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    South Carolina Medical Office Space for Lease

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    180 properties
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    Hospital-Anchored Medical Office Building
    Hospital-Anchored Medical Office Building

    986 Wellness Way, Fort Mill, SC 29715

    Contact for pricing
    1,831 sqft

    Three-story medical outpatient building with an enclosed walkway connection to Fort Mill Hospital–Piedmont Medical Center.

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    Two-Story Medical Office Suite
    Two-Story Medical Office Suite

    277 Willbrook Blvd., Unit B, Pawleys Island, SC 29585

    Contact for pricing
    2,420 sqft

    Configured with exam rooms, reception, patient waiting, and three restrooms.

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    Medical Office Suite with Studio Room
    Medical Office Suite with Studio Room

    102 Buford Avenue, Anderson, SC 29621

    Contact for pricing
    2,000 sqft

    Well-maintained medical/office suite includes multiple private offices and a large mirrored studio room for flexible use.

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    Turn-Key Medical Office Suite
    Turn-Key Medical Office Suite

    14 OAK FOREST RD, Bluffton, SC 29910

    Contact for pricing
    950 sqft

    Turn-key medical office suite with a waiting area, three exam rooms, private restroom, and kitchenette, ready for immediate occupancy.

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    Medical Office on Oakland Avenue
    Medical Office on Oakland Avenue

    356 Oakland Avenue, Rock Hill, SC 29732

    Contact for pricing
    3,600 sqft

    3,600 SF medical office space for lease in Rock Hill.

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    Medical Office Suite with Private Offices
    Medical Office Suite with Private Offices

    101 Rice Bent Way, Columbia, SC 29229

    Contact for pricing
    1,500 sqft

    Office suite includes five private offices, reception, conference room, break room, and two ADA restrooms.

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    Medical Office Space with Private Offices
    Medical Office Space with Private Offices

    1721 Ebenezer Rd, Rock Hill, SC 29732

    Contact for pricing
    2,588 sqft

    Second-floor office suite with a waiting area, seven private offices, and a break area in an established medical office complex.

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    Retail, Restaurant, or Medical Office
    Retail, Restaurant, or Medical Office

    2800 Rosewood Dr., Columbia, SC 29205

    Contact for pricing
    24,000 sqft

    Located in a Publix-anchored shopping center with high visibility.

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    Rock Hill Medical/Office Suites
    Rock Hill Medical/Office Suites

    420 S Herlong Ave, Rock Hill, SC 29732

    Contact for pricing
    2,100 sqft

    Medical/office suites in established Rock Hill medical complex for rent.

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    Second-Generation Medical Office
    Second-Generation Medical Office

    35 Ray E Talley Ct, Simpsonville, SC 29680

    Contact for pricing
    7,880 sqft

    Located near Fairview Road with convenient access to I-385.

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    Class A Medical Office Space
    Class A Medical Office Space

    85 Springview Ln, Summerville, SC 29485

    $18 SF/Yr

    Professional suites are available for specialty healthcare practices under NNN lease terms.

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    East Greenville Street Office Space
    East Greenville Street Office Space

    1403 East Greenville Street, Anderson, SC 29621

    Contact for pricing
    2,000 sqft

    Office or medical suite with ample parking and high visibility.

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    Medical Office Space with Marquee Signage
    Medical Office Space with Marquee Signage

    800 Pelham Rd, Greenville, SC 29615

    Contact for pricing

    Second-generation medical space with existing clinical lab infrastructure and free surface parking near Prisma and Bon Secours.

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    Medical Office Space Available
    Medical Office Space Available

    3221, 3223, 3225, & 3231 Sunset Blvd., West Columbia, SC 29169

    Contact for pricing
    39,722 sqft

    Accessible medical office space in a growing Columbia corridor.

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    Office/Medical Suite
    Office/Medical Suite

    1264 Ribaut Rd, Beaufort, SC 29902

    Contact for pricing
    1,484 sqft

    Suite offers a large open work area, two offices, data room, and one bathroom, plus washer/dryer hookups.

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    Greenville Office/Medical Space For Rent
    Greenville Office/Medical Space For Rent

    20 Creekview Ct, Greenville, SC

    Contact for pricing
    1,005 sqft 1.17 AC lot

    Office or medical space available in Greenville, SC.

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    Medical/Professional Office Suite
    Medical/Professional Office Suite

    3145 Carlisle St, Columbia, SC 29205

    Contact for pricing
    1,463 sqft

    Office suite offers a private office and conference room layout with parking and TI allowance included for interior upfit.

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    North Charleston Office Space Available
    North Charleston Office Space Available

    2070 Northbrook Blvd, North Charleston, SC

    Contact for pricing
    1,664 sqft 6.44 AC lot

    Office space for rent in North Rivers Business Center.

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    Medical Office Suite with Parking
    Medical Office Suite with Parking

    Rock Hill, SC 29732

    Contact for pricing
    3,675 sqft

    Former orthodontics office with existing medical buildout and entry access from the main parking area.

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    Medical Office Space with Multiple Offices
    Medical Office Space with Multiple Offices

    104 Florence Street SW, Aiken, SC 29801

    Contact for pricing

    Recently renovated medical office suite with multiple individual offices, waiting area, and several bathrooms.

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    Medical Office Space with New Roof
    Medical Office Space with New Roof

    90 Brighton Hill Rd, Columbia, SC 29223

    Contact for pricing
    6,564 sqft 1.75 AC lot

    Flexible medical office space on a substantial commercial parcel with GC zoning and updated building systems.

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    Medical/Professional Office Space Available
    Medical/Professional Office Space Available

    235 S. Herlong Avenue, Rock Hill, SC 29732

    Contact for pricing
    1,200 sqft

    Office space with frontage near Piedmont Medical Center.

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    Medical Office Condo End Cap
    Medical Office Condo End Cap

    5401 Netherby Lane Ste 601, North Charleston, SC 29420

    Contact for pricing

    End cap medical office condo with private offices, conference space, and parking within a professional park.

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    Single-Story Retail Office Medical Building
    Single-Story Retail Office Medical Building

    128 Bluffton Rd, Bluffton, SC 29910

    Contact for pricing
    2,730 sqft

    Pre-leasing is underway for a single-story retail, office, and medical building with a planned Fall 2026 delivery.

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