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    Florence County, SC Commercial Real Estate for Sale

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    Columbia, SC Greenville, SC Spartanburg, SC
    129 results
    Historic Downtown Office Building
    $2,700,000
    16,304 SF

    Historic Downtown Office Building

    248-260 W Evans st., Florence, SC 29501

    Historic office building with multiple suites and ample on-site parking in downtown Florence.

    • 16,000 SF historic building built in 1939 in Downtown Florence
    • Tenant space includes a law firm (13,759 SF) with 23 offices, 7 bathrooms, 8 boardrooms/meeting spaces, kitchen, library, and reception/waiting area
    • Additional tenants include H&R Block (1,977 SF) and Smith Hair Studio (568 SF)
    • Set on 1.47 acres with over 100 parking spaces
    • Heating includes electric and heat pump; cooling is central air
    Updated: Mar 14
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    Office Property with Parking
    $250,000
    1,405 SF

    Office Property with Parking

    2228 W Palmetto St., Florence, SC 29501

    Office space on a 0.31-acre lot with parking and strong visibility along W Palmetto St in Florence.

    • Commercial property located along high‑traffic W Palmetto St in Florence
    • Wood frame construction with wood flooring
    • Central air and heat pump heating
    • Generous lot with ample space for parking, expansion, or business use
    • Suitable for uses such as a tax office, professional services, or small business operations
    Updated: May 4
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    Remodeled Medical Office Building
    $320,000
    2,165 SF

    Remodeled Medical Office Building

    Turnkey, fully remodeled office building with five rooms and private patient or work-ready treatment configurations.

    910 W Evans st, Florence, SC 29501
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    Fully Occupied Retail Center
    $1,650,000
    15,450 SF

    Fully Occupied Retail Center

    Retail center in good condition with high traffic count.

    823-817 S Cashua Drive, Florence, SC 29501
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    Vacant Specialty Commercial Building
    $265,000
    2,422 SF

    Vacant Specialty Commercial Building

    Vacant specialty building sold as-is, with access via a Sentri lockbox at the back door near a small patio.

    818 S Cashua Drive, Florence, SC 29501
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    Commercial Land with Water and Sewer
    $225,000
    3.03 Acres

    Commercial Land with Water and Sewer

    Commercial tract off I-95 with public water and sewer access and a rear easement for smaller tenant opportunities.

    Cale Yarborough HWY, Timmonsville, SC 29161
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    Day Care Center For Sale
    $285,000
    2,067 SF

    Day Care Center For Sale

    Existing day care center offered as-is with special showing requirements and lockbox access on the back door.

    822 S Cashua, Florence, SC 29501
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    Buildable Retail Development Land
    $1,500,000
    7.27 Acres

    Buildable Retail Development Land

    Level, buildable two-parcel land package suited for a range of retail and service-oriented development uses.

    3312 Meadors Road, Florence, SC 29501
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    Development-Ready Commercial Land Site
    $980,000
    4.76 Acres

    Development-Ready Commercial Land Site

    4.76-acre B3-zoned parcel on a four-lane corridor with SCDOT-reported traffic near major daily-use anchors.

    917 S Cashua Drive, Florence, SC 29501
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    Prime Commercial Land Opportunity
    $599,000
    2.90 Acres

    Prime Commercial Land Opportunity

    2.9-acre commercial site in Lake City, SC.

    791 S Ron McNair Blvd., Lake City, SC 29560
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    78.4 Acres Farmland with Home
    $515,000
    1,376 SF

    78.4 Acres Farmland with Home

    78.4 acres featuring cropland, wetlands, and a 1,376-SF home.

    711 Cade Rd., Lake City, SC 29560
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    Florence Office Building For Sale
    $1,500,000
    7,517 SF

    Florence Office Building For Sale

    7,517 SF office building on 1.34 acres in Florence.

    1706 Second Loop Rd., Florence, SC 29501
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    Industrial Property with Warehouse and Pond
    $1,149,000
    158.59 Acres

    Industrial Property with Warehouse and Pond

    Large acreage with a metal warehouse, finished back room, roll-up door, and a stocked pond with dock.

    1315 Hill Harrell Road, Effingham, SC 29541
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    Corner Commercial Development Lot
    $59,900
    1,200 SF

    Corner Commercial Development Lot

    Corner commercial lot on a major route between Florence and Charleston, suited for office, retail, or restaurant development.

    360 S Ron McNair Blvd, Lake City, SC 29560
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    Prime Commercial Site on Highway
    $599,000
    2.90 Acres

    Prime Commercial Site on Highway

    Development opportunity in high-traffic commercial corridor near industrial area.

    791 S Ron McNair Blvd, Lake City, SC 29560
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    Lake City Acreage For Sale
    $125,000
    13.32 Acres

    Lake City Acreage For Sale

    13.32 acres in Lake City, SC, ideal for development.

    13.32 Ac - 1014 W Highway 378 Bypass, Lake City, SC 29560
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    Commercial Land Opportunity
    $129,900
    4.00 Acres

    Commercial Land Opportunity

    4-acre commercial land in Florence County, positioned in a high-traffic area for a wide range of business uses.

    W Leggs Cir, Florence, SC 29501
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    B-6 Zoned Commercial Land Opportunity
    $47,900
    840 SF

    B-6 Zoned Commercial Land Opportunity

    B-6 zoned parcel suited for a range of commercial development options.

    720 S Barringer Street, Florence, SC 29506
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    Downtown Lake City Commercial Building
    $199,000
    2,500 SF

    Downtown Lake City Commercial Building

    2,500 sq ft commercial building in downtown Lake City.

    112 E Main St, Lake City, SC 29560
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    Commercial Land with Bus Terminal
    $395,000
    5,500 SF

    Commercial Land with Bus Terminal

    1.05-acre site with 5,500 SF bus terminal building.

    611 S Irby St, Florence, SC 29501
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    Olanta Commercial Building on US 301
    $60,000
    1,500 SF

    Olanta Commercial Building on US 301

    Commercial building in Olanta, SC, with multiple business possibilities.

    405 N Jones Road, Olanta, SC 29114
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    Florence Area Investment Opportunity
    Contact for pricing

    Florence Area Investment Opportunity

    Prime land in Florence, SC, with development potential.

    5723 E National Cemetery Rd, Florence, SC 29506
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    Florence Commercial Land For Sale
    $792,792
    1.82 Acres

    Florence Commercial Land For Sale

    1.82 acre commercial land near I-95 in Florence, SC.

    Presbyterian Road, Florence, SC 29501
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    Commercial Corner Land Parcel
    $125,000
    0.10 Acres

    Commercial Corner Land Parcel

    Corner lot in Commercial zoning, suited for buyers looking to develop on a small in-fill site.

    360 N Dargan St, Florence, SC 29501
    View details

    Florence County, SC Commercial Real Estate Investment Opportunities Market Analysis

    Explore 129 commercial real estate for sale in Florence County, SC, showcased through 129 active listings on our real estate platform. These investment opportunities span a total of 1,192,918 square feet of properties for sale, with an estimated market value of $74,492,614.

    Sale prices for business properties in Florence County, SC start at $47,900, averaging $1,354,411, and reaching up to $16,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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