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Florence County, SC Commercial Real Estate for Sale

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Columbia, SC Greenville, SC Aiken, SC

148 results

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Remodeled Commercial Building Near Downtown

$340,000

2,165 SF

Remodeled Commercial Building Near Downtown

910 W Evans st, Florence, SC 29501

Turnkey commercial property in prime location with excellent visibility.

Completely remodeled/rebuilt from the ground up with new roof, HVAC, electrical, and plumbing.
Prime location minutes from downtown Florence with excellent visibility and access.
Turnkey property suitable for a medical office, salon, law firm, or small business.
Five spacious rooms that can serve as private offices or treatment spaces.
Modern kitchen with brand‑new cabinets and granite countertops.

Updated: Apr 1

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Historic Downtown Florence Commercial Building

$2,700,000

16,304 SF

Historic Downtown Florence Commercial Building

248-260 W Evans st., Florence, SC 29501

16,000 SF historic building in thriving downtown Florence.

Prime downtown Florence location in a thriving area.
Large 16,000 sq ft historic building with limitless potential.
Significant parking available (over 100 spaces), rare for downtown.
Versatile space currently configured with multiple tenants (Law Firm, H&R Block, Hair Studio).
Spacious 1.47‑acre lot allows for growth and development.

Updated: Mar 9

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$550,000

67,518 SF

Industrial Building in Florence, SC

Standalone industrial building suitable for various commercial and industrial uses.

121 Lawson St, Florence, SC 29501

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$1,305,000

4,125 SF

Established Auto Body Business For Sale

Turn-key auto body business with equipment, client roster, and real estate.

803 Ranch Rd., Florence, SC 29506

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Industrial Buildings with Power & Access

$199,000

40,000 SF

Industrial Buildings with Power & Access

Two industrial buildings ideal for fabrication, automotive, or storage.

120 N Guerry Street, Florence, SC 29501

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$980,000

4.76 Acres

Prime Commercial Development Site

4.76-acre commercial land with high traffic exposure in Florence, SC.

917 S Cashua Drive, Florence, SC 29501

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$599,000

2.90 Acres

Prime Commercial Lot on Highway

2.9-acre commercial site on S. Ron McNair Boulevard, Lake City.

791 S Ron McNair Blvd., Lake City, SC 29560

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$1,500,000

7.27 Acres

Prime Commercial Land Near I-95

7.27 acres of commercial land near I-95 in Florence, SC.

3312 Meadors Road, Florence, SC 29501

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$515,000

78.40 Acres

78.4 Acres with Cropland

78.4-acre property featuring cropland, wetlands, and a 1,376-square-foot home.

711 Cade Rd., Lake City, SC 29560

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$265,000

2,422 SF

Prime Location Commercial Land

Commercial land in a prime location, sold as is.

818 S Cashua Drive, Florence, SC 29501

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$79,000

1,200 SF

Florence Commercial Building on Evans

Standalone building on Evans Street with redevelopment potential.

617 W Evans St, Florence, SC 29501

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$59,900

1,200 SF

Downtown Lake City Commercial Lot

Commercial lot in downtown Lake City, South Carolina.

360 S Ron McNair Blvd, Lake City, SC 29560

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$285,000

2,067 SF

Commercial Property Near Walmart Market

Commercial property for sale next to Walmart market in Florence.

822 S Cashua, Florence, SC 29501

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$99,000

2.00 Acres

Prime Land in Pamplico, SC

Two-acre commercial land with high visibility and road frontage.

S Pamplico Highway, Pamplico, SC 29583

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$155,000

13.32 Acres

Lake City Acreage For Sale

13.32 acres in Lake City, SC, ideal for development.

13.32 Ac - 1014 W Highway 378 Bypass, Lake City, SC 29560

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$90,000

0.22 Acres

Land Near Walmart Market

Commercial land for sale next to Walmart Market.

2416 W Delmae Dr, Florence, SC 29501

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$129,900

4.00 Acres

Prime Commercial Land Opportunity

4-acre commercial land in high-traffic Florence County.

TBD W Leggs Cir, Florence, SC 29501

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$114,900

7.11 Acres

Cleared and Wooded Land

7.11 acres of land in Johnsonville, South Carolina.

Lot 4 Sheila Dr., Johnsonville, SC 29555

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$49,900

840 SF

Florence Commercial Land For Sale

B-6 zoned property with commercial and redevelopment options.

720 S Barringer, Florence, SC 29506

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$396,396

0.91 Acres

Florence Commercial Land For Sale

0.91 acre commercial land parcel in Florence, South Carolina.

Presbyterian Road, Florence, SC 29501

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$144,000

20.00 Acres

20 Acres Vacant Land

20-acre tract suitable for small farm or recreational use.

00 East Myrtle Beach Highway TRACT 4, Johnsonville, SC 29555

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$180,000

25.00 Acres

25 Acres Near Great Pee Dee

25-acre tract suitable for small farm or recreational use.

00 East Myrtle Beach Highway TRACT 3, Johnsonville, SC 29555

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Riverfront Land with Development Potential

$660,000

120.00 Acres

Riverfront Land with Development Potential

120-acre riverfront tract ideal for recreation, agriculture, and investment.

00 East Myrtle Beach Highway TRACT 1 Johnsonville, SC 29555, Johnsonville, SC 29555

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$792,792

1.82 Acres

Florence Commercial Land For Sale

1.82 acre commercial land near I-95 in Florence, SC.

TBD Presbyterian Road, Florence, SC 29501

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Florence County, SC Commercial Real Estate Investment Opportunities Market Analysis

Explore 148 commercial real estate for sale in Florence County, SC, showcased through 148 active listings on our real estate platform. These investment opportunities span a total of 24,851,416 square feet of properties for sale, with an estimated market value of $21,769,397.

Sale prices for business properties in Florence County, SC start at $31,000, averaging $435,387, and reaching up to $4,092,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Florence County, SC Commercial Real Estate for Sale

Remodeled Commercial Building Near Downtown

Turnkey commercial property in prime location with excellent visibility.