main St, Anderson, SC 29621
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    Clemson Boulevard Retail Opportunity
    $35 SF/Yr

    Clemson Boulevard Retail Opportunity

    Retail spaces available in Clemson Common Development, Anderson, SC.

    4629 Clemson Boulevard, Anderson, SC 29621
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    Retail Space at Anderson Mall
    Contact for pricing
    5,590 SF

    Retail Space at Anderson Mall

    Inline retail space available for lease in Anderson, SC.

    3131 N Main St, Anderson, SC 29621
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    Prime Corner Lot For Lease
    $120,000

    Prime Corner Lot For Lease

    1-acre hard corner lot available for ground lease or build-to-suit.

    4640 Clemson Blvd, Anderson, SC 29621
    View details

    Anderson County, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Anderson County, SC with 88 listings featured on our commercial real estate exchange. The current inventory includes 1,460,767,180 square feet of properties with an estimated lease value of $49 SF/Yr.

    Estimated lease rates for Commercial real estate in Anderson County, SC begin at $5 SF/Yr, with an average of $9 SF/Yr and extend to $15 SF/Yr.
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