Buffalo, NY Medical offices for Rent & Lease

Spacious Commercial Building, Buffalo, NY

$499,900

5,012 SF

Spacious Commercial Building, Buffalo, NY

1609 Genesee St, Buffalo, NY 14211

Versatile commercial building with parking, suitable for various businesses.

High‑visibility location on Genesee St with oversized parking lot (25+ spaces).
Over 5,000 sq. ft. of versatile commercial space suitable for various business types.
Fully accessible with elevator, wheelchair ramp, and wide hallways.
Valid Certificate of Occupancy and ready for immediate use.
Two‑story brick building with 4 bathrooms, laundry areas on each level, and kitchen area.

Updated: Dec 3, 2025

View details

Jefferson Utica Plaza: Medical & Office Space

$8 SF/Yr

28,290 SF

Jefferson Utica Plaza: Medical & Office Space

1307 Jefferson Ave, Buffalo, NY 14208

Prime Erie County medical/office suites available.

28,290 SF multi‑tenant office/retail building in Erie County.
1,432 SF minimum divisible space, up to 10,298 SF contiguous.
13,800 SF of vacant space available.
Class B building, constructed in 1988, single‑story with 105 parking spaces.
Located at the high‑traffic intersection of Jefferson Avenue and E Utica Street, zoned D‑S (Retail Strip).

Updated: Dec 11, 2024

View details

Contact for pricing

18,607 SF

West Seneca Medical Office Space

Prime Medical Office Suites Available in Buffalo, NY

550 Orchard Park Rd, West Seneca, NY 14224

View details

$13 SF/Yr

76,088 SF

170 Franklin Street Office Space

Historic Downtown Buffalo Office Building

172 Franklin St, Buffalo, NY 14202

View details

$14 SF/Yr

36,399 SF

Main Street Office Building

Prime Buffalo Office Space, 1,331-12,133 SF

1010 Main Rd, Buffalo, NY 14202

View details

$16 SF/Yr

38,450 SF

Delaware Ave Office Space

Prime Buffalo Office, 1,196 SF Available

936 Delaware Ave, Buffalo, NY 14209

View details

$21 SF/Yr

32,211 SF

1115 Main St Office Space

Prime Buffalo Medical Campus Office

1115 Main Rd, Buffalo, NY 14209

View details

$10 SF/Yr

11,512 SF

Prime Williamsville Office Building

11,512 SF Executive/Medical Office

8705 Sheridan Dr, Buffalo, NY 14221

View details

$240 SF/Yr

15,181 SF

West Seneca Office Space Available

15,181 SF Office Building, 5,940 SF Vacant

1900 Ridge Rd, West Seneca, NY 14224

View details

$22 SF/Yr

51,552 SF

110 Broadway Office Space

Downtown Buffalo Office Building, Multiple Suites Available

110 Broadway St, Buffalo, NY 14203

View details

$17 SF/Yr

38,682 SF

Prime Buffalo Office Space

10,000+ SF Available, Main Street Location

1100 Main Rd, Buffalo, NY 14209

View details

$8 SF/Yr

12,270 SF

Kenmore Ave Office Suites

Buffalo Office Space: Flexible Lease Options

974-976 Kenmore Ave, Buffalo, NY 14216

View details

$15 SF/Yr

15,696 SF

Prime Buffalo Office Space

Class A Office Suites Available

531 Farber Lakes Dr, Buffalo, NY 14221

View details

$19 SF/Yr

40,000 SF

Williamsville Medical Office Building

Class A Office Space, Flexible Lease Options

1150 Youngs Rd, Buffalo, NY 14221

View details

$19 SF/Yr

109,880 SF

270 Michigan Ave Office Space

Buffalo CBD Office, Retail, Industrial

270 Michigan Ave, Buffalo, NY 14203

View details

$12 SF/Yr

4,800 SF

Elmwood Ave Office Space For Lease

Versatile Office Building, 4,500 SF Available

2282 Elmwood Ave, Buffalo, NY 14217

View details

$18 SF/Yr

79,112 SF

University Commons Office Park

Amherst Office Space: 1,395-2,666 SF Available

1400-1416 Sweet Home Rd, Buffalo, NY 14228

View details

$9 SF/Yr

5,921 SF

Buffalo Office Space: Chandler St.

Modern Office Suites in Buffalo, NY

155 Chandler St, Buffalo, NY 14207

View details

$16 SF/Yr

4,309 SF

Ellicott Street Office Space Available

Versatile Office Space, Prime Location

969 Ellicott St, Buffalo, NY 14209

View details

$22 SF/Yr

11,000 SF

1088 Niagara St Office Space

West Buffalo Office/Retail Opportunity

1088 Niagara St, Buffalo, NY 14213

View details

Contact for pricing

10,228 SF

Amherst Medical Office Suite

1,400 SF Medical Office, High Visibility

1630 Maple Rd, Buffalo, NY 14221

View details

$31 SF/Yr

194,500 SF

1091 Main Street Office Space

Modern Buffalo Office Building, Multiple Suites Available

1091 Main Rd, Buffalo, NY 14209

View details

$16 SF/Yr

12,000 SF

Prime Buffalo Office Building

12,000 SF Office, Sale/Lease

2060 Sheridan Dr, Buffalo, NY 14223

View details

$11 SF/Yr

300,000 SF

295 Main Rd

Medical offices • 300,000 SF

295 Main Rd, Buffalo, NY 14203

View details

Buffalo, NY Medical offices Leasing Opportunities Market Analysis

Explore Medical offices leasing options in Buffalo, NY with 79 listings featured on our commercial real estate exchange. The current inventory includes 58,001,533,920 square feet of properties with an estimated lease value of $812 /Mo.

Estimated lease rates for Medical offices in Buffalo, NY begin at $8 SF/Yr, with an average of $23 SF/Yr and extend to $240 SF/Yr.

Buffalo, NY Medical Offices for Lease

Spacious Commercial Building, Buffalo, NY

Versatile commercial building with parking, suitable for various businesses.