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    South Carolina Commercial Real Estate for Lease

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    Columbia, SC Greenville, SC Charleston, SC
    Showing 24 of 3,221 results
    James Island Office Space Available
    $20 SF/Yr
    2,200 SF

    James Island Office Space Available

    Office space for lease in a convenient Charleston location.

    125 Wappoo Creek Dr, Charleston, SC 29412
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    Retail Space on Socastee Boulevard
    $16 SF/Yr

    Retail Space on Socastee Boulevard

    Retail space in high-traffic Myrtle Beach location.

    4659 Socastee Blvd, Myrtle Beach, SC 29588
    View details
    Class A Medical Office Building
    $28 SF/Yr
    14,084 SF

    Class A Medical Office Building

    Renovated medical/office building with ample parking in Mt. Pleasant.

    1200 Innovation Way, Mount Pleasant, SC 29466
    View details
    Flex Space Near Interstate I-26
    $15 SF/Yr
    2,520 SF

    Flex Space Near Interstate I-26

    Professional flex and light manufacturing space with easy interstate access.

    104 Corporate Boulevard, West Columbia, SC 29169
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    Oceanfront Retail Space Available
    $24 SF/Yr
    2,200 SF

    Oceanfront Retail Space Available

    Prime retail space near campgrounds, available Q1 2026.

    5905 S Kings Hwy, Myrtle Beach, SC 29575
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    Retail Space in Whitehall Commons
    $13 SF/Yr
    1,200 SF

    Retail Space in Whitehall Commons

    Retail or office space available in a high-traffic area.

    1486 Pearman Dairy Road, Anderson, SC 29625
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    Class A Office Space Available
    $34 SF/Yr
    8,452 SF

    Class A Office Space Available

    Four-story, 102,024 SF Class A office building for lease.

    4401 Leeds Avenue, North Charleston, SC 29405
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    Remodeled Restaurant Space on Main
    $2,000/Mo

    Remodeled Restaurant Space on Main

    Prime restaurant property in a high-traffic, growing tourist area.

    100 -102 W Main Street, Walhalla, SC 29691
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    Functional Space in Sea Island
    $12 SF/Yr
    2,710 SF

    Functional Space in Sea Island

    2,710 SF warehouse and office space for lease.

    3609 River Road, Johns Island, SC 29455
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    Warehouse Building Near Anderson Airport
    $9 SF/Yr
    4,960 SF

    Warehouse Building Near Anderson Airport

    4960 SF warehouse space available for lease near airport.

    3226 Highway 24, Anderson, SC 29626
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    Loft Retail and Office Space
    $20 SF/Yr
    20,000 SF

    Loft Retail and Office Space

    Retail and office spaces in historic Woodside Mill district.

    1 E Main Street, Greenville, SC 29611
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    Class A Office Space Available
    $24 SF/Yr
    3,607 SF

    Class A Office Space Available

    Office space available November 2025 in Myrtle Beach, SC.

    2050 Corporate Center Dr., Myrtle Beach, SC 29577
    View details
    Prime Office Space on Devine
    $23 SF/Yr
    12,200 SF

    Prime Office Space on Devine

    Office space for lease in the Devine Street District.

    2422 Devine Street, Columbia, SC 29205
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    Industrial Building Near GSP Airport
    $16 SF/Yr
    5,000 SF

    Industrial Building Near GSP Airport

    Industrial building for lease near I-85 and GSP International Airport.

    2581 E Phillips Rd, Greer, SC 29650
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    Retail Center in North Myrtle Beach
    $20 SF/Yr
    185,000 SF

    Retail Center in North Myrtle Beach

    Retail center in the heart of North Myrtle Beach retail corridor.

    200 Highway 17 North, North Myrtle Beach, SC 29582
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    Myrtle Beach Office Space Available
    $3,250/Mo
    2,400 SF

    Myrtle Beach Office Space Available

    Office space for rent in Myrtle Beach, South Carolina.

    1455 Commerce Pl., Myrtle Beach, SC 29577
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    Highway 170 Retail/Office/Medical Space
    $36 SF/Yr

    Highway 170 Retail/Office/Medical Space

    Retail, office, or medical space for lease on Highway 170.

    48 Terrace Drive, Okatie, SC 29909
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    Premier Greenville Office Complex
    $19 SF/Yr
    1,422 SF

    Premier Greenville Office Complex

    Variety of office spaces with extensive upgrades and easy access.

    37 Villa Rd, Greenville, SC 29615
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    Warehouse with Secured Yard
    $12 SF/Yr
    5,000 SF

    Warehouse with Secured Yard

    5,000 SF warehouse with office and secured yard.

    125 North Shorecrest Drive, Columbia, SC 29209
    View details
    Flex Space Near I-26
    $10 SF/Yr
    3,000 SF

    Flex Space Near I-26

    3,000 SF flex space with office, warehouse, and laydown yard.

    7120 Broad River Road, Irmo, SC 29063
    View details
    Prime Retail Space on George
    $45 SF/Yr
    2,030 SF

    Prime Retail Space on George

    Retail space for lease in downtown Charleston near King Street.

    51 George Street, Charleston, SC 29401
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    Retail Space in Calhoun Falls
    $10 SF/Yr
    9,014 SF

    Retail Space in Calhoun Falls

    9,014 SF retail space for lease in Calhoun Falls.

    274 E Savannah St, Calhoun Falls, SC 29628
    View details
    Class A Office Space
    $43 SF/Yr
    9,675 SF

    Class A Office Space

    Multi-tenant office building in Charleston's Historic District.

    100 Calhoun Street, Charleston, SC 29401
    View details
    Forestbrook Road Office Space
    $16 SF/Yr
    1,400 SF

    Forestbrook Road Office Space

    1,400 SF office space in Myrtle Beach for lease.

    2523 Forestbrook Road, Unit D, Myrtle Beach, SC 29579
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