Florence County, SC Commercial real estate for sale

Updated: Aug 12

Historic Storefront Building

165 W Main Street, Timmonsville, SC 29161

$150,000

10,260 sqft 0.25 AC lot

10,260 square feet of commercial building space
0.25‑acre corner parcel on W Main Street
1920 construction with original brick character
Newly installed upstairs windows
Tile and wood flooring

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Updated: May 19

Heavy Truck Repair Shop

N Cashua Dr., Florence, SC 29501

$580,000

1,000 sqft 2.00 AC lot

Established heavy truck and mobile repair franchise serving commercial fleets and roadside service customers
Contracts in place with 16 national and regional commercial fleet accounts
Sale includes equipment, inventory, operational systems, trade secrets, customer relationships, and training
Mobile service capability supports fleet assistance throughout the Florence market
1,000‑square‑foot facility situated on 2 acres

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Historic Office Building

248-260 W Evans st., Florence, SC 29501

$2,700,000

16,304 sqft 1.47 AC lot

Established professional layout with multiple occupants, meeting rooms, reception space, and dedicated parking in downtown Florence.

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Freestanding Storefront Building

205 W Main St, Lake City, SC 29560

$700,000

5,410 sqft

Downtown setting near businesses, banks, restaurants, and public services supports multiple commercial use options.

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Church Property with Classrooms

111 Williams Blvd., Florence, SC 29501

$350,000

2,968 sqft 2.00 AC lot

A roughly two-acre site includes a sanctuary, educational rooms, and central air conditioning.

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Fully Occupied Shopping Center

823-817 S Cashua Drive, Florence, SC 29501

$1,550,000

15,450 sqft

Two connected buildings provide an established retail configuration with GC zoning and a Walmart Neighborhood Market across S. Cashua Drive.

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Medical Office with Exam Rooms

1706 2nd Loop Rd., Florence, SC 29501

$1,650,000

8,291 sqft 1.34 AC lot

Brick medical facility with exam rooms, administrative offices, covered patient arrival, and dedicated on-site parking.

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Historic Downtown Office Building

260 W Evans St, Florence, SC 29501

$2,700,000

16,000 sqft 1.47 AC lot

A 16,000-square-foot historic office building with multiple suites, including a law firm and other tenants, plus over 100 parking spaces.

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Vacant Specialty Property

818 S Cashua Drive, Florence, SC 29501

$265,000

2,422 sqft 0.37 AC lot

Vacant brick building with mixed flooring, heat pump heating, and central air conditioning.

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Day Care Center with Frontage

822 S Cashua, Florence, SC 29501

$285,000

2,067 sqft 0.60 AC lot

Existing daycare facility with direct frontage on S Cashua and an as-is sale condition.

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Manufacturing Facility with Land

253 S Hampton Ave, Johnsonville, SC 29555

$679,000

35,736 sqft 8.72 AC lot

The property combines a large building with an extensive land component for manufacturing and warehouse uses.

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Cleared Commercial Land

207 S Irby St., Florence, SC 29501

$699,000

0.52 AC lot

Level, cleared parcel with utilities available for commercial development.

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Commercial Land Along Four-Lane Corridor

917 S Cashua Drive, Florence, SC 29501

$850,000

4.76 AC lot

High, level parcel near retail, grocery, restaurant, and service businesses along a four-lane commercial corridor.

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Storefront Property with Parking

208 W Broadway St., Johnsonville, SC 29555

$399,000

9,000 sqft

Commercial building with an adaptable layout near stores and established businesses.

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Corner Commercial Land

TBD Hwy 51 Pamplico Hwy, Florence, SC 29505

$250,000

1.30 AC lot

B-3-zoned parcel positioned at the intersection of Pamplico Hwy and E Broach Street in Florence.

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Private Airport Hangar

715 Pilots Lane, Timmonsville, SC 29161

$119,900

0.08 AC lot

Steel aviation facility with runway access, electrical service, storage shelving, and a recently replaced fiberglass door.

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Historic Downtown Florence Building For Sale

248,258, and 268 W. Evans St., Florence, SC 29501

$2,700,000

16,304 sqft 1.47 AC lot

16,000 SF historic building in downtown Florence for sale.

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Unzoned Commercial Land

880 Freedom Boulevard, Florence, SC 29506

$1,800,000

59.44 AC lot

Unzoned commercial tract with water and sewer on site and flexibility for varied land-use plans.

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Storefront Building with Rear Parking

105 W Main St, Lake City, SC 29560

$247,000

2,425 sqft 0.50 AC lot

Storefront building with flexible interior space, tin ceilings, and a rear lot that supports parking and future expansion.

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Commercial Land at Interstate Exit

Cale Yarborough HWY, Timmonsville, SC 29161

$225,000

3.03 AC lot

Commercial-zoned acreage with public water and sewer access at a major interstate interchange.

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Commercial Land with Utilities

3104 Hoffmeyer Road, Florence, SC 29501

$1,600,000

4 sqft

Public sewer is installed, with water, electricity, and high-speed internet available for future development.

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Corner Commercial Land

360 S Ron McNair Blvd, Lake City, SC 29560

$59,900

1,200 sqft 0.12 AC lot

Corner commercial parcel with brick construction, concrete flooring, and central air.

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Former Talon Zipper Plant

701 South Ron McNair Boulevard |, Lake City, SC 29560

$1,470,350

105,000 sqft 20.00 AC lot

Manufacturing/warehouse space on 20 acres near airport runway.

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Highway Commercial Land

791 S Ron McNair Blvd., Lake City, SC 29560

$599,000

2.90 AC lot

Commercial land with GC zoning, planned structure removal, and access to an established industrial and commercial corridor.

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Florence County, SC Commercial Real Estate Market Trends and Statistics

Explore 124 commercial real estate for sale in Florence County, SC, showcased through 124 active listings on our real estate platform. These investment opportunities span a total of 951,499 square feet of properties for sale, with an estimated market value of $49,802,602.

Sale prices for business properties in Florence County, SC start at $32,725, averaging $830,043, and reaching up to $5,250,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.