Florence County, SC Commercial real estate for sale

Updated: Aug 11

Storefront with Original Brick

165 W Main Street, Timmonsville, SC 29161

$150,000

10,260 sqft 0.25 AC lot

10,260‑square‑foot storefront property on a 0.25‑acre lot
Prominent corner position along Main Street in downtown Timmonsville
Upper‑level area includes newly installed windows
Original brick architectural character remains in the building
Built in 1920 with tile and wood flooring

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Updated: Aug 10

Storefront Property with Loading Dock

208 W Broadway St., Johnsonville, SC 29555

$399,000

9,000 sqft 1.40 AC lot

9,000 square feet of commercial space on 1.4 acres
Loading dock and truck doors included
440‑Volt Power and fire alarm system
Inside and outside storage areas
Private restrooms with handicap access

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Heavy Truck Repair Shop

N Cashua Dr., Florence, SC 29501

$580,000

1,000 sqft 2.00 AC lot

Established mobile repair franchise serving commercial fleets and roadside service customers.

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Freestanding Storefront Building

205 W Main St, Lake City, SC 29560

$700,000

5,410 sqft

Downtown setting near businesses, banks, restaurants, and public services supports multiple commercial use options.

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Historic Office Building

248-260 W Evans st., Florence, SC 29501

$2,700,000

16,304 sqft 1.47 AC lot

Established professional layout with multiple occupants, meeting rooms, reception space, and dedicated parking in downtown Florence.

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Office Building with Central Air

2228 W Palmetto St., Florence, SC 29501

$225,000

1,405 sqft 0.31 AC lot

Wood-frame office property with wood flooring, heat-pump heating, and a central air-conditioning system.

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Fully Occupied Shopping Center

823-817 S Cashua Drive, Florence, SC 29501

$1,550,000

15,450 sqft

Two connected retail buildings sit across from a Walmart Neighborhood Market.

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Historic Downtown Office Building

260 W Evans St, Florence, SC 29501

$2,700,000

16,000 sqft 1.47 AC lot

A 16,000-square-foot historic office building with multiple suites, including a law firm and other tenants, plus over 100 parking spaces.

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Medical Office with Exam Rooms

1706 2nd Loop Rd., Florence, SC 29501

$1,650,000

8,291 sqft 1.34 AC lot

Brick medical facility with exam rooms, administrative offices, covered patient arrival, and dedicated on-site parking.

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Vacant Specialty Property

818 S Cashua Drive, Florence, SC 29501

$265,000

2,422 sqft 0.37 AC lot

Vacant brick building with mixed flooring, heat pump heating, and central air conditioning.

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Manufacturing Facility with Land

253 South Hampton Avenue, Johnsonville, SC 29555

$679,000

35,736 sqft 8.72 AC lot

The property combines a large building with an extensive land component for manufacturing and warehouse uses.

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Day Care Center with Frontage

822 S Cashua, Florence, SC 29501

$285,000

2,067 sqft 0.60 AC lot

Existing daycare facility with direct frontage on S Cashua and an as-is sale condition.

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Commercial Land Along Four-Lane Corridor

917 S Cashua Drive, Florence, SC 29501

$850,000

4.76 AC lot

High, level parcel near retail, grocery, restaurant, and service businesses along a four-lane commercial corridor.

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Storefront Property with Parking

208 W Broadway St, Johnsonville, SC 29555

$399,000

9,000 sqft

Commercial building with an adaptable layout near stores and established businesses.

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Remodeled Office Building

910 W Evans st, Florence, SC 29501

$300,000

2,165 sqft 0.27 AC lot

Five-room commercial layout with a kitchen, full bathroom, and additional half bath.

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Cleared Commercial Land

207 S Irby St., Florence, SC 29501

$699,000

0.52 AC lot

Level, cleared parcel with utilities available for commercial development.

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Historic Downtown Florence Building For Sale

248,258, and 268 W. Evans St., Florence, SC 29501

$2,700,000

16,304 sqft 1.47 AC lot

16,000 SF historic building in downtown Florence for sale.

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Private Airplane Hangar

715 Pilots Lane, Timmonsville, SC 29161

$119,900

0.08 AC lot

Steel airplane hangar with concrete floor, electricity, built-in shelving, and a new fiberglass door at a private airport.

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Storefront Building with Rear Parking

105 W Main St, Lake City, SC 29560

$247,000

2,425 sqft 0.50 AC lot

Storefront building with flexible interior space, tin ceilings, and a rear lot that supports parking and future expansion.

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Commercial Land at Interstate Exit

Cale Yarborough HWY, Timmonsville, SC 29161

$225,000

3.03 AC lot

Commercial-zoned acreage with public water and sewer access at a major interstate interchange.

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Commercial Land with Utilities

3104 Hoffmeyer Road, Florence, SC 29501

$1,600,000

4 sqft

Public sewer is installed, with water, electricity, and high-speed internet available for future development.

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Unzoned Commercial Land Tract

880 Freedom Blvd, Florence, SC 29506

$1,900,000

59.44 AC lot

Large unzoned tract with existing water and sewer infrastructure and flexible land-use potential.

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Former Talon Zipper Plant

701 South Ron McNair Boulevard |, Lake City, SC 29560

$1,470,350

105,000 sqft 20.00 AC lot

Manufacturing/warehouse space on 20 acres near airport runway.

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Highway Commercial Land

791 S Ron McNair Blvd., Lake City, SC 29560

$599,000

2.90 AC lot

Commercial land with GC zoning, planned structure removal, and access to an established industrial and commercial corridor.

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Florence County, SC Commercial Real Estate Market Trends and Statistics

Explore 182 commercial real estate for sale in Florence County, SC, showcased through 182 active listings on our real estate platform. These investment opportunities span a total of 1,721,045 square feet of properties for sale, with an estimated market value of $48,866,502.

Sale prices for business properties in Florence County, SC start at $32,725, averaging $740,401, and reaching up to $4,950,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.